Geoff J M Parker

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Voxel-wise quantification of myocardial blood flow with cardiovascular magnetic resonance: effect of variations in methodology and validation with positron emission tomography
    Christopher A Miller
    North West Heart Centre, University Hospital of South Manchester, Wythenshawe Hospital, Manchester, UK
    J Cardiovasc Magn Reson 16:11. 2014
  2. ncbi request reprint Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI
    Geoff J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 56:993-1000. 2006
  3. pmc Probabilistic anatomical connectivity derived from the microscopic persistent angular structure of cerebral tissue
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 360:893-902. 2005
  4. doi request reprint Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 61:75-83. 2009
  5. ncbi request reprint Comparison of the performance of tracer kinetic model-driven registration for dynamic contrast enhanced MRI using different models of contrast enhancement
    Giovanni A Buonaccorsi
    Department of Imaging Science and Biomedical Engineering, Stopford Building, Oxford Road, University of Manchester, and Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, UK
    Acad Radiol 13:1112-23. 2006
  6. doi request reprint Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Int J Radiat Oncol Biol Phys 75:1209-15. 2009
  7. ncbi request reprint Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, and Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, UK
    Magn Reson Med 58:490-6. 2007
  8. ncbi request reprint Tracer kinetic model-driven registration for dynamic contrast enhanced MRI time series
    Giovanni A Buonaccorsi
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Med Image Comput Comput Assist Interv 8:91-8. 2005
  9. doi request reprint Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies
    James P B O'Connor
    Imaging, Genomics and Proteomics Research Group, School of Cancer and enabling Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK james o connor manchester ac uk
    Nat Rev Clin Oncol 9:167-77. 2012
  10. doi request reprint The effect of blood inflow and B(1)-field inhomogeneity on measurement of the arterial input function in axial 3D spoiled gradient echo dynamic contrast-enhanced MRI
    Caleb Roberts
    Imaging Science and Biomedical Engineering, School of Cancer and enabling Sciences, The University of Manchester, Manchester, United Kingdom
    Magn Reson Med 65:108-19. 2011

Detail Information

Publications50

  1. pmc Voxel-wise quantification of myocardial blood flow with cardiovascular magnetic resonance: effect of variations in methodology and validation with positron emission tomography
    Christopher A Miller
    North West Heart Centre, University Hospital of South Manchester, Wythenshawe Hospital, Manchester, UK
    J Cardiovasc Magn Reson 16:11. 2014
    ..The aim of this study was to evaluate the effect of common methodological differences in CMR voxel-wise measurement of MBF, using position emission tomography (PET) as external validation...
  2. ncbi request reprint Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI
    Geoff J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 56:993-1000. 2006
    ....
  3. pmc Probabilistic anatomical connectivity derived from the microscopic persistent angular structure of cerebral tissue
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 360:893-902. 2005
    ..Using the extracted PAS in probabilistic fibre tracking allows higher specificity and sensitivity than previously reported fibre tracking using diffusion-weighted MRI in the corticospinal tract...
  4. doi request reprint Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 61:75-83. 2009
    ..These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology...
  5. ncbi request reprint Comparison of the performance of tracer kinetic model-driven registration for dynamic contrast enhanced MRI using different models of contrast enhancement
    Giovanni A Buonaccorsi
    Department of Imaging Science and Biomedical Engineering, Stopford Building, Oxford Road, University of Manchester, and Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, UK
    Acad Radiol 13:1112-23. 2006
    ....
  6. doi request reprint Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Int J Radiat Oncol Biol Phys 75:1209-15. 2009
    ..Here we report application of this method to detect alteration in tumor oxygenation status...
  7. ncbi request reprint Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, and Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, UK
    Magn Reson Med 58:490-6. 2007
    ..Shortening of tissue T1 by oxygen is more pronounced and more complex than previously recognized. The effect may be useful as a biomarker of arterial flow and oxygen delivery to vascular beds...
  8. ncbi request reprint Tracer kinetic model-driven registration for dynamic contrast enhanced MRI time series
    Giovanni A Buonaccorsi
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Med Image Comput Comput Assist Interv 8:91-8. 2005
    ..Also, model-driven registration influences parameter estimates and reduces repeat study variability in measurements of blood volume...
  9. doi request reprint Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies
    James P B O'Connor
    Imaging, Genomics and Proteomics Research Group, School of Cancer and enabling Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK james o connor manchester ac uk
    Nat Rev Clin Oncol 9:167-77. 2012
    ..Finally, major hurdles in imaging biomarker development, validation and qualification that hinder a wide application of DCE-MRI techniques in clinical trials are addressed...
