K R Matthews

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc The cell biology of Trypanosoma brucei differentiation
    Katelyn Fenn
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Microbiol 10:539-46. 2007
  2. ncbi request reprint Molecular regulation of the life cycle of African trypanosomes
    Keith R Matthews
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Trends Parasitol 20:40-7. 2004
  3. ncbi request reprint Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form
    K R Matthews
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 110:2609-18. 1997
  4. ncbi request reprint Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
    K R Matthews
    University of Manchester, UK
    Mol Biochem Parasitol 95:81-95. 1998
  5. ncbi request reprint Developments in the differentiation of Trypanosoma brucei
    K R Matthews
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester, UK M13 9PT
    Parasitol Today 15:76-80. 1999
  6. pmc The bloodstream differentiation-division of Trypanosoma brucei studied using mitochondrial markers
    K M Tyler
    School of Biological Sciences, University of Manchester, UK
    Proc Biol Sci 264:1481-90. 1997
  7. ncbi request reprint Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927
    F J van Deursen
    Division of Biochemistry, School of Biological Sciences, University of Manchester, Manchester, UK
    Mol Biochem Parasitol 112:163-71. 2001
  8. pmc Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes
    P Bastin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 19:8191-200. 1999
  9. pmc A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form
    E F Hendriks
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    EMBO J 20:6700-11. 2001
  10. pmc Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei
    Christian J Janzen
    Laboratory of Molecular Parasitology, The Rockefeller University, Box 185, 1230 York Avenue, New York, NY 10021 6399, USA
    Mol Biochem Parasitol 149:102-7. 2006

Collaborators

  • Edward F Hendriks
  • Paula MacGregor
  • Samuel D Dean
  • Katelyn Fenn
  • Amy E Gruszynski
  • Christian J Janzen
  • Balazs Szoor
  • Frederick J van Deursen
  • Mark W Timms
  • E F Hendriks
  • F J van Deursen
  • P Bastin
  • K Gull
  • Jude Wilson
  • Nicholas A Malmquist
  • George A Punkosdy
  • Lydia Tabernero
  • James D Bangs
  • Jennifer B Palenchar
  • Qian Wang
  • Joe Dan Dunn
  • Kshitiz Chaudhary
  • Laura J Cliffe
  • Sara Prickett
  • Frederick van Deursen
  • Giel van Dooren
  • Louise Ellis
  • Elisabetta Ullu
  • George A M Cross
  • Anant K Menon
  • Laura Del Rio
  • Huafang Shi
  • Juliana M Figueiredo
  • Yusuf Omosun
  • Krystal J Evans
  • Maria C Albareda
  • Helen McElhinney
  • Alexander Best
  • K M Tyler
  • Ammar Abdul-Razak
  • C Guerra-Giraldez
  • D R Robinson
  • C E Clayton
  • C Hartmann
  • S K Shahi
  • C M Turner
  • M Hinkins
  • T H MacRae
  • S B Francis

