D S Latchman

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint How can we use our growing understanding of gene transcription to discover effective new medicines?
    D S Latchman
    Department of Molecular Pathology, Windeyer Institute of Medical Science, University College London Medical School, UK
    Curr Opin Biotechnol 8:713-7. 1997
  2. ncbi request reprint Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues
    D S Latchman
    Institute of Child Health, University College London, UK
    Pharmacol Ther 85:29-37. 2000
  3. ncbi request reprint Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701
    A Stephanou
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    J Biol Chem 276:28340-7. 2001
  4. ncbi request reprint Molecular cloning and expression of the Fabs of human autoantibodies in Escherichia coli. Determination of the heavy or light chain contribution to the anti-DNA/-cardiolipin activity of the Fab
    S Kumar
    Centre for Rheumatology, Bloomsbury Rheumatology Unit, the Department of Medicine and the Department of Biochemistry and Molecular Biology, University College London, London W1P 9PG, UK
    J Biol Chem 275:35129-36. 2000
  5. ncbi request reprint The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells
    K Freeland
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Brain Res Mol Brain Res 92:98-106. 2001
  6. ncbi request reprint Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, UK
    FASEB J 17:2313-5. 2003
  7. ncbi request reprint CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase, Akt and MEK1/2 pathways
    B K Brar
    Medical Molecular Biology Unit, Institute of Child Health, 30 Guilford Street, London, WC1 1EH, UK
    Cytokine 16:93-6. 2001
  8. ncbi request reprint Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect
    J E Railson
    Medical Molecular Biology Unit, The Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    J Mol Cell Cardiol 33:1209-21. 2001
  9. ncbi request reprint Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro
    M D Smith
    Medical Molecular Biology Unit, Institute of Child Health, University College London, United Kingdom
    Mol Cell Neurosci 17:460-70. 2001
  10. ncbi request reprint Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation
    B K Brar
    Institute of Child Health, University College London, WC1N 1EH, London, UK
    Cardiovasc Res 51:265-74. 2001

Collaborators

Detail Information

Publications92

  1. ncbi request reprint How can we use our growing understanding of gene transcription to discover effective new medicines?
    D S Latchman
    Department of Molecular Pathology, Windeyer Institute of Medical Science, University College London Medical School, UK
    Curr Opin Biotechnol 8:713-7. 1997
    ....
  2. ncbi request reprint Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues
    D S Latchman
    Institute of Child Health, University College London, UK
    Pharmacol Ther 85:29-37. 2000
    ..CT-1, therefore, may be of use as a novel cardioprotective agent, particularly if its hypertrophic effect can be specifically inhibited...
  3. ncbi request reprint Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701
    A Stephanou
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    J Biol Chem 276:28340-7. 2001
    ..These results indicate that Fas/FasL genes and apoptosis are activated by STAT-1 in cardiac myocytes exposed to I/R and these effects are dependent on the Ser-727 but not the Tyr-701 phosphorylation sites of STAT-1...
  4. ncbi request reprint Molecular cloning and expression of the Fabs of human autoantibodies in Escherichia coli. Determination of the heavy or light chain contribution to the anti-DNA/-cardiolipin activity of the Fab
    S Kumar
    Centre for Rheumatology, Bloomsbury Rheumatology Unit, the Department of Medicine and the Department of Biochemistry and Molecular Biology, University College London, London W1P 9PG, UK
    J Biol Chem 275:35129-36. 2000
    ..However, a compatible partner chain is necessary for optimum antigen binding activity of the antibody...
  5. ncbi request reprint The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells
    K Freeland
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Brain Res Mol Brain Res 92:98-106. 2001
    ..This finding establishes the importance of the CRE in the induction of Bcl-2 gene expression by hypoxia, allowing the Bcl-2 protein to protect neuronal cells against this damaging stimulus...
  6. ncbi request reprint Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, UK
    FASEB J 17:2313-5. 2003
    ..This, to our knowledge, is the first study linking the cardioprotective effect of urocortin to a decrease in a specific enzyme protein and a subsequent decrease in the concentration of its cardiotoxic metabolite...