  10. doi request reprint The effect of blood inflow and B(1)-field inhomogeneity on measurement of the arterial input function in axial 3D spoiled gradient echo dynamic contrast-enhanced MRI
    Caleb Roberts
    Imaging Science and Biomedical Engineering, School of Cancer and enabling Sciences, The University of Manchester, Manchester, United Kingdom
    Magn Reson Med 65:108-19. 2011
    ..These errors emphasize the importance of careful placement of the arterial input function definition location to avoid the effects of blood inflow...
  11. doi request reprint Tumour enhancing fraction (EnF) in glioma: relationship to tumour grade
    Samantha J Mills
    Wolfson Molecular Imaging Centre, Imaging Science and Biomedical Engineering, University of Manchester, 27 Palatine Road, Withington, Manchester, M20 3LJ, UK
    Eur Radiol 19:1489-98. 2009
    ..These observations suggest that these metrics may provide important biological information concerning tumour biology and therapeutic responses and encourage further research to characterise and validate these novel biomarkers...
  12. doi request reprint Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Lancet Oncol 9:766-76. 2008
    ....
  13. doi request reprint Probabilistic fibre tracking: differentiation of connections from chance events
    David M Morris
    Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building, Oxford Road, M13 9PT Manchester, UK
    Neuroimage 42:1329-39. 2008
    ..This is achieved by applying an objective statistical interpretation of observed patterns of connection which cannot be achieved by simple thresholding of conventional probabilistic tractography maps due to the distance effect...
  14. doi request reprint Glandular function in Sjögren syndrome: assessment with dynamic contrast-enhanced MR imaging and tracer kinetic modeling--initial experience
    Caleb Roberts
    Department of Imaging Science and Biomedical Engineering, University of Manchester, Stopford Bldg, Oxford Rd, Manchester M13 9PT, England
    Radiology 246:845-53. 2008
    ....
  15. pmc Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging
    James P B O'Connor
    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 15:6674-82. 2009
    ..Such knowledge would help guide the rational development of targeted therapeutics from bench to bedside and optimize use of imaging technologies that quantify tumor function in early-phase clinical trials...
  16. ncbi request reprint Prostate cancer: evaluation of vascular characteristics with dynamic contrast-enhanced T1-weighted MR imaging--initial experience
    David L Buckley
    Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, England
    Radiology 233:709-15. 2004
    ..To use contrast material-enhanced magnetic resonance (MR) imaging and a distributed-parameter tracer kinetics model for prospectively evaluating the vascular characteristics of prostate cancer...
  17. ncbi request reprint Comparison of errors associated with single- and multi-bolus injection protocols in low-temporal-resolution dynamic contrast-enhanced tracer kinetic analysis
    Caleb Roberts
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 56:611-9. 2006
    ..Insufficient data sampling of the single bolus AIF at temporal resolutions in excess of 9 s leads to large errors, which can be reduced by employing an additional, appropriately administered, second CA bolus injection...
  18. pmc Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome
    James P B O'Connor
    CRUK EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, United Kingdom Department of Radiology, Christie Hospital, Manchester, United Kingdom
    Clin Cancer Res 21:249-57. 2015
    ..Finally, we identify the challenges that must be overcome before measurements of intratumoral heterogeneity can be used routinely to guide patient care...
  19. doi request reprint R1 and R2 * changes in the human placenta in response to maternal oxygen challenge
    Isaac Huen
    Centre for Imaging Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK The University of Manchester Biomedical Imaging Institute, University of Manchester, Manchester, UK
    Magn Reson Med 70:1427-33. 2013
    ..Oxygen-enhanced MRI (R1 contrast) and BOLD MRI (R2 * contrast) have the potential to noninvasively investigate this oxygen environment at a range of gestational ages...
  20. ncbi request reprint What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL?
    John P Carr
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 58:281-9. 2007
    ..We conclude that with current MR capabilities and with the experimental approach used in this study, acceptable levels of precision in the measurement of PS are not possible...
  21. ncbi request reprint Probabilistic Monte Carlo based mapping of cerebral connections utilising whole-brain crossing fibre information
    Geoff J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
    Inf Process Med Imaging 18:684-95. 2003
    ..This information is used for standard and Monte Carlo streamline methods. Deterministic and probabilistic maps of anatomical voxel scale connectivity between brain regions are generated...
  22. doi request reprint Comparison of model-based arterial input functions for dynamic contrast-enhanced MRI in tumor bearing rats
    Deirdre M McGrath
    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
    Magn Reson Med 61:1173-84. 2009
    ....
  23. ncbi request reprint Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging
    Alan Jackson
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 13:3449-59. 2007
    ..We then review the potential for future developments, with particular reference to the application of dynamic contrast-enhanced magnetic resonance imaging to evaluate the heterogeneity of tumor tissues...
