Philip Coan

Summary

Affiliation: University of Cambridge
Location: Cambridge,
Summary:
Interests: fetal origins of adult disease (placental morphology, gene expression, imprinted genes, epigenetic regulation, physiology) and the epidemiology of chronic diseases and risk factors thereof.

Publications

  1. ncbi Developmental dynamics of the definitive mouse placenta assessed by stereology
    Philip M Coan
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Biol Reprod 70:1806-13. 2004
  2. pmc Dietary composition programmes placental phenotype in mice
    P M Coan
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 589:3659-70. 2011
  3. doi Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth
    Emily Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    FASEB J 25:1737-45. 2011
  4. doi Imprinted genes and the epigenetic regulation of placental phenotype
    A L Fowden
    Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB23EG, United Kingdom
    Prog Biophys Mol Biol 106:281-8. 2011
  5. pmc Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice
    P M Coan
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 588:527-38. 2010
  6. pmc Placental structure in type 1 diabetes: relation to fetal insulin, leptin, and IGF-I
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, University of Glasgow, Glasgow, U K
    Diabetes 58:2634-41. 2009
  7. pmc Placental efficiency and adaptation: endocrine regulation
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 587:3459-72. 2009
  8. pmc Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice
    P M Coan
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 586:4567-76. 2008
  9. doi The placenta and intrauterine programming
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 20:439-50. 2008
  10. ncbi Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region
    Shau Ping Lin
    Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, UK
    Development 134:417-26. 2007

Detail Information

Publications19

  1. ncbi Developmental dynamics of the definitive mouse placenta assessed by stereology
    Philip M Coan
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Biol Reprod 70:1806-13. 2004
    ..39 microm by E18.5. The specific diffusion capacity for oxygen of the interhemal membrane is maximal by E16.5, which may be necessary to support rapid fetal growth until the end of gestation...
  2. pmc Dietary composition programmes placental phenotype in mice
    P M Coan
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 589:3659-70. 2011
    ..This has important implications for the intrauterine programming of life expectancy...
  3. doi Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth
    Emily Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    FASEB J 25:1737-45. 2011
    ..Our findings are indicative of fetal-placental signaling mechanisms that limit total demand for maternal nutrients...
  4. doi Imprinted genes and the epigenetic regulation of placental phenotype
    A L Fowden
    Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB23EG, United Kingdom
    Prog Biophys Mol Biol 106:281-8. 2011
    ..These genes, therefore, have a major role in the epigenetic regulation of placental phenotype with long term consequences for the developmental programming of adult health and disease...
  5. pmc Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice
    P M Coan
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 588:527-38. 2010
    ..Consequently, placental phenotype is responsive to environmental conditions and may help predict the risk of adult disease programmed in utero...
  6. pmc Placental structure in type 1 diabetes: relation to fetal insulin, leptin, and IGF-I
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, University of Glasgow, Glasgow, U K
    Diabetes 58:2634-41. 2009
    ..We examined the placenta in a cohort of offspring of mothers with type 1 diabetes (OT1DM) to assess structural changes and determine whether these were related to maternal A1C, fetal hematocrit, fetal hormonal, or metabolic axes...
  7. pmc Placental efficiency and adaptation: endocrine regulation
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 587:3459-72. 2009
    ..This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes...
  8. pmc Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice
    P M Coan
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 586:4567-76. 2008
    ..Thus, this adaptability in placental phenotype provides a functional reserve capacity for maximizing fetal growth during late gestation when placental growth is compromised...
  9. doi The placenta and intrauterine programming
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 20:439-50. 2008
    ....
  10. ncbi Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region
    Shau Ping Lin
    Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, UK
    Development 134:417-26. 2007
    ..This indicates that the mechanism of action of the IG-DMR is different in the embryo and the placenta and suggests that the epigenetic control of imprinting differs in these two lineages...
  11. ncbi Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006
    ..Thus stereology and immunohistochemistry have provided useful insights into Jz development and function of the glycogen cells...
  12. ncbi Regulation of placental efficiency for nutrient transport by imprinted genes
    E Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Placenta 27:S98-102. 2006
    ..We propose that signalling mechanisms involving growth demand signals and nutrient transporters are likely to occur and are important for fine tuning normal fetal growth...
  13. pmc Ultrastructural changes in the interhaemal membrane and junctional zone of the murine chorioallantoic placenta across gestation
    P M Coan
    Department of Anatomy, University of Cambridge, UK
    J Anat 207:783-96. 2005
    ..This is the first study to use both scanning and transmission electron microscopy in an ultrastructural description of murine placental development and is complementary to contemporary genetic investigations...
  14. ncbi Imprinted genes in the placenta--a review
    P M Coan
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Placenta 26:S10-20. 2005
    ..We review the current information on, and suggest possible functional roles for, imprinted genes in placental development...
  15. pmc Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta
    C P Sibley
    Academic Unit of Child Health, Medical School, University of Manchester, St Mary s Hospital, Manchester M13 OJH, United Kingdom
    Proc Natl Acad Sci U S A 101:8204-8. 2004
    ..This provides a mechanism for the role of imprinted genes in controlling placental nutrient supply and fetal growth. Altered placental Igf2 could be a cause of idiopathic intrauterine growth restriction in the human...
  16. ncbi Genes and development--a workshop report
    J C Cross
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary Faculty of Medicine, HSC Room 2279, 3330 Hospital Drive, N W, Calgary, Alberta T2N 4N1, Canada
    Placenta 25:S39-41. 2004
  17. ncbi Water modulation of stratum corneum chymotryptic enzyme activity and desquamation
    A Watkinson
    Skin and Hair Biology, Unilever Research, Sharnbrook, Bedford, UK
    Arch Dermatol Res 293:470-6. 2001
    ..In addition, SCCE may be adapted to function in the water-restricted stratum corneum intercellular space...
  18. pmc Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
    Philip M Coan
    Centre for Genomic and Experimental Medicine and Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, UK
    Dis Model Mech . 2017
    ..Further study of these genes in the congenic strains will lead to robust identification of the underlying genes and cellular mechanisms...
  19. pmc Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse
    P M Coan
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Physiol 586:5023-32. 2008
    ..Thus, placental phenotype depends on the degree of Igf2 gene ablation and the interplay between placental and fetal Igf2 in the mouse...