K Ersfeld

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei
    N S Alsford
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Mol Microbiol 47:277-89. 2003
  2. ncbi request reprint Genomes and genome projects of protozoan parasites
    Klaus Ersfeld
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Curr Issues Mol Biol 5:61-74. 2003
  3. ncbi request reprint Direct visualisation of individual gene organisation in Trypanosoma brucei by high-resolution in situ hybridisation
    K Ersfeld
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Chromosoma 107:237-40. 1998
  4. ncbi request reprint Nuclear and genome organization of Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester, UK M13 9PT
    Parasitol Today 15:58-63. 1999
  5. ncbi request reprint Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei
    K Ersfeld
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 114:141-148. 2001
  6. ncbi request reprint Partitioning of large and minichromosomes in Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Science 276:611-4. 1997
  7. ncbi request reprint Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms
    K Gull
    School of Biological Sciences, University of Manchester, UK
    Trends Microbiol 6:319-23. 1998
  8. ncbi request reprint Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei
    S Alsford
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 113:79-88. 2001
  9. ncbi request reprint A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma brucei
    K Ersfeld
    School of Biological Sciences, University of Manchester, UK
    Mol Biochem Parasitol 81:201-9. 1996
  10. ncbi request reprint CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei
    C Hertz-Fowler
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 116:25-34. 2001

Collaborators

  • M Navarro
  • Bill Wickstead
  • K Gull
  • Katie Hughes
  • Mickaël Durand-Dubief
  • S Alsford
  • N S Alsford
  • C Hertz-Fowler
  • Rosanna Young
  • Gloria Rudenko
  • Philippe Bastin
  • Sandra Ngwabyt
  • Kate Harley
  • Linda Menzer
  • Lucy Foulston
  • Matthew Wand
  • Sabrina Absalon
  • Stephen Terry
  • H Dunbar
  • M Ackroyd
  • H R Jamnadass
  • N B Murphy

Detail Information

Publications18

  1. ncbi request reprint The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei
    N S Alsford
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Mol Microbiol 47:277-89. 2003
    ..Therefore, we discuss a functional connection between the occurrence of this circular DNA and subtelomeric recombination events in T. brucei...
  2. ncbi request reprint Genomes and genome projects of protozoan parasites
    Klaus Ersfeld
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Curr Issues Mol Biol 5:61-74. 2003
    ..Here, I will review the current status of protozoan parasite genome projects, present findings obtained as a result of the availability of genomic data and discuss the potential impact of genome information on disease control...
  3. ncbi request reprint Direct visualisation of individual gene organisation in Trypanosoma brucei by high-resolution in situ hybridisation
    K Ersfeld
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Chromosoma 107:237-40. 1998
    ..We demonstrated the repetitive nature of the tubulin gene cluster, which consists of up to 19 alpha- and beta-tubulin genes arranged in tandem repeats...
  4. ncbi request reprint Nuclear and genome organization of Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester, UK M13 9PT
    Parasitol Today 15:58-63. 1999
    ..However, recent work emphasizes the need for a more holistic approach to understanding these aspects of the biology of this parasite...
  5. ncbi request reprint Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei
    K Ersfeld
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 114:141-148. 2001
    ..We propose that this motif represents an essential part of a flagellar targeting machinery in trypanosomes and possibly in other flagellated organisms...
  6. ncbi request reprint Partitioning of large and minichromosomes in Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Science 276:611-4. 1997
    ..However, their positional dynamics differed from that of the large chromosomes, which were partitioned by kinetochore microtubules...
  7. ncbi request reprint Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms
    K Gull
    School of Biological Sciences, University of Manchester, UK
    Trends Microbiol 6:319-23. 1998
    ..This minichromosomal population is segregated on the mitotic spindle. How this is achieved provides insight into potential segregation mechanisms for small DNA molecules in eukaryotic microorganisms...
  8. ncbi request reprint Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei
    S Alsford
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 113:79-88. 2001
    ..This steady telomeric growth, counteracted by stochastic large losses of telomeric sequences is the most likely cause of minichromosome karyotype heterogeneity within a population...
  9. ncbi request reprint A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma brucei
    K Ersfeld
    School of Biological Sciences, University of Manchester, UK
    Mol Biochem Parasitol 81:201-9. 1996
    ....
  10. ncbi request reprint CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei
    C Hertz-Fowler
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 116:25-34. 2001
    ..5, but of varying length. We suggest a nomenclature for this new family of proteins in T. brucei...
  11. pmc The frequency of gene targeting in Trypanosoma brucei is independent of target site copy number
    Bill Wickstead
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Nucleic Acids Res 31:3993-4000. 2003
    ..It is also not seen in the related parasite Leishmania, a distinction that may be the consequence of the different usage of recombination within the mechanisms of pathogenicity in the two species...
  12. ncbi request reprint Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei
    Bill Wickstead
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 125:211-6. 2002
  13. pmc Repetitive elements in genomes of parasitic protozoa
    Bill Wickstead
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Microbiol Mol Biol Rev 67:360-75, table of contents. 2003
    ..The story which emerges is one of opportunism and upheaval which have been employed to add genetic diversity and genomic flexibility...
  14. ncbi request reprint The mitotic stability of the minichromosomes of Trypanosoma brucei
    Bill Wickstead
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
    Mol Biochem Parasitol 132:97-100. 2003
  15. pmc The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes
    Bill Wickstead
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, United Kingdom
    Genome Res 14:1014-24. 2004
    ..Moreover, palindromy appears to be a feature of (peri)centromeres in other species that can be easily overlooked. We propose that sequence inversion is one of the higher-order sequence motifs that confer chromosomal stability...
  16. ncbi request reprint Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites
    Klaus Ersfeld
    Department of Biological Sciences, University of Hull, Hull, HU6 7RX, UK
    J Mol Evol 61:742-57. 2005
    ..The discovery of this surprisingly large family of calpain-like proteins in lower eukaryotes that combines novel and conserved sequence modules contributes to our understanding of the evolution of this abundant protein family...
  17. pmc A novel ISWI is involved in VSG expression site downregulation in African trypanosomes
    Katie Hughes
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
    EMBO J 26:2400-10. 2007
    ..VSG ES activation in African trypanosomes therefore appears to be a multistep process, whereby an increase in transcription from a silent ES promoter is necessary but not sufficient for full ES activation...
  18. ncbi request reprint The Argonaute protein TbAGO1 contributes to large and mini-chromosome segregation and is required for control of RIME retroposons and RHS pseudogene-associated transcripts
    Mickaël Durand-Dubief
    Régulation et Dynamique des Génomes, Museum national d histoire naturelle, INSERM and CNRS, 75005 Paris, France
    Mol Biochem Parasitol 156:144-53. 2007
    ..However, analysis of retroposon abundance and arrangement in the genome of multiple clonal cell lines of TbAGO1-/- failed to reveal movement of mobile elements despite the increased amounts of retroposon transcripts...