D L Becker

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Indicators of replicative damage in equine tendon fibroblast monolayers
    Tina Rich
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    BMC Vet Res 9:180. 2013
  2. pmc Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases
    Ariadna Mendoza-Naranjo
    Department of Cell and Developmental Biology, University College London, London, United Kingdom
    PLoS ONE 7:e37374. 2012
  3. doi request reprint Connexins in wound healing; perspectives in diabetic patients
    David L Becker
    Department of Cell and Developmental Biology, University College, London, WC1E 6BT, UK
    Biochim Biophys Acta 1818:2068-75. 2012
  4. pmc Multiphoton imaging of chick retinal development in relation to gap junctional communication
    David L Becker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, UK
    J Physiol 585:711-9. 2007
  5. ncbi request reprint Changing patterns of ganglion cell coupling and connexin expression during chick retinal development
    David L Becker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurobiol 52:280-93. 2002
  6. ncbi request reprint Use of pIRES vectors to express EGFP and connexin constructs in studies of the role of gap junctional communication in the early development of the chick retina and brain
    D Becker
    Department of Anatomy and Developmental Biology, University College London, UK
    Cell Commun Adhes 8:355-9. 2001
  7. ncbi request reprint Expression of major gap junction connexin types in the working myocardium of eight chordates
    D L Becker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, U K
    Cell Biol Int 22:527-43. 1998
  8. ncbi request reprint Roles for alpha 1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach
    D L Becker
    Department of Anatomy and Developmental Biology, University College London, UK
    Dev Genet 24:33-42. 1999
  9. ncbi request reprint Connexin43 gap junction protein plays an essential role in morphogenesis of the embryonic chick face
    I M McGonnell
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Dev Dyn 222:420-38. 2001
  10. ncbi request reprint Connexin expression in homotypic and heterotypic cell coupling in the developing cerebral cortex
    Kevin Bittman
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 443:201-12. 2002

Collaborators

  • Colin R Green
  • Rachael A Pearson
  • Patrick N Anderson
  • I M McGonnell
  • P Mobbs
  • S Spanos
  • K Patel
  • J E Cook
  • W H Evans
  • K Hardy
  • S Frank
  • A Forge
  • Federico Cicirata
  • Theodossis A Theodossiou
  • G Burnstock
  • Rachael L Stanley
  • Roland A Fleck
  • Aniko Gorbe
  • Chiuhui Mary Wang
  • Lee Yong Law
  • Michael Cronin
  • Ruth Roberts
  • Tibor Krenacs
  • Tina Rich
  • Ariadna Mendoza-Naranjo
  • Kieran T Power
  • Nephtali Marina
  • Yuan Lei
  • Petr Valasek
  • Ryoichi Mori
  • Laszlo Dux
  • Laszlo Krenacs
  • P Coutinho
  • Stephen Franks
  • Jaroslav Stark
  • Paul Martin
  • Aikaterini Iatropoulou
  • Porncharn Saitongdee
  • Cindy Qiu
  • Nerissa K Marziano
  • Kevin Bittman
  • Janet C Patterson-Kane
  • Livia B Henderson
  • Hannah Cornell
  • Alexis White
  • Thomas Serena
  • Shay O'Neill
  • Anthony R J Phillips
  • Antonio E Serrano
  • Peter Cormie
  • Christopher Thrasivoulou
  • Rebecca Hu
  • Michael E Boulton
  • Boris Hermann
  • James E Morgan
  • Nigel Garrahan
  • Michael P Gilbey
  • M Rosario Hernandez
  • Winfried L Neuhuber
  • Raymond Macharia
  • Jill Lincoln
  • Joerg Wilting
  • N Susan Stott
  • Wei V Zhang
  • Daniel Ciantar
  • Eniko Bagdi
  • C M Wang
  • Eva Stelkovics
  • T Brown
  • C Qiu
  • Pam Milner
  • H Makarenkova
  • Gillian E Knight
  • Susanne Franke
  • Petula Coutinho
  • Stefano O Casalotti
  • Anne E Portelli
  • John G Parnavelas
  • Jun Sheng Lin
  • A E Warner
  • C Tickle

Detail Information

Publications36

  1. pmc Indicators of replicative damage in equine tendon fibroblast monolayers
    Tina Rich
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    BMC Vet Res 9:180. 2013
    ..We investigated indicators of replicative damage in SDFT fibroblast monolayers, effects of this on their reparative ability, and measures that can be taken to reduce it...
