P Mastroeni

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Expert Rev Mol Med 13:e12. 2011
  2. ncbi request reprint Dynamics of spread of Salmonella enterica in the systemic compartment
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom Electronic address
    Microbes Infect 15:849-57. 2013
  3. ncbi request reprint Salmonella infections in the mouse model: host resistance factors and in vivo dynamics of bacterial spread and distribution in the tissues
    Pietro Mastroeni
    Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Microbes Infect 6:398-405. 2004
  4. pmc Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Cambridge CB3 OES, United Kingdom
    Infect Immun 68:46-53. 2000
  5. pmc Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein
    B A Degnan
    School of Clinical Medical Sciences Rheumatology, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    Infect Immun 68:2441-8. 2000
  6. doi request reprint A dynamic view of the spread and intracellular distribution of Salmonella enterica
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Nat Rev Microbiol 7:73-80. 2009
  7. ncbi request reprint Salmonella: immune responses and vaccines
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge, CB3 OES, UK
    Vet J 161:132-64. 2001
  8. ncbi request reprint Development of acquired immunity to Salmonella
    Pietro Mastroeni
    Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Med Microbiol 52:453-9. 2003
  9. ncbi request reprint Immunity to systemic Salmonella infections
    Pietro Mastroeni
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Curr Mol Med 2:393-406. 2002
  10. ncbi request reprint Protection against oral challenge three months after i.v. immunization of BALB/c mice with live Aro Salmonella typhimurium and Salmonella enteritidis vaccines is serotype (species)-dependent and only partially determined by the main LPS O antigen
    C E Hormaeche
    Department of Microbiology, Medical School, University of Newcastle, UK
    Vaccine 14:251-9. 1996

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Expert Rev Mol Med 13:e12. 2011
    ..We conclude by discussing how understanding the within-host quantitative, spatial and temporal dynamics of S. enterica infections might aid the development of novel targeted preventative measures and drug regimens...
  2. ncbi request reprint Dynamics of spread of Salmonella enterica in the systemic compartment
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom Electronic address
    Microbes Infect 15:849-57. 2013
    ..Bacterial escape from infected cells, spread in the tissues and attempts to restrain this process by the host give rise to fascinating scenarios that underpin the pathogenesis of salmonelloses. ..
  3. ncbi request reprint Salmonella infections in the mouse model: host resistance factors and in vivo dynamics of bacterial spread and distribution in the tissues
    Pietro Mastroeni
    Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Microbes Infect 6:398-405. 2004
    ..Salmonella growth in the tissues results in the spatial segregation of bacterial populations and in their continuous distribution to new phagocytes. High bacterial numbers within infected phagocytes are uncommon in vivo...
  4. pmc Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Cambridge CB3 OES, United Kingdom
    Infect Immun 68:46-53. 2000
    ....
  5. pmc Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein
    B A Degnan
    School of Clinical Medical Sciences Rheumatology, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    Infect Immun 68:2441-8. 2000
    ..The difference in acid susceptibility between wild-type and mutant bacteria may explain the reduced capacity of the isogenic mutant bacteria to invade and survive intracellularly...
  6. doi request reprint A dynamic view of the spread and intracellular distribution of Salmonella enterica
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Nat Rev Microbiol 7:73-80. 2009
    ..We further describe implications for our understanding of the pathogenic mechanism inside the host...
  7. ncbi request reprint Salmonella: immune responses and vaccines
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge, CB3 OES, UK
    Vet J 161:132-64. 2001
    ..Despite the great recent advances in the development of Salmonella vaccines a large proportion of the work has been conducted in laboratory rodents and more research in other animal species is required...
  8. ncbi request reprint Development of acquired immunity to Salmonella
    Pietro Mastroeni
    Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Med Microbiol 52:453-9. 2003
    ..An ideal live Salmonella vaccine should therefore be safe, regardless of the immunological status of the vaccinee, but still immunogenic...
  9. ncbi request reprint Immunity to systemic Salmonella infections
    Pietro Mastroeni
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Curr Mol Med 2:393-406. 2002
    ..Thus, the development of protective immunity to Salmonella infections relies on the cross-talk between the humoral and cellular branches of the immune system...
  10. ncbi request reprint Protection against oral challenge three months after i.v. immunization of BALB/c mice with live Aro Salmonella typhimurium and Salmonella enteritidis vaccines is serotype (species)-dependent and only partially determined by the main LPS O antigen
    C E Hormaeche
    Department of Microbiology, Medical School, University of Newcastle, UK
    Vaccine 14:251-9. 1996
    ..It remains to be seen whether there is a T-cell mediated component to the specificity of protection conferred by live Salmonella vaccines...
  11. pmc Salmonella enterica serovar typhimurium trxA mutants are protective against virulent challenge and induce less inflammation than the live-attenuated vaccine strain SL3261
    S E Peters
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
    Infect Immun 78:326-36. 2010
    ..We tested this by deleting trxA in SL3261. SL3261 trxA was also less inflammatory than SL3261 but was slightly less effective as a vaccine strain than either the SL3261 parent strain or SL1344 trxA...
