S E O'Sullivan

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Time-dependent vascular effects of Endocannabinoids mediated by peroxisome proliferator-activated receptor gamma (PPARγ)
    Saoirse E O'Sullivan
    School of Graduate Entry Medicine and Health, Derby City General Hospital, University of Nottingham, Derby DE22 3DT, UK
    PPAR Res 2009:425289. 2009
  2. pmc Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA)
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 141:803-12. 2004
  3. pmc Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors
    S E O'Sullivan
    School of Biomedical Sciences, University of Notttingham, Queen s Medical Center, Nottingham, UK
    Br J Pharmacol 152:576-82. 2007
  4. ncbi request reprint The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase
    Saoirse E O'Sullivan
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Pharmacol Exp Ther 321:663-72. 2007
  5. pmc What is the significance of vascular hydrogen sulphide (H2S)?
    S E O'Sullivan
    University of Nottingham, School of Biomedical Sciences, University of Nottingham, Nottingham, Notts, UK
    Br J Pharmacol 149:609-10. 2006
  6. ncbi request reprint Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol
    Saoirse E O'Sullivan
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    J Pharmacol Exp Ther 317:428-38. 2006
  7. ncbi request reprint Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma
    Saoirse E O'Sullivan
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Biochem Biophys Res Commun 337:824-31. 2005
  8. pmc The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 145:514-26. 2005
  9. ncbi request reprint Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Eur J Pharmacol 507:211-21. 2005
  10. pmc Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 142:435-42. 2004

Collaborators

  • Sheila M Gardiner
  • A Alhamoruni
  • V C M Shang
  • K L Wright
  • M Larvin
  • R E Roberts
  • D A Kendall
  • A C Lee

Detail Information

Publications14

  1. pmc Time-dependent vascular effects of Endocannabinoids mediated by peroxisome proliferator-activated receptor gamma (PPARγ)
    Saoirse E O'Sullivan
    School of Graduate Entry Medicine and Health, Derby City General Hospital, University of Nottingham, Derby DE22 3DT, UK
    PPAR Res 2009:425289. 2009
    ..These data indicate that endocannabinoids cause time-dependent, PPARγ-mediated vasorelaxation. Activation of PPARγ in the vasculature may represent a novel mechanism by which endocannabinoids are involved in vascular regulation...
  2. pmc Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA)
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 141:803-12. 2004
    ..In G3, the effects of NADA are mediated by stimulation of the VR and the novel endothelial CB receptor, while in G0, vasorelaxation is mediated through VR(1) and CB(1) receptors...
  3. pmc Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors
    S E O'Sullivan
    School of Biomedical Sciences, University of Notttingham, Queen s Medical Center, Nottingham, UK
    Br J Pharmacol 152:576-82. 2007
    ....
  4. ncbi request reprint The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase
    Saoirse E O'Sullivan
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Pharmacol Exp Ther 321:663-72. 2007
    ..However, in vivo, THC causes a CB1 receptor-mediated pressor effect with hindquarters vasodilatation. There was no evidence of enhanced vasodilator effects of THC in L-NAME-treated animals in vivo...
  5. pmc What is the significance of vascular hydrogen sulphide (H2S)?
    S E O'Sullivan
    University of Nottingham, School of Biomedical Sciences, University of Nottingham, Nottingham, Notts, UK
    Br J Pharmacol 149:609-10. 2006
    ..This commentary discusses the implications and questions raised by these results...
  6. ncbi request reprint Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol
    Saoirse E O'Sullivan
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    J Pharmacol Exp Ther 317:428-38. 2006
    ..These data demonstrate further the time-dependent vascular actions of THC and also highlight the heterogenous effects of THC in different arterial types...
  7. ncbi request reprint Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma
    Saoirse E O'Sullivan
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Biochem Biophys Res Commun 337:824-31. 2005
    ..The present results provide strong evidence that THC is a PPARgamma ligand, stimulation of which causes time-dependent vasorelaxation, implying some of the pleiotropic effects of cannabis may be mediated by nuclear receptors...
  8. pmc The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 145:514-26. 2005
    ..In G0, THC does not cause relaxation and at high concentrations causes contractions. Importantly, THC antagonises the effects of anandamide, possibly through inhibition of EDHF activity...
  9. ncbi request reprint Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Eur J Pharmacol 507:211-21. 2005
    ..This gives further indication of the different vascular actions of cannabinoid compounds...
  10. pmc Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries
    Saoirse E O'Sullivan
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 142:435-42. 2004
    ..By contrast, in the larger mesenteric artery, vasorelaxation is almost entirely due to stimulation of vanilloid receptors and CB1 receptors, and is endothelium-independent...
  11. pmc Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
    A Alhamoruni
    School of Graduate Entry Medicine and Health, Derby City General Hospital, University of Nottingham, Derby, UK
    Br J Pharmacol 165:2598-610. 2012
    ..The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro...
  12. doi request reprint Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability
    A Alhamoruni
    School of Graduate Entry Medicine and Health, Royal Derby Hospital, University of Nottingham, Nottingham, United Kingdom
    J Pharmacol Exp Ther 335:92-102. 2010
    ....
  13. doi request reprint Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease
    S E O'Sullivan
    School of Graduate Entry Medicine and Health, University of Nottingham, Nottingham, UK
    Immunobiology 215:611-6. 2010
    ..There is a convergence of effects of cannabinoids, acting via cell surface and nuclear receptors, on immune cell function which provides promise for the targeted therapy of a variety of immune, particularly neuroinflammatory, diseases...
  14. doi request reprint The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite
    V C M Shang
    School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom Electronic address
    Pharmacol Res 105:152-63. 2016
    ....