W N Hunter

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate
    Tanja Sgraja
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:625-9. 2005
  2. pmc The nucleotide-binding site of Aquifex aeolicus LpxC
    Lori Buetow
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1082-6. 2006
  3. pmc Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
    Paul K Fyfe
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland
    Acta Crystallogr D Biol Crystallogr 66:881-8. 2010
  4. pmc Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases
    Lindsay B Tulloch
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, UK
    J Med Chem 53:221-9. 2010
  5. pmc High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:504-8. 2006
  6. pmc Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
    Scott Cameron
    University of Dundee, Scotland, UK
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:450-4. 2009
  7. pmc A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
    Nicola L Ramsden
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, United Kingdom
    J Med Chem 52:2531-42. 2009
  8. pmc Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery
    Tanja Sgraja
    Division of Biological Chemistry and Drug Discovery, University of Dundee, UK
    FEBS J 275:2779-94. 2008
  9. pmc Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:829-34. 2006
  10. pmc Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
    Alice Dawson
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Mol Microbiol 61:1457-68. 2006

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. pmc A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate
    Tanja Sgraja
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:625-9. 2005
    ....
  2. pmc The nucleotide-binding site of Aquifex aeolicus LpxC
    Lori Buetow
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1082-6. 2006
    ..However, based on the position of uracil revealed in this study and on the previously reported complex of LpxC with an inhibitor, a model is proposed for substrate binding...
  3. pmc Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
    Paul K Fyfe
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland
    Acta Crystallogr D Biol Crystallogr 66:881-8. 2010
    ..The distinct subunit-subunit interfaces may provide a potential area to target by exploiting the observation that creation of the enzyme active site is dependent on oligomerization...
  4. pmc Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases
    Lindsay B Tulloch
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, UK
    J Med Chem 53:221-9. 2010
    ..We tested two new compounds with known DHFR inhibitors. A synergistic effect was observed for one particular combination highlighting the potential of such an approach for treatment of African sleeping sickness...
  5. pmc High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:504-8. 2006
    ..The assignment of the fragment sequences is consistent with the specificity of the protease...
  6. pmc Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
    Scott Cameron
    University of Dundee, Scotland, UK
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:450-4. 2009
    ....
  7. pmc A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
    Nicola L Ramsden
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, United Kingdom
    J Med Chem 52:2531-42. 2009
    ..92 +/- 0.18 muM). These data provide a framework for the development of IspF inhibitors to generate lead compounds of therapeutic potential against microbial pathogens...
  8. pmc Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery
    Tanja Sgraja
    Division of Biological Chemistry and Drug Discovery, University of Dundee, UK
    FEBS J 275:2779-94. 2008
    ....
  9. pmc Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:829-34. 2006
    ....
  10. pmc Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
    Alice Dawson
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Mol Microbiol 61:1457-68. 2006
    ..TbPTR1 therefore offers novel structural features to exploit in the search for inhibitors of therapeutic value against African trypanosomiasis...
  11. pmc Structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase
    Vincenzo A Rao
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:243-7. 2013
    ..Specific differences that have been proven to contribute to selectivity against the human enzyme in a study of Cryptosporidium parvum IMPDH are also conserved, highlighting the potential value of IMPDH as a drug target...
  12. pmc Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment
    Martin Zoltner
    College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Biochem J 449:469-77. 2013
    ....
  13. pmc Structure of Leishmania major cysteine synthase
    Paul K Fyfe
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:738-43. 2012
    ..The structure surprisingly revealed that the cofactor pyridoxal phosphate had been lost during crystallization...
  14. pmc IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening
    Naomi Tidten-Luksch
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 7:e35792. 2012
    ..It is noteworthy that compounds identified by virtual screening methods provided the controls for the biochemical screens...
  15. pmc Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target
    Thomas C Eadsforth
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 7:e35973. 2012
    ....
  16. pmc Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme
    Patrick E F O'Rourke
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 6:e24158. 2011
    ..The model and our comparisons rather support the hypothesis that an active site threonine hydroxyl contributes a proton used in the reduction of the substrate methylene to pyruvate methyl in the final stage of the mechanism...
  17. pmc Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site
    Keri L Barrack
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:33-7. 2011
    ..The crystal form obtained under these conditions is therefore unsuitable for the characterization of inhibitor complexes...
