Susan C Welburn

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics
    Susan C Welburn
    Centre for Infectious Diseases, Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK Electronic address
    Trends Parasitol 32:230-41. 2016
  2. doi request reprint The neglected zoonoses--the case for integrated control and advocacy
    S C Welburn
    Division of Infection and Pathway Medicine, Edinburgh Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK Electronic address
    Clin Microbiol Infect 21:433-43. 2015
  3. pmc Collateral benefits of restricted insecticide application for control of African trypanosomiasis on Theileria parva in cattle: a randomized controlled trial
    Dennis Muhanguzi
    Department of Biomolecular and Biolaboratory Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P, O, Box 7062, Kampala, Uganda
    Parasit Vectors 7:432. 2014
  4. pmc Prevalence and spatial distribution of Theileria parva in cattle under crop-livestock farming systems in Tororo District, Eastern Uganda
    Dennis Muhanguzi
    College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P, O, Box 7062, Kampala, Uganda
    Parasit Vectors 7:91. 2014
  5. pmc Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania
    Harriet K Auty
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    PLoS Negl Trop Dis 6:e1501. 2012
  6. pmc Quantifying the burden of rhodesiense sleeping sickness in Urambo District, Tanzania
    Lucas E Matemba
    Tabora Research Centre, National Institute for Medical Research, Tabora, Tanzania
    PLoS Negl Trop Dis 4:e868. 2010
  7. pmc Factors affecting trypanosome maturation in tsetse flies
    Ewan Thomas Macleod
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, United Kindgom
    PLoS ONE 2:e239. 2007
  8. pmc An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis
    Nicola A Wardrop
    Geography and Environment, University of Southampton, Highfield Campus, Southampton SO17 1BJ, United Kingdom
    BMC Infect Dis 12:316. 2012
  9. pmc Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda
    Kevin Bardosh
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Parasit Vectors 6:204. 2013
  10. pmc Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda
    Thomas Zoller
    Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117Berlin, Germany
    BMC Infect Dis 8:88. 2008

Collaborators

Detail Information

Publications78

  1. doi request reprint Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics
    Susan C Welburn
    Centre for Infectious Diseases, Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK Electronic address
    Trends Parasitol 32:230-41. 2016
    ....
  2. doi request reprint The neglected zoonoses--the case for integrated control and advocacy
    S C Welburn
    Division of Infection and Pathway Medicine, Edinburgh Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK Electronic address
    Clin Microbiol Infect 21:433-43. 2015
    ..Evidence of the disease burdens imposed on communities by the NZDs and demonstration of the cost-effectiveness of integrated control can strengthen the case for a One Health approach to endemic zoonotic disease control...
  3. pmc Collateral benefits of restricted insecticide application for control of African trypanosomiasis on Theileria parva in cattle: a randomized controlled trial
    Dennis Muhanguzi
    Department of Biomolecular and Biolaboratory Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P, O, Box 7062, Kampala, Uganda
    Parasit Vectors 7:432. 2014
    ..parva prevalence in crop-livestock production systems in Tororo district, south-eastern Uganda was determined...
  4. pmc Prevalence and spatial distribution of Theileria parva in cattle under crop-livestock farming systems in Tororo District, Eastern Uganda
    Dennis Muhanguzi
    College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P, O, Box 7062, Kampala, Uganda
    Parasit Vectors 7:91. 2014
    ..The aim of the present work was to estimate the burden presented by T. parva and its spatial distribution in a crop-livestock production system in Eastern Uganda...
  5. pmc Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania
    Harriet K Auty
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    PLoS Negl Trop Dis 6:e1501. 2012
    ..b. rhodesiense in tsetse are applied and interpreted inconsistently, and discrepancies between studies suggest this value is not consistently estimated even to within an order of magnitude...
  6. pmc Quantifying the burden of rhodesiense sleeping sickness in Urambo District, Tanzania
    Lucas E Matemba
    Tabora Research Centre, National Institute for Medical Research, Tabora, Tanzania
    PLoS Negl Trop Dis 4:e868. 2010
    ..Human African trypanosomiasis is a severely neglected vector-borne disease that is always fatal if untreated. In Tanzania it is highly focalised and of major socio-economic and public health importance in affected