  7. ncbi request reprint CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase, Akt and MEK1/2 pathways
    B K Brar
    Medical Molecular Biology Unit, Institute of Child Health, 30 Guilford Street, London, WC1 1EH, UK
    Cytokine 16:93-6. 2001
    ..Hence the PI3-kinase/Akt pathway is required in addition to MEK1/2 to mediate CT-1 cardioprotection in IR...
  8. ncbi request reprint Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect
    J E Railson
    Medical Molecular Biology Unit, The Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    J Mol Cell Cardiol 33:1209-21. 2001
    ..This is the first time that a hypertrophic effect has been demonstrated for a heat shock protein and demonstrates that CT-1-induced hypertrophy involves a specific hsp, which is not involved in its protective effect...
  9. ncbi request reprint Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro
    M D Smith
    Medical Molecular Biology Unit, Institute of Child Health, University College London, United Kingdom
    Mol Cell Neurosci 17:460-70. 2001
    ..Most importantly, both Bcl-x(L) expression and neuronal survival are enhanced by the overexpression of Brn-3a in dorsal root ganglion in vivo in a model of sciatic nerve injury in the intact animal...
  10. ncbi request reprint Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation
    B K Brar
    Institute of Child Health, University College London, WC1N 1EH, London, UK
    Cardiovasc Res 51:265-74. 2001
    ..Hence CT-1 may have therapeutic potential when added at the time of reperfusion following ischaemic damage...
  11. ncbi request reprint CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment
    Y Z Liu
    Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, UK
    Neuroreport 10:1239-43. 1999
    ..These results indicate that phosphorylation of CBP itself by the p42/p44 MAPK pathway is likely to be critical for its role in NGF-mediated stimulation of gene expression...
  12. ncbi request reprint The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis
    V Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH, London, UK
    Int J Biochem Cell Biol 33:1027-39. 2001
    ..Hence, as observed in neuronal cells, Brn-3a and Brn-3b may play distinct and important functional roles in the regulation of gene expression during germ cell development...
  13. pmc A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53
    K L Sugars
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nucleic Acids Res 29:4530-40. 2001
    ..p53 therefore appears to specifically target the activation by Brn-3a of promoters derived from genes with an anti-apoptotic effect and this may be involved in the pro-apoptotic activity of p53...
  14. ncbi request reprint Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a
    D Ndisang
    Medical Molecular Biology Unit, Institute of Child Health, University College London, and Department of Women s and Children s Health, The Whittington Hospital, London, UK
    Oncogene 25:51-60. 2006
    ..These results help explain why the specific interplay between viral and cellular factors necessary for the progression to cervical carcinoma only occurs in a minority of those infected with HPV-16...
  15. pmc STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy
    J McCormick
    Institute of Child Health, University College London, London, UK
    J Cell Mol Med 16:386-93. 2012
    ..These results reveal a new function of STAT1 in the control of autophagy and indicate a cross-talk between the cardioprotective versus the damaging effects of STAT1 in the intact heart exposed to MI injury...
  16. ncbi request reprint Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 35:1295-305. 2003
    ..In addition, we showed that SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced...
  17. ncbi request reprint Cardioprotection mediated by urocortin is dependent on PKCepsilon activation
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College, London, UK
    FASEB J 19:831-3. 2005
    ..This loss of cardioprotection by Ucn was also seen in whole hearts from PKCepsilon knockout mice. These findings indicate that the cardioprotective effect of Ucn is dependent upon PKCepsilon...
  18. ncbi request reprint Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors
    M Calissano
    MMBU, Institute of Child Health, University College London 30 Guilford Street, London WC1N 1EH, UK
    Neuroreport 15:483-6. 2004
    ....
  19. ncbi request reprint Signal-transduction pathways involved in the hypertrophic effect of hsp56 in neonatal cardiomyocytes
    Y Jamshidi
    Medical Molecular Biology Unit, The Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 36:381-92. 2004
    ....
  20. ncbi request reprint Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells
    V S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Oncogene 27:145-54. 2008
    ..Site-directed mutagenesis of this sequence resulted in loss of transactivation of the CD1 promoter by Brn-3b. Thus, Brn-3b may act to alter growth properties of breast cancer and NB cells by enhancing CD1 expression in these cells...
