A Christy Hunter

Summary

Affiliation: University of Brighton
Country: UK

Publications

  1. ncbi Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, East Sussex BN2 4GJ, UK
    Adv Drug Deliv Rev 58:1523-31. 2006
  2. ncbi Therapeutic synthetic polymers: a game of Russian roulette?
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ UK
    Drug Discov Today 7:998-1001. 2002
  3. doi Transformation of a series of saturated isomeric steroidal diols by Aspergillus tamarii KITA reveals a precise stereochemical requirement for entrance into the lactonization pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, The Huxley Biosciences Building, University of Brighton, East Sussex BN2 4GJ, UK
    J Steroid Biochem Mol Biol 122:352-8. 2010
  4. doi Cationic carriers of genetic material and cell death: a mitochondrial tale
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Building, Lewes Road, Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1797:1203-9. 2010
  5. doi Transformation of some 3alpha-substituted steroids by Aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, East Sussex BN2 4GJ, UK
    J Steroid Biochem Mol Biol 118:171-6. 2010
  6. doi An unusual ring--a opening and other reactions in steroid transformation by the thermophilic fungus Myceliophthora thermophila
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, East Sussex BN2 4GJ, UK
    J Steroid Biochem Mol Biol 116:171-7. 2009
  7. doi Transformation of 5-ene steroids by the fungus Aspergillus tamarii KITA: mixed molecular fate in lactonization and hydroxylation pathways with identification of a putative 3beta-hydroxy-steroid dehydrogenase/Delta5-Delta4 isomerase pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Building, Lewes Road, Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1791:110-7. 2009
  8. ncbi Natural Products and Medicinal Chemistry--the 22nd Mona Symposium
    A Christy Hunter
    University of Brighton, School of Pharmacy, Cockcroft Building, Brighton, East Sussex, BN2 4GJ, UK
    IDrugs 11:169-70. 2008
  9. ncbi Predominant allylic hydroxylation at carbons 6 and 7 of 4 and 5-ene functionalized steroids by the thermophilic fungus Rhizomucor tauricus IMI23312
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Lewes Road, Brighton, East Sussex, UK
    J Steroid Biochem Mol Biol 108:155-63. 2008
  10. ncbi Distinct metabolic handling of 3beta-hydroxy-17a-oxa-D-homo-5alpha-androstan-17-one by the filamentous fungus Aspergillus tamarii KITA: Evidence in support of steroid/hydroxylase binding hypothesis
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, East Sussex, BN2 4GJ, UK
    Biochim Biophys Acta 1771:1254-61. 2007

