Jill A McKay

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Folate and DNA methylation during in utero development and aging
    J A McKay
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle upon Tyne, NE1 7RU, UK
    Biochem Soc Trans 32:1006-7. 2004
  2. pmc Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion
    Jill A McKay
    Human Nutrition Research Centre, Institute for Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Nutrients 8:. 2016
  3. pmc Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy
    Jill A McKay
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 60:2031-42. 2016
  4. pmc Effect of maternal and post-weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult apc and wild type mice
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University Newcastle upon Tyne, UK
    Front Genet 2:23. 2011
  5. pmc Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12
    Jill A McKay
    Institute for Ageing and Health, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    PLoS ONE 7:e33290. 2012
  6. ncbi request reprint Gender-specific modulation of tumorigenesis by folic acid supply in the Apc mouse during early neonatal life
    Jill A McKay
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, NE2 4HH, UK
    Br J Nutr 99:550-8. 2008
  7. pmc Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation
    J A McKay
    Human Nutrition Research Centre, Medical School, Newcastle University, Framlington Place, Newcastle, NE2 4HH, UK
    Genes Nutr 3:167-71. 2008
  8. pmc Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle, NE2 4HH, UK
    Genes Nutr 6:189-96. 2011
  9. doi request reprint Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 55:1026-35. 2011
  10. doi request reprint Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 55:1717-23. 2011

Detail Information

Publications18

  1. ncbi request reprint Folate and DNA methylation during in utero development and aging
    J A McKay
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle upon Tyne, NE1 7RU, UK
    Biochem Soc Trans 32:1006-7. 2004
    ..This review describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging...
  2. pmc Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion
    Jill A McKay
    Human Nutrition Research Centre, Institute for Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Nutrients 8:. 2016
    ..Only 25 differentially expressed genes were common between organs. Maternal folate intake during pregnancy influences fetal gene expression in a highly organ specific manner which may reflect organ-specific functions...
  3. pmc Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy
    Jill A McKay
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 60:2031-42. 2016
    ..We observed transcriptional changes in fetal liver in response to maternal folate depletion and hypothesized that these changes are concomitant with altered gene promoter methylation...
  4. pmc Effect of maternal and post-weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult apc and wild type mice
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University Newcastle upon Tyne, UK
    Front Genet 2:23. 2011
    ....
  5. pmc Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12
    Jill A McKay
    Institute for Ageing and Health, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    PLoS ONE 7:e33290. 2012
    ..In addition, gestational length appears to be an important determinant of infant DNA methylation patterns...
  6. ncbi request reprint Gender-specific modulation of tumorigenesis by folic acid supply in the Apc mouse during early neonatal life
    Jill A McKay
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, NE2 4HH, UK
    Br J Nutr 99:550-8. 2008
    ....
  7. pmc Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation
    J A McKay
    Human Nutrition Research Centre, Medical School, Newcastle University, Framlington Place, Newcastle, NE2 4HH, UK
    Genes Nutr 3:167-71. 2008
    ....
  8. pmc Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle, NE2 4HH, UK
    Genes Nutr 6:189-96. 2011
    ..These observations demonstrate that early life folate depletion affects epigenetic markings, that this effect is not modulated by post-weaning folate supply and that altered epigenetic marks persist into adulthood...
  9. doi request reprint Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 55:1026-35. 2011
    ..Given the increased requirement for folate during pregnancy, mothers may be susceptible to aberrant DNA methylation due to folate depletion...
  10. doi request reprint Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 55:1717-23. 2011
    ..We reported low folate supply in utero was associated with reduced global DNA methylation in the murine small intestine of adult offspring. We hypothesised that aberrant methylation would be observed during early development...
  11. doi request reprint Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring
    Jill A McKay
    Human Nutrition Research Centre, Institute for Health and Society, Newcastle University, UK
    Mol Nutr Food Res . 2016
    ..Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mechanisms...
  12. doi request reprint Analysis of differential gene-regulatory responses to zinc in human intestinal and placental cell lines
    Kelly A Jackson
    Human Nutrition Research Centre, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Br J Nutr 101:1474-83. 2009
    ....
  13. pmc DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia
    Jessica A Timms
    Institute of Health and Society, Newcastle University, Newcastle, UK
    Epigenomics 8:519-36. 2016
    ..Here we explore the potential that DNA methylation may be involved in the causal pathway toward disease by acting as a mediator between established environmental factors and childhood ALL development. ..
  14. doi request reprint Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK Institute for Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 58:1087-97. 2014
    ..Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype...
  15. doi request reprint Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring
    Sabine A S Langie
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    FASEB J 27:3323-34. 2013
    ..In summary, our data suggest that low-folate supply during early life may leave an epigenetic mark that can predispose the offspring to further dietary insults, causing adverse effects during adult life...
  16. ncbi request reprint Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability
    Kelly A Jackson
    Human Nutrition Research Centre, Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4NN, United Kingdom
    J Biol Chem 282:10423-31. 2007
    ..To our knowledge, this is the first report that zinc affects the stability of a transcript with a direct role in cellular zinc homeostasis...
  17. ncbi request reprint Maternal folate deficiency and metabolic dysfunction in offspring
    Jill A McKay
    Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Proc Nutr Soc 75:90-95. 2016
    ..The widespread prevalence of overweight and obesity and of folate deficiency among women of child-bearing age highlights the possibility that this double nutritional insult may exacerbate the risk of metabolic disease in their offspring...
  18. doi request reprint Epigenetics - potential contribution to fetal programming
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, William Leech Building, Newcastle on Tyne, UK
    Adv Exp Med Biol 646:119-23. 2009
    ..Studies of altered epigenetic marking will be of profound importance for mechanistic understanding of the role of nutrition in health but especially for studies of the developmental origins of health...