Annette MacLeod

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors
    Whitney Bullard
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA
    Virulence 3:72-6. 2012
  2. ncbi request reprint Evidence for multiple origins of human infectivity in Trypanosoma brucei revealed by minisatellite variant repeat mapping
    A MacLeod
    Wellcome Centre of Molecular Parasitology, Anderson College, University of Glasgow, Scotland
    J Mol Evol 52:290-301. 2001
  3. ncbi request reprint The detection of geographical substructuring of Trypanosoma brucei populations by the analysis of minisatellite polymorphisms
    A MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow
    Parasitology 123:475-82. 2001
  4. ncbi request reprint A high level of mixed Trypanosoma brucei infections in tsetse flies detected by three hypervariable minisatellites
    A MacLeod
    Wellcome Centre of Molecular Parasitology, Anderson College, University of Glasgow, Scotland, UK
    Mol Biochem Parasitol 102:237-48. 1999
  5. pmc The genetic map and comparative analysis with the physical map of Trypanosoma brucei
    Annette MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College Complex, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Nucleic Acids Res 33:6688-93. 2005
  6. doi request reprint Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom
    Infect Genet Evol 8:847-54. 2008
  7. pmc The population structure of the Cryptosporidium parvum population in Scotland: a complex picture
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK
    Infect Genet Evol 8:121-9. 2008
  8. pmc Discovery of mating in the major African livestock pathogen Trypanosoma congolense
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow, United Kingdom
    PLoS ONE 4:e5564. 2009
  9. ncbi request reprint Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis
    Annette MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Mol Biochem Parasitol 143:12-9. 2005
  10. pmc Use of multiple displacement amplification to increase the detection and genotyping of trypanosoma species samples immobilized on FTA filters
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
    Am J Trop Med Hyg 76:1132-7. 2007

