Gordon T Plant

Summary

Affiliation: University Hospital Aintree
Country: UK

Publications

  1. ncbi request reprint A serial MRI study following optic nerve mean area in acute optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:2498-505. 2004
  2. ncbi request reprint Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 58:383-91. 2005
  3. doi request reprint Optic neuritis and multiple sclerosis
    Gordon T Plant
    The National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital and St Thomas Hospital, London, UK
    Curr Opin Neurol 21:16-21. 2008
  4. ncbi request reprint Optic neuritis: a review
    P N Shams
    The National Hospital for Neurology and Neurosurgery, London, UK
    Int MS J 16:82-9. 2009
  5. doi request reprint Understanding and interpreting vision safety issues with vigabatrin therapy
    G T Plant
    Department of Neuro Ophthalmology, National Hospital for Neurology and Neurosurgery, London, UK
    Acta Neurol Scand Suppl . 2011
  6. doi request reprint A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    Brain 133:2592-602. 2010
  7. doi request reprint Neuroplasticity predicts outcome of optic neuritis independent of tissue damage
    Thomas M Jenkins
    Department of Brain Repair and Rehabilitation, University College London UCL Institute of Neurology, University College London, London, UK
    Ann Neurol 67:99-113. 2010
  8. ncbi request reprint An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
  9. doi request reprint Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    Madhan Kolappan
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    J Neurol 256:305-19. 2009
  10. doi request reprint A longitudinal functional MRI study of non-arteritic anterior ischaemic optic neuropathy patients
    Maria Aguirregomozcorta
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:905-13. 2011