  18. pmc High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies
    Vadim Rimsa
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 70:279-89. 2014
    ..However, there are significant differences that indicate the recognition of substrates with different properties. Of note is the presence of a lysine in the S1' recognition subsite that suggests specificity towards an acidic substrate...
  19. pmc The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function
    Jennifer R Fleming
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK
    FEBS J 280:3270-80. 2013
    ..The interaction of TBC-B with the α-tubulin C-terminus may, in particular, protect from post-translational modifications, or simply assist in the shepherding of the protein into polymerization...
  20. pmc Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii
    Alice Dawson
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:611-7. 2013
    ..The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain...
  21. pmc Structure of the SCAN domain of human paternally expressed gene 3 protein
    Vadim Rimsa
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 8:e69538. 2013
    ..The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion. ..
  22. pmc The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system
    Vincenzo A Rao
    College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 67:1065-72. 2011
    ..A relatively low level of sequence conservation amongst Lip homologues is noted and is restricted to parts of the structure that might be involved in interactions with physiological partners...
  23. pmc Two high-resolution structures of the human E3 ubiquitin ligase Siah1
    Vadim Rimsa
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:1339-43. 2013
    ..The crystallization conditions and improved models of Siah1 may aid future studies investigating Siah1-ligand complexes. ..
  24. pmc Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment
    Patrick E F O'Rourke
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    BMC Struct Biol 14:1. 2014
    ..Structural studies of IspF from these two important yet distinct pathogens, and comparisons with orthologues have been carried out to generate reagents, to support and inform a structure-based approach to early stage drug discovery...
  25. pmc The architecture of EssB, an integral membrane component of the type VII secretion system
    Martin Zoltner
    College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Structure 21:595-603. 2013
    ....
  26. pmc The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target
    Thomas C Eadsforth
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Mol Biochem Parasitol 181:178-85. 2012
    ..Additionally, residues that interact and participate in catalysis in the human homologue are conserved amongst trypanosomatid sequences and this may complicate attempts to derive potent, parasite specific DHCH inhibitors...
  27. pmc Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme
    Paul K Fyfe
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom
    Mol Biochem Parasitol 170:93-9. 2010
    ..We conclude that it would be difficult to target the parasite enzyme in preference to the host enzyme and therefore glutathione synthetase may not be a suitable target for antiparasitic drug discovery...
  28. pmc Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis
    Alice Dawson
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    J Mol Biol 401:253-64. 2010
    ..These data allow for a detailed description of the structure-reactivity relationship that governs MenD function and refinement of the model for the catalytic intermediate that supports the Stetter-like conjugate addition...
  29. pmc Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate
    Rachel E Morgan
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    BMC Struct Biol 11:21. 2011
    ..Our characterization of the DHPS active site and interactions with the enzyme product are designed to underpin early stage drug discovery...
  30. pmc Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity
    Alice Dawson
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    BMC Struct Biol 11:19. 2011
    ....
  31. pmc The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery
    Lori Buetow
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    BMC Struct Biol 7:68. 2007
    ..To underpin future drug development it is important to assess which enzymes in this biosynthetic pathway are essential in the actual pathogens and to characterize them...
  32. pmc Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase
    Tanja Sgraja
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK
    BMC Struct Biol 7:20. 2007
    ..Since isoprenoid biosynthesis is essential for trypanosomatid viability and may provide new targets for therapeutic intervention it is important to characterize the pathway components...
  33. ncbi request reprint Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis
    W N Hunter
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 31:537-42. 2003
    ..Since both enzymes are validated drug targets, the models provide templates for structure-based design of anti-microbial agents targeting a number of serious human diseases...
  34. pmc Structure-based ligand design and the promise held for antiprotozoan drug discovery
    William N Hunter
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 284:11749-53. 2009
    ..A structure-centric approach to support discovery of antiparasitic compounds promises much. Current strategies and benefits of a structure-based approach to support early stage drug discovery will be described...
  35. ncbi request reprint Targeting metabolic pathways in microbial pathogens: oxidative stress and anti-folate drug resistance in trypanosomatids
    W N Hunter
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 31:607-10. 2003
    ....
  36. ncbi request reprint Picking pockets to fuel antimicrobial drug discovery
    W N Hunter
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Tayside, Scotland, U K
    Biochem Soc Trans 35:980-4. 2007
    ....
  37. pmc Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites
    William N Hunter
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, UK
    Curr Top Med Chem 11:2048-59. 2011
    ..Particular attention will be paid to how these data inform on the apicomplexan orthologues concentrating on the enzymes from Plasmodium spp. these cause malaria, one the most important parasitic diseases in the world today...
