Matthias Braun

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs
    Jovita Karanauskaite
    OCDEM, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Pflugers Arch 458:389-401. 2009
  2. doi Exocytotic properties of human pancreatic beta-cells
    Matthias Braun
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    Ann N Y Acad Sci 1152:187-93. 2009
  3. doi The αβδ of ion channels in human islet cells
    Matthias Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Islets 1:160-2. 2009
  4. pmc Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets
    Reshma Ramracheya
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Diabetes 59:2198-208. 2010
  5. pmc Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells
    Matthias Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Diabetes 59:1694-701. 2010
  6. pmc Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells
    Matthias Braun
    Oxford Center for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    J Gen Physiol 129:221-31. 2007
  7. doi Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells
    M Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX37 LJ, UK
    Diabetologia 52:1566-78. 2009
  8. doi Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion
    Matthias Braun
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Diabetes 57:1618-28. 2008
  9. pmc Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes
    Quan Zhang
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Cell Metab 18:871-82. 2013
  10. pmc SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
    Balrik Kailey
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Physiol Endocrinol Metab 303:E1107-16. 2012

Collaborators

Detail Information

Publications21

  1. doi Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs
    Jovita Karanauskaite
    OCDEM, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Pflugers Arch 458:389-401. 2009
    ..Our results indicate that measurements of ATP release and DeltaC(m) principally (> or =85-95%) report exocytosis of insulin granules...
  2. doi Exocytotic properties of human pancreatic beta-cells
    Matthias Braun
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    Ann N Y Acad Sci 1152:187-93. 2009
    ..These results reveal both similarities and differences between human and rodent beta-cells...
  3. doi The αβδ of ion channels in human islet cells
    Matthias Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Islets 1:160-2. 2009
    ..In addition, differences between the ion channel complements of human β-cells and islet non-β-cells are addressed...
  4. pmc Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets
    Reshma Ramracheya
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Diabetes 59:2198-208. 2010
    ..To document the properties of the voltage-gated ion channels in human pancreatic alpha-cells and their role in glucagon release...
  5. pmc Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells
    Matthias Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Diabetes 59:1694-701. 2010
    ..Paracrine signaling via gamma-aminobutyric acid (GABA) and GABA(A) receptors (GABA(A)Rs) has been documented in rodent islets. Here we have studied the importance of GABAergic signaling in human pancreatic islets...
  6. pmc Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells
    Matthias Braun
    Oxford Center for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    J Gen Physiol 129:221-31. 2007
    ....
  7. doi Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells
    M Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX37 LJ, UK
    Diabetologia 52:1566-78. 2009
    ..The aim of this study was to characterise electrical activity, ion channels, exocytosis and somatostatin release in human delta cells/pancreatic islets...
  8. doi Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion
    Matthias Braun
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Diabetes 57:1618-28. 2008
    ..To characterize the voltage-gated ion channels in human beta-cells from nondiabetic donors and their role in glucose-stimulated insulin release...
  9. pmc Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes
    Quan Zhang
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Cell Metab 18:871-82. 2013
    ..These data suggest that impaired metabolic control of the KATP channels underlies the defective glucose regulation of glucagon secretion in type 2 diabetes...
  10. pmc SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
    Balrik Kailey
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Physiol Endocrinol Metab 303:E1107-16. 2012
    ..These effects are mediated predominantly by SSTR2 in both cell types...
  11. ncbi R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion
    Quan Zhang
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Nat Cell Biol 9:453-60. 2007
    ..Glucose-induced somatostatin secretion is instead primarily dependent on Ca(2+)-induced Ca(2+)-release (CICR). This constitutes a novel mechanism for K(ATP)-channel-independent metabolic control of pancreatic hormone secretion...
  12. pmc Regulation of calcium in pancreatic α- and β-cells in health and disease
    Patrik Rorsman
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Cell Calcium 51:300-8. 2012
    ..We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes...
  13. doi K(ATP)-channels and glucose-regulated glucagon secretion
    Patrik Rorsman
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Trends Endocrinol Metab 19:277-84. 2008
    ..Here we consider the possible mechanisms involved with a focus on ATP-regulated K(+)-channels and changes in alpha-cell membrane potential...
  14. ncbi Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells
    Patrick E MacDonald
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, United Kingdom
    Cell Metab 4:283-90. 2006
    ..Therefore, the LDCV kiss-and-run fusion pores allow small transmitter release but likely retain the larger insulin peptide. This may represent a mechanism for selective intraislet signaling...
  15. doi Regulation of insulin secretion in human pancreatic islets
    Patrik Rorsman
    Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, United Kingdom
    Annu Rev Physiol 75:155-79. 2013
    ..Finally, we consider the pathophysiology of insulin secretion and the interactions between genetics and environmental factors that may explain the current diabetes epidemic...
  16. pmc Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content
    Juris Galvanovskis
    Department of Physiology, Anatomy and Genetics, University of Oxford, Henry Wellcome Building, Parks Road, Oxford OX1 3PT, UK
    Interface Focus 1:143-52. 2011
    ..Our findings suggest that the fusion pore functions as a molecular sieve, allowing differential release of low- and high-molecular-weight granule constituents...
  17. doi GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus
    Laura J McCulloch
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Mol Genet Metab 104:648-53. 2011
    ..Direct extrapolation from rodent to human islet glucose transporter activity is unlikely to be appropriate...
  18. ncbi Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells
    Anna Wendt
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Diabetes 53:1038-45. 2004
    ..This effect was not observed in the presence of SR95531, and we therefore conclude that isradipine stimulates glucagon secretion by inhibition of GABA release...
  19. pmc Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells
    Matthias Braun
    Department of Physiological Sciences, Lund University, BMC B11 SE 22184 Lund, Sweden
    J Gen Physiol 123:191-204. 2004
    ..This provides a basis for paracrine GABAergic signaling within the islet...
  20. pmc GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin
    Matthias Braun
    Department of Physiological Sciences, BMC B11, SE 221 84 Lund, Sweden
    J Physiol 559:397-409. 2004
    ..These data indicate that GABA released from beta-cells functions as an autocrine inhibitor of insulin secretion in pancreatic islets and that the effect is principally due to direct suppression of exocytosis...
  21. pmc Novel aspects of the molecular mechanisms controlling insulin secretion
    Lena Eliasson
    Department of Clinical Sciences in Malmo, Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Clinical Research Centre, Malmo SE 205 02, Sweden
    J Physiol 586:3313-24. 2008
    ..We finally consider the possibility that defective fusion pore expansion accounts for the decrease in insulin secretion observed in pathophysiological states including long-term exposure to lipids...