  2. pmc Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases
    Ariadna Mendoza-Naranjo
    Department of Cell and Developmental Biology, University College London, London, United Kingdom
    PLoS ONE 7:e37374. 2012
    ..Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available...
  3. doi request reprint Connexins in wound healing; perspectives in diabetic patients
    David L Becker
    Department of Cell and Developmental Biology, University College, London, WC1E 6BT, UK
    Biochim Biophys Acta 1818:2068-75. 2012
    ..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics...
  4. pmc Multiphoton imaging of chick retinal development in relation to gap junctional communication
    David L Becker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, UK
    J Physiol 585:711-9. 2007
    ..The ability to perform extended time-lapse imaging over 3D volumes in living retina using multiphoton microscopy should now allow fundamental mechanisms governing development of the retinal neuroepithelium to be probed in detail...
  5. ncbi request reprint Changing patterns of ganglion cell coupling and connexin expression during chick retinal development
    David L Becker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurobiol 52:280-93. 2002
    ..These results suggest specific roles for gap junctions and Cx's during retinal development...
  6. ncbi request reprint Use of pIRES vectors to express EGFP and connexin constructs in studies of the role of gap junctional communication in the early development of the chick retina and brain
    D Becker
    Department of Anatomy and Developmental Biology, University College London, UK
    Cell Commun Adhes 8:355-9. 2001
    ..Expression of both wild type and dominant negative constructs in the developing chick retina perturbs the normal development of the eye...
  7. ncbi request reprint Expression of major gap junction connexin types in the working myocardium of eight chordates
    D L Becker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, U K
    Cell Biol Int 22:527-43. 1998
    ..The beta and alpha connexin subfamilies have different permeabilities and gating properties, and we discuss factors that might have made this shift beneficial...
  8. ncbi request reprint Roles for alpha 1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach
    D L Becker
    Department of Anatomy and Developmental Biology, University College London, UK
    Dev Genet 24:33-42. 1999
    ..The results imply a major role for alpha 1 connexin communication in the integration of signaling required for pattern formation during embryonic development. This novel antisense technique may also be widely applicable...
  9. ncbi request reprint Connexin43 gap junction protein plays an essential role in morphogenesis of the embryonic chick face
    I M McGonnell
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Dev Dyn 222:420-38. 2001
    ..Taken together, these results indicate that connexin43 plays an essential role during early morphogenesis and subsequent outgrowth of the developing chick face...
  10. ncbi request reprint Connexin expression in homotypic and heterotypic cell coupling in the developing cerebral cortex
    Kevin Bittman
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 443:201-12. 2002
    ..It may be that coupling between cells in the developing neocortex is a function of the spatial and temporal expression of these and other connexin proteins...
  11. ncbi request reprint Ca(2+) signalling and gap junction coupling within and between pigment epithelium and neural retina in the developing chick
    Rachael A Pearson
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT
    Eur J Neurosci 19:2435-45. 2004
    ..We conclude that gap junctions between progenitor cells, and between these cells and the RPE, may orchestrate retinal proliferation/differentiation, via the propagation of Ca(2+) or other signalling molecules...
  12. ncbi request reprint Limiting burn extension by transient inhibition of Connexin43 expression at the site of injury
    P Coutinho
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT London, UK
    Br J Plast Surg 58:658-67. 2005
    ..These findings suggest that Cx43 antisense treatment speeds partial thickness burn wound healing and reduces scarring. We suggest that this approach may provide an effective adjunct to managing partial thickness burn wounds...