  38. ncbi request reprint The non-mevalonate pathway of isoprenoid precursor biosynthesis
    William N Hunter
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Scotland, UK
    J Biol Chem 282:21573-7. 2007
    ..Detailed knowledge of the pathway may also be exploited to genetically modify microorganisms and plants to produce compounds of agricultural and medical interest...
  39. ncbi request reprint Two crystal forms of ModE, the molybdate-dependent transcriptional regulator from Escherichia coli
    D R Hall
    The Wellcome Trust Building, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 55:542-3. 1999
    ..8 A resolution. Structural analysis, in combination with ongoing biochemical characterization, will assist the elucidation of the structure-activity relationship in regulating the uptake of molybdate in bacteria...
  40. ncbi request reprint The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins
    M S Alphey
    Department of Biochemistry, The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 300:903-16. 2000
    ....
  41. ncbi request reprint Oxyanion binding alters conformation and quaternary structure of the c-terminal domain of the transcriptional regulator mode. Implications for molybdate-dependent regulation, signaling, storage, and transport
    D G Gourley
    Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, United Kingdom
    J Biol Chem 276:20641-7. 2001
    ..Sequence and structure-based comparisons lead to a classification of molybdate-binding proteins...
  42. ncbi request reprint Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites
    D G Gourley
    The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK
    Nat Struct Biol 8:521-5. 2001
    ..Both DHB and MTX form extensive hydrogen bonding networks with NADP(H) but differ in the orientation of the pteridine...
  43. ncbi request reprint Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase
    L E Kemp
    The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 57:1189-91. 2001
    ..60, c = 175.56 A. Diffraction data have been recorded to 2.4 A resolution using synchrotron radiation...
  44. ncbi request reprint Crystallization and X-ray diffraction measurements on recombinant molbindin, MopII, from Clostridium pasteurianum
    J A Harrison
    School of Life Sciences, The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 57:1715-7. 2001
    ..8 and 1.6 A resolution for the molybdate and tungstate complexes, respectively. Data were collected on apoMopII crystals to a resolution of 1.8 A in-house...
  45. ncbi request reprint Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex
    Charles S Bond
    Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Mol Biol 316:1071-81. 2002
    ..The sequence similarity of E.coli and human dPGMs allows us to correlate structure with clinical pathology...
  46. ncbi request reprint The crystal structure of Escherichia coli class II fructose-1, 6-bisphosphate aldolase in complex with phosphoglycolohydroxamate reveals details of mechanism and specificity
    D R Hall
    Department of Biochemistry, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 287:383-94. 1999
    ..A reaction mechanism distinct from that proposed for other class II aldolases is discussed. The results suggest that the class II aldolases should be sub-divided into two groups on the basis of both distinct folds and mechanism...
  47. ncbi request reprint Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design
    Alexander W Schuttelkopf
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 352:105-16. 2005
    ..The molecular detail provided by these complex structures identifies the important interactions necessary to assist the structure-based development of novel enzyme inhibitors of potential therapeutic value...
  48. ncbi request reprint The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods
    Lauris E Kemp
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 61:45-52. 2005
    ..The observation that MECP synthase binds three metabolites that are produced by enzymes two, three and four stages downstream in isoprenoid biosynthesis suggests that feedback regulation of the non-mevalonate pathway is possible...
  49. pmc Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development
    Lauris E Kemp
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 99:6591-6. 2002
    ..Our model will therefore serve as a template to facilitate the structure-based design of potential antimicrobial agents targeting two of the most serious human diseases, tuberculosis and malaria...
  50. ncbi request reprint High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase
    C S Bond
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 276:3247-53. 2001
    ..E. coli dPGM, like the mammalian dPGMs, is a dimer, whereas previous structural work has concentrated on monomeric and tetrameric yeast forms. We can now analyze the sequence differences that cause this variation of quaternary structure...
  51. pmc The high-resolution crystal structure of the molybdate-dependent transcriptional regulator (ModE) from Escherichia coli: a novel combination of domain folds
    D R Hall
    The Wellcome Trust Building, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 18:1435-46. 1999
    ..Modelling of ModE interacting with DNA suggests that a large distortion of DNA is not necessary for complex formation...