Collaborators

Detail Information

Publications48

  1. ncbi request reprint A serial MRI study following optic nerve mean area in acute optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:2498-505. 2004
    ..Over the longer term, there was loss of tissue. The lack of association between 1 year optic nerve mean area and visual outcome may reflect a mild loss of tissue, redundancy or remodelling of function...
  2. ncbi request reprint Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 58:383-91. 2005
    ..This noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal loss...
  3. doi request reprint Optic neuritis and multiple sclerosis
    Gordon T Plant
    The National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital and St Thomas Hospital, London, UK
    Curr Opin Neurol 21:16-21. 2008
    ..To discuss recent neuro-ophthalmic advances relevant to the management of optic neuritis and multiple sclerosis...
  4. ncbi request reprint Optic neuritis: a review
    P N Shams
    The National Hospital for Neurology and Neurosurgery, London, UK
    Int MS J 16:82-9. 2009
    ..Since there is evidence of early axonal damage in acute demyelinating ON, disease-modifying drugs should be considered in patients at high risk of developing MS in the future as prophylaxis against permanent neurological impairment...
  5. doi request reprint Understanding and interpreting vision safety issues with vigabatrin therapy
    G T Plant
    Department of Neuro Ophthalmology, National Hospital for Neurology and Neurosurgery, London, UK
    Acta Neurol Scand Suppl . 2011
    ..We also reviewed published data suggesting an association between vigabatrin-associated retinal toxicity and taurine deficiency, as well as the potential role of taurine in the prevention of this retinopathy...
  6. doi request reprint A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    Brain 133:2592-602. 2010
    ..Optical coherence tomography-measured retinal nerve fibre layer loss after 6 months is a suitable outcome measure for proof-of-concept trials of acute neuroprotection in optic neuritis...
  7. doi request reprint Neuroplasticity predicts outcome of optic neuritis independent of tissue damage
    Thomas M Jenkins
    Department of Brain Repair and Rehabilitation, University College London UCL Institute of Neurology, University College London, London, UK
    Ann Neurol 67:99-113. 2010
    ..To investigate the reasons behind good recovery following ON, despite residual optic nerve demyelination and neuroaxonal damage...
  8. ncbi request reprint An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS...
  9. doi request reprint Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    Madhan Kolappan
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    J Neurol 256:305-19. 2009
    ..These collective investigative methods have advanced knowledge of pathophysiological mechanisms in MS and optic neuritis. Relevant ongoing studies and future directions are discussed...
  10. doi request reprint A longitudinal functional MRI study of non-arteritic anterior ischaemic optic neuropathy patients
    Maria Aguirregomozcorta
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:905-13. 2011
    ..The aim of the study was to determine whether there was significant cortical reorganisation with functional MRI (fMRI) after acute NA-AION by comparing affected individuals with healthy controls...
  11. ncbi request reprint Optic nerve diffusion tensor imaging in optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 30:498-505. 2006
    ..57, P = 0.006) and lambda( perpendicular) (r = -0.56, P = 0.007). These findings suggest that optic nerve DT-MRI measures provide an indication of the structural integrity of axons...
  12. doi request reprint Distinguishing optic neuritis in neuromyelitis optica spectrum disease from multiple sclerosis: a novel magnetic resonance imaging scoring system
    Mithu Storoni
    Department of Neuro Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
    J Neuroophthalmol 33:123-7. 2013
    ..The management of acute optic neuritis differs according to the underlying etiology and techniques which may help with early differential diagnosis are therefore of considerable value...
  13. ncbi request reprint Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis
    Bertrand Audoin
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Brain 129:1031-9. 2006
    ....
  14. doi request reprint Low prevalence of bilateral (presumed nutritional) optic neuropathy as a cause of blindness in the Gambia
    Abdirisak A Dalmar
    National Hospital for Neurology and Neurosurgery, London, United Kingdom
    J Neuroophthalmol 33:256-9. 2013
    ..Our study aimed to measure the prevalence of optic neuropathy in The Gambia, a West African country, and compare this prevalence with a simultaneously occurring epidemic of optic neuropathy, now considered endemic, in Tanzania...
  15. doi request reprint The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans
    Panitha Jindahra
    The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Brain 135:534-41. 2012
    ....
  16. doi request reprint Optical coherence tomography of the retina: applications in neurology
    Panitha Jindahra
    The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Curr Opin Neurol 23:16-23. 2010
    ..The application of optical coherence tomography imaging of the retina in multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease are reviewed...
  17. pmc Extra-ocular muscle MRI in genetically-defined mitochondrial disease
    Robert D S Pitceathly
    MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Eur Radiol 26:130-7. 2016
