Christopher G Bell

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Human-specific CpG "beacons" identify loci associated with human-specific traits and disease
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Epigenetics 7:1188-99. 2012
  2. pmc Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    BMC Med Genomics 3:33. 2010
  3. pmc The epigenomic interface between genome and environment in common complex diseases
    Christopher G Bell
    University College London Cancer Institute, UK
    Brief Funct Genomics 9:477-85. 2010
  4. pmc Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom
    PLoS ONE 5:e14040. 2010
  5. doi request reprint Accessing and selecting genetic markers from available resources
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Methods Mol Biol 760:1-17. 2011
  6. pmc Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis
    Vardhman K Rakyan
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS Genet 7:e1002300. 2011
  7. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
  8. doi request reprint Molecular confirmation of pathological specimen integrity in Australasia
    Christopher G Bell
    Sonic Clinical Institute, Douglass Hanly Moir Pathology, Sydney, NSW, Australia
    Pathology 41:280-3. 2009
  9. ncbi request reprint No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases
    Christopher G Bell
    Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Eur J Hum Genet 15:320-7. 2007
  10. doi request reprint Human-specific CpG 'beacons' identify human-specific prefrontal cortex H3K4me3 chromatin peaks
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Epigenomics 6:21-31. 2014

Detail Information

Publications12

  1. pmc Human-specific CpG "beacons" identify loci associated with human-specific traits and disease
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Epigenetics 7:1188-99. 2012
    ..Taken together, our data support a model for CpG beacons to contribute to CGI evolution from genesis to tissue-specific to constitutively active CGIs...
  2. pmc Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    BMC Med Genomics 3:33. 2010
    ..Cases had T1D and nephropathy whereas controls had T1D but no evidence of renal disease...
  3. pmc The epigenomic interface between genome and environment in common complex diseases
    Christopher G Bell
    University College London Cancer Institute, UK
    Brief Funct Genomics 9:477-85. 2010
    ..Due to the reversibility of these marks, the potential for sequence-specific targeted therapeutics exists. This review surveys recent epigenomic advances and their current and prospective application to the study of common diseases...
  4. pmc Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom
    PLoS ONE 5:e14040. 2010
    ....
  5. doi request reprint Accessing and selecting genetic markers from available resources
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Methods Mol Biol 760:1-17. 2011
    ..Central gene or disease-based searches are considered and then followed through systematically...
  6. pmc Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis
    Vardhman K Rakyan
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS Genet 7:e1002300. 2011
    ....
  7. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
    ..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features...
  8. doi request reprint Molecular confirmation of pathological specimen integrity in Australasia
    Christopher G Bell
    Sonic Clinical Institute, Douglass Hanly Moir Pathology, Sydney, NSW, Australia
    Pathology 41:280-3. 2009
    ..Investigations into 14 suspected pathology sample identification errors and mix-ups were performed, as a service for several public hospital and private laboratories, from 2005 to 2007...
  9. ncbi request reprint No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases
    Christopher G Bell
    Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Eur J Hum Genet 15:320-7. 2007
    ..Such a study design exemplifies the strategy needed to clearly define the contribution of the ACE gene to the plethora of complex genetic diseases where weak associations have been previously reported...
  10. doi request reprint Human-specific CpG 'beacons' identify human-specific prefrontal cortex H3K4me3 chromatin peaks
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Epigenomics 6:21-31. 2014
    ..Due to their human-specific CpG density change, extreme CpG 'beacon' clusters (≥20 CpG beacons/kb) were predicted to identify permissive chromatin peaks within the human genome...
  11. ncbi request reprint Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q
    Christopher G Bell
    Hammersmith Genome Centre and Department of Genomic Medicine, Hammersmith Hospital, Imperial College Faculty of Medicine, London, UK
    Diabetes 53:1857-65. 2004
    ..3-q21.3 (LOD = 2.68) and 10q24.32-26.2 (LOD = 2.47). Plausible positional candidate genes include NR1H2 and TULP2...
  12. pmc Advances in the identification and analysis of allele-specific expression
    Christopher G Bell
    Medical Genomics, University College London Cancer Institute, Huntley Street, London WC1E 6BT, UK
    Genome Med 1:56. 2009
    ....