  12. ncbi request reprint Salmonella enterica serovar Typhimurium mutants completely lacking the F(0)F(1) ATPase are novel live attenuated vaccine strains
    H Northen
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Vaccine 28:940-9. 2010
    ..We have shown that the F(0)F(1) ATPase is important for bacterial growth in vivo and that atp mutants are effective live attenuated vaccines against Salmonella infection...
  13. pmc Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB/c mice: role of gamma interferon and macrophage activation
    P Mastroeni
    School of Microbiological, Immunological and Virological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    Infect Immun 66:4767-76. 1998
    ..Administration of recombinant IFN-gamma to anti-IL-12-treated mice was able to restore host resistance, granuloma formation, and expression of major histocompatibility complex class II antigens in F4/80(+) and CD11b+ spleen cells...
  14. ncbi request reprint Early responses to Salmonella typhimurium infection in mice occur at focal lesions in infected organs
    S A Khan
    Department of Clinical Veterinary Medicine, The Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Microb Pathog 30:29-38. 2001
    ..These data show that there is a very early host response to S. typhimurium infection in mice, limited to foci within the infected organs...
  15. pmc Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance
    Suzanne Talbot
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Immunology 128:472-83. 2009
    ..Typhimurium, suggesting that TLR4 signalling is not important in driving bacterial clearance in comparison to its critical role in controlling early bacterial growth in mouse typhoid...
  16. pmc Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages
    Hazel Uppington
    Centre for Veterinary Science, University of Cambridge, Cambridge, UK
    Immunology 119:147-58. 2006
    ..However, opsonization of bacteria with immune serum did not increase either nitric oxide production in response to S. enterica serovar Typhimurium or fusion of phagosomes with lysosomes...
  17. ncbi request reprint Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers
    Mbithe Mutunga
    School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Vaccine 22:4124-31. 2004
    ....
  18. ncbi request reprint Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice
    Paola Zaccone
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, UK
    Eur J Immunol 34:3246-56. 2004
    ..These data reinforce the idea that prevention of T1D in the NOD mouse cannot be reduced to the simple Th1/Th2 paradigm and that different infections may involve different protective mechanisms...
  19. pmc Fcgamma receptors are crucial for the expression of acquired resistance to virulent Salmonella enterica serovar Typhimurium in vivo but are not required for the induction of humoral or T-cell-mediated immunity
    Nathalie Menager
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Immunology 120:424-32. 2007
    ..enterica. The work indicates that targeting S. enterica to FcgammaR is needed for the expression of vaccine-induced acquired immunity, but is not essential for the engenderment of T- and B-cell immunity to the bacterium in vivo...
  20. pmc Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88
    Gemma L Foster
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Immunology 124:469-79. 2008
    ....
  21. pmc Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Exp Med 192:237-48. 2000
    ..The NADPH phagocye oxidase and iNOS are both required for host resistance to wild-type Salmonella, but appear to operate principally at different stages of infection...
  22. pmc Rapid expression of chemokines and proinflammatory cytokines in newly hatched chickens infected with Salmonella enterica serovar typhimurium
    G S K Withanage
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Infect Immun 72:2152-9. 2004
    ..This is the first description of in vivo expression of chemokines and proinflammatory cytokines in response to oral infection with Salmonella in newly hatched chickens...
  23. ncbi request reprint Dynamics of bacterial growth and distribution within the liver during Salmonella infection
    Mark Sheppard
    Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Cell Microbiol 5:593-600. 2003
    ..These findings suggest a novel mechanism underlying growth of salmonellae in vivo with important consequences for understanding mechanisms of resistance and immunity...
  24. pmc Modelling within-host spatiotemporal dynamics of invasive bacterial disease
    Andrew J Grant
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 6:e74. 2008
    ....
  25. pmc Bacterial growth rate and host factors as determinants of intracellular bacterial distributions in systemic Salmonella enterica infections
    Andrew J Grant
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 77:5608-11. 2009
    ..enterica within the host. We show that both bacterial and host factors determine the numerical distributions of bacteria within host cells and thus the level of dispersiveness of the infection...
  26. pmc Activation of murine dendritic cells and macrophages induced by Salmonella enterica serovar Typhimurium
    Ruwani Sagarika Kalupahana
    Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Immunology 115:462-72. 2005
    ....
  27. pmc Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection
    Joanna Warren
    Rheumatology Section, Division of Medicine, Department of Biochemistry, Imperial College School of Medicine London, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 70:551-7. 2002
    ..The data presented here suggest the possibility of novel pathways by which C1q may modulate the pathogenesis of infectious diseases caused by intracellular pathogens...
  28. pmc Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice
    Andrew J Grant
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Immunology 125:28-37. 2008
    ....
  29. ncbi request reprint Oxidative and nitrosative responses of the chicken macrophage cell line MQ-NCSU to experimental Salmonella infection
    G S K Withanage
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, England
    Br Poult Sci 46:261-7. 2005
    ....
  30. ncbi request reprint Salmonella typhimurium infection in nonobese diabetic mice generates immunomodulatory dendritic cells able to prevent type 1 diabetes
    Tim Raine
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom
    J Immunol 177:2224-33. 2006
    ..The effects we observe on autoreactive T cell trafficking are recapitulated by the immunomodulatory dendritic cell transfers in the cyclophosphamide model...