    ....
  18. pmc Optic neuritis in an ethnically diverse population: higher risk of atypical cases in patients of African or African-Caribbean heritage
    Mithu Storoni
    The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 312:21-5. 2012
    ..To investigate the presence of an ethnicity bias within patients presenting with optic neuritis in London...
  19. ncbi request reprint MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study
    Josephine K Swanton
    Nuclear Magnetic Resonance Research Unit, Department of Neuroinflammation and Headache, Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:677-86. 2007
    ..We applied all three criteria in a large cohort of CIS patients to assess their performance by use of conversion to clinically definite multiple sclerosis (CDMS) as the outcome...
  20. ncbi request reprint Visual recovery following acute optic neuritis--a clinical, electrophysiological and magnetic resonance imaging study
    Simon J Hickman
    NMR Research Unit, Dept of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 251:996-1005. 2004
    ....
  21. doi request reprint Strawberries on the brain--intracranial capillary hemangioma: two case reports and systematic literature review in children and adults
    Bilal Mirza
    Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, United Kingdom Electronic address
    World Neurosurg 80:900.e13-21. 2013
    ..Capillary hemangioma in the cranial cavity is rare. This report describes 2 additional cases presenting shortly after pregnancy and provides a systematic review summarizing clinical experience to date...
  22. pmc Risk factors for early visual deterioration in temporal arteritis
    Tobias Loddenkemper
    National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 78:1255-9. 2007
    ..Despite corticosteroid treatment, patients with temporal arteritis may continue to lose vision. However, predictors of progressive visual loss are not known...
  23. pmc The use of serum glial fibrillary acidic protein measurements in the diagnosis of neuromyelitis optica spectrum optic neuritis
    Mithu Storoni
    The National Hospital for Neurology and Neurosurgery, London, United Kingdom
    PLoS ONE 6:e23489. 2011
    ..The aim of this study was to ascertain the extent to which serum GFAP levels can distinguish between an episode of optic neuritis (ON) related to NMO spectrum disease and ON from other causes...
  24. doi request reprint Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography
    Panitha Jindahra
    The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 132:628-34. 2009
    ..The data have also been analysed in 12 sectors around the optic disc: it has been shown that the RNT thinning follows the known trajectories of the crossing and non-crossing retinal ganglion cell axons approaching the disc...
  25. doi request reprint 'Hemispherical asymmetry in the Meyer's Loop': a prospective study of visual-field deficits in 105 cases undergoing anterior temporal lobe resection for epilepsy
    N u Owase Jeelani
    Department of Neurosurgery, Great Ormond Street Hospital, London, UK
    J Neurol Neurosurg Psychiatry 81:985-91. 2010
    ....
  26. doi request reprint Migraine-like visual aura due to focal cerebral lesions: case series and review
    Pari N Shams
    The National Hospital for Neurology and Neurosurgery, London, UK
    Surv Ophthalmol 56:135-61. 2011
    ....
  27. pmc Peripheral neuropathy predicts nuclear gene defect in patients with mitochondrial ophthalmoplegia
    Alejandro Horga
    1 MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Brain 137:3200-12. 2014
    ..We suggest that nuclear gene testing may enable a more rapid diagnosis and avoid muscle biopsy in patients with progressive external ophthalmoplegia and peripheral neuropathy...
  28. doi request reprint Acute visual loss in papilloedema: the diagnostic pitfalls
    Hon Shing Ong
    Department of Neuro Ophthalmology, Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, UK
    Int Ophthalmol 34:607-12. 2014
    ..However they were subsequently found to have papilloedema. ..
  29. doi request reprint The time course and phenotype of Uhthoff phenomenon following optic neuritis
    Clare L Fraser
    Department of Neuro Ophthalmology, Moorfields Eye Hospital, London, UK
    Mult Scler 18:1042-4. 2012
    ..If full recovery from UP has not occurred within the first 2 months from the onset of ON, then recovery appears to be uncommon and may therefore be a surrogate marker of remyelination in future drug trials...
  30. ncbi request reprint Clinical disorders affecting mesopic vision
    Axel Petzold
    Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Ophthalmic Physiol Opt 26:326-41. 2006
    ..The current diagnostic gold standards for each disease are discussed and curative and symptomatic treatment strategies are summarized...
  31. pmc Ocular Flutter Following Adenoviral Conjunctivitis in an Adult
    Mano S Sira
    Department of Neuro Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
    Neuroophthalmology 35:22-23. 2011
    ..Clinicians are made aware of the possibility of a transient encephalitic illness following adenoviral conjunctivitis...
  32. doi request reprint Ocular Myasthenia Gravis: Toward a Risk of Generalization Score and Sample Size Calculation for a Randomized Controlled Trial of Disease Modification
    Sui H Wong
    Department of Neuro ophthalmology SHW, GTP, Moorfields Eye Hospital, London, United Kingdom Medical Eye Unit, St Thomas Hospital SHW, GTP, London, United Kingdom Department of Neuro ophthalmology SHW, GTP, National Hospital for Neurology and Neurosurgery, London, United Kingdom and Biostatistics Unit AP, University College London Eastman Dental Institute, London, United Kingdom
