Marco Beato

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors
    James P Boorman
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London, WC1N 1AX United Kingdom
    J Biol Chem 278:44033-40. 2003
  2. ncbi Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation
    Valeria Burzomato
    The School of Pharmacy, London, United Kingdom
    Receptors Channels 9:353-61. 2003
  3. ncbi The activation mechanism of alpha1 homomeric glycine receptors
    Marco Beato
    Department of Pharmacology, University College London, WC1E 6BT, United Kingdom
    J Neurosci 24:895-906. 2004
  4. pmc Single-channel properties of glycine receptors of juvenile rat spinal motoneurones in vitro
    Marco Beato
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 580:497-506. 2007
  5. pmc The time course of transmitter at glycinergic synapses onto motoneurons
    Marco Beato
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 28:7412-25. 2008
  6. pmc Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice
    G S Bhumbra
    Department of Neuroscience, Physiology and Pharmacology, University College London London, UK
    Front Cell Neurosci 6:8. 2012
  7. pmc Determining the neurotransmitter concentration profile at active synapses
    Annalisa Scimemi
    Synaptic Physiology Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3701, USA
    Mol Neurobiol 40:289-306. 2009
  8. pmc The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531
    Marco Beato
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 580:171-9. 2007
  9. pmc Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound
    Marco Beato
    Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, United Kingdom
    J Gen Physiol 119:443-66. 2002
  10. ncbi Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens
    Valeria Burzomato
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 24:10924-40. 2004

Collaborators

Detail Information

Publications20

  1. ncbi The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors
    James P Boorman
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London, WC1N 1AX United Kingdom
    J Biol Chem 278:44033-40. 2003
    ..The shortening of the burst length of beta3-containing receptors implies that any synaptic currents mediated by such channels would have faster decay kinetics...
  2. ncbi Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation
    Valeria Burzomato
    The School of Pharmacy, London, United Kingdom
    Receptors Channels 9:353-61. 2003
    ..The magnitude of the leftward shift in the agonist dose-response curve for the two mutant combinations was in agreement with a subunit stoichiometry of 3alpha:2beta...
  3. ncbi The activation mechanism of alpha1 homomeric glycine receptors
    Marco Beato
    Department of Pharmacology, University College London, WC1E 6BT, United Kingdom
    J Neurosci 24:895-906. 2004
    ..Successive binding steps are not identical, implying that binding sites can interact while the channel is shut. These interactions can be interpreted in the light of the topology of the binding sites within a homopentamer...
  4. pmc Single-channel properties of glycine receptors of juvenile rat spinal motoneurones in vitro
    Marco Beato
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 580:497-506. 2007
    ..Our results suggest that glycine receptors on ventral horn neurones in the juvenile rat are heteromers and have fast gating, similar to that of recombinant alpha1beta receptors...
  5. pmc The time course of transmitter at glycinergic synapses onto motoneurons
    Marco Beato
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 28:7412-25. 2008
    ..2-3.5 mM and is cleared from the cleft with a time constant of 0.6-0.9 ms...
  6. pmc Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice
    G S Bhumbra
    Department of Neuroscience, Physiology and Pharmacology, University College London London, UK
    Front Cell Neurosci 6:8. 2012
    ..It is thus unlikely that GABA is co-released in biologically relevant amounts at glycinergic synapses onto lumbar motoneurons in mice of this age...
  7. pmc Determining the neurotransmitter concentration profile at active synapses
    Annalisa Scimemi
    Synaptic Physiology Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3701, USA
    Mol Neurobiol 40:289-306. 2009
    ....
  8. pmc The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531
    Marco Beato
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 580:171-9. 2007
    ..The fast unbinding rate of SR-95531 from the glycine receptor will make it useful for establishing the time course of glycine concentration at glycinergic synapses...
  9. pmc Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound
    Marco Beato
    Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, United Kingdom
    J Gen Physiol 119:443-66. 2002
    ....
  10. ncbi Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens
    Valeria Burzomato
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 24:10924-40. 2004
    ..Distinguishing between the two mechanisms will be important for our understanding of the structural dynamics of activation in the nicotinic superfamily and is important for our understanding of mutations in these receptors...
  11. ncbi Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors
    Steven Broadbent
    Department of Pharmacology, University College London, Gower St, London, WC1E 6BT, UK
    Mol Pharmacol 70:1350-7. 2006
    ..This raises the possibility of a novel regulatory role for the beta3 subunit on neuronal nicotinic signaling in the central nervous system...
  12. pmc High intracellular chloride slows the decay of glycinergic currents
    Samantha J Pitt
    Department of Neuroscience, UCL, London, United Kingdom
    J Neurosci 28:11454-67. 2008
    ....
  13. pmc Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition
    Paul S Miller
    Department of Pharmacology, University College London, Medical Sciences Building, Gower Street, London WC1E 6BT, UK
    J Physiol 566:657-70. 2005
    ..This strongly suggests that the alpha subunit is responsible for Zn2+-mediated inhibition and that this is effectively transduced, asymmetrically, from the side of the Zn2+-binding site where H109 and T133 are located...
  14. ncbi Constraining the expression of nicotinic acetylcholine receptors by using pentameric constructs
    Paul J Groot-Kormelink
    Department of Pharmacology, University College London, UK
    Mol Pharmacol 69:558-63. 2006
    ..This approach can be applied to any nicotinic superfamily receptor to produce channels with a defined subunit arrangement and to introduce specific mutations at any desired location of the pentameric fusion protein...
  15. pmc Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents
    Mirko Moroni
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 31:14095-106. 2011
    ..These observations suggest that permeant chloride affects gating by a foot-in-the-door effect, binding to a channel site with asymmetrical access from the intracellular and extracellular sides of the membrane...
  16. ncbi Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of alpha 1 glycine receptors in HEK293 cells
    Paul J Groot-Kormelink
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, WC1N 1AX London, UK
    J Neurosci Methods 113:207-14. 2002
    ..Optimum results for steady-state single channel experiments at low glycine concentrations were obtained with 5% of alpha 1 plasmid DNA in the transfection mix...
  17. pmc Intracellular chloride ions regulate the time course of GABA-mediated inhibitory synaptic transmission
    Catriona M Houston
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    J Neurosci 29:10416-23. 2009
    ....
  18. pmc Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells
    Paraskevi Krashia
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
    PLoS ONE 5:e13611. 2010
    ..We compared the properties of human α3β4 neuronal nicotinic receptors expressed in Human embryonic kidney cells (HEK293) and in Xenopus oocytes, to examine the effect of the expression system and α:β subunit ratio...
  19. pmc How to impose microscopic reversibility in complex reaction mechanisms
    David Colquhoun
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Biophys J 86:3510-8. 2004
    ..The third method uses linear algebra to solve for constrained rates...
  20. pmc Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization
    Paikan Marcaggi
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 106:11388-93. 2009
    ....