W Gibson

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Epidemiology and diagnosis of African trypanosomiasis using DNA probes
    Wendy Gibson
    School of Biological Sciences, University of Bristol, BS8 1UG, UK
    Trans R Soc Trop Med Hyg 96:S141-3. 2002
  2. doi request reprint Liaisons dangereuses: sexual recombination among pathogenic trypanosomes
    Wendy Gibson
    School of Biological Sciences, Life Sciences Building, 24 Tyndall Avenue, Bristol BS8 1TQ, UK Electronic address
    Res Microbiol 166:459-66. 2015
  3. pmc Morphological and molecular characterization of a marine fish trypanosome from South Africa, including its development in a leech vector
    Polly M Hayes
    Water Research Group Ecology, Unit for Environmental Sciences and Management, North West University, Potchefstroom Campus, Potchefstroom 2520, South Africa
    Parasit Vectors 7:50. 2014
  4. pmc The development of Trypanosoma brucei within the tsetse fly midgut observed using green fluorescent trypanosomes
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Kinetoplastid Biol Dis 2:1. 2003
  5. pmc Species concepts for trypanosomes: from morphological to molecular definitions?
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Kinetoplastid Biol Dis 2:10. 2003
  6. pmc Fly transmission and mating of Trypanosoma brucei brucei strain 427
    Lori Peacock
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol, UK
    Mol Biochem Parasitol 160:100-6. 2008
  7. pmc Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes
    Senthil Ka Natesan
    Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QP, UK
    BMC Res Notes 3:63. 2010
  8. ncbi request reprint Phylogenetic analysis of freshwater fish trypanosomes from Europe using ssu rRNA gene sequences and random amplification of polymorphic DNA
    W C Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Parasitology 130:405-12. 2005
  9. ncbi request reprint The SRA gene: the key to understanding the nature of Trypanosoma brucei rhodesiense
    W C Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 I UG, UK
    Parasitology 131:143-50. 2005
  10. ncbi request reprint Analysis of a cross between green and red fluorescent trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol BS81UG, UK
    Biochem Soc Trans 34:557-9. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Epidemiology and diagnosis of African trypanosomiasis using DNA probes
    Wendy Gibson
    School of Biological Sciences, University of Bristol, BS8 1UG, UK
    Trans R Soc Trop Med Hyg 96:S141-3. 2002
    ..Limited use of the polymerase chain reaction has been made for diagnosis of human and animal trypanosomiasis, due to its high cost...
  2. doi request reprint Liaisons dangereuses: sexual recombination among pathogenic trypanosomes
    Wendy Gibson
    School of Biological Sciences, Life Sciences Building, 24 Tyndall Avenue, Bristol BS8 1TQ, UK Electronic address
    Res Microbiol 166:459-66. 2015
    ..The process involves meiosis and production of haploid gametes, and thus appears to be true sexual reproduction. This review looks at the experimental evidence concerning genetic exchange and identifies current gaps in our knowledge. ..
  3. pmc Morphological and molecular characterization of a marine fish trypanosome from South Africa, including its development in a leech vector
    Polly M Hayes
    Water Research Group Ecology, Unit for Environmental Sciences and Management, North West University, Potchefstroom Campus, Potchefstroom 2520, South Africa
    Parasit Vectors 7:50. 2014
    ..Furthermore, life cycle studies on marine fish trypanosomes have focused on those of the northern hemisphere. In this investigation, we have examined the life cycle and molecular taxonomy of a marine fish trypanosome from South Africa...
  4. pmc The development of Trypanosoma brucei within the tsetse fly midgut observed using green fluorescent trypanosomes
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Kinetoplastid Biol Dis 2:1. 2003
    ..This timecourse coincides with lectin secretion, development of the PM and the digestion and movement of the bloodmeal along the gut. Further experiments are needed to discriminate between these factors...
  5. pmc Species concepts for trypanosomes: from morphological to molecular definitions?
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Kinetoplastid Biol Dis 2:10. 2003
    ..Molecular taxonomy has led the way in identifying these new genotypes and now offers the key to elucidating the biology of these organisms...
  6. pmc Fly transmission and mating of Trypanosoma brucei brucei strain 427
    Lori Peacock
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol, UK
    Mol Biochem Parasitol 160:100-6. 2008
    ..Since Variant 3 grows fast both as bloodstream forms and procyclics and is readily genetically manipulable, it may prove useful where a fly transmissible version of 427 is required...
  7. pmc Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes
    Senthil Ka Natesan
    Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QP, UK
    BMC Res Notes 3:63. 2010
    ..Here we asked if endocytic down-regulation in the procyclic form was associated with resistance to innate trypanolytic immune factors in the blood meal or tsetse fly midgut...