  21. ncbi request reprint The POU domain transcription factor Brn-3a protects cortical neurons from apoptosis
    M D Smith
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Neuroreport 12:3183-8. 2001
    ..Hence the protective effect of Brn-3a is not confined to neurons of the peripheral nervous system but can also occur in neurons of the CNS...
  22. doi request reprint Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription
    C D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Cell Death Differ 15:1266-78. 2008
    ..Thus, the physical interaction of Brn-3a with specific p73 isoforms will be critical for determining cell fate during neuronal development or in injured neurons expressing both factors...
  23. ncbi request reprint Expression of the Fabs of human auto-antibodies in Escherichia coli: optimization and determination of their fine binding characteristics and cross-reactivity
    S Kumar
    Centre for Rheumatology, and Department of Biochemistry and Molecular Biology, University College London, UK
    J Mol Biol 308:527-39. 2001
    ..Such auto- antigen specificity and/or cross-reactivity may dictate the potential of an auto-antibody to cause pathogenicity and may provide an explanation as to why apparently similar auto-antibodies behave differently in vivo...
  24. ncbi request reprint Beta-subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression
    J K J Diss
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Prostate Cancer Prostatic Dis 11:325-33. 2008
    ..The possible role(s) of VGSCbetas (VGSCalpha-associated and VGSCalpha-independent) in prostate cancer are discussed...
  25. ncbi request reprint MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia
    D A West
    Royal College of Surgeons Unit of Biophysics, Institute of Child Health, University College London, London WC1N 1EH, UK
    Neuroscience 127:333-9. 2004
    ..There is limited information on the role of STAT-1 following stroke. In this study we use MRI measurements of cerebral perfusion and bioenergetic status to target measurements of regional STAT-1 activity...
  26. ncbi request reprint Pharmacological preconditioning of primary rat cardiac myocytes by FK506
    D V Cumming
    Department of Molecular Pathology, University College London Medical School, United Kingdom
    Basic Res Cardiol 91:367-73. 1996
    ..These results suggest the FK506 is acting via a novel mechanism to protect cardiac cells against cellular ischaemia which may not be related to its immunosuppressant action...
  27. pmc A human anti-dsDNA monoclonal antibody caused hyaline thrombi formation in kidneys of 'leaky' SCID mice
    L J Mason
    Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, London, UK
    Clin Exp Immunol 126:137-42. 2001
    ....
  28. ncbi request reprint Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90
    B J Ripley
    Institute of Child Health, University College London, UK
    J Autoimmun 17:341-6. 2001
    ..These results support a model in which elevated levels of IL-6 in SLE patients induce elevated levels of hsp90 protein which in turn results in the production of autoantibodies to this protein...
  29. ncbi request reprint The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo
    D Ndisang
    Medical Molecular Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 20:4899-903. 2001
    ..Hence they establish Brn-3a as a key factor in cervical tumorigenesis and as a potential therapeutic target in human cervical neoplasia...
  30. ncbi request reprint Brn-3a neuronal transcription factor functional expression in human prostate cancer
    J K J Diss
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Prostate Cancer Prostatic Dis 9:83-91. 2006
    ..7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP...
  31. ncbi request reprint EWS differentially activates transcription of the Brn-3a long and short isoform mRNAs from distinct promoters
    G R Thomas
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Biochem Biophys Res Commun 318:1045-51. 2004
    ..The implications of these results are discussed in terms of the functional role of EWS and the distinct functional activities of the two isoforms of Brn-3a...
  32. ncbi request reprint The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation
    E J Parkinson
    Department of Paediatric Surgery, Institute of Child Health, London, England, UK
    J Pediatr Surg 39:696-701. 2004
    ..The aim of this study is to investigate the mechanism of hypothermic protection during IIR...
  33. ncbi request reprint The Urocortins: mechanisms of cardioprotection and therapeutic potential
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College, London, UK
    Mini Rev Med Chem 6:1119-26. 2006
    ..Such studies may enable scientists to develop clinical therapies based on their mechanism of action, which may be used to alleviate a diverse range of pathologies...
  34. ncbi request reprint Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury
    C M Dollery
    Hatter Institute, University College London Hospitals, the Division of Cardiovascular Genetics, Department of Medicine, University College London, London, UK
    Circulation 99:3199-205. 1999
    ..This is partly mediated by the matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs)...
