A S Curtis

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Topographical control of cells
    A Curtis
    Centre for Cell Engineering, University of Glasgow, UK
    Biomaterials 18:1573-83. 1997
  2. ncbi request reprint Cell reactions with biomaterials: the microscopies
    A S Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Eur Cell Mater 1:59-65. 2001
  3. pmc Nanoprinting onto cells
    Adam S G Curtis
    Department of Electronics and Electrical Engineering, Centre for Cell Engineering, IBLS, University of Glasgow, Glasgow, Scotland, UK
    J R Soc Interface 3:393-8. 2006
  4. pmc "Shimmying like my sister" cell
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Biophys J 94:3741. 2008
  5. ncbi request reprint The potential for the use of nanofeaturing in medical devices
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Expert Rev Med Devices 2:293-301. 2005
  6. ncbi request reprint Comment on "Nanorobotics control design: a collective behavior approach for medicine"
    A S G Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 4:201-2; discussion 202-3. 2005
  7. ncbi request reprint An in vivo microfabricated scaffold for tendon repair
    A S G Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    Eur Cell Mater 9:50-7; discussion 57. 2005
  8. ncbi request reprint Tutorial on the biology of nanotopography
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 3:293-5. 2004
  9. ncbi request reprint Cell forces in tissues
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    Med Eng Phys 27:773-9. 2005
  10. pmc Orthogonal (transverse) arrangements of actin in endothelia and fibroblasts
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    J R Soc Interface 3:753-6. 2006

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Topographical control of cells
    A Curtis
    Centre for Cell Engineering, University of Glasgow, UK
    Biomaterials 18:1573-83. 1997
    ..The review ends with a summary of the types of prosthesis where advantage has been taken of the ability to fabricate topography...
  2. ncbi request reprint Cell reactions with biomaterials: the microscopies
    A S Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Eur Cell Mater 1:59-65. 2001
    ..These methods show that those discrete contact areas well known as focal contacts are frequently present. The results of FRETM suggest that the separation from the substratum even in a focal contact is about 5 nm...
  3. pmc Nanoprinting onto cells
    Adam S G Curtis
    Department of Electronics and Electrical Engineering, Centre for Cell Engineering, IBLS, University of Glasgow, Glasgow, Scotland, UK
    J R Soc Interface 3:393-8. 2006
    ..This nanoprinting of cells would appear to be a novel type of cell signalling...
  4. pmc "Shimmying like my sister" cell
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Biophys J 94:3741. 2008
  5. ncbi request reprint The potential for the use of nanofeaturing in medical devices
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Expert Rev Med Devices 2:293-301. 2005
    ..This review looks at potential developments in medical devices which may be based upon nanofeaturing implant and tissue engineering scaffolds, and describes the basic science upon which such expectations are based...
  6. ncbi request reprint Comment on "Nanorobotics control design: a collective behavior approach for medicine"
    A S G Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 4:201-2; discussion 202-3. 2005
    ..It is shown that severe problems exist for a nanorobot designed to enter tissues for therapeutic purposes when it is smaller than about 1 microm in any one of its dimensions...
  7. ncbi request reprint An in vivo microfabricated scaffold for tendon repair
    A S G Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    Eur Cell Mater 9:50-7; discussion 57. 2005
    ..After six weeks an apparently normal functional tendon is reformed...
  8. ncbi request reprint Tutorial on the biology of nanotopography
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 3:293-5. 2004
    ....
  9. ncbi request reprint Cell forces in tissues
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    Med Eng Phys 27:773-9. 2005
    ..It does not review the effects of forces originating from movement of tissues, muscular activity, movement and gravity...
  10. pmc Orthogonal (transverse) arrangements of actin in endothelia and fibroblasts
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    J R Soc Interface 3:753-6. 2006
    ..The orthogonal actin is most obvious in cells grown on groove ridge structures, but can be detected in cells grown on flat surfaces...
  11. pmc Measuring cell forces by a photoelastic method
    Adam Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Biophys J 92:2255-61. 2007
    ..The observations and measurements tend to argue that microtopography and embedded beads can concentrate the forces...
  12. ncbi request reprint Reactions of cells to topography
    A S Curtis
    Centre for Cell Engineering, University of Glasgow, UK
    J Biomater Sci Polym Ed 9:1313-29. 1998
    ..Recently it has become clear that the these reactions occur at the nanometric scale and have importance for use in cellular engineering and tissue repair. Topography appears to provide a set of very powerful signals for cells...