  52. pmc Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus
    C S Bond
    Wellcome Trust Biocentre, University of Dundee, Dundee, Tayside DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 98:5509-14. 2001
    ..A model of the Hjc-Holliday junction complex is proposed, based on the available functional and structural data...
  53. ncbi request reprint Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur
    C S Bond
    The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Acta Crystallogr D Biol Crystallogr 57:755-8. 2001
    ..33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given...
  54. ncbi request reprint The crystal structure of a class II fructose-1,6-bisphosphate aldolase shows a novel binuclear metal-binding active site embedded in a familiar fold
    S J Cooper
    Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    Structure 4:1303-15. 1996
    ..Characterization is sought to enable a dissection of structure/activity relationships which may assist the construction of designed aldolases for use as biocatalysts in synthetic chemistry...
  55. ncbi request reprint Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis
    Venkatasubramanian Ulaganathan
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 369:305-12. 2007
    ..Comparisons with an LpxA:peptide inhibitor complex indicate that the peptide competes with both nucleotide and acyl carrier protein substrates...
  56. ncbi request reprint Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex
    Karen McLuskey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 60:1780-5. 2004
    ..PTR1 is a target for the development of improved therapies for infections caused by trypanosomatid parasites and this analysis provides information to assist the structure-based development of novel enzyme inhibitors...
  57. ncbi request reprint Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis
    Mads Gabrielsen
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    J Biol Chem 279:52753-61. 2004
    ..We propose that complex formation of the three enzymes at the core of the DOXP pathway can produce an assembly localizing 18 catalytic centers for the early stages of isoprenoid biosynthesis...
  58. ncbi request reprint Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity
    Emma Byres
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 371:540-53. 2007
    ..This model facilitates discussion of the molecular determinants of substrate recognition and contributions made by specific residues to the enzyme mechanism...
  59. ncbi request reprint Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases
    David R Hall
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 277:22018-24. 2002
    ..The availability of more space and a wider range of aldehyde partners used by TBPA together with the highly specific nature of FBPA suggest that TBPA might be a preferred enzyme to modify for use in biotransformation chemistry...
  60. pmc Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase)
    Alice Dawson
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 384:1353-68. 2008
    ..This, in addition to structural and sequence comparisons with putative MenD orthologues, provides insight into the specificity and reactivity of MenD and allows a two-stage reaction mechanism to be proposed...
  61. ncbi request reprint Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 278:25919-25. 2003
    ..Comparisons with chloroplast TrX and its substrate fructose 1,6-bisphosphate phosphatase suggest that this movement may represent a general feature of redox regulation in the trypanothione and thioredoxin peroxidase pathways...
  62. pmc Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
    Linda Miallau
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 100:9173-8. 2003
    ..Our model therefore provides an accurate template to facilitate the structure-based design of broad-spectrum antimicrobial agents...
  63. ncbi request reprint The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 278:48219-27. 2003
    ..This domain may be involved in mediating protein folding and sulfurtransferase-protein interactions...
  64. ncbi request reprint Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, United Kingdom
    J Biol Chem 280:3068-77. 2005
    ..Key to the acquisition of a solvent-derived proton is the orientation of substrate and stabilization of a dienolate intermediate by Tyr-199, Asn-148, and the oxidized nicotinamide...
  65. ncbi request reprint Insight into the role of Escherichia coli MobB in molybdenum cofactor biosynthesis based on the high resolution crystal structure
    Karen McLuskey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 278:23706-13. 2003
    ..We propose therefore that MobB is an adapter protein that acts in concert with MobA to achieve the efficient biosynthesis and utilization of molybdopterin guanine dinucleotide...
  66. ncbi request reprint Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni
    Mads Gabrielsen
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, UK
    Eur J Biochem 271:3028-35. 2004
    ..These bifunctional proteins are potential drug targets in several human pathogens (e.g. Helicobacter pylori, C. jejuni and Treponema pallidum)...
  67. ncbi request reprint Passive acquisition of ligand by the MopII molbindin from Clostridium pasteurianum: structures of apo and oxyanion-bound forms
    Alexander W Schuttelkopf
    The Wellcome Trust Biocentre, Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 277:15013-20. 2002
    ..In the absence of ligand this effects the movement of an important lysine side chain, thereby partially inactivating the binding sites. The differences are consistent with a biological role in molybdate storage/buffering...
  68. pmc Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis
    Lori Buetow
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 104:4321-6. 2007
    ..The placement of UDP-N-acetylglucosamine and the FA provides details of N-acyltransferase ligand interactions and allows for a description of structure and reactivity at an early stage of LPS assembly...