  8. ncbi request reprint Phylogenetic analysis of freshwater fish trypanosomes from Europe using ssu rRNA gene sequences and random amplification of polymorphic DNA
    W C Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Parasitology 130:405-12. 2005
    ..The polymorphic DNA markers we have identified will facilitate future comparisons of the biology of these 2 groups of fish trypanosomes...
  9. ncbi request reprint The SRA gene: the key to understanding the nature of Trypanosoma brucei rhodesiense
    W C Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 I UG, UK
    Parasitology 131:143-50. 2005
  10. ncbi request reprint Analysis of a cross between green and red fluorescent trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol BS81UG, UK
    Biochem Soc Trans 34:557-9. 2006
    ..Our findings are consistent with the hypothesis that mating takes place between trypanosomes in the salivary glands of the fly before they attach to the salivary gland epithelium...
  11. ncbi request reprint Conservation of the genomic location of the human serum resistance associated gene in Trypanosoma brucei rhodesiense
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Mol Biochem Parasitol 130:159-62. 2003
  12. ncbi request reprint The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Infect Genet Evol 1:207-14. 2002
    ..These results are consistent with the hypothesis that new T.b. rhodesiense strains arise by genetic exchange among T. brucei ssp. spreading the SRA gene and thereby the trait for human serum resistance and human infectivity...
  13. ncbi request reprint Molecular characterization of field isolates of human pathogenic trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol, UK
    Trop Med Int Health 6:401-6. 2001
    ..However, virulence or fly transmissibility have been correlated with molecular markers in some instances...
  14. ncbi request reprint Will the real Trypanosoma brucei rhodesiense please step forward?
    Wendy Gibson
    School of Biological Sciences, University of Bristol, BS8 1UG, Bristol, UK
    Trends Parasitol 18:486-90. 2002
    ..The discovery of a gene associated with human-serum resistance in T. brucei rhodesiense and the consequent reappraisal of the identity of this trypanosome prompt this companion article...
  15. ncbi request reprint Frontiers in research on parasitic protozoa
    Wendy Gibson
    School of Biological Sciences, University of Bristol, UK
    Trends Parasitol 18:521-2. 2002
    ..Frontiers in research on parasitic protozoa was the theme of the Autumn Symposium of the British Section of the Society of Protozoologists, held 2 September 2002, in London, UK...
  16. ncbi request reprint Structure and sequence variation of the trypanosome spliced leader transcript
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol, UK
    Mol Biochem Parasitol 107:269-77. 2000
    ..No obvious correlation could be seen between the length of this stem-loop and trypanosome biology. We conclude that the SL repeat is not an informative phylogenetic marker for long range evolutionary studies of genus Trypanosoma...
  17. ncbi request reprint Unravelling the phylogenetic relationships of African trypanosomes of suids
    W C Gibson
    School of Biological Sciences, University of Bristol, UK
    Parasitology 122:625-31. 2001
    ..congolense Tsavo on database. In phylogenetic analysis of the SSU rRNA genes of Salivarian trypanosomes, T. congolense Tsavo grouped with T. simiae rather than T. congolense, suggesting that the name T. simiae Tsavo is more appropriate...
  18. doi request reprint New Trypanosoma (Duttonella) vivax genotypes from tsetse flies in East Africa
    E R Adams
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Parasitology 137:641-50. 2010
    ..Investigation of mammalian host range and pathogenicity will reveal the importance of these new trypanosomes for the epidemiology and control of animal trypanosomiasis in East Africa...
  19. doi request reprint Species-specific probes for the identification of the African tsetse-transmitted trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol, UK
    Parasitology 136:1501-7. 2009
    ....
  20. ncbi request reprint Molecular epidemiology of African trypanosomiasis: the contributions of David George Godfrey OBE to the biochemical characterization of trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Parasite 15:233-6. 2008
    ..These investigations had a major impact on our understanding of the zoonotic nature of human trypanosomiasis in Africa and of the genetic diversity of African trypanosomes...
  21. ncbi request reprint Multiple effects of the lectin-inhibitory sugars D-glucosamine and N-acetyl-glucosamine on tsetse-trypanosome interactions
    L Peacock
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Parasitology 132:651-8. 2006
    ..The sugars cause multiple effects, not restricted solely to the inhibition of midgut lectins. These findings have implications for current models of tsetse susceptibility to trypanosome infection...
  22. ncbi request reprint The evolution of trypanosomes infecting humans and primates
    J Stevens
    School of Biological Sciences, University of Bristol, UK
    Mem Inst Oswaldo Cruz 93:669-76. 1998
    ..Perhaps significantly, Salivarian trypanosomes appear, from these data, to be evolving several times faster than Schizotrypanum species, a factor which may have contributed to previous anomalous estimates of divergence times...