    J Neuroophthalmol 36:252-8. 2016
    ..Most studies that report risk factors are flawed by the inclusion of patients on immunosuppression, which is likely to reduce the risk...
  33. doi request reprint Autoimmunity in visual loss
    Axel Petzold
    The Dutch Expert Center for Neuro ophthalmology, VU University Medical Center, Amsterdam, The Netherlands and Molecular Neuroscience, UCL Institute of Neurology, London, UK
    Handb Clin Neurol 133:353-76. 2016
    ..Visual loss in autoimmunity is an expanding field: the most significant advances in research have resulted from taking a well characterised phenotype and making educated guesses at the possible molecular targets of autoimmune attack. ..
  34. doi request reprint Progressive cortical visual failure associated with occipital calcification and coeliac disease with relative preservation of the dorsal 'action' pathway
    Gordon T Plant
    National Hospital for Neurology and Neurosurgery, London, UK
    Cortex 71:160-70. 2015
    ..We conclude that occipital calcification following coeliac disease can lead to prominent higher visual failure that, under prescribed viewing conditions, is consistent with separable mechanisms for visual perception and action control. ..
  35. pmc Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
    Helen Ling
    Reta Lila Weston Institute of Neurological Studies, Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London, London, UK
    Acta Neuropathol Commun 2:24. 2014
    ..Possible mechanisms for the co-occurrence of these two tau pathologies are discussed. ..
  36. pmc Read-Right: a "web app" that improves reading speeds in patients with hemianopia
    Yean Hoon Ong
    UCL Multimedia, Information Services Division, University College, London, UK
    J Neurol 259:2611-5. 2012
    ....
  37. doi request reprint Pupillary dysfunction in an atypical case of mitochondrial myopathy with tubular aggregates
    Nadeem Ali
    Department of Neuro Ophthalmology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    J Neuroophthalmol 30:153-6. 2010
    ..The combination of pupillary abnormalities and TAs suggests that mitochondrial dysfunction may not explain the full extent of abnormalities in this case...
  38. doi request reprint Epidemic optic neuropathy is evident in the Somalian population
    Abdirisak A Dalmar
    National Hospital for Neurology and Neurosurgery, London, UK
    J Neuroophthalmol 31:127-30. 2011
    ..We conducted a case series in Mogadishu, the Somalian capital, with the aim of identifying and characterizing any cases of epidemic optic neuropathy...
  39. doi request reprint The syndrome of pseudotumour cerebri and idiopathic intracranial hypertension
    Clare Fraser
    Moorfields Eye Hospital, City Road, London, UK
    Curr Opin Neurol 24:12-7. 2011
    ..It is one cause of the syndrome of pseudotumour cerebri but the cause and the link with a rise in body weight are not understood. Furthermore the treatment of the more severe, sight-threatening cases is controversial...
  40. ncbi request reprint Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes
    Catherine M Dalton
    NMR Research Group, Institute of Neurology, London, UK
    Brain 127:1101-7. 2004
    ..Longer-term follow-up is required to determine whether early grey matter atrophy is associated with subsequent disability or cognitive impairment...
  41. ncbi request reprint Optical coherence tomography (OCT) findings in congenital/long-standing homonymous hemianopia
    Jodhbir S Mehta
    Department of Neuro Ophthalmology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Am J Ophthalmol 140:727-9. 2005
    ..To report abnormalities of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) in patients with trans-synaptic degeneration...
  42. ncbi request reprint Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Neuroimage 31:286-93. 2006
    ..By inference, axonal loss due to other post-inflammatory brain lesions is likely to contribute to the global MRI measure of brain atrophy in multiple sclerosis...
  43. ncbi request reprint OCT and Band Atrophy Correlation
    Jodhbir S Mehta
    Ophthalmology 112:2055-6; author reply 2056-7. 2005
  44. ncbi request reprint No evidence for MSRV viraemia and glial cell death in acute optic neuritis
    A Petzold
    Mult Scler 11:495-6. 2005
  45. ncbi request reprint Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    AJNR Am J Neuroradiol 26:951-6. 2005
    ..DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging...
  46. ncbi request reprint Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis
    Catherine M Dalton
    NMR Research Unit, Institute of Neurology, University College London, United Kingdom
    Ann Neurol 52:47-53. 2002
    ..The high specificity, positive predictive value, and accuracy of the new criteria for clinically definite MS support their clinical relevance...
  47. ncbi request reprint New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes
    Catherine M Dalton
    NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, United Kingdom
    Ann Neurol 53:673-6. 2003
    ..If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients...
  48. ncbi request reprint Adaptive cortical plasticity in higher visual areas after acute optic neuritis
    Ahmed T Toosy
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 57:622-33. 2005
    ..The key findings of this study are from the second analysis and suggest a genuine adaptive role for cortical reorganization within extrastriate visual areas early after optic neuritis...