Marc Sturrock

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling
    Marc Sturrock
    Division of Mathematics, University of Dundee, Dundee, DD1 4HN, UK
    Bull Math Biol 74:1531-79. 2012
  2. pmc Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
    Marc Sturrock
    Department of Mathematics, University of Dundee, Dundee DD1 4HN, UK
    J R Soc Interface 10:20120988. 2013
  3. doi Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
    Marc Sturrock
    Division of Mathematics, University of Dundee, Dundee DD1 4HN, UK
    J Theor Biol 273:15-31. 2011
  4. pmc The role of dimerisation and nuclear transport in the Hes1 gene regulatory network
    Marc Sturrock
    University of Dundee, Dundee, DD1 4HN, UK
    Bull Math Biol 76:766-98. 2014
  5. pmc A spatio-temporal model of Notch signalling in the zebrafish segmentation clock: conditions for synchronised oscillatory dynamics
    Alan J Terry
    Division of Mathematics, University of Dundee, Dundee, United Kingdom
    PLoS ONE 6:e16980. 2011

Detail Information

Publications5

  1. doi Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling
    Marc Sturrock
    Division of Mathematics, University of Dundee, Dundee, DD1 4HN, UK
    Bull Math Biol 74:1531-79. 2012
    ..For the extended p53-Mdm2 model, we consider the effect of microtubule-disrupting drugs and proteasome inhibitor drugs, obtaining results that are in agreement with experimental studies...
  2. pmc Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
    Marc Sturrock
    Department of Mathematics, University of Dundee, Dundee DD1 4HN, UK
    J R Soc Interface 10:20120988. 2013
    ..We also propose experiments to control the precise differentiation response using drug treatment...
  3. doi Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
    Marc Sturrock
    Division of Mathematics, University of Dundee, Dundee DD1 4HN, UK
    J Theor Biol 273:15-31. 2011
    ..The ability to determine spatial localisation of proteins within the cell is likely to yield fresh insight into a range of cellular diseases such as diabetes and cancer...
  4. pmc The role of dimerisation and nuclear transport in the Hes1 gene regulatory network
    Marc Sturrock
    University of Dundee, Dundee, DD1 4HN, UK
    Bull Math Biol 76:766-98. 2014
    ....
  5. pmc A spatio-temporal model of Notch signalling in the zebrafish segmentation clock: conditions for synchronised oscillatory dynamics
    Alan J Terry
    Division of Mathematics, University of Dundee, Dundee, United Kingdom
    PLoS ONE 6:e16980. 2011
    ..Our spatially-explicit modelling approach, together with new imaging technologies that can measure intracellular protein diffusion rates, is likely to yield significant new insight into somitogenesis and other biological processes...