Sam M Janes

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Genetically modified mesenchymal stromal cells in cancer therapy
    Elizabeth K Sage
    Lungs for Living Research Centre, UCL Respiratory, Rayne Institute, University College London, London, United Kingdom
    Cytotherapy 18:1435-1445. 2016
  2. pmc Mesenchymal stromal cell delivery of full-length tumor necrosis factor-related apoptosis-inducing ligand is superior to soluble type for cancer therapy
    Zhengqiang Yuan
    Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom
    Cytotherapy 17:885-96. 2015
  3. pmc Cryopreservation of human mesenchymal stromal cells expressing TRAIL for human anti-cancer therapy
    Zhengqiang Yuan
    Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom
    Cytotherapy 18:860-9. 2016
  4. pmc Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.
    Colin R Butler
    Biomaterials 124:95-105. 2017
  5. pmc Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold
    Claire Crowley
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK UCL Centre of Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, Royal Free London NHS Foundation Trust Hospital and University College London, London, UK
    Biomaterials 83:283-93. 2016
  6. doi request reprint Streamlining staging of lung and colorectal cancer with whole body MRI; study protocols for two multicentre, non-randomised, single-arm, prospective diagnostic accuracy studies (Streamline C and Streamline L)
    Stuart A Taylor
    Centre for Medical Imaging, University College London, 250 Euston Road, London, NW1 2BU, UK
    BMC Cancer 17:299. 2017
  7. pmc Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors
    Sofia Lourenço
    Lungs for Living Research Centre, Division of Medicine, University College London, London WC1E 6JF, United Kingdom
    J Immunol 194:3463-74. 2015
  8. pmc Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade
    M R Loebinger
    Centre for Respiratory Research, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Br J Cancer 98:380-7. 2008
  9. pmc TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population
    M R Loebinger
    Centre for Respiratory Research, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Br J Cancer 103:1692-7. 2010
  10. pmc Cell migration leads to spatially distinct but clonally related airway cancer precursors
    Christodoulos P Pipinikas
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK
    Thorax 69:548-57. 2014

