H K Bayele

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Complementation of a glucose transporter mutant of Schizosaccharomyces pombe by a novel Trypanosoma brucei gene
    H K Bayele
    Department of Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    J Biol Chem 275:14217-22. 2000
  2. ncbi request reprint Versatile peptide dendrimers for nucleic acid delivery
    Henry K Bayele
    Department of Haematology, University College London, Royal Free Campus, London NW3 2PF, UK
    J Pharm Sci 94:446-57. 2005
  3. ncbi request reprint Simple shifts in redox/thiol balance that perturb blood coagulation
    Henry K Bayele
    Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, London NW3 2PF, UK
    FEBS Lett 510:67-70. 2002
  4. ncbi request reprint Triazinyl derivatives that are potent inhibitors of glucose transport in Trypanosoma brucei
    H K Bayele
    Department of Biochemistry, University of Bath, UK
    Parasitol Res 87:911-4. 2001
  5. ncbi request reprint Critical parameters for functional reconstitution of glucose transport in Trypanosoma brucei membrane vesicles
    H K Bayele
    Department of Biochemistry, University of Bath, Bath, UK
    Biochim Biophys Acta 1513:223-31. 2001
  6. doi request reprint Residual factor VIII-like cofactor activity of thioredoxin and related oxidoreductases
    Henry K Bayele
    Department of Haematology, Royal Free and University College Medical School, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    Biochim Biophys Acta 1800:398-404. 2010
  7. doi request reprint Divalent metal-dependent regulation of hepcidin expression by MTF-1
    Sara Balesaria
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
    FEBS Lett 584:719-25. 2010
  8. doi request reprint Trypanosoma brucei: a putative RNA polymerase II promoter
    Henry K Bayele
    Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Exp Parasitol 123:313-8. 2009
  9. doi request reprint Regulatory variation in hepcidin expression as a heritable quantitative trait
    Henry K Bayele
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
    Biochem Biophys Res Commun 384:22-7. 2009
  10. ncbi request reprint HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite
    Henry K Bayele
    Department of Biochemistry and Molecular Biology, University College London, NW3 2PF, United Kingdom
    Blood 110:3039-48. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Complementation of a glucose transporter mutant of Schizosaccharomyces pombe by a novel Trypanosoma brucei gene
    H K Bayele
    Department of Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    J Biol Chem 275:14217-22. 2000
    ..The kinetics of glucose uptake reflected those in T. brucei. In addition to complementation in yeast, we also showed that the gene enhanced glucose uptake in cultured mammalian cells...
  2. ncbi request reprint Versatile peptide dendrimers for nucleic acid delivery
    Henry K Bayele
    Department of Haematology, University College London, Royal Free Campus, London NW3 2PF, UK
    J Pharm Sci 94:446-57. 2005
    ..These vectors, therefore, have potential applications as epigenetic modifiers of gene function...
  3. ncbi request reprint Simple shifts in redox/thiol balance that perturb blood coagulation
    Henry K Bayele
    Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, London NW3 2PF, UK
    FEBS Lett 510:67-70. 2002
    ..These data also suggest that blood clotting may be influenced by unidentified redox or thiol equilibria...
  4. ncbi request reprint Triazinyl derivatives that are potent inhibitors of glucose transport in Trypanosoma brucei
    H K Bayele
    Department of Biochemistry, University of Bath, UK
    Parasitol Res 87:911-4. 2001
    ..This may suggest structural differences between the trypanosome and mammalian glucose transporters and also suggests that the triazine moiety may serve as a template for the design potent trypanocides targeted at the glucose transporter...
  5. ncbi request reprint Critical parameters for functional reconstitution of glucose transport in Trypanosoma brucei membrane vesicles
    H K Bayele
    Department of Biochemistry, University of Bath, Bath, UK
    Biochim Biophys Acta 1513:223-31. 2001
    ..A stoichiometry of 0.78 mol of glucose per mol of transporter was estimated...
  6. doi request reprint Residual factor VIII-like cofactor activity of thioredoxin and related oxidoreductases
    Henry K Bayele
    Department of Haematology, Royal Free and University College Medical School, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    Biochim Biophys Acta 1800:398-404. 2010
    ..Although the biochemistry of the cascade has been well studied, the molecular mechanism underlying the cofactor role of Factor VIII is not understood...
  7. doi request reprint Divalent metal-dependent regulation of hepcidin expression by MTF-1
    Sara Balesaria
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
    FEBS Lett 584:719-25. 2010
    ..These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins...
  8. doi request reprint Trypanosoma brucei: a putative RNA polymerase II promoter
    Henry K Bayele
    Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Exp Parasitol 123:313-8. 2009
    ..This suggests that the transcription machinery in the parasite may be very similar to those of other eukaryotes...
  9. doi request reprint Regulatory variation in hepcidin expression as a heritable quantitative trait
    Henry K Bayele
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
    Biochem Biophys Res Commun 384:22-7. 2009
    ..Thus, regulatory variation in hepcidin expression may be just as important as structural variation or mutations within its coding sequence...
  10. ncbi request reprint HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite
    Henry K Bayele
    Department of Biochemistry and Molecular Biology, University College London, NW3 2PF, United Kingdom
    Blood 110:3039-48. 2007
    ..This report also suggests that microsatellites may play critical roles in the directional evolution of complex heritable traits by regulating gene expression phenotypes...
  11. ncbi request reprint Delineation of epitopes on the Py235 rhoptry antigen of Plasmodium yoelii YM
    Henry K Bayele
    Division of Parasitology, National Institute for Medical Research, London, UK
    FEMS Immunol Med Microbiol 50:389-95. 2007
    ..Both epitopes were more reactive with protective than with nonprotective monoclonal antibodies. This may explain the differential protection conferred by these antibodies upon their passive transfer into mice...
  12. ncbi request reprint Plasmodium yoelii: combinatorial expression of variants of the 235 kDa rhoptry antigen during infection
    Henry K Bayele
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Exp Parasitol 116:354-60. 2007
    ..The implications of these observations are discussed with respect to the ability of a cloned parasite line to express distinct antigenic variants in vivo...
  13. ncbi request reprint Protein transduction by lipidic peptide dendrimers
    Henry K Bayele
    Department of Biochemistry and Molecular Biology, University College London, London NW3 2PF, United Kingdom
    J Pharm Sci 95:1227-37. 2006
    ..This finding has important implications for the use of these dendrimers in protein therapeutics and vaccinology...
  14. doi request reprint Isotopic biomarker discovery and application in translational medicine
    Henry K Bayele
    Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Drug Discov Today 15:127-36. 2010
    ..Here, we provide an overview of recent developments and some insight into the future role of isotopes in biomarker discovery and disease therapy...
  15. ncbi request reprint Cis and trans regulation of hepcidin expression by upstream stimulatory factor
    Henry K Bayele
    Department of Biochemistry and Molecular Biology, University College London, NW3 2PF, United Kingdom
    Blood 108:4237-45. 2006
    ..Taken together, it would appear that synergy between these members of the bHLH-ZIP family of transcriptional regulators may subserve an important role in iron metabolism as well as other pathways in which hepcidin may be involved...
  16. ncbi request reprint Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin
    Basharut A Syed
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, London NW3 2PF, UK
    Protein Eng 15:205-14. 2002
    ..The overall tertiary structure for the hephaestin and the putative residues involved in binding copper and iron appear to be highly conserved between these proteins, which suggests they share the same fold and a conserved function...