  35. ncbi request reprint Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells
    Z Deans
    Department of Molecular Pathology, University College London Medical School, UK
    J Mol Neurosci 6:159-67. 1995
    ..The significance of this effect is discussed in terms of the processes that regulate tyrosine hydroxylase gene expression and the role of Oct-2 in neuronal cells...
  36. pmc The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements
    S J Dawson
    Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, U K
    Biochem J 314:439-43. 1996
    ..4 or Oct-2.5 being different. These effects are discussed in the context of the mechanisms by which POU factors activate or repress their target genes...
  37. ncbi request reprint The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis
    S Janjua
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Cell Death Differ 9:1140-6. 2002
    ....
  38. ncbi request reprint Heat shock proteins and cardiac protection
    D S Latchman
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Cardiovasc Res 51:637-46. 2001
    ..These findings indicate the potential importance of developing procedures for elevating hsp expression in a safe and efficient manner in human individuals using either pharmacological or gene therapy procedures...
  39. pmc Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter
    C Perez-Sanchez
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nucleic Acids Res 30:4872-80. 2002
    ..The significance of these effects is discussed in terms of the different responses of the Bax and p21 promoters and the overlapping but distinct roles of Brn-3a and p53 in neuronal growth arrest and apoptosis...
  40. ncbi request reprint The different activities of the two activation domains of the Brn-3a transcription factor are dependent on the context of the binding site
    V Budhram-Mahadeo
    Department of Molecular Pathology, University College London Medical School, London W1P 6DB, United Kingdom
    J Biol Chem 271:9108-13. 1996
    ....
  41. pmc Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia
    B J M Ripley
    Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UK
    Ann Rheum Dis 64:849-53. 2005
    ..Raised levels of the cytokines interleukin (IL) 6 and IL10 have been reported in patients with systemic lupus erythematosus (SLE)...
  42. ncbi request reprint HSP27 and cell survival in neurones
    D S Latchman
    Institute of Child Health, London, UK
    Int J Hyperthermia 21:393-402. 2005
    ....
  43. ncbi request reprint Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90
    B J M Ripley
    University College London, London, UK
    Arthritis Rheum 52:1171-9. 2005
    ....
  44. ncbi request reprint Differential regulation of the two neuronal nitric-oxide synthase gene promoters by the Oct-2 transcription factor
    Z Deans
    Department of Molecular Pathology, University College London Medical School, London W1P 6DB, United Kingdom
    J Biol Chem 271:32153-8. 1996
    ..1 promoter is activated by Oct-2, whereas the 5.2 promoter is unaffected. These effects are discussed in terms of the potential role of Oct-2 in regulating nNOS expression in the nervous system...
  45. ncbi request reprint Gene therapy with herpes simplex virus vectors: progress and prospects for clinical neuroscience
    D S Latchman
    Institute of Child Health, University College London
    Neuroscientist 7:528-37. 2001
    ..It is likely that these viruses may ultimately be of use in human gene therapy procedures for otherwise intractable neurological diseases such as Parkinson's disease...
  46. ncbi request reprint SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH, London, UK
    J Mol Cell Cardiol 35:257-64. 2003
    ..Hence, we conclude that SAG is a cardioprotective agent in cardiac cells exposed to ischaemic stress and an important protein involved in cardiomyocyte survival...
  47. doi request reprint The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix
    D Ndisang
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Oncogene 29:2701-11. 2010
    ....
  48. ncbi request reprint Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits
    M K Bolla
    Department of Medicine, University College London Medical School, Rayne Institute, UK
    Dis Markers 13:227-35. 1998
    ..37-0.40), and there was no association of genotype with BMI. Thus there appears to be no strong association of the Hsp70-1 promoter polymorphism with risk of myocardial infarction, BMI or any coronary disease traits analysed here...
  49. ncbi request reprint Gene delivery and gene therapy with herpes simplex virus-based vectors
    D S Latchman
    Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH, London, UK
    Gene 264:1-9. 2001
    ..These vectors thus offer a valuable tool for testing gene function in neuronal cells in vivo and may ultimately be safe enough for use in human gene therapy procedures...
  50. doi request reprint In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of concept
    Y Ioannou
    Centre for Rheumatology Research, Windeyer Building, University College London, London, UK
    J Thromb Haemost 7:833-42. 2009
    ..Hence, we hypothesized that DI and DI(D8S/D9G) would inhibit aPL-induced pathogenicity in vivo...