Collaborators

Detail Information

Publications27

  1. pmc Genetically modified mesenchymal stromal cells in cancer therapy
    Elizabeth K Sage
    Lungs for Living Research Centre, UCL Respiratory, Rayne Institute, University College London, London, United Kingdom
    Cytotherapy 18:1435-1445. 2016
    ....
  2. pmc Mesenchymal stromal cell delivery of full-length tumor necrosis factor-related apoptosis-inducing ligand is superior to soluble type for cancer therapy
    Zhengqiang Yuan
    Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom
    Cytotherapy 17:885-96. 2015
    ..However, a comparison between the two forms has never been performed, leaving it unclear which approach is most effective. This study addresses the issue for the possible clinical application of TRAIL-expressing MSCs in the future...
  3. pmc Cryopreservation of human mesenchymal stromal cells expressing TRAIL for human anti-cancer therapy
    Zhengqiang Yuan
    Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom
    Cytotherapy 18:860-9. 2016
    ..To do this, we need to prepare a cryopreserved allogeneic MSCTRAIL cell bank for further expansion before patient delivery. The effects of cryopreservation on a genetically modified cell therapy product have not been clearly determined...
  4. pmc Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.
    Colin R Butler
    Biomaterials 124:95-105. 2017
    ..3-8 weeks) does not compromise the quality of human tracheal scaffold generated. These findings might inform clinical decellularization techniques as VAD offers accelerated scaffold production and reduces the associated costs...
  5. pmc Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold
    Claire Crowley
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK UCL Centre of Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, Royal Free London NHS Foundation Trust Hospital and University College London, London, UK
    Biomaterials 83:283-93. 2016
    ....
  6. doi request reprint Streamlining staging of lung and colorectal cancer with whole body MRI; study protocols for two multicentre, non-randomised, single-arm, prospective diagnostic accuracy studies (Streamline C and Streamline L)
    Stuart A Taylor
    Centre for Medical Imaging, University College London, 250 Euston Road, London, NW1 2BU, UK
    BMC Cancer 17:299. 2017
    ..The Streamline trials aim to evaluate whether WB-MRI increases per patient detection of metastases in non-small cell lung and colorectal cancer compared to standard staging pathways...
  7. pmc Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors
    Sofia Lourenço
    Lungs for Living Research Centre, Division of Medicine, University College London, London WC1E 6JF, United Kingdom
    J Immunol 194:3463-74. 2015
    ..This improved understanding of MSC tumor tropism will further enable development of novel cellular therapies for cancers. ..
  8. pmc Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade
    M R Loebinger
    Centre for Respiratory Research, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Br J Cancer 98:380-7. 2008
    ..Future chemotherapeutic strategies should therefore consider coupling identification and targeting of this potential stem cell-like population with standard treatment methodologies...
  9. pmc TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population
    M R Loebinger
    Centre for Respiratory Research, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Br J Cancer 103:1692-7. 2010
    ..Tumours contain stem-like, side population (SP) cells, which have increased tumorigenic potential, resistance to traditional therapies and may be responsible for treatment failures and relapse in patients...
  10. pmc Cell migration leads to spatially distinct but clonally related airway cancer precursors
    Christodoulos P Pipinikas
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK
    Thorax 69:548-57. 2014
    ..Synchronous preinvasive lesions identified at autopsy have been previously shown to be clonally related...
  11. pmc LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development
    Liwen Lu
    Lungs for Living Research Centre, UCL Respiratory, University College London, 5 University Street, London, WC1E 6JF, UK
    J Pathol 229:608-20. 2013
    ..Our findings imply that the early stages of squamous carcinoma development are driven by a change in amplitude of EGFR signalling governed by the loss of contact inhibition...
  12. pmc Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial
    Neal Navani
    Centre for Respiratory Research, University College London, London, UK
    Am J Respir Crit Care Med 186:255-60. 2012
    ..Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is established as an alternative to mediastinoscopy in patients with lung cancer...
  13. pmc Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles
    Michael R Loebinger
    Centre for Respiratory Research, Rayne Institute, University College London, London, United Kingdom
    Cancer Res 69:8862-7. 2009
    ..This technique has the potential to show MSC integration into human tumors, allowing early-phase clinical studies examining MSC homing in patients with metastatic tumors...
  14. pmc Systemic but not topical TRAIL-expressing mesenchymal stem cells reduce tumour growth in malignant mesothelioma
    Elizabeth K Sage
    Division of Medicine, Lungs for Living Research Centre, University College London, London, UK
    Thorax 69:638-47. 2014
    ..Finally, we show that intravenous delivery of MSCTRAIL results in a reduction in malignant pleural mesothelioma tumour growth in vivo via an increase in tumour cell apoptosis. ..
  15. pmc Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance
    Adam Giangreco
    Centre for Respiratory Research, University College London, Rayne Institute, 5 University Street, London WC1E 6JF, UK
    J Pathol 224:190-202. 2011
    ..Overall, this study represents the first identification of Myd88 as a regulator of adult tracheal epithelial cell phenotype...
  16. ncbi request reprint Therapeutic potential of stem cells in lung disease: progress and pitfalls
    Michael R Loebinger
    Centre of Respiratory Research, Rayne Building, University College London, 5 University Street, London WC1E 6JJ, UK
    Clin Sci (Lond) 114:99-108. 2008
    ..This review evaluates the progress made and the pitfalls encountered to date, and critically assesses the evidence for the use of stem cells in lung disease...
  17. pmc Stem cells as vectors for antitumour therapy
    Michael R Loebinger
    Centre for Respiratory Research, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Thorax 65:362-9. 2010
    ..This review investigates the different MSC-delivered anticancer agents, addresses the questions and concerns, and tries to place this potential therapy in future cancer management...
  18. pmc Mesenchymal stem cells as vectors for lung cancer therapy
    Krishna K Kolluri
    Lungs for Living Research Centre, University College London, London, UK
    Respiration 85:443-51. 2013
    ..This review outlines various agents which can be delivered by MSCs with substantial emphasis on TRAIL (tumour necrosis factor-related apoptosis-inducing ligand)...
  19. pmc Integrated 18F-fluorodeoxyglucose-positron emission tomography/dynamic contrast-enhanced computed tomography to phenotype non-small cell lung carcinoma
    Manu Shastry
    Institute of Nuclear Medicine and Centre for Respiratory Research, University College London, London, UK
    Mol Imaging 11:353-60. 2012
    ..028). We show that tumor subtypes have different vascular-metabolic associations, which can be helpful clinically in managing lung cancer patients to hone targeted therapy...
  20. pmc Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study
    Neal Navani
    Centre for Respiratory Research, University College London, 5 University Street, London WC1E 6JJ, UK
    Thorax 66:889-93. 2011
    ..The aim of this study was to describe the diagnostic utility of EBUS-TBNA in patients with intrathoracic lymphadenopathy due to tuberculosis (TB)...
  21. pmc β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition
    Adam Giangreco
    Centre for Respiratory Research, University College London, UK
    J Pathol 226:575-87. 2012
    ..Overall, the data show that airway basal cell β-catenin determines cell fate and its mis-expression is associated with the development of human lung cancer...
  22. doi request reprint Stem cells and pulmonary fibrosis: cause or cure?
    Katrina McNulty
    Centre for Respiratory Research, University College London, 5 University Street, London, UK
    Proc Am Thorac Soc 9:164-71. 2012
    ..Strategies using other stem cell populations hold promise, but currently these are a lot further from the bedside...
  23. pmc Rac1 deletion causes thymic atrophy
    Lukas Hunziker
    Centre for Respiratory Research, University College London, London, United Kingdom
    PLoS ONE 6:e19292. 2011
    ....
  24. pmc Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis
    Neal Navani
    Centre for Respiratory Research, University College London, London, UK
    Respirology 16:467-72. 2011
    ..The aim of this study was to evaluate the feasibility, safety and efficacy of combined EBUS-TBNA and standard bronchoscopic techniques in patients with suspected sarcoidosis and enlarged mediastinal or hilar lymphadenopathy...
  25. ncbi request reprint Stem cells for lung disease
    Michael R Loebinger
    Centre of Respiratory Research, Rayne Building, University College London, 5 University St, London, WC1E 6JJ, UK
    Chest 132:279-85. 2007
    ..This article critically reviews the evidence for this plasticity and the use of predominantly adult stem cells to help with lung regeneration and repair and assesses how this technology may be utilized in clinical medicine...
  26. pmc Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis
    Susana Aguilar
    Centre for Respiratory Research, Rayne Institute, University College London, London, United Kingdom
    PLoS ONE 4:e8013. 2009
    ....
  27. pmc Mesenchymal stem cells as vectors for lung disease
    Michael R Loebinger
    Centre of Respiratory Research, Rayne Building, University College London, 5 University Street, London WC1E 6JJ, UK
    Proc Am Thorac Soc 5:711-6. 2008
    ..Here we address the evidence for the incorporation of bone marrow stem cells into areas of stroma formation as a prelude to possible future treatment options for common lung diseases...