Collaborators

Detail Information

Publications26

  1. ncbi Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, East Sussex BN2 4GJ, UK
    Adv Drug Deliv Rev 58:1523-31. 2006
    ..There is a clear and immediate need for understanding of the mechanisms which cause polyfectin toxicity which will ultimately facilitate improved vector design and safer gene delivery...
  2. ncbi Therapeutic synthetic polymers: a game of Russian roulette?
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ UK
    Drug Discov Today 7:998-1001. 2002
    ..Acceptance of the importance of immunotoxicological factors in response to the presence of these macromolecules must be addressed if emergent technologies, such as polymer-based gene-delivery systems, are going to succeed...
  3. doi Transformation of a series of saturated isomeric steroidal diols by Aspergillus tamarii KITA reveals a precise stereochemical requirement for entrance into the lactonization pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, The Huxley Biosciences Building, University of Brighton, East Sussex BN2 4GJ, UK
    J Steroid Biochem Mol Biol 122:352-8. 2010
    ..All metabolites were isolated by column chromatography and were identified by (1)H, (13)C NMR and DEPT analysis and further characterized using infra-red, elemental analysis and accurate mass measurement...
  4. doi Cationic carriers of genetic material and cell death: a mitochondrial tale
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Building, Lewes Road, Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1797:1203-9. 2010
    ..It is the aim of this review to discuss the mechanisms behind the observed polycation toxicity including roles for little studied cellular organelles in the process such as the lysosome and endoplasmic reticulum...
  5. doi Transformation of some 3alpha-substituted steroids by Aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, East Sussex BN2 4GJ, UK
    J Steroid Biochem Mol Biol 118:171-6. 2010
    ..Apart from oxidative transformations observed a minor reductive pathway was revealed with the C-17 ketone being reduced to a C-17beta-alcohol for the first time in this organism...
  6. doi An unusual ring--a opening and other reactions in steroid transformation by the thermophilic fungus Myceliophthora thermophila
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, East Sussex BN2 4GJ, UK
    J Steroid Biochem Mol Biol 116:171-7. 2009
    ..The range of steroidal modification achieved with this fungus indicates that these organisms may be a rich source of novel steroid biocatalysis which deserve greater investigation in the future...
  7. doi Transformation of 5-ene steroids by the fungus Aspergillus tamarii KITA: mixed molecular fate in lactonization and hydroxylation pathways with identification of a putative 3beta-hydroxy-steroid dehydrogenase/Delta5-Delta4 isomerase pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Building, Lewes Road, Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1791:110-7. 2009
    ..The presence of the 3beta-HSD/isomerase in A. tamarii and the transformation results obtained in this study highlight an important potential role that fungi may have in the generation of environmental androgens...
  8. ncbi Natural Products and Medicinal Chemistry--the 22nd Mona Symposium
    A Christy Hunter
    University of Brighton, School of Pharmacy, Cockcroft Building, Brighton, East Sussex, BN2 4GJ, UK
    IDrugs 11:169-70. 2008
  9. ncbi Predominant allylic hydroxylation at carbons 6 and 7 of 4 and 5-ene functionalized steroids by the thermophilic fungus Rhizomucor tauricus IMI23312
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Lewes Road, Brighton, East Sussex, UK
    J Steroid Biochem Mol Biol 108:155-63. 2008
    ....
  10. ncbi Distinct metabolic handling of 3beta-hydroxy-17a-oxa-D-homo-5alpha-androstan-17-one by the filamentous fungus Aspergillus tamarii KITA: Evidence in support of steroid/hydroxylase binding hypothesis
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, East Sussex, BN2 4GJ, UK
    Biochim Biophys Acta 1771:1254-61. 2007
    ..tamarii rather than dehydrogenation as reported in man and microorganisms. The importance of these findings in relation to steroid/hydroxylase binding interactions is discussed...
  11. ncbi Ring-B functionalized androst-4-en-3-ones and ring-C substituted pregn-4-en-3-ones undergo differential transformation in Aspergillus tamarii KITA: ring-A transformation with all C-6 substituted steroids and ring-D transformation with C-11 substituents
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular, Sciences, University of Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1761:360-6. 2006
    ....
  12. ncbi An efficient one-pot synthesis generating 4-ene-3,6-dione functionalised steroids from steroidal 5-en-3beta-ols using a modified Jones oxidation methodology
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, East Sussex BN2 4GJ, UK
    Steroids 71:30-3. 2006
    ..The new reaction affords high yields (77-89%) of product in relatively short reaction times (1-2h). The simplicity of this reaction gives significant advantages over previously reported methodologies...
