A Forge

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Rapid hair cell loss: a mouse model for cochlear lesions
    Ruth Rebecca Taylor
    Centre for Auditory Research, UCL Ear Institute, University College London, 332 Gray s Inn Road, London, WC1X 8EE, UK
    J Assoc Res Otolaryngol 9:44-64. 2008
  2. doi request reprint Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea
    Andrew Forge
    Centre for Auditory Research, UCL Ear Institute, London WC1X 8EE, UK
    J Cell Sci 126:1703-12. 2013
  3. pmc β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear
    Ivan Brunetta
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK
    BMC Cell Biol 13:5. 2012
  4. pmc Opioid modulation of GABA release in the rat inferior colliculus
    Walaiporn Tongjaroenbungam
    Neuro Behavioural Biology Centre, Mahidol University Salaya Nakom Pathom 73170 Thailand
    BMC Neurosci 5:31. 2004
  5. ncbi request reprint The inner ear contains heteromeric channels composed of cx26 and cx30 and deafness-related mutations in cx26 have a dominant negative effect on cx30
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London, United Kingdom
    Cell Commun Adhes 10:341-6. 2003
  6. ncbi request reprint Developmental biology. Life after deaf for hair cells?
    Ruth Taylor
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK
    Science 307:1056-8. 2005
  7. ncbi request reprint Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
    J Comp Neurol 467:207-31. 2003
  8. ncbi request reprint Connexins and gap junctions in the inner ear
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, UCL, London, UK
    Audiol Neurootol 7:141-5. 2002
  9. ncbi request reprint Apoptotic death of hair cells in mammalian vestibular sensory epithelia
    A Forge
    Institute of Laryngology and Otology, University College London, 330 332 Gray s Inn Road, London, UK
    Hear Res 139:97-115. 2000
  10. ncbi request reprint Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs
    A Forge
    Institute of Laryngology and Otology, University College London, United Kingdom
    J Comp Neurol 397:69-88. 1998