  31. pmc Intracellular demography and the dynamics of Salmonella enterica infections
    Sam P Brown
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 4:e349. 2006
    ....
  32. ncbi request reprint Salmonella infection of afferent lymph dendritic cells
    Simon S M Chan
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    J Leukoc Biol 83:272-9. 2008
    ..However, the low efficiency of infection of ALDC compared with macrophages or monocyte-derived DCs may account for the poor immune responses induced in large animal models...
  33. pmc LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium
    M H Karavolos
    Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Bacteriol 190:769-71. 2008
    ..This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals...
  34. ncbi request reprint Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis
    Christine Hale
    The Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Vaccine 24:4312-20. 2006
    ..typhimurium). In contrast, Vi vaccination did not confer protection against oral challenge with virulent Vi-positive S. typhimurium or S. dublin...
  35. pmc Characterization and development of T-Cell immune responses in B-cell-deficient (Igh-6(-/-)) mice with Salmonella enterica serovar Typhimurium infection
    Sanja Ugrinovic
    Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Infect Immun 71:6808-19. 2003
    ..Our results show that B cells are important for the development of T-cell responses in the early stage of a Salmonella infection and that this property may be due to their ability to present antigens to T cells...
  36. doi request reprint Multiple redundant stress resistance mechanisms are induced in Salmonella enterica serovar Typhimurium in response to alteration of the intracellular environment via TLR4 signalling
    John A Wright
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Microbiology 155:2919-29. 2009
    ..Our study shows that TLR4 activity, either directly or indirectly, induces the expression of multiple stress resistance genes during the intracellular life of S. Typhimurium...
  37. pmc DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination biases towards T helper 1 responses and enhances protection against Leishmania major infection in mice
    Uta G Lange
    Cambridge Institute for Medical Research, and Department of Medicine, School of Clinical Medicine, University of Cambridge, United Kingdom
    Infect Immun 72:4924-8. 2004
    ....
  38. pmc In vivo regulation of the Vi antigen in Salmonella and induction of immune responses with an in vivo-inducible promoter
    Carole Janis
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
    Infect Immun 79:2481-8. 2011
    ..Our work highlights that Vi is downregulated in vivo and provides proof of principle that it is possible to generate a live attenuated vaccine that induces Vi-specific antibodies after single oral administration...
  39. ncbi request reprint Inhibition of cell surface MHC class II expression by Salmonella
    Erin K Mitchell
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, GB
    Eur J Immunol 34:2559-67. 2004
    ..SifA has been shown to be involved in recruiting membrane for the Salmonella-containing vacuoles. Our data suggest an additional role for SifA in interfering with MHC class II antigen-presentation...
  40. ncbi request reprint Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity
    Jacqueline K White
    Wellcome Trust MRC Building, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, UK
    J Leukoc Biol 77:311-20. 2005
    ..This highlights the adaptive differences in tissue and cellular tropisms between L. donovani and L. major and the different genes and mechanisms that regulate visceral versus cutaneous forms of the disease...
  41. ncbi request reprint Interactions of proteoliposomes from serogroup B Neisseria meningitidis with bone marrow-derived dendritic cells and macrophages: adjuvant effects and antigen delivery
    Tamara Rodríguez
    Department of Immunology, Finlay Institute, PO Box 16017, Havana, Cuba
    Vaccine 23:1312-21. 2005
    ..The work also shows the potential of PL as a general system to deliver antigens to DC for presentation to CD4+ and CD8+ T-cells...
  42. pmc Intracellular adhesion molecule 1 plays a key role in acquired immunity to salmonellosis
    Simon Clare
    Department of Biological Sciences, Centre for Molecular Microbiology and Infection, Level 1, Flowers Building, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Infect Immun 71:5881-91. 2003
    ..In this study we show that ICAM-1 plays a critical role during rechallenge of immunized mice with virulent S. enterica serovar Typhimurium...
  43. pmc Cytokine and chemokine responses associated with clearance of a primary Salmonella enterica serovar Typhimurium infection in the chicken and in protective immunity to rechallenge
    G S K Withanage
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Infect Immun 73:5173-82. 2005
    ....
  44. ncbi request reprint Bacterial derived proteoliposome as ideal delivery system and cellular adjuvant
    Tamara Rodríguez
    Department of Immunology, Finlay Institute, 27 Ave, b 198 and 202 La Lisa, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-24-5. 2006
    ..PL exerts an immunomodulatory effect on DC and is a general system to deliver antigens for presentation to CD4+ and CD8+ T-cells possibly implicated in the induction CD8+ cytotoxic T lymphocytes (CTLs) responses...
  45. ncbi request reprint Live bacteria as the basis for immunotherapies against cancer
    Jose A Chabalgoity
    Department of Biochemistry, Instituto de Higiene, Facultad de Medicina, Montevideo, Uruguay
    Expert Rev Vaccines 1:495-505. 2002
    ..In this paper, we will review the current state of such applications and highlight some of the directions that the field may take...