  69. ncbi request reprint The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation
    Ramasubramanian Sundaramoorthy
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 359:347-57. 2006
    ..This indicates that KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation with redox regulation...
  70. ncbi request reprint Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form
    Stewart A Fyffe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell 21:1-2. 2006
  71. pmc A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure
    Justyna Kalinowska-Tłuścik
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:237-41. 2010
    ..The surface area of interaction in the triclinic form is almost double that observed in the monoclinic form, implying that the dimeric assembly in the monoclinic form may also be an artifact of crystallization...
  72. ncbi request reprint High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides
    Matthew P Shaw
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Mol Biochem Parasitol 126:173-80. 2003
    ..brucei enzyme. Such a significant difference could be exploited by the structure-based design of selective inhibitors using the structure of the trypanosomatid enzyme as a template...
  73. pmc Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design
    Ahilan Saravanamuthu
    Division of Biological Chemistry and Molecular Microbiology, The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 279:29493-500. 2004
    ....
  74. ncbi request reprint Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates
    Ramasubramanian Sundaramoorthy
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, UK
    FEBS J 274:275-86. 2007
    ..LlPDH can now serve as a model system for structure-based inhibitor design targeting the enzyme from Trypanosoma species...
  75. pmc Structure of Staphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA
    Venkatasubramanian Ulaganathan
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Tayside, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:908-13. 2007
    ..The presence of acetoacetyl-CoA in one of the two active sites present in the asymmetric unit indicates how part of the substrate binds and facilitates comparisons with the structure of Mycobacterium tuberculosis MenB...
  76. ncbi request reprint The organization of divalent cations in the active site of cadmium Escherichia coli fructose-1,6-bisphosphate aldolase
    David R Hall
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 59:611-4. 2003
    ..These Cd(2+) sites are equivalent to two Zn(2+) ions observed when the enzyme is complexed with a transition-state mimic and confirm our assignment of the roles played by these ions...
  77. ncbi request reprint Crystal structure of activated ModE reveals conformational changes involving both oxyanion and DNA-binding domains
    Alexander W Schuttelkopf
    Division of Biological Chemistry and Molecular Microbiology, The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 326:761-7. 2003
    ..Manual docking of an idealized DNA structure suggests that this conformational change should improve DNA binding of the activated molybdate-bound ModE...
  78. ncbi request reprint The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate
    Mads Gabrielsen
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, UK
    FEBS J 273:1065-73. 2006
    ....
  79. pmc Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis
    Scott Cameron
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:534-6. 2005
    ..7 A3 Da(-1) corresponds to two subunits, each of approximate weight 21.4 kDa, in the asymmetric unit with 55% solvent content. These crystals diffract to high resolution and experimental phases are being sought to determine the structure...
  80. pmc Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
    Paul K Fyfe
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    J Biol Chem 283:17672-80. 2008
    ..The potential inhibitory role of the C terminus provides a mechanism to control relative levels of the critical metabolites, trypanothione, glutathionylspermidine, and spermidine in Leishmania...
  81. pmc Structure of Staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein
    Ramasubramanian Sundaramoorthy
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK
    J Mol Biol 383:603-14. 2008
    ....
  82. pmc Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases
    Federica Gibellini
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 415:135-44. 2008
    ..Both enzymes recognized analogues with substituents on C-2, but substitutions on C-1 and elongations of the carbon chain were not well tolerated...
  83. ncbi request reprint Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
    Lauris E Kemp
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 59:607-10. 2003
    ..2001), Nature Struct. Biol. 8, 641-647]...
  84. doi request reprint Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues
    Scott Cameron
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Mol Biochem Parasitol 158:131-8. 2008
    ..The molecular determinants of ligand recognition and PCD reactivity are therefore highly conserved across species...
  85. pmc One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening
    Chidochangu P Mpamhanga
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Med Chem 52:4454-65. 2009
    ..On the basis of the alternative binding mode of 1-(3,4-dichloro-benzyl)-2-amino-benzimidazole, derivatives were designed and selective PTR1 inhibitors with low nanomolar potency and favorable physicochemical properties were obtained...
  86. pmc The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei
    Federica Gibellini
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Mol Microbiol 73:826-43. 2009
    ..TbECT is therefore genetically validated as a potential drug target against the African trypanosome...
