J P Venables

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc The RNA-binding specificity of the mouse Dazl protein
    J P Venables
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 29:2479-83. 2001
  2. pmc EASI--enrichment of alternatively spliced isoforms
    Julian P Venables
    Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Nucleic Acids Res 34:e103. 2006
  3. ncbi Downstream intronic splicing enhancers
    Julian P Venables
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Centre de Développement des Biotechnologies CDB de Sherbrooke 3201, Rue Jean Mignault, Sherbrooke, Quebec, Canada
    FEBS Lett 581:4127-31. 2007
  4. ncbi Alternative splicing in the testes
    Julian P Venables
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Curr Opin Genet Dev 12:615-19. 2002
  5. ncbi Unbalanced alternative splicing and its significance in cancer
    Julian P Venables
    University of Newcastle upon Tyne, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    Bioessays 28:378-86. 2006
  6. ncbi Aberrant and alternative splicing in cancer
    Julian P Venables
    University of Newcastle upon Tyne, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom
    Cancer Res 64:7647-54. 2004
  7. ncbi Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon
    Julian P Venables
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Hum Mol Genet 14:2289-303. 2005
  8. ncbi The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo
    J K Thornton
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle, UK
    Oncogene 25:3104-12. 2006
  9. ncbi An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:2117-24. 2000
  10. ncbi Lessons from knockout and transgenic mice for infertility in men
    J P Venables
    Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh, UK
    J Endocrinol Invest 23:584-91. 2000

Collaborators

  • D J Elliott
  • James Stevenin
  • John Burn
  • X Lu
  • P T K Saunders
  • Pellegrino Rossi
  • H J Cooke
  • Roscoe Klinck
  • Kate A Sergeant
  • J K Thornton
  • Maria Paola Paronetto
  • Lyna Inkel
  • Eric R Paquet
  • Julien Gervais-Bird
  • Sherif Abou Elela
  • Anne Bramard
  • Raymund Wellinger
  • Benoit Chabot
  • Richard Madden
  • Manuela Jilaveanu-Pelmus
  • Panagiotis Prinos
  • Claudine Rancourt
  • Geneviève Dufresne-Martin
  • Chushin Koh
  • Cyril F Bourgeois
  • Caroline Dalgliesh
  • K A Sergeant
  • C Dalgleish
  • I E Ehrmann
  • Claudio Sette
  • Raffaele Geremia

Detail Information

Publications17

  1. pmc The RNA-binding specificity of the mouse Dazl protein
    J P Venables
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 29:2479-83. 2001
    ..CDC25C 5' UTR also interacted specifically with Dazl in vitro. The tri-hybrid screen retrieved UTRs of known genes that may be physiological substrates of Dazl...
  2. pmc EASI--enrichment of alternatively spliced isoforms
    Julian P Venables
    Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Nucleic Acids Res 34:e103. 2006
    ..These contain missing exons, cryptic splice sites or include completely novel exons. EASI beads are stable for months in the fridge and can be easily combined with standard protocols to speed the cloning of novel transcripts...
  3. ncbi Downstream intronic splicing enhancers
    Julian P Venables
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Centre de Développement des Biotechnologies CDB de Sherbrooke 3201, Rue Jean Mignault, Sherbrooke, Quebec, Canada
    FEBS Lett 581:4127-31. 2007
    ..This review summarises what is known about these intronic splicing enhancers and their RNA-binding proteins that cause spliceosome assembly on the upstream exon...
  4. ncbi Alternative splicing in the testes
    Julian P Venables
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Curr Opin Genet Dev 12:615-19. 2002
    ..A network of testes-specific splicing factor interactions has been uncovered and combining our knowledge of these RNAs and proteins should lead to an understanding of the regulation of alternative splicing and male fertility...
  5. ncbi Unbalanced alternative splicing and its significance in cancer
    Julian P Venables
    University of Newcastle upon Tyne, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    Bioessays 28:378-86. 2006
    ....
  6. ncbi Aberrant and alternative splicing in cancer
    Julian P Venables
    University of Newcastle upon Tyne, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom
    Cancer Res 64:7647-54. 2004
    ..As well as being associated with cancer, the nature of the alternative gene products is usually consistent with an active role in cancer; therefore, the alternative splicing process itself is a potential target for gene therapy...
  7. ncbi Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon
    Julian P Venables
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Hum Mol Genet 14:2289-303. 2005
    ..Therefore, our data imply an evolutionarily conserved role for Tra2 proteins in spermatogenesis and suggest that an elevated concentration of Tra2beta may convert it into a tissue-specific splicing factor...
  8. ncbi The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo
    J K Thornton
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle, UK
    Oncogene 25:3104-12. 2006
    ....
  9. ncbi An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:2117-24. 2000
    ..The existence of an additional testis-specific hnRNP G family member provides evidence for the importance of these proteins in normal germ cell development...
  10. ncbi Lessons from knockout and transgenic mice for infertility in men
    J P Venables
    Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh, UK
    J Endocrinol Invest 23:584-91. 2000
    ..In conclusion knockout mice remain the ultimate test of spermatogenic hypotheses as well as providing detailed information about this complex process...
  11. ncbi SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome
    Julian P Venables
    Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK
    Hum Mol Genet 13:1525-34. 2004
    ..Collectively these data suggest that SIAH-mediated down regulation of alternative splicing may be an important developmental difference between otherwise highly conserved T-STAR proteins...
  12. ncbi Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2
    Kate A Sergeant
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle, NE1 3BZ, UK
    J Cell Sci 120:309-19. 2007
    ....
  13. doi Enrichment of alternatively spliced isoforms
    Julian P Venables
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke Centre de développement des biotechologies CDB de Sherbrooke, Quebec, Canada
    Methods Mol Biol 419:161-70. 2008
    ..This chapter provides a detailed protocol of the technique I have developed to identify spliced isoforms called enrichment of alternatively spliced isoforms or EASI...
  14. ncbi Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
    Oncogene 22:8707-15. 2003
    ..Thus, our data suggest that tr-kit promotes the formation of a multimolecular complex composed of Fyn, PLCgamma1 and Sam68, which allows phosphorylation of PLCgamma1 by Fyn, and may modulate RNA metabolism...
  15. pmc Atypical haemolytic uraemic syndrome associated with a hybrid complement gene
    Julian P Venables
    Institute of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    PLoS Med 3:e431. 2006
    ..In this study we tested the hypothesis that nonallelic homologous recombination between low-copy repeats in the RCA cluster could result in the formation of a hybrid CFH/CFHL1 gene that predisposes to the development of aHUS...
  16. doi Multiple alternative splicing markers for ovarian cancer
    Roscoe Klinck
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Cancer Res 68:657-63. 2008
    ..High-volume identification of cancer-associated splice forms by the LISA paves the way for the use of alternative splicing profiling to diagnose subtypes of cancer...
  17. pmc Multiple and specific mRNA processing targets for the major human hnRNP proteins
    Julian P Venables
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, 3001, 12th Avenue Nord, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Mol Cell Biol 28:6033-43. 2008
    ..Overall, our study highlights the potential contribution of all of these major hnRNP proteins in alternative splicing control and shows that the targets for individual hnRNP proteins can vary in different cellular contexts...