  13. ncbi Fate of novel Quasi reverse steroidal substrates by Aspergillus tamarii KITA: bypass of lactonisation and an exclusive role for the minor hydroxylation pathway
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1734:190-7. 2005
    ..All metabolites were isolated by column chromatography and were identified by 1H and 13C NMR spectroscopy, DEPT analysis and other spectroscopic and crystallographic data...
  14. ncbi Flexibility of the endogenous progesterone lactonisation pathway in Aspergillus tamarii KITA: transformation of a series of cortical steroid analogues
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ East Sussex, UK
    J Steroid Biochem Mol Biol 87:301-8. 2003
    ..Evidence is also presented for the presence of a highly flexible but stereospecific keto-reductase. All metabolites were isolated by column chromatography and were identified by 1H, 13C NMR, DEPT analysis and other spectroscopic data...
  15. doi Transformation of structurally diverse steroidal analogues by the fungus Corynespora cassiicola CBS 161.60 results in generation of 8β-monohydroxylated metabolites with evidence in favour of 8β-hydroxylation through inverted binding in the 9α-hydroxylase
    A Christy Hunter
    University of Brighton, School of Pharmacy, Brighton, East Sussex BN2 4GJ, UK
    Biochim Biophys Acta 1811:1054-61. 2011
    ..In general all maximally oxidised metabolites contained four oxygen atoms. The importance of these findings in relation to 8β-hydroxylation of these steroids is discussed...
  16. doi Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering
    Islam Hamad
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, U K
    ACS Nano 4:6629-38. 2010
    ....
  17. ncbi A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Mol Ther 11:990-5. 2005
    ..The reported observations have important implications for the design and execution of gene therapy protocols as well for controlling intracellular distribution of drugs with cationic-based polymer-delivery systems...
  18. ncbi Nanomedicine: current status and future prospects
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    FASEB J 19:311-30. 2005
    ..Potential pitfalls or side effects associated with nanoparticles are also discussed...
  19. ncbi Real-time evaluation of macromolecular surface modified quartz crystal resonant sensors under cryogenic stress for biological applications
    Karl D Pavey
    Acoustic Sensors Research Group, School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, Lewes Road, Brighton, East Sussex BN2 4GJ, UK
    Biosens Bioelectron 18:1349-54. 2003
    ....
  20. ncbi Activation of the human complement system by cholesterol-rich and PEGylated liposomes-modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology, School of Pharmacy, University of Brighton, Brighton, UK
    J Liposome Res 16:167-74. 2006
    ..The net anionic charge on the phosphate moiety of the phospholipid-mPEG conjugate seemed to play a critical role in activation of both the classical and alternative pathways of the complement system...
  21. ncbi Modification of the Stewart biphasic colorimetric assay for stable and accurate quantitative determination of Pluronic and Tetronic block copolymers for application in biological systems
    Othman Al-Hanbali
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, East Sussex BN2 4GJ, UK
    Anal Biochem 361:287-93. 2007
    ..In such systems the colorimetric assay directly determines the fraction of unbound (free) copolymer in the presence of proteins...
  22. ncbi Synthetic polymers in 21st century therapeutics: the way forward
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK
    Drug Discov Today 8:154-6. 2003
  23. ncbi Blood hot in Boston
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK BN3 1NJ
    Drug Discov Today 7:1082-4. 2002
  24. doi Novel quartz crystal microbalance based biosensor for detection of oral epithelial cell-microparticle interaction in real-time
    Jacqueline Elsom
    School of Pharmacy, University of Brighton, Lewes Road, Brighton BN2 4GJ, UK
    Biosens Bioelectron 23:1259-65. 2008
    ..Furthermore, a cellular uptake process, in response to microsphere loading was identified and this, by influencing the rigidity of the cellular cytoskeleton, was also detectable through the frequency responses obtained...
  25. ncbi Causative factors behind poloxamer 188 (Pluronic F68, Flocor)-induced complement activation in human sera. A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewis Road, Brighton BN2 4GJ, UK
    Biochim Biophys Acta 1689:103-13. 2004
    ..Our findings could provide the basis of novel approaches to the prevention of poloxamer-mediated complement activation...
  26. ncbi Low and high molecular weight poly(L-lysine)s/poly(L-lysine)-DNA complexes initiate mitochondrial-mediated apoptosis differently
    Peter Symonds
    Cancer Research UK, Tumour Cytokine Biology Group, University Hospital, Nottingham NG7 2UH, UK
    FEBS Lett 579:6191-8. 2005
    ..The importance of our data in relation to design of novel and safer cationic non-viral vectors for human gene therapy is discussed...