  13. ncbi request reprint Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells
    Rachael A Pearson
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:10803-14. 2005
    ..The gap junction mimetic peptide Gap26 also acts to slow movement, an effect that we show may be attributable to the blockade of gap junction hemichannels...
  14. ncbi request reprint The inner ear contains heteromeric channels composed of cx26 and cx30 and deafness-related mutations in cx26 have a dominant negative effect on cx30
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London, United Kingdom
    Cell Commun Adhes 10:341-6. 2003
    ..The functional disruption caused by some cx26 mutations upon such heteromeric channels may underlie the non-syndromic nature of their effects on hearing...
  15. doi request reprint Gap-junction proteins in retinal development: new roles for the "nexus"
    Jeremy E Cook
    Department of Cell and Developmental Biology, University College London, Gower Street, London, United Kingdom
    Physiology (Bethesda) 24:219-30. 2009
    ..Thus, studies of the junctional and nonjunctional nexus roles of gap-junction proteins in coordinating retinal development should throw useful light on cell signaling in other developing nervous tissues...
  16. pmc Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb Bud
    H Makarenkova
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Cell Biol 138:1125-37. 1997
    ..Without FGF4, polarizing activity is reduced and the signaling mechanism changes. We conclude that FGF4 regulation of cell-cell communication and polarizing signaling are intimately connected...
  17. ncbi request reprint Anti-apoptotic action of insulin-like growth factor-I during human preimplantation embryo development
    S Spanos
    Department of Reproductive Science and Medicine, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Medicine, Hammersmith Hospital, London, W12 ONN, United Kingdom
    Biol Reprod 63:1413-20. 2000
    ..1 without IGF-I). The increased number of blastocysts combined with reduced cell death suggests that IGF-I is rescuing embryos in vitro which would otherwise arrest and acting as a survival factor during preimplantation human development...
  18. ncbi request reprint Abnormal connexin expression underlies delayed wound healing in diabetic skin
    Chiuhui Mary Wang
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Diabetes 56:2809-17. 2007
    ..We have examined the dynamics of Cx expression during wound healing in diabetic rats, which is known to be slow...
  19. ncbi request reprint Targeting connexin43 expression accelerates the rate of wound repair
    Cindy Qiu
    Department of Anatomy and Developmental Biology, University College London, Gower St, WC1E 6BT London, UK
    Curr Biol 13:1697-703. 2003
    ..This approach is likely to have widespread therapeutic applications in other injured tissues and opens up new avenues of research into improving the wound healing process...
  20. ncbi request reprint Antisense delivery and protein knockdown within the intact central nervous system
    Michael Cronin
    Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom
    Front Biosci 11:2967-75. 2006
    ....
  21. pmc Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections
    Theodossis A Theodossiou
    Department of Medicine, The Rayne Institute, University College London, London, UK
    Biophys J 91:4665-77. 2006
    ..The various stages of collagen thermal denaturation were investigated in rat-tendon cryosections using SHG and bright-field imaging. Thermal denaturation resulted in the gradual destruction of the SHG signal...
  22. doi request reprint Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury
    Michael Cronin
    Research Department of Cell and Developmental Biology, University College London, London, UK
    Mol Cell Neurosci 39:152-60. 2008
    ..Cx43 has many potential roles in the pathophysiology of CNS injury and may be a valuable target for therapeutic intervention...
  23. pmc Immunohistochemical detection of connexin36 in sympathetic preganglionic and somatic motoneurons in the adult rat
    Nephtali Marina
    Department of Physiology, University College London, London, WC1 E6BT, UK
    Auton Neurosci 139:15-23. 2008
    ..The presence of Cx36 in ChAT-ir neurons is consistent with electrical coupling between sympathetic preganglionic motoneurons and between somatic motoneurons through gap junctions in the adult spinal cord...
  24. ncbi request reprint Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30
    Nerissa K Marziano
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, 330 332 Gray s Inn Road, London WC1X 8EE, UK
    Hum Mol Genet 12:805-12. 2003
    ..Disruption of these heteromeric channels by certain mutations may underlie the non-syndromic nature of the deafness...