  87. pmc TarO: a target optimisation system for structural biology
    Ian M Overton
    School of Life Sciences Research, University of Dundee, Dow Street, Dundee, UK
    Nucleic Acids Res 36:W190-6. 2008
    ..Future development of TarO will include further analysis steps and integration with the Protein Information Management System (PIMS), a sister project in the BBSRC 'Structural Proteomics of Rational Targets' initiative...
  88. ncbi request reprint Sensing of remote oxyanion binding at the DNA binding domain of the molybdate-dependent transcriptional regulator, ModE
    David H Boxer
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK
    Org Biomol Chem 2:2829-37. 2004
    ....
  89. pmc Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism
    Karen McLuskey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 102:14221-6. 2005
    ....
  90. ncbi request reprint Enantioselective synthesis of C3 fluoro-MEP
    Stephanos Ghilagaber
    School of Life Sciences, University of Dundee, DD1 5EH, UK
    Org Biomol Chem 5:97-102. 2007
    ..The first enantioselective synthesis of C(3) fluoro-MEP is herein reported. The synthetic pathway developed takes advantage of a selective hydrofluorination of a 2,3-epoxy-1-alcohol to introduce the required tertiary fluoride unit...
  91. ncbi request reprint Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids
    Stewart A Fyffe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 356:1005-13. 2006
    ....
  92. pmc A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei
    Emma Byres
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:581-4. 2005
    ..These crystals are well ordered and data to high resolution have been recorded using synchrotron radiation...
  93. ncbi request reprint Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis
    Christine M Crane
    Laboratorium fur Organische Chemie, ETH Zurich, HCI, CH 8093 Zurich, Switzerland
    ChemMedChem 3:91-101. 2008
    ..aeolicus IspE directs the OH group of a tyrosine residue into a pocket in the active site. In the E. coli enzyme, on the other hand, this pocket is lined by phenylalanine and has a more pronounced hydrophobic character...
  94. pmc Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development
    Hyungjin Eoh
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Bacteriol 189:8922-7. 2007
    ..tuberculosis IspD had Km values of 58.5 microM for MEP and 53.2 microM for CTP. Calculated kcat and kcat/Km values were 0.72 min(-1) and 12.3 mM(-1) min(-1) for MEP and 1.0 min(-1) and 18.8 mM(-1) min(-1) for CTP, respectively...
  95. ncbi request reprint Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism
    Linda Miallau
    Macromolecular Crystallography Group, European Synchrotron Radiation Facility, 38043 Grenoble, France
    J Biol Chem 282:19948-57. 2007
    ..A new motif of amino acid sequence conservation common to the pfkB subfamily of carbohydrate kinases is identified...
  96. ncbi request reprint Biological chemistry: the making of Moco
    William N Hunter
    Nature 430:736-7. 2004
  97. pmc Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
    Antonio Cavazzuti
    Dipartimento di Scienze Farmaceutiche, Universita di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Proc Natl Acad Sci U S A 105:1448-53. 2008
    ..The successful combination of antifolates targeting two enzymes indicates high potential for such an approach in the development of previously undescribed antiparasitic drugs...
  98. doi request reprint Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis
    Anna K H Hirsch
    Laboratorium fur Organische Chemie, ETH Zurich, HCI, CH 8093, Zurich, Switzerland
    Org Biomol Chem 6:2719-30. 2008
    ..This structure provides useful insights for future structure-based developments of inhibitors for the parasite enzymes...
  99. ncbi request reprint High-resolution structure of recombinant Trichomonas vaginalis thioredoxin
    Jorge Iulek
    Department of Chemistry, Biotechnology Center, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil
    Acta Crystallogr D Biol Crystallogr 62:216-20. 2006
    ..These residues may contribute to the interactions that specific thioredoxins form with their cognate physiological partners...
  100. ncbi request reprint Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy
    Christine M Crane
    Laboratorium fur Organische Chemie, ETH Honggerberg, HCI, 8093 Zurich, Switzerland
    Angew Chem Int Ed Engl 45:1069-74. 2006
  101. ncbi request reprint De novo phasing of two crystal forms of tryparedoxin II using the anomalous scattering from S atoms: a combination of small signal and medium resolution reveals this to be a general tool for solving protein crystal structures
    Elena Micossi
    Macromolecular Crystallography, European Synchrotron Radiation Facility, BP 220, F 38043 Grenoble Cedex, France
    Acta Crystallogr D Biol Crystallogr 58:21-8. 2002
    ....