  24. doi request reprint Using the model-based residual bootstrap to quantify uncertainty in fiber orientations from Q-ball analysis
    Hamied A Haroon
    Faculty of Medical and Human Sciences, The University of Manchester, M13 9PT Manchester, UK
    IEEE Trans Med Imaging 28:535-50. 2009
    ..Also, we have shown that these methods can be used to provide input for probabilistic tractography, avoiding existing limitations associated with data calibration and model selection...
  25. doi request reprint Modeling of contrast agent kinetics in the lung using T1-weighted dynamic contrast-enhanced MRI
    Josephine H Naish
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 61:1507-14. 2009
    ..In the normal lung parenchyma the temporal resolution was insufficient to separate effects of flow and contrast agent leakage and in this case the extended Kety model yielded the best fit to the data...
  26. ncbi request reprint Tracer kinetic model-driven registration for dynamic contrast-enhanced MRI time-series data
    Giovanni A Buonaccorsi
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 58:1010-9. 2007
    ..Sufficient improvement was observed in the modeling results to salvage clinical trial DCE-MRI data sets that would otherwise have to be rejected due to motion corruption...
  27. ncbi request reprint Enhancing fraction predicts clinical outcome following first-line chemotherapy in patients with epithelial ovarian carcinoma
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Clin Cancer Res 13:6130-5. 2007
    ..To define a simple radiologic biomarker of prognosis in patients with advanced epithelial ovarian carcinoma on first-line chemotherapy...
  28. doi request reprint Quantifying spatial heterogeneity in dynamic contrast-enhanced MRI parameter maps
    Chris J Rose
    School of Medicine, The University of Manchester, Manchester, United Kingdom
    Magn Reson Med 62:488-99. 2009
    ..An experiment using 23 DCE-MRI parameter maps of gliomas-a class of tumour that is graded on the basis of heterogeneity-shows that the proposed heterogeneity biomarkers are able to differentiate between low- and high-grade tumours...
  29. ncbi request reprint Improved quantitative dynamic regional oxygen-enhanced pulmonary imaging using image registration
    Josephine H Naish
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Magn Reson Med 54:464-9. 2005
    ..Registration-corrected mapping of these parameters is likely to provide improved information in the regional assessment of a range of lung diseases...
  30. pmc Production and cross-sectional characterization of aligned co-electrospun hollow microfibrous bulk assemblies
    Feng Lei Zhou
    Centre for Imaging Sciences, The University of Manchester, Manchester M13 9PT, UK The School of Materials, The University of Manchester, Manchester M13 9PL, UK CRUK EPSRC Cancer Imaging Centre in Cambridge and Manchester, UK
    Mater Charact 109:25-35. 2015
    ....
  31. doi request reprint Distortion correction for diffusion-weighted MRI tractography and fMRI in the temporal lobes
    Karl V Embleton
    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Hum Brain Mapp 31:1570-87. 2010
    ..The distortion correction routine was applied to SE-EPI fMRI acquisitions and allowed detection of activation in the temporal lobe that had been previously found using PET but not conventional fMRI...
  32. ncbi request reprint Comparative study into the robustness of compartmental modeling and model-free analysis in DCE-MRI studies
    Caleb Roberts
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    J Magn Reson Imaging 23:554-63. 2006
    ....
  33. ncbi request reprint Lateralization of ventral and dorsal auditory-language pathways in the human brain
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
    Neuroimage 24:656-66. 2005
    ..The connections are stronger in the dominant hemisphere, in agreement with previous studies of functional lateralization of auditory-language processing...
  34. ncbi request reprint Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging
    Geoffrey J M Parker
    Division of Imaging Science and Biomedical Engineering, University of Manchester, UK
    IEEE Trans Med Imaging 21:505-12. 2002
    ..Maps of connectivity between brain regions are also determined. Four options are described for estimating the degree of connectivity between regions...
  35. pmc Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
    James P B O'Connor
    Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom Department of Radiology, Christie NHS Foundation Trust, Manchester, United Kingdom
    Cancer Res 76:787-95. 2016
    ..Our results show that the Oxy-R fraction accurately quantifies tumor hypoxia noninvasively and is immediately translatable to the clinic...
  36. doi request reprint Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD
    Alexandra R Morgan
    Bioxydyn Ltd, Manchester, UK Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK Electronic address
    Eur J Radiol 83:2093-101. 2014
    ..The objective was to evaluate how OE-MRI parameters of regional ventilation and oxygen uptake respond to standard pharmacological interventions in COPD, and how the response compares to that of gold standard pulmonary function tests...
  37. ncbi request reprint Is volume transfer coefficient (K(trans)) related to histologic grade in human gliomas?
