Helen P Price

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi ARL1 has an essential role in Trypanosoma brucei
    H P Price
    Immunology and Infection Unit, Department of Biology, Hull York Medical School, University of York, Heslington, York YO10 5YW, UK
    Biochem Soc Trans 33:643-5. 2005
  2. pmc Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, UK
    Mol Biochem Parasitol 169:55-8. 2010
  3. pmc Validation of a new method for immobilising kinetoplastid parasites for live cell imaging
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, UK
    Mol Biochem Parasitol 169:66-9. 2010
  4. pmc The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei
    Helen P Price
    Centre for Immunology and Infection, Department of Biology Hull York Medical School, University of York, York YO10 5YW, UK
    Mol Biochem Parasitol 173:123-31. 2010
  5. pmc A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York YO10 5YW, UK
    Biochim Biophys Acta 1823:1178-91. 2012
  6. pmc The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, United Kingdom
    PLoS ONE 7:e31842. 2012
  7. pmc TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei
    Helen P Price
    Immunology and Infection Unit, Department of Biology, University of York, Heslington, York YO10 5YW, UK
    Mol Biochem Parasitol 155:123-7. 2007
  8. pmc Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking
    Helen P Price
    Immunology and Infection Unit, Department of Biology, University of York, Heslington, York YO10 5YW, United Kingdom
    Mol Biol Cell 18:864-73. 2007
  9. pmc The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Mol Microbiol 90:597-611. 2013
  10. pmc N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis
    James A Brannigan
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    J Mol Biol 396:985-99. 2010

Detail Information

Publications11

  1. ncbi ARL1 has an essential role in Trypanosoma brucei
    H P Price
    Immunology and Infection Unit, Department of Biology, Hull York Medical School, University of York, Heslington, York YO10 5YW, UK
    Biochem Soc Trans 33:643-5. 2005
    ....
  2. pmc Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, UK
    Mol Biochem Parasitol 169:55-8. 2010
    ..Critically we show that following NMT knockdown, T. brucei bloodstream form cells are unable to establish an infection in a mouse model, therefore providing further validation of this enzyme as a target for drug development...
  3. pmc Validation of a new method for immobilising kinetoplastid parasites for live cell imaging
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, UK
    Mol Biochem Parasitol 169:66-9. 2010
    ..This allows reproducible live cell imaging of these highly motile organisms, thus enabling a full complement of advanced microscopic techniques to be utilised to better understand these pathogenic species...
  4. pmc The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei
    Helen P Price
    Centre for Immunology and Infection, Department of Biology Hull York Medical School, University of York, York YO10 5YW, UK
    Mol Biochem Parasitol 173:123-31. 2010
    ..Our data indicate that Arl2 has a fundamentally conserved role in trypanosome microtubule biogenesis that correlates with -tubulin acetylation...
  5. pmc A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York YO10 5YW, UK
    Biochim Biophys Acta 1823:1178-91. 2012
    ..Our findings indicate that ARL6 in trypanosomes contributes to flagellum biogenesis, most likely through an interaction with the BBSome...
  6. pmc The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, United Kingdom
    PLoS ONE 7:e31842. 2012
    ..brucei has little effect on parasite growth or morphology, indicating either a degree of functional redundancy or a function in an alternative stage of the parasite life cycle...
  7. pmc TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei
    Helen P Price
    Immunology and Infection Unit, Department of Biology, University of York, Heslington, York YO10 5YW, UK
    Mol Biochem Parasitol 155:123-7. 2007
    ..Our data indicate that protein trafficking and lysosomal function are differentially regulated by multiple factors, including TbARF1, during progression through the T. brucei lifecycle...
  8. pmc Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking
    Helen P Price
    Immunology and Infection Unit, Department of Biology, University of York, Heslington, York YO10 5YW, United Kingdom
    Mol Biol Cell 18:864-73. 2007
    ..We conclude that the essential Golgi-localizing T. brucei ARF1 has a primary role in the maintenance of both post-Golgi transport and endocytosis and that it is significantly divergent from other characterized ARFs...
  9. pmc The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host
    Helen P Price
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Mol Microbiol 90:597-611. 2013
    ..This is the first report of an association between the BBSome complex and pathogen infectivity. ..
  10. pmc N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis
    James A Brannigan
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    J Mol Biol 396:985-99. 2010
    ..These studies validate L. donovani NMT as a potential target for development of new therapeutic agents against visceral leishmaniasis...
  11. pmc Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei
    Glyn R Hemsworth
    Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom
    Protein Sci 22:196-203. 2013
    ..Our structural analysis thus provides the basis for future biochemical characterisation of this important family of small GTPases...