  51. ncbi request reprint K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, England
    Circulation 106:1556-62. 2002
    ..Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion...
  52. ncbi request reprint Urocortin protects against ischemic injury via a MAPK-dependent pathway
    D S Latchman
    Institute of Child Health, University College London, London, United Kingdom
    Trends Cardiovasc Med 11:167-9. 2001
    ..Hence, UCN is a cardioprotective agent, which acts when given prior to ischemia or after ischemia at reperfusion...
  53. pmc Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer
    S E Conroy
    Department of Molecular Pathology, University College London Medical School, UK
    Br J Cancer 77:1875-9. 1998
    ..These effects are discussed in terms of the mechanisms that provoke an immune response to the hsps and the protective/non-protective effects of such a response...
  54. ncbi request reprint Gene therapy using herpes simplex virus-based vectors
    D S Latchman
    Institute of Child Health, University College London, UK
    Histol Histopathol 15:1253-9. 2000
    ....
  55. ncbi request reprint Viral vectors for gene therapy in Parkinson's disease
    D S Latchman
    Institute of Child Health, University College London, UK
    Rev Neurosci 12:69-78. 2001
    ..These are discussed together with the particular advantages of herpes simplex virus-based vectors which have the potential to deliver multiple therapeutic genes in a single virus vector...
  56. ncbi request reprint The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells
    J H Dennis
    Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 20:4961-71. 2001
    ..These results thus further indicate a role for the Brn-3b transcription factor in regulating mammary cell growth and suggest that its elevation in breast cancer is of functional significance...
  57. ncbi request reprint Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs
    M J Wagstaff
    Department of Molecular Pathology, University College London Medical School, UK
    Brain Res Mol Brain Res 42:236-44. 1996
    ..HSP56 protein levels appeared to rise on the occluded side, but HSP90 protein levels remained constant...
  58. ncbi request reprint Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor
    M Calissano
    Institute of Child Health, Medical Molecular Biology Unit, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 22:5408-14. 2003
    ..In this work, we describe the evidence for a functional interaction between Brn-3a and Rin and demonstrate the role of Rin in modulating the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a...
  59. ncbi request reprint Transcription factors as potential targets for therapeutic drugs
    D S Latchman
    Institute of Child Health, University College London, UK
    Curr Pharm Biotechnol 1:57-61. 2000
    ....
  60. pmc Cardiotrophin-1 (CT-1): a novel hypertrophic and cardioprotective agent
    D S Latchman
    Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
    Int J Exp Pathol 80:189-96. 1999
    ..CT-1 may therefore be of use as a novel cardio-protective agent, particularly if its hypertrophic effect can be specifically inhibited...
  61. pmc Do heat shock proteins have a role in breast cancer?
    S E Conroy
    Medical Molecular Biology Unit, Department of Molecular Pathology, London, UK
    Br J Cancer 74:717-21. 1996
    ..1993). Thus, hsps and the immune response to them are of interest as diagnostic and prognostic tools as well as a novel form of immunotherapy...
  62. ncbi request reprint Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK1/2-dependent manner
    B K Brar
    Medical Molecular Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Endocrinol 172:283-93. 2002
    ..This is the first report of heat shock protein induction by urocortin or any other member of the corticotrophin-releasing hormone family...
  63. ncbi request reprint The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis
    E Ensor
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 276:5204-12. 2001
    ....
  64. ncbi request reprint Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody
    C T Ravirajan
    Centre for Rheumatology, Department of Medicine, University College London, Arthur Stanley House, London W1T 4NJ, UK
    Rheumatology (Oxford) 43:442-7. 2004
    ..In this study we have further analysed the effect of activated terminal complement proteins and interleukin-10 (IL-10) in the pathogenesis of glomerulonephritis caused by the RH-14...
  65. ncbi request reprint FKBP12 mRNA expression is upregulated by intrinsic CNS neurons regenerating axons into peripheral nerve grafts in the brain
    M R J Mason
    Department of Anatomy and Developmental Biology, University College London, Gower Street, UK
    Exp Neurol 181:181-9. 2003
    ..No upregulation was seen in neurons in animals that received freeze-killed grafts, which do not support axonal regeneration. We conclude that FKBP12 is a regeneration-associated gene in intrinsic CNS neurons...