  13. ncbi request reprint Nantotechniques and approaches in biotechnology
    A Curtis
    Centre for Cell Engineering, University of Glasgow, G12 8QQ, Glasgow, UK
    Trends Biotechnol 19:97-101. 2001
    ....
  14. ncbi request reprint Substratum nanotopography and the adhesion of biological cells. Are symmetry or regularity of nanotopography important?
    A S Curtis
    Centre for Cell Engineering, IBLS, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, Scotland, UK
    Biophys Chem 94:275-83. 2001
    ..Parallel results were obtained in the adhesion of carboxylate-surfaced 2-microm-diameter particles to these surfaces. These results are in agreement with recent predictions from non-biological nanometric systems...
  15. ncbi request reprint Cells react to nanoscale order and symmetry in their surroundings
    A S G Curtis
    Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 3:61-5. 2004
    ..The cells appear to be able to distinguish between different symmetries of array. We suggest that interfacial forces may be organized by the nanostructures to affect the cells in the same way as they affect liquid crystal orientations...
  16. ncbi request reprint Small is beautiful but smaller is the aim: review of a life of research
    A S G Curtis
    Centre for Cell Engineering, University of Glasgow, UK
    Eur Cell Mater 8:27-36. 2004
    ..The results will be discussed in terms of very recent theories of cell interaction and cell signals and possible future developments will be outlined...
  17. ncbi request reprint Cell signaling arising from nanotopography: implications for nanomedical devices
    Adam S G Curtis
    University of Glasgow, Centre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Science, Glasgow, UK
    Nanomedicine (Lond) 1:67-72. 2006
    ..Nanoparticle-based therapies are recognized as having some appreciable hazards, while those based on extended nanofeatured surfaces probably have fewer risks...
  18. ncbi request reprint The response of primary articular chondrocytes to micrometric surface topography and sulphated hyaluronic acid-based matrices
    D W Hamilton
    Centre for Cell Engineering, University of Glasgow, UK
    Cell Biol Int 29:605-15. 2005
    ....
  19. ncbi request reprint Articular chondrocyte passage number: influence on adhesion, migration, cytoskeletal organisation and phenotype in response to nano- and micro-metric topography
    D W Hamilton
    Centre for Cell Engineering, Joseph Black Building, University of Glasgow, G12 8QQ, Glasgow, UK
    Cell Biol Int 29:408-21. 2005
    ..This study demonstrates that passage number alters the response of chondrocytes to micrometric and nanometric topography, and could be important in ex vivo cartilage engineering...
  20. ncbi request reprint Nuclear localization of HIV-1 tat functionalized gold nanoparticles
    C C Berry
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    IEEE Trans Nanobioscience 6:262-9. 2007
    ....
  21. ncbi request reprint Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates
    C C Berry
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 6:201-9. 2007
    ..Critically, in combination, topography modulated the effects of chemical environment...
  22. ncbi request reprint Morphological and microarray analysis of human fibroblasts cultured on nanocolumns produced by colloidal lithography
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Eur Cell Mater 9:1-8; discussion 8. 2005
    ..The results indicate that changes in cell spreading correlate with a number of gene up- and down-regulations as will be described within the manuscript...
  23. ncbi request reprint Is surface chemical composition important for orthopaedic implant materials?
    D O Meredith
    AO Research Institute, AO Foundation, Clavadelerstrasse, CH 7270 Davos, Switzerland
    J Mater Sci Mater Med 18:405-13. 2007
    ..For biomaterials studies, the standardisation of surface chemistry used here is a valuable tool in allowing vastly different materials and surface finishes to be compared solely on the basis of their topography...
  24. ncbi request reprint In vitro reaction of endothelial cells to polymer demixed nanotopography
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Biomaterials 23:2945-54. 2002
    ..Of the nanotopographies, the 13 nm islands were seen to give the largest response, with highly spread cell morphologies containing well-defined cytoskeleton...
  25. ncbi request reprint Polymer-demixed nanotopography: control of fibroblast spreading and proliferation
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Tissue Eng 8:1099-108. 2002
    ..Interaction of filopodia with the islands could been seen to increase as island size was increased...
  26. ncbi request reprint Nonadhesive nanotopography: fibroblast response to poly(n-butyl methacrylate)-poly(styrene) demixed surface features
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    J Biomed Mater Res A 67:1025-32. 2003
    ..The results indicated that the cells do not respond differently to the 10-nm islands compared with planar samples but, in contrast, the 50-nm islands are nonadhesive...