Collaborators

Detail Information

Publications33

  1. pmc Rapid hair cell loss: a mouse model for cochlear lesions
    Ruth Rebecca Taylor
    Centre for Auditory Research, UCL Ear Institute, University College London, 332 Gray s Inn Road, London, WC1X 8EE, UK
    J Assoc Res Otolaryngol 9:44-64. 2008
    ..This in vivo protocol provides a robust model in which to obtain extensive OHC loss in the mature cochleae of mice and is a means with which to examine different aspects of cochlear pathology in transgenic or mutant strains...
  2. doi request reprint Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea
    Andrew Forge
    Centre for Auditory Research, UCL Ear Institute, London WC1X 8EE, UK
    J Cell Sci 126:1703-12. 2013
    ..These observations demonstrate a role for Cx30 and intercellular communication in regulating repair responses in an epithelial tissue...
  3. pmc β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear
    Ivan Brunetta
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK
    BMC Cell Biol 13:5. 2012
    ..The OC-2 cells are thus a useful model system for testing mechanism of hair cells differentiation...
  4. pmc Opioid modulation of GABA release in the rat inferior colliculus
    Walaiporn Tongjaroenbungam
    Neuro Behavioural Biology Centre, Mahidol University Salaya Nakom Pathom 73170 Thailand
    BMC Neurosci 5:31. 2004
    ....
  5. ncbi request reprint The inner ear contains heteromeric channels composed of cx26 and cx30 and deafness-related mutations in cx26 have a dominant negative effect on cx30
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London, United Kingdom
    Cell Commun Adhes 10:341-6. 2003
    ..The functional disruption caused by some cx26 mutations upon such heteromeric channels may underlie the non-syndromic nature of their effects on hearing...
  6. ncbi request reprint Developmental biology. Life after deaf for hair cells?
    Ruth Taylor
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK
    Science 307:1056-8. 2005
  7. ncbi request reprint Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
    J Comp Neurol 467:207-31. 2003
    ..Heteromeric cx26/cx30 connexons may be unique to the inner ear, which could be one factor underlying the non-syndromic character of the deafness caused by mutations in cx26...
  8. ncbi request reprint Connexins and gap junctions in the inner ear
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, UCL, London, UK
    Audiol Neurootol 7:141-5. 2002
    ....
  9. ncbi request reprint Apoptotic death of hair cells in mammalian vestibular sensory epithelia
    A Forge
    Institute of Laryngology and Otology, University College London, 330 332 Gray s Inn Road, London, UK
    Hear Res 139:97-115. 2000
    ..Explant cultures of mature vestibular organs may be, therefore, a useful model system for examining putative hair cell protecting agents...
  10. ncbi request reprint Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs
    A Forge
    Institute of Laryngology and Otology, University College London, United Kingdom
    J Comp Neurol 397:69-88. 1998
    ..There was also no evidence of any hair cell recovery in the organ of Corti. Thus, there appear to be limitations on the capacity for spontaneous replacement of lost hair cells in the mammalian inner ear...
  11. ncbi request reprint Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30
    Nerissa K Marziano
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, 330 332 Gray s Inn Road, London WC1X 8EE, UK
    Hum Mol Genet 12:805-12. 2003
    ..Disruption of these heteromeric channels by certain mutations may underlie the non-syndromic nature of the deafness...
  12. ncbi request reprint Postnatal maturation of the organ of Corti in gerbils: morphology and physiological responses
    M Souter
    Institute of Laryngology and Otology, University College London Medical School, England
    J Comp Neurol 386:635-51. 1997
    ....
  13. doi request reprint Gap junctions and connexins in the inner ear: their roles in homeostasis and deafness
    Regina Nickel
    Centre for Auditory Research, UCL Ear Institute, University College London, London, UK
    Curr Opin Otolaryngol Head Neck Surg 16:452-7. 2008
    ..In this review, we discuss current ideas about the roles of gap junctions in the inner ear and the implications of connexin mutations on auditory function...
  14. ncbi request reprint Molecular and functional characterization of gap junctions in the avian inner ear
    Regina Nickel
    Centre for Auditory Research, The Ear Institute, University College London, London WC1X 8EE, United Kingdom
    J Neurosci 26:6190-9. 2006
    ..Furthermore, it demonstrates asymmetric GJC within the supporting cell population of the auditory sensory epithelium, which might mediate potassium cycling and/or intercellular signaling...
  15. pmc Alström Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity
    Daniel Jagger
    UCL Ear Institute, University College London, 332 Gray s Inn Road, London WC1X 8EE, UK
    Hum Mol Genet 20:466-81. 2011
    ....
  16. ncbi request reprint Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea
    Daniel J Jagger
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, United Kingdom
    J Neurosci 26:1260-8. 2006
    ..Furthermore, they suggest that separate medial and lateral buffering compartments exist in the hearing cochlea, which are individually dedicated to the homeostasis of inner hair cells and outer hair cells...
  17. ncbi request reprint The molecular architecture of the inner ear
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, UK
    Br Med Bull 63:5-24. 2002
    ..This work is providing new insights into how the tissues of the inner ear are built to perform their tasks, and into the pathogenesis of a range of inner ear disorders...
  18. ncbi request reprint Hair cell regeneration in sensory epithelia from the inner ear of a urodele amphibian
    Ruth R Taylor
    UCL Centre for Auditory Research, University College London, London WC1X 8EE, United Kingdom
    J Comp Neurol 484:105-20. 2005
