Tansy C Hammarton

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow, G11 6NU, UK
    Prog Cell Cycle Res 5:91-101. 2003
  2. pmc Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei
    Jiangtao Ma
    Division of Infection and Immunity, Faculty of Biomedical and Life Sciences and Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Biol Chem 285:15356-68. 2010
  3. pmc Cell cycle regulation in Trypanosoma brucei
    Tansy C Hammarton
    Division of Infection and Immunity and Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom
    Mol Biochem Parasitol 153:1-8. 2007
  4. pmc Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis
    Tansy C Hammarton
    Infection and Immunity, Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK
    Mol Microbiol 65:1229-48. 2007
  5. pmc Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin
    Corinna Benz
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e30367. 2012
  6. ncbi request reprint The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, United Kingdom
    J Biol Chem 279:24757-64. 2004
  7. pmc Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Mol Microbiol 56:104-16. 2005
  8. pmc The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement
    Sophie F May
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
    Mol Microbiol 84:77-92. 2012
  9. ncbi request reprint Cytokinesis in trypanosomatids
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom
    Curr Opin Microbiol 10:520-7. 2007
  10. ncbi request reprint Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow, G11 6NU, United Kingdom
    J Biol Chem 278:22877-86. 2003

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow, G11 6NU, UK
    Prog Cell Cycle Res 5:91-101. 2003
    ..Potential targets include protein kinases from the cyclin-dependent kinase, cAMP-dependent kinase and mitogen activated protein kinase families...
  2. pmc Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei
    Jiangtao Ma
    Division of Infection and Immunity, Faculty of Biomedical and Life Sciences and Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Biol Chem 285:15356-68. 2010
    ....
  3. pmc Cell cycle regulation in Trypanosoma brucei
    Tansy C Hammarton
    Division of Infection and Immunity and Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom
    Mol Biochem Parasitol 153:1-8. 2007
    ..brucei appears to use different checkpoint control strategies compared to model eukaryotes. It is therefore probable that T. brucei has evolved novel pathways to control its cell cycle...
  4. pmc Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis
    Tansy C Hammarton
    Infection and Immunity, Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK
    Mol Microbiol 65:1229-48. 2007
    ..Notably, no additional roles were detected for trypanosome PLK in mitosis, setting this protein kinase apart from its counterparts in other eukaryotes...
  5. pmc Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin
    Corinna Benz
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e30367. 2012
    ..We propose that the stable microtubule cytoskeleton of T. brucei necessitates the coordinated action of a family of katanins and spastin to bring about the cytoskeletal remodelling necessary to complete cell division...
  6. ncbi request reprint The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, United Kingdom
    J Biol Chem 279:24757-64. 2004
    ....
  7. pmc Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Mol Microbiol 56:104-16. 2005
    ..Unlike its counterpart in budding yeast, T. brucei MOB1 does not appear to be required for mitotic exit...
  8. pmc The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement
    Sophie F May
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
    Mol Microbiol 84:77-92. 2012
    ..Our data provide insight into the control of nucleus positioning in this important pathogen and emphasize differences in the cytoskeleton and cell cycle control between two life cycle stages of the T. brucei parasite...
  9. ncbi request reprint Cytokinesis in trypanosomatids
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom
    Curr Opin Microbiol 10:520-7. 2007
    ..In this review, we discuss direct and indirect effects on cytokinesis, using Trypanosoma brucei as a model...
  10. ncbi request reprint Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow, G11 6NU, United Kingdom
    J Biol Chem 278:22877-86. 2003
    ..This indicates that there are fundamental differences in cell cycle controls between life cycle forms of T. brucei and that key cell cycle checkpoints present in higher eukaryotes are absent from trypanosomes...
  11. doi request reprint Hydroxyurea-induced synchronisation of bloodstream stage Trypanosoma brucei
    Glynn R Forsythe
    Division of Infection and Immunity and Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow, Scotland, UK
    Mol Biochem Parasitol 164:131-6. 2009
    ..brucei...
  12. doi request reprint Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen
    Nathaniel G Jones
    Wellcome Trust Centre for Molecular Parasitology and Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Pathog 10:e1003886. 2014
    ..Thus, the RNAi kinome library provides a valuable asset for functional analysis of cell signalling pathways in African trypanosomes as well as drug target identification and validation. ..
  13. pmc Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen
    Séverine Monnerat
    Division of Infection and Immunity, Faculty of Biomedical and Life Sciences and Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, UK
    BMC Res Notes 2:46. 2009
    ..A small scale RNA interference (RNAi) screen was carried out in Trypanosoma brucei to evaluate the prospects for identifying novel cycle regulators...