  23. ncbi request reprint Antioxidant gene expression in the blood-feeding fly Glossina morsitans morsitans
    R J L Munks
    School of Biological Sciences, University of Wales, Bangor, Gwynedd, UK
    Insect Mol Biol 14:483-91. 2005
    ..Overall, nine of the 11 genes studied showed responses to changes in physiological circumstance, with the peroxiredoxin group showing the smallest variations throughout...
  24. ncbi request reprint Resolution of the species problem in African trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Int J Parasitol 37:829-38. 2007
    ..Thus, the species problem can be resolved by bringing together considerations of utility, genetic difference and adaptation...
  25. pmc Adult midgut expressed sequence tags from the tsetse fly Glossina morsitans morsitans and expression analysis of putative immune response genes
    M J Lehane
    School of Biological Sciences, University of Wales, Bangor, LL57 2UW, UK
    Genome Biol 4:R63. 2003
    ..We have undertaken an expressed sequence tag (EST) project on the adult tsetse midgut, the major organ system for establishment and early development of trypanosomes...
  26. doi request reprint Trypanosoma melophagium from the sheep ked Melophagus ovinus on the island of St Kilda
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol BS81UG, UK
    Parasitology 137:1799-804. 2010
    ..The close genetic relationship of T. melophagium and T. theileri suggests that T. melophagium represents a lineage of T. theileri that adapted to transmission by sheep keds and hence became a specific parasite of sheep...
  27. ncbi request reprint Sex and evolution in trypanosomes
    W Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, BS8 1UG, Bristol, UK
    Int J Parasitol 31:643-7. 2001
    ..The remarkable biparental inheritance of organelle DNA (=kinetoplast DNA) in T. brucei is without precedent in other eukaryotes. The result of genetic exchange is to enhance the heterogeneity of the kinetoplast DNA minicircles...
  28. ncbi request reprint Trypanosoma (Nannomonas) simiae and T. (N.) godfreyi have genes encoding glutamic acid and alanine-rich proteins
    Karin Asbeck
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Mol Biochem Parasitol 134:159-62. 2004
  29. doi request reprint Conserved sequence of the TgsGP gene in Group 1 Trypanosoma brucei gambiense
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Infect Genet Evol 10:453-8. 2010
    ..The TgsGp-like genes in some isolates of T. b. brucei, T. b. rhodesiense and Group 2 T. b. gambiense are closely similar to VSG Tb10.v4.0178, which may be the ancestral gene from which TgsGP was derived...
  30. ncbi request reprint Tetracycline induction of gene expression in Trypanosoma brucei within the tsetse fly vector
    Lori Peacock
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Mol Biochem Parasitol 140:247-9. 2005
  31. ncbi request reprint The use of specific and generic primers to identify trypanosome infections of wild tsetse flies in Tanzania by PCR
    Imna Malele
    Tsetse and Trypanosomiasis Research Institute, PO Box 1026, Tanga, Tanzania
    Infect Genet Evol 3:271-9. 2003
    ..Molecular identification of these two new trypanosomes should now facilitate their isolation and full biological characterisation...
  32. ncbi request reprint Two genotypic groups of morphologically similar fish trypanosomes from the Okavango Delta, Botswana
    Angela J Davies
    School of Life Sciences, Kingston University, Kingston upon Thames, UK
    Dis Aquat Organ 66:215-20. 2005
    ..It was concluded that the identification of T. mukasai remains a problem, but at least 2 genotypic groups of trypanosomes occur in Okavango Delta fishes, and catfishes in this region appear to contain both types...
  33. ncbi request reprint Genetic characterization of Trypanosoma evansi isolated from a patient in India
    Philippe Truc
    Institut de Recherche pour le Developpement, UR177, Instituto de Combate e Controlo das Tripanossomiases ICCT, CP 2657, Luanda, Angola
    Infect Genet Evol 7:305-7. 2007
    ..Thus, the T. evansi isolated from an Indian patient appears to be a typical T. evansi as far as we can judge, suggesting that the explanation for this unusual infection may lie with the patient...
  34. ncbi request reprint Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes
    Reuben Sharma
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Protist 159:137-51. 2008
    ..Thus, the asymmetric cell division cycle provides a mechanism for a change in cell morphology and also an explanation for how a reduction in cell length can occur in a cell shaped by a stable microtubule array...
  35. pmc Activation of endocytosis as an adaptation to the mammalian host by trypanosomes
    Senthil Kumar A Natesan
    The Molteno Building, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Eukaryot Cell 6:2029-37. 2007
    ..These data suggest that high-level endocytosis in Trypanosoma brucei is an adaptation required for viability in the mammalian host...