Detail Information

Publications18

  1. pmc The cell biology of Trypanosoma brucei differentiation
    Katelyn Fenn
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Microbiol 10:539-46. 2007
    ..Interestingly, the new molecular discoveries provide insights into the biology of the parasite in the field...
  2. ncbi request reprint Molecular regulation of the life cycle of African trypanosomes
    Keith R Matthews
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Trends Parasitol 20:40-7. 2004
  3. ncbi request reprint Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form
    K R Matthews
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 110:2609-18. 1997
    ....
  4. ncbi request reprint Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
    K R Matthews
    University of Manchester, UK
    Mol Biochem Parasitol 95:81-95. 1998
    ....
  5. ncbi request reprint Developments in the differentiation of Trypanosoma brucei
    K R Matthews
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester, UK M13 9PT
    Parasitol Today 15:76-80. 1999
    ..Here, Keith Matthews presents an overview of recent advances in the understanding of the regulation of these complex differentiation events...
  6. pmc The bloodstream differentiation-division of Trypanosoma brucei studied using mitochondrial markers
    K M Tyler
    School of Biological Sciences, University of Manchester, UK
    Proc Biol Sci 264:1481-90. 1997
    ..The results implicate a temporal order of events: commitment, division, phenotypic differentiation...
  7. ncbi request reprint Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927
    F J van Deursen
    Division of Biochemistry, School of Biological Sciences, University of Manchester, Manchester, UK
    Mol Biochem Parasitol 112:163-71. 2001
    ..The generated lines and analyses of their growth and differentiation will provide a basic resource for the analysis and interpretation of gene function in the T. brucei genome reference strain...
  8. pmc Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes
    P Bastin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 19:8191-200. 1999
    ..This seven-amino-acid sequence is conserved in all PFRA and PFRC proteins and shows homology to a sequence in the flagellar dynein heavy chain of Chlamydomonas reinhardtii...
  9. pmc A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form
    E F Hendriks
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    EMBO J 20:6700-11. 2001
    ..TbZFP1 and tbZFP2 represent the first molecules implicated in the control of trypanosome differentiation to the procyclic form...
  10. pmc Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei
    Christian J Janzen
    Laboratory of Molecular Parasitology, The Rockefeller University, Box 185, 1230 York Avenue, New York, NY 10021 6399, USA
    Mol Biochem Parasitol 149:102-7. 2006
  11. pmc Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites
    Samuel D Dean
    Institute for Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Cell Host Microbe 2:279-81. 2007
    ..quot; Consequently, they are swept to the cell posterior, internalized via the flagellar-pocket, and degraded. Hydrodynamic sorting is a novel biological process, possibly applicable in other contexts...
  12. pmc Protein tyrosine phosphatase TbPTP1: A molecular switch controlling life cycle differentiation in trypanosomes
    Balazs Szoor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Cell Biol 175:293-303. 2006
    ..It may be possible to use PTP1B inhibitors to block trypanosomatid transmission...
  13. ncbi request reprint Regulation of surface coat exchange by differentiating African trypanosomes
    Amy E Gruszynski
    Department of Biomolecular Chemistry, University of Wisonsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Mol Biochem Parasitol 147:211-23. 2006
    ..The relegation of short stumpy surface GPI-PLC to a secondary role in differentiation suggests that it may play a more important role as a virulence factor within the mammalian host...
  14. pmc Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein
    Edward F Hendriks
    Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Microbiol 57:706-16. 2005
    ..brucei. It demonstrates that programmed events in parasite development can be uncoupled at the molecular level. It also further supports the importance of CCCH proteins in key aspects of trypanosome cell function...
  15. pmc The developmental cell biology of Trypanosoma brucei
    Keith R Matthews
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    J Cell Sci 118:283-90. 2005
    ..Therefore, understanding the developmental cell biology of the African trypanosome is providing insight into both fundamentally conserved and fundamentally different aspects of the organization of the eukaryotic cell...
  16. ncbi request reprint tbCPSF30 depletion by RNA interference disrupts polycistronic RNA processing in Trypanosoma brucei
    Edward F Hendriks
    School of Biological Sciences, Division of Biochemistry, 2 205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 278:26870-8. 2003
    ..This study is the first to identify and characterize a core component of the T. brucei CPSF and show its involvement in polycistronic RNA processing...
  17. pmc Mitochondrial development during life cycle differentiation of African trypanosomes: evidence for a kinetoplast-dependent differentiation control point
    Mark W Timms
    School of Biological Sciences, University of Manchester, Manchester, M13 9PT United Kingdom
    Mol Biol Cell 13:3747-59. 2002
    ..These results provide strong evidence for a requirement for kinetoplast DNA in the bloodstream and for a kinetoplast-dependent control point during differentiation to procyclic forms...
  18. pmc Modelling trypanosome chronicity: VSG dynasties and parasite density
    Paula MacGregor
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Trends Parasitol 24:1-4. 2008
    ..The study has important implications for understanding the dynamics of antigenic variation and for modelling the consequences of therapeutic strategies directed against trypanosomes...