  66. ncbi request reprint Opposing actions of STAT-1 and STAT-3
    A Stephanou
    Institute of Child Health, University College London, Medical Molecular Biology Unit, London, UK
    Growth Factors 23:177-82. 2005
    ....
  67. pmc A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells
    K A Lillycrop
    Department of Biochemistry and Chemical Pathology, University College and Middlesex School of Medicine, London, UK
    Nucleic Acids Res 20:5093-6. 1992
    ..The significance of these distinct but overlapping expression patterns is discussed in terms of the possible role of these two factors in regulating neuronal gene expression...
  68. ncbi request reprint Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor
    Y Z Liu
    Department of Molecular Pathology, University College London Medical School, UK
    AIDS 10:1323-9. 1996
    ..To examine the interaction of the HIV Tat protein and the inhibitory domain of the cellular transcription factor Oct-2...
  69. ncbi request reprint A single amino acid change converts an inhibitory transcription factor into an activator
    S J Dawson
    Department of Molecular Pathology, University College London Medical School, United Kingdom
    J Biol Chem 271:11631-3. 1996
    ..Hence a single amino acid difference determines the difference between an activator and a repressor in the Brn-3 family...
  70. pmc The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain
    C J Ring
    Division of Molecular Pathology, University College London Medical School, UK
    Nucleic Acids Res 21:2946. 1993
  71. ncbi request reprint Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit
    J J Willoughby
    Sandoz Institute for Medical Research, London, UK
    Neurosci Lett 155:136-9. 1993
    ..Northern blots demonstrated the presence of a 1.7 kb transcript in RNA extracted from adult human Pons. This clone has therefore been designated the human beta 3 neuronal nicotinic receptor subunit...
  72. ncbi request reprint Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart
    M A C Fauchon
    Trafford Centre for Graduate Medical Education and Research, University of Sussex, Falmer, Brighton BN1 9RY, UK
    Exp Mol Med 37:311-22. 2005
    ..Expression of Trip1 and Ncbp1 also implicates TGFbeta signalling pathways and RNA processing and transport in delayed adaptation to stress in the myocardium...
  73. ncbi request reprint Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera
    N G Sharpe
    Medical Molecular Biology Unit, University College, London, England
    FEBS Lett 250:585-90. 1989
    ..The potential use of this clone in a diagnostic assay for SLE and in elucidating the processes regulating the expression of SmB and B' is discussed...
  74. pmc Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation
    N G Sharpe
    Department of Biochemistry, University College and Middlesex School of Medicine, London, United Kingdom
    Mol Cell Biol 10:6817-20. 1990
    ..This decline is due to a corresponding decrease in the level of the SmN mRNA. The potential role of SmN in the regulation of alternative splicing in embryonic cell lines and early embryos is discussed...
  75. pmc Cloning and sequencing of the rat Oct-1 POU box
    K A Lillycrop
    Department of Biochemistry, University College and Middlesex School of Medicine, London, UK
    Nucleic Acids Res 19:3744. 1991
  76. pmc The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins
    M D Smith
    Department of Molecular Pathology, University College London Medical School, United Kingdom
    Mol Cell Biol 17:345-54. 1997
    ..Thus, Brn-3a appears to play a critical role in the specification of the mature neuronal phenotype, acting by stimulating the expression of genes whose products are required for process outgrowth and synapse formation...
  77. ncbi request reprint Pharmacological attenuation of apoptosis in reoxygenated endothelial cells
    A E Kabakov
    Medical Radiology Research Center, 4 Korolev Street, Obninsk 249036, Russia
    Cell Mol Life Sci 61:3076-86. 2004
    ..In the case of post-hypoxic drug administration, the cytoprotection was strongly inhibited by SB202190 and SB203580 and appears to be associated with enhanced p38 kinase activation in reoxygenated ECs...
  78. ncbi request reprint Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis
    Chantelle D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom
    J Neurosci Res 78:803-14. 2004
    ..Thus, p53 is expressed in neuronal cells undergoing differentiation as well as apoptosis. Interaction with Brn-3a in sensory neurons may be critical for modulating p53-mediated gene expression and hence cell fate...
