Pablo Navarro

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells
    Pablo Navarro
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland, UK
    Hum Genet 130:255-64. 2011
  2. pmc OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells
    Pablo Navarro
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    EMBO J 31:4547-62. 2012
  3. doi Molecular coupling of Tsix regulation and pluripotency
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Nature 468:457-60. 2010
  4. doi Molecular coupling of Xist regulation and pluripotency
    Pablo Navarro
    Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS, URA2578, F 75015, Paris, France
    Science 321:1693-5. 2008
  5. pmc Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, Institut Pasteur 75724, Paris Cedex 15, France
    Genes Dev 20:2787-92. 2006
  6. pmc Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, URA 2578, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 19:1474-84. 2005
  7. pmc Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells
    Nicola Festuccia
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, Scotland
    Cell Stem Cell 11:477-90. 2012
  8. pmc The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene
    Céline Morey
    Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    EMBO J 23:594-604. 2004
  9. doi When X-inactivation meets pluripotency: an intimate rendezvous
    Pablo Navarro
    Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS, URA2578, F 75015 Paris, France
    FEBS Lett 583:1721-7. 2009
  10. doi Spontaneous reactivation of clusters of X-linked genes is associated with the plasticity of X-inactivation in mouse trophoblast stem cells
    Agnès Dubois
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris Cedex 15, France Epigenetics of Stem Cells, Institut Pasteur, Paris Cedex 15, France
    Stem Cells 32:377-90. 2014

Collaborators

Detail Information

Publications13

  1. pmc The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells
    Pablo Navarro
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland, UK
    Hum Genet 130:255-64. 2011
    ..We conclude that in mouse ES cells the pluripotency-associated machinery exerts an exhaustive control of X-inactivation by taking over the regulation of all three major regulators of X-inactivation: Xist, Tsix, and Rnf12...
  2. pmc OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells
    Pablo Navarro
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    EMBO J 31:4547-62. 2012
    ..Therefore, cellular variability in self-renewal efficiency is an emergent property of the pluripotency gene regulatory network...
  3. doi Molecular coupling of Tsix regulation and pluripotency
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Nature 468:457-60. 2010
    ..The holistic pattern of Xist/Tsix regulation by pluripotent factors that we have identified suggests a general direct governance of complex epigenetic processes by the machinery dedicated to pluripotency...
  4. doi Molecular coupling of Xist regulation and pluripotency
    Pablo Navarro
    Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS, URA2578, F 75015, Paris, France
    Science 321:1693-5. 2008
    ..We conclude that the three main genetic factors underlying pluripotency cooperate to repress Xist and thus couple X inactivation reprogramming to the control of pluripotency during embryogenesis...
  5. pmc Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, Institut Pasteur 75724, Paris Cedex 15, France
    Genes Dev 20:2787-92. 2006
    ..Our results provide mechanistic insights into the Tsix-mediated epigenetic regulation of Xist resulting in Xist promoter activation and initiation of X inactivation in differentiating ES cells...
  6. pmc Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, URA 2578, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 19:1474-84. 2005
    ..In this model, Tsix, by resetting the epigenetic state of the Xist/Tsix locus, mediates the transition from imprinted to random XCI...
  7. pmc Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells
    Nicola Festuccia
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, Scotland
    Cell Stem Cell 11:477-90. 2012
    ..Finally, Esrrb deletion abolishes the defining ability of Nanog to confer LIF-independent ESC self-renewal. These findings are consistent with the functional placement of Esrrb downstream of Nanog...
  8. pmc The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene
    Céline Morey
    Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    EMBO J 23:594-604. 2004
    ..Our results raise the possibility that H3 Lys-4 dimethylation within Xist may be functionally implicated in the counting process...
  9. doi When X-inactivation meets pluripotency: an intimate rendezvous
    Pablo Navarro
    Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS, URA2578, F 75015 Paris, France
    FEBS Lett 583:1721-7. 2009
    ....
  10. doi Spontaneous reactivation of clusters of X-linked genes is associated with the plasticity of X-inactivation in mouse trophoblast stem cells
    Agnès Dubois
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris Cedex 15, France Epigenetics of Stem Cells, Institut Pasteur, Paris Cedex 15, France
    Stem Cells 32:377-90. 2014
    ..Our study suggests that this type of "metastable epigenetic" states may underlie the plasticity of TS cells and predispose specific genes to relaxed regulation in specific subtypes of placental cells...
  11. pmc A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur 75724, Paris Cedex 15, France
    Epigenetics Chromatin 2:8. 2009
    ..Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtaposed to a large domain of H3K27 trimethylation (H3K27me3)...
  12. doi An embryonic story: analysis of the gene regulative network controlling Xist expression in mouse embryonic stem cells
    Pablo Navarro
    Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS URA2578, Paris, France
    Bioessays 32:581-8. 2010
    ..In this paper we summarise recent advances in our knowledge of the regulation of Xist and Tsix in embryonic stem (ES) and differentiating ES cells...
  13. ncbi Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression
    Claire Rougeulle
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Hum Mol Genet 12:3343-8. 2003
    ....