Collaborators

Detail Information

Publications22

  1. pmc Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors
    Whitney Bullard
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA
    Virulence 3:72-6. 2012
    ..Together the findings reported here extend our previously published studies and suggest that group 1 T. b. gambiense has evolved multiple mechanisms to avoid killing by trypanolytic human serum factors...
  2. ncbi request reprint Evidence for multiple origins of human infectivity in Trypanosoma brucei revealed by minisatellite variant repeat mapping
    A MacLeod
    Wellcome Centre of Molecular Parasitology, Anderson College, University of Glasgow, Scotland
    J Mol Evol 52:290-301. 2001
    ....
  3. ncbi request reprint The detection of geographical substructuring of Trypanosoma brucei populations by the analysis of minisatellite polymorphisms
    A MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow
    Parasitology 123:475-82. 2001
    ..This geographical substructuring needs to be taken into account in considering the origins of the linkage disequilibrium in a number of populations...
  4. ncbi request reprint A high level of mixed Trypanosoma brucei infections in tsetse flies detected by three hypervariable minisatellites
    A MacLeod
    Wellcome Centre of Molecular Parasitology, Anderson College, University of Glasgow, Scotland, UK
    Mol Biochem Parasitol 102:237-48. 1999
    ..brucei...
  5. pmc The genetic map and comparative analysis with the physical map of Trypanosoma brucei
    Annette MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College Complex, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Nucleic Acids Res 33:6688-93. 2005
    ....
  6. doi request reprint Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom
    Infect Genet Evol 8:847-54. 2008
    ..The finding of distinct clades in different places suggests the possibility that samples from humans with clinical signs represent clonal expansions from an underlying population that requires identifying and characterising...
  7. pmc The population structure of the Cryptosporidium parvum population in Scotland: a complex picture
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK
    Infect Genet Evol 8:121-9. 2008
    ..Thus, the population structure of C. parvum is complex, with sub-populations differing in structure and being influenced by host movements, including the introduction of novel multilocus genotypes from geographically distinct regions...
  8. pmc Discovery of mating in the major African livestock pathogen Trypanosoma congolense
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow, United Kingdom
    PLoS ONE 4:e5564. 2009
    ....
  9. ncbi request reprint Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis
    Annette MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Mol Biochem Parasitol 143:12-9. 2005
    ..The results obtained are discussed in relation to previously proposed models of mating and support the occurrence of meiosis to form haploid gametes that then fuse to form the diploid progeny in a single round of mating...
  10. pmc Use of multiple displacement amplification to increase the detection and genotyping of trypanosoma species samples immobilized on FTA filters
    Liam J Morrison
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
    Am J Trop Med Hyg 76:1132-7. 2007
    ..The use of MDA allows maximal use of finite DNA samples and may prove a valuable tool in studies where multiple reactions are necessary, such as population genetic analyses...
  11. pmc Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map
    Anneli Cooper
    Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University Place, Glasgow G12 8TA, UK
    Genome Biol 9:R103. 2008
    ..As an essential step toward identifying loci that determine important traits in the human-infective subspecies, we report the construction of a high-resolution genetic map of the STIB 386 strain of T. b. gambiense...
  12. pmc Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development
    Andy Tait
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, 120, University Place, Glasgow G12 8TA, UK
    Mol Biochem Parasitol 151:133-6. 2007
  13. doi request reprint Trypanosoma vivax displays a clonal population structure
    Craig W Duffy
    Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, Faculty of Veterinary Medicine, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Int J Parasitol 39:1475-83. 2009
    ..vivax...
  14. doi request reprint Exploiting genetic variation to discover genes involved in important disease phenotypes
    Paul Capewell
    Wellcome Trust Centre for Molecular Parasitology, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, 464 Bearsden Road, Glasgow, G61 1QH, UK
    Methods Mol Biol 1201:91-107. 2015
    ....
  15. ncbi request reprint Multilocus genotyping of Cryptosporidium parvum Type 2: population genetics and sub-structuring
    Marianne E Mallon
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Infect Genet Evol 3:207-18. 2003
    ..parvum 'monkey type' isolates from two separate human cases indicating that this genotype is not restricted to monkey hosts with the multilocus genotypes of these isolates distinguishing them from all other isolates...
  16. pmc Population genomics reveals the origin and asexual evolution of human infective trypanosomes
    William Weir
    Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
    elife 5:e11473. 2016
    ..Our study sheds new light on the genomic and evolutionary consequences of strict asexuality, which this pathogen uses as it exploits a new biological niche, the human population. ..
  17. pmc A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome
    Paul Capewell
    Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, UK
    Parasitology 142:S108-19. 2015
    ..b. gambiense and T. b. rhodesiense, with several populations of humans and primates displaying resistance to infection by these two sub-species...
  18. pmc Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits
    Andy Tait
    Wellcome Centre for Molecular Parasitology, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Philos Trans R Soc Lond B Biol Sci 357:89-99. 2002
    ..The general conclusion, from the results presented, is that a genetic-mapping approach is feasible and will, in the future, allow the genes determining a number of important traits to be identified...
  19. pmc The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense
    Paul Capewell
    Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Pathog 9:e1003686. 2013
    ..Reintroducing TgsGP into knockout parasite lines restored resistance. We conclude that TgsGP is essential for human serum resistance in T. b. gambiense. ..
  20. ncbi request reprint Minisatellites and MVR-PCR for the individual identification of parasite isolates
    Annette MacLeod
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, UK
    Methods Mol Biol 270:187-202. 2004
    ..In this chapter, the methods for genotyping of T. brucei parasites using both minisatellite allele length and MVR mapping are described in full and can be easily adapted to apply to mini-satellites in other parasites...
  21. pmc Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes
    Nicola J Veitch
    Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, UK
    BMC Genomics 11:124. 2010
    ....
  22. ncbi request reprint Population structures and the role of genetic exchange in the zoonotic pathogen Cryptosporidium parvum
    Marianne Mallon
    Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland
    J Mol Evol 56:407-17. 2003
    ....