    Tufail F Patankar
    Imaging Science and Biomedical Engineering, Faculty of Medicine, University of Manchester, Manchester, United Kingdom
    AJNR Am J Neuroradiol 26:2455-65. 2005
    ..The purpose of this study was to examine the relationship between contrast transfer coefficient [K(trans)] and grade in gliomas...
  38. doi request reprint Distortion correction for a double inversion-recovery sequence with an echo-planar imaging readout
    Simon J P Meara
    Imaging Science and Biomedical Engineering Research Group, Stopford Building, University of Manchester, Manchester, United Kingdom
    Magn Reson Imaging 26:943-53. 2008
    ....
  39. ncbi request reprint A framework for a streamline-based probabilistic index of connectivity (PICo) using a structural interpretation of MRI diffusion measurements
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    J Magn Reson Imaging 18:242-54. 2003
    ..To establish a general methodology for quantifying streamline-based diffusion fiber tracking methods in terms of probability of connection between points and/or regions...
  40. pmc Preparation and characterization of polycaprolactone microspheres by electrospraying
    Feng Lei Zhou
    Centre for Imaging Sciences, The University of Manchester, Manchester, United Kingdom The School of Materials, The University of Manchester, Manchester, United Kingdom
    Aerosol Sci Technol 50:1201-1215. 2016
    ..Unlike 2D bulk structures collected on the other substrates, a 3D tubular structure of microspheres was formed on the copper wire which could find application in the construction of 3D tumor mimics...
  41. doi request reprint Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma
    Inna V Linnik
    Centre for Imaging Sciences, The University of Manchester, Manchester, UK University of Manchester Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK
    Magn Reson Med 71:1854-62. 2014
    ....
  42. doi request reprint A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours
    Laura Horsley
    Institute for Cancer Studies Christie Hospital NHS Foundation Trust, Wilmslow Road, Withington, Manchester, M20 4BX, UK
    Cancer Chemother Pharmacol 72:1343-52. 2013
    ..Pharmacodynamics of GSAO was evaluated by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and circulating markers of angiogenesis...
  43. ncbi request reprint Oxygen-induced changes in longitudinal relaxation times in skeletal muscle
    Deirdre M McGrath
    Imaging Science and Biomedical Engineering, University of Manchester, Oxford Road, Manchester M13 9 PT, UK
    Magn Reson Imaging 26:221-7. 2008
    ..This measurement may provide new biomarkers for evaluation of oxygen delivery and consumption in normal and diseased skeletal muscle...
  44. ncbi request reprint Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo
    Maxime Guye
    The National Society of Epilepsy MRI Unit, Department of Clinical and Experimental Epilepsy, University College London, London, UK
    Neuroimage 19:1349-60. 2003
    ..The patient had differences in M1 connectivity from the control group. Thus, fMRI-correlated DTI-FMT is a promising tool to study the structural basis of functional networks in the human brain in vivo...
  45. ncbi request reprint Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography
    Geoffrey J M Parker
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 15:797-809. 2002
    ..Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed...
  46. ncbi request reprint Investigating cervical spinal cord structure using axial diffusion tensor imaging
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 16:93-102. 2002
    ..The high axial resolution allowed preliminary evaluation of fiber connectivity using the fast-marching tractography algorithm, which generated traces of fiber paths consistent with the well-known cord anatomy...
  47. ncbi request reprint Exploring white matter tracts in band heterotopia using diffusion tractography
    Sofia H Eriksson
    MRI Unit, National Society for Epilepsy, Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 52:327-34. 2002
    ..The results are in agreement with previous histopathological studies and indicate the structural basis of the functional connectivity and absence of focal deficits in these patients...
  48. ncbi request reprint ADC mapping of the human optic nerve: increased resolution, coverage, and reliability with CSF-suppressed ZOOM-EPI
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, University Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Magn Reson Med 47:24-31. 2002
    ..Averaging of magnitude images is used to compensate for the inherently low signal-to-noise ratio (SNR) of the acquired images; the effects of the Rayleigh distributed noise in such images are allowed for during ADC calculations...
  49. pmc Non-invasive mapping of corticofugal fibres from multiple motor areas--relevance to stroke recovery
    Jennifer M Newton
    Wellcome Department of Imaging Neuroscience, University College London London, UK
    Brain 129:1844-58. 2006
    ..These results confirm that selective disruption of motor corticofugal fibres influences functional reorganization and outcome in individual patients...
  50. pmc White matter tracts in first-episode psychosis: a DTI tractography study of the uncinate fasciculus
    Gary Price
    Institute of Neurology, University College London, Queen Square, London, UK
    Neuroimage 39:949-55. 2008
    ..The SCV of FA was lower in females across both groups and there was no correlation between the SCV of FA and clinical ratings...