  27. ncbi request reprint Rapid fibroblast adhesion to 27nm high polymer demixed nano-topography
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow, G12 8QQ, UK
    Biomaterials 25:77-83. 2004
    ..The results showed that an initial rapid adhesion and cytoskeletal formation on the islands at 4 days of culture gave way to poorly formed contacts and vimentin cytoskeleton at 30 days of culture...
  28. ncbi request reprint Fibroblast reaction to island topography: changes in cytoskeleton and morphology with time
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow, Scotland G12 8QQ, UK
    Biomaterials 24:927-35. 2003
    ..The results also show a change in cell response from initial fast organisation of cytoskeleton in reaction to the islands, through to lack of cell spreading and low recruitment of cell numbers on the islands...
  29. ncbi request reprint Investigating the limits of filopodial sensing: a brief report using SEM to image the interaction between 10 nm high nano-topography and fibroblast filopodia
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, UK
    Cell Biol Int 28:229-36. 2004
    ..Fluorescence microscopy has also been used to look at adhesion formation. The results showed distinct filopodial/nano-island interaction and changes in adhesion morphology...
  30. ncbi request reprint Effective extra-cellular recording from vertebrate neurons in culture using a new type of micro-electrode array
    M Sandison
    Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Neurosci Methods 114:63-71. 2002
    ..If rigid control over neuron placement has been achieved the patterns of electrodes can be matched to the neuron positions...
  31. ncbi request reprint Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning
    Matthew J Dalby
    Division of Infection and Immunity, Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Cell Biochem 100:326-38. 2007
    ..We have also obtained evidence that these subtrata result in downregulation of gene expression which suggests that this may be due to the changed tension on the nucleus: an intriguing possibility that merits further investigation...
  32. ncbi request reprint Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro
    Catherine C Berry
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, Scotland, UK
    Biomaterials 24:4551-7. 2003
    ..The results indicate that the derivatised particles induce alterations in cell behaviour and morphology distinct from the plain particles, suggesting that cell response can be directed via specifically engineered particle surfaces...
  33. ncbi request reprint Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography
    Matthew J Dalby
    Centre for Cell Engineering, Faculty of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Exp Cell Res 284:274-82. 2003
    ..5 x 2-microm grooves) with time. The results showed many initial gene changes and also down-regulation of gene response with time. Cell and nucleus morphology were also considered, with nuclear deformation linked to cell signaling...
  34. ncbi request reprint Use of nanotopography to study mechanotransduction in fibroblasts--methods and perspectives
    Matthew J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Cell Biol 83:159-69. 2004
    ....
  35. ncbi request reprint Nanomechanotransduction and interphase nuclear organization influence on genomic control
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK
    J Cell Biochem 102:1234-44. 2007
    ..We hypothesize that as changes in cell and thus nuclear morphology occur, that this may alter the probability of transcription through opening or closing areas of the chromosomes to transcription factors...
  36. ncbi request reprint Microtopography of metal surfaces influence fibroblast growth by modifying cell shape, cytoskeleton, and adhesion
    David O Meredith
    AO Research Institute, AO Foundation, Clavadelerstrasse, CH 7270 Davos, Switzerland
    J Orthop Res 25:1523-33. 2007
    ..We believe, as demonstrated with standard cpTi and TAN, that a difference in surface morphology is influential for controlling cell behavior on implant surfaces...
  37. ncbi request reprint Increasing fibroblast response to materials using nanotopography: morphological and genetic measurements of cell response to 13-nm-high polymer demixed islands
    Matthew J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    Exp Cell Res 276:1-9. 2002
    ..Microscopical results provide confirmation of the microarray findings...
  38. ncbi request reprint Nanotopographical control of human osteoprogenitor differentiation
    Matthew J Dalby
    Centre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Curr Stem Cell Res Ther 2:129-38. 2007
    ..Finally, it will make some speculations of the future of nanomaterials and progenitor cells in tissue engineering...
  39. ncbi request reprint The effects of colloidal nanotopography on initial fibroblast adhesion and morphology
    Mairead A Wood
    Division of Infection and Immunity, Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 5:20-31. 2006
    ..Moreover, by 3 h, cells on the colloidal substrates initiate cell-cell adhesions, also absent in controls...
  40. ncbi request reprint Nanoparticle targeting at cells
    Jesus M de la Fuente
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Langmuir 22:3286-93. 2006
    ....
  41. ncbi request reprint The influence of transferrin stabilised magnetic nanoparticles on human dermal fibroblasts in culture
    Catherine C Berry
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, Scotland, UK
    Int J Pharm 269:211-25. 2004
    ..The microscopy results further support these findings...