  25. doi request reprint Quantification of retinal transneuronal degeneration in human glaucoma: a novel multiphoton-DAPI approach
    Yuan Lei
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK
    Invest Ophthalmol Vis Sci 49:1940-5. 2008
    ..A method was developed based on multiphoton imaging of 4',6'-diamino-2-phenylindole (DAPI)-stained tissue to quantify neuron loss in postmortem human glaucomatous retinas...
  26. pmc Gap junction protein expression and cellularity: comparison of immature and adult equine digital tendons
    Rachael L Stanley
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, Hertfordshire, UK
    J Anat 211:325-34. 2007
    ....
  27. ncbi request reprint Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 119:5193-203. 2006
    ....
  28. ncbi request reprint In differentiating prefusion myoblasts connexin43 gap junction coupling is upregulated before myoblast alignment then reduced in post-mitotic cells
    Aniko Gorbe
    Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Histochem Cell Biol 125:705-16. 2006
    ..These and our in vivo results in early muscle differentiation are consistent with the role of Cx43 gap junctions in synchronizing cell cycle control of myoblasts to make them competent for a coordinated syncytial fusion...
  29. ncbi request reprint Transient upregulation of connexin43 gap junctions and synchronized cell cycle control precede myoblast fusion in regenerating skeletal muscle in vivo
    Aniko Gorbe
    Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Histochem Cell Biol 123:573-83. 2005
    ..The potential of Cx43 channels to stimulate p21(waf1/Cip1) and p27(kip1) is known. In the muscle, proving the involvement of Cx43 in either a direct or a bystander cell cycle regulation requires functional investigations...
  30. ncbi request reprint Knockdown of connexin43-mediated regulation of the zone of polarizing activity in the developing chick limb leads to digit truncation
    Lee Yong Law
    Anatomy with Radiology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Dev Growth Differ 44:537-47. 2002
    ..Cx43 expression is therefore involved in some, but not all patterning cascades, and appears to play a role in the regulation of ZPA activity...
  31. ncbi request reprint Lymph heart in chick--somitic origin, development and embryonic oedema
    Petr Valasek
    School of Biological Sciences, University of Reading, Reading RG6 6AJ, UK
    Development 134:4427-36. 2007
    ..Finally, we assessed the function of the lymph heart during embryogenesis and demonstrate that it is responsible for preventing embryonic oedema in birds, a role previously thought to be played by body skeletal muscle contractions...
  32. ncbi request reprint Myoblast proliferation and syncytial fusion both depend on connexin43 function in transfected skeletal muscle primary cultures
    Aniko Gorbe
    Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Exp Cell Res 313:1135-48. 2007
    ..These results highlight the critical role of gap-junctional coupling in myotube formation...
  33. pmc In vitro optimization of antisense oligodeoxynucleotide design: an example using the connexin gene family
    Lee Yong Law
    Department of Developmental and Cell Biology, University of California, Irvine, CA, USA
    J Biomol Tech 17:270-82. 2006
    ..We show, for the first time, an inexpensive and empirical approach to the preparation of specific and functional antisense oligodeoxynucleotides against known gene targets in the post-genomic era...
  34. ncbi request reprint Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro
    Ruth Roberts
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Biol Reprod 72:107-18. 2005
    ..These results demonstrate that exposure to high levels of FSH during IVM can accelerate nuclear maturation and induce chromosomal abnormalities and highlights the importance of the judicious use of FSH during IVM...
  35. ncbi request reprint Energy substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the phosphatidylinositol 3-kinase pathway and is associated with oocyte maturation
    Ruth Roberts
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Biol Reprod 71:199-209. 2004
    ....
  36. ncbi request reprint Levels of gap junction proteins in coronary arterioles and aorta of hamsters exposed to the cold and during hibernation and arousal
    Porncharn Saitongdee
    Department of Anatomy, Mahidol University, Bangkok, Thailand
    J Histochem Cytochem 52:603-15. 2004
    ..Cx43 immunoexpression in the aorta remained constant under all conditions examined. These changes in connexin expression did not occur during the rapid circulatory changes associated with arousal from hibernation...