    ..A similar mechanism has been proposed for the hair cell recovery phenomenon observed in the vestibular organs of mammals...
  19. doi request reprint Development of gap junctional intercellular communication within the lateral wall of the rat cochlea
    J J Kelly
    UCL Ear Institute, University College London, 332 Gray s Inn Road, London WC1X8EE, UK
    Neuroscience 180:360-9. 2011
    ..These data suggest that lateral wall function matures several days in advance of hearing onset, and provide anatomical evidence of the existence of a putative K+ recirculation pathway within the cochlear lateral wall...
  20. ncbi request reprint Intercellular junctional maturation in the stria vascularis: possible association with onset and rise of endocochlear potential
    M Souter
    Institute of Laryngology and Otology, University College London Medical School, UK
    Hear Res 119:81-95. 1998
    ....
  21. doi request reprint Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions
    Helen L May-Simera
    Institute of Child Health, University College London, London WC1N1EH, United Kingdom
    J Comp Neurol 514:174-88. 2009
    ..In summary, our findings indicate that BBS proteins adopt a range of cellular distributions in vivo, not restricted to the centrosome or cilium, and so broaden the possible underlying pathomechanisms of the disease...
  22. ncbi request reprint Arp2/3 complex-mediated actin polymerisation occurs on specific pre-existing networks in cells and requires spatial restriction to sustain functional lamellipod extension
    D Shao
    Division of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom
    Cell Motil Cytoskeleton 63:395-414. 2006
    ....
  23. pmc A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes
    Siobhan O Burns
    Molecular Immunology Unit, Centre for Immunodeficiency, Institute of Child Health, University College London, London, UK
    Blood 115:5355-65. 2010
    ..Together, our results demonstrate that WASp(I294T) significantly affects lymphocyte membrane topography and L-selectin-dependent adhesion, which may be linked to defective hematopoiesis and leukocyte function in affected patients...
  24. ncbi request reprint Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
    Alison J Ross
    Molecular Medicine Unit, Institute of Child Health, University College London, WC1N 1EH, UK
    Nat Genet 37:1135-40. 2005
    ..We also show that Vangl2 localizes to the basal body and axoneme of ciliated cells, a pattern reminiscent of that of the BBS proteins. These data suggest that cilia are intrinsically involved in PCP processes...
  25. pmc MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469 2320, USA
    Biochem Biophys Res Commun 362:940-5. 2007
    ..This is the first report to correlate expression of miRNAs as novel regulators of vertebrate regeneration, alluding to a novel mechanism whereby transdifferentiation occurs...
  26. ncbi request reprint Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration
    Tamar Ben-Yosef
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Hum Mol Genet 12:2049-61. 2003
    ..Our data suggest that the TJ complex at the apex of the reticular lamina requires claudin 14 as a cation-restrictive barrier to maintain the proper ionic composition of the fluid surrounding the basolateral surface of outer hair cells...
  27. ncbi request reprint The existence of opioid receptors in the cochlea of guinea pigs
    Nopporn Jongkamonwiwat
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya Campus, Nakornpathom 73170, Thailand
    Eur J Neurosci 23:2701-11. 2006
    ....
  28. pmc Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses
    Stuart L Johnson
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    J Neurosci 28:7670-8. 2008
    ..Together, our findings provide the first evidence for a tonotopic difference in the properties of the synaptic machinery in mammalian IHCs, which could be essential for fine-tuning their receptor characteristics during sound stimulation...
  29. pmc Tricellulin is a tight-junction protein necessary for hearing
    Saima Riazuddin
    Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Am J Hum Genet 79:1040-51. 2006
    ..A wild-type isoform of tricellulin, which lacks this conserved region, is unaffected by the mutant alleles and is hypothesized to be sufficient for structural and functional integrity of epithelial barriers outside the inner ear...
  30. ncbi request reprint Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
    Mireille Montcouquiol
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:5265-75. 2006
    ..Together, our data support the idea that protein asymmetry plays an important role in the development of PCP, but the colocalization and interaction of Fz3 and Vangl2 suggests that novel PCP mechanisms exist in vertebrates...
  31. ncbi request reprint The presence of opioid receptors in rat inner ear
    Nopporn Jongkamonwiwat
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, 73170 Nakornpathom, Thailand
    Hear Res 181:85-93. 2003
    ..These findings are the first report of the presence of all three classical opioid receptors in the inner ear and suggest that these receptors may have both presynaptic and postsynaptic roles...
  32. ncbi request reprint Low density of membrane particles in auditory hair cells of lizards and birds suggests an absence of somatic motility
    Christine Köppl
    Lehrstuhl für Zoologie, Technische Universitat Munchen, 85747 Garching, Germany
    J Comp Neurol 479:149-55. 2004
    ..This suggests that nonmammalian hair cells do not possess high densities of motor protein in their membranes and are thus unlikely to be capable of somatic motility...
  33. ncbi request reprint The opioid receptors in inner ear of different stages of postnatal rats
    Pansiri Phansuwan-Pujito
    Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand
    Hear Res 184:1-10. 2003
    ..The data provide further evidence that the opioid system may play a role in the development and functioning of the inner ear...