  42. ncbi request reprint Surface modified superparamagnetic nanoparticles for drug delivery: interaction studies with human fibroblasts in culture
    Ajay Kumar Gupta
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Mater Sci Mater Med 15:493-6. 2004
    ..The modification of nanoparticle surface induced alterations in cell behaviour distinct from the unmodified particles, suggesting that cell response can be directed via specifically engineered particle surfaces...
  43. ncbi request reprint Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size
    Matthew J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, UK
    Int J Biochem Cell Biol 36:2005-15. 2004
    ..We suggest that this may occur through nanocontact guidance as filopodia are moved over the pits...
  44. ncbi request reprint The influence of microscale topography on fibroblast attachment and motility
    Catherine C Berry
    Centre for Cell Engineering Joseph Black Building, University of Glasow, IBLS University Avenue, Glasgow G12 8QQ, UK
    Biomaterials 25:5781-8. 2004
    ..Such information may provide details on possible pore sizes for use in synthetic tissue engineering scaffolds that aim to support fibroblast in-growth and subsequent proliferation...
  45. ncbi request reprint Cell response to dextran-derivatised iron oxide nanoparticles post internalisation
    Catherine Cecilia Berry
    Centre for Cell Engineering, University of Glasgow, Joseph Black Building, IBLS University Avenue, Glasgow G12 8QQ, UK catherine berry bio gla ac uk
    Biomaterials 25:5405-13. 2004
    ....
  46. ncbi request reprint Attempted endocytosis of nano-environment produced by colloidal lithography by human fibroblasts
    Matthew J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Cell Res 295:387-94. 2004
    ..These observations could have implications for nanomaterials science in areas such as cell transfection and drug delivery...
  47. ncbi request reprint Quantum dots protected with tiopronin: a new fluorescence system for cell-biology studies
    Jesus M de la Fuente
    Centre for Cell Engineering, Institute of Biomedical and Life Science, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Chembiochem 6:989-91. 2005
  48. ncbi request reprint Neutralisation of TGF beta or binding of VLA-4 to fibronectin prevents rat tendon adhesion following transection
    Heather G Jørgensen
    ATMU and Division of Cancer Sciences, University of Glasgow, Level 3 Queen Elizabeth Building, UK
    Cytokine 30:195-202. 2005
    ..It is concluded from this pilot study that the treatments described hold promise in improving outcomes of the common clinical problem of tendon injury in man...
  49. ncbi request reprint Fibroblast response to a controlled nanoenvironment produced by colloidal lithography
    Matthew J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    J Biomed Mater Res A 69:314-22. 2004
    ..By studying cell adhesion with time and cytoskeletal (actin, tubulin, and vimentin) maturity, insight has been gained as to how fibroblasts adhere to these nanofeatures...
  50. ncbi request reprint Changes in fibroblast morphology in response to nano-columns produced by colloidal lithography
    Matthew John Dalby
    Centre for Cell Engineering Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, UK
    Biomaterials 25:5415-22. 2004
    ..By understanding as to which features evoke spatial reactions in cells, it may be possible to design better biomaterials...
  51. ncbi request reprint Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts
    Ajay Kumar Gupta
    Centre for Cell Engineering, IBLS, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Control Release 95:197-207. 2004
    ..These studies show that the gelatin nanoparticles prepared by water-in-oil microemulsion systems are endocytosed by the fibroblasts without being toxic to cells even at high concentration of nanoparticles...
  52. ncbi request reprint Human fibroblast reactions to standard and electropolished titanium and Ti-6Al-7Nb, and electropolished stainless steel
    D Osian Meredith
    AO Research Institute, Clavadelerstrasse, CH 7270 Davos Platz, Switzerland
    J Biomed Mater Res A 75:541-55. 2005
    ..We believe that the particle uptake coupled with the characteristic surface topography contribute to the noncytocompatibility of fibroblasts on standard TAN...
  53. ncbi request reprint Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors
    Ajay Kumar Gupta
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    Biomaterials 25:3029-40. 2004
    ..These experiments provide a route to prevent this problem, suggesting that cell response can be directed via specifically engineered particle surfaces...
  54. ncbi request reprint The influence of elastin-coated 520-nm- and 20-nm-diameter nanoparticles on human fibroblasts in vitro
    Catherine C Berry
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
    IEEE Trans Nanobioscience 1:105-9. 2002
    ..However, little difference was observed between the different diameters...
  55. ncbi request reprint The NanoBioWorld
    Carmelina Ruggiero
    IEEE Trans Nanobioscience 1:1-3. 2002