  79. ncbi request reprint Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration
    M T Akbar
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College of Science, Technology and Medicine, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
    Brain Res Mol Brain Res 93:148-63. 2001
    ..The present study demonstrates the unique early expression of HSP27 mRNA by glial cells and distinct populations of neurones which extends beyond those in which HSP70 and CPP32 induction occurs with subsequent cell loss...
  80. ncbi request reprint Molecular expression systems for anti-DNA antibodies--1
    A Rahman
    Centre for Rheumatology, Department of Medicine, University College London, London, UK
    Lupus 11:824-32. 2002
    ..These motifs can be present on either the heavy or the light chain, but are particularly reported in V(H)CDR3...
  81. ncbi request reprint Molecular expression systems for anti-DNA antibodies--2
    S Kumar
    Centre for Rheumatology, Bloomsbury Rheumatology Unit, Department of Medicine, University College London Hospital, London, UK
    Lupus 11:833-42. 2002
    ....
  82. ncbi request reprint POU family transcription factors in the nervous system
    D S Latchman
    Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, United Kingdom
    J Cell Physiol 179:126-33. 1999
    ....
  83. ncbi request reprint Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters
    A Stephanou
    Departments of Molecular Pathology, Windyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1P 6DB, United Kingdom
    J Biol Chem 274:1723-8. 1999
    ....
  84. ncbi request reprint The different alternatively spliced isoforms of the Oct-2 transcription factor repress the involucrin promoter in a cell type-specific manner
    C M Chapman
    Department of Molecular Pathology, The Windeyer Institute of Medical Sciences, University College London Medical School, UK
    Mol Biol Rep 25:253-7. 1998
    ..In other cell types however, all three isoforms activate the involucrin promoter and this effect is also observed at low concentrations of Oct-2 in keratinocytes. The mechanisms responsible for these effects are discussed...
  85. ncbi request reprint Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies
    A Stephanou
    Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London Medical School, London, UK
    J Autoimmun 11:249-53. 1998
    ..In turn the elevated levels of hsp90 produced in autoimmune diseases are likely to be responsible for the observed production of anti-hsp90 autoantibodies...
  86. ncbi request reprint NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons
    S Wyatt
    Department of Molecular Pathology, University College London Medical School, The Windeyer Building, 46 Cleveland Street, London, WIP 6DB, UK
    Brain Res Mol Brain Res 55:254-64. 1998
    ..Similarly, Brn3b may mediate some of the effects that FGF2, TGFbeta1 and retinoic acid have on neurons...
  87. pmc POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element
    V Budhram-Mahadeo
    Department of Molecular Pathology, The Windeyer Institute of Medical Sciences, University College Medical School, London, United Kingdom
    Mol Cell Biol 18:1029-41. 1998
    ..These observations and their implications for transcriptional regulation by the ER are discussed...
  88. ncbi request reprint Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor
    M D Smith
    Department of Molecular Pathology, University College London Medical School, United Kingdom
    J Biol Chem 272:1382-8. 1997
    ..Hence a single amino acid difference results in these closely related factors having opposite effects and allows the balance between them to regulate differentiation...
  89. ncbi request reprint Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a
    S R Farooqui-Kabir
    Cell Death Differ 11:1242-4. 2004
  90. ncbi request reprint Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury
    D Schulman
    Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, WC1E 6DB, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H1630-6. 2001
    ..These results suggest that there are defects within the IP signaling cascade of the aged heart. Clinical relevance is important if we are to use any IP-like mimetics to the benefit of an aging population...
  91. ncbi request reprint The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC
    K L Jang
    Department of Biochemistry, University College and Middlesex School of Medicine, London, U K
    J Acquir Immune Defic Syndr 5:1142-7. 1992
    ..The significance of this effect for the life cycle of HIV and its interaction with infected cells is discussed...
  92. pmc Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B'
    J D Huntriss
    Clinical Immunology Division, Mathilda and Terence Kennedy Institute of Rheumatology, London, UK
    Clin Exp Immunol 92:263-7. 1993
    ..The data also indicate that brain and heart-specific anti-Sm antibodies do not exist in SLE sera, suggesting that these tissues do not participate in the induction or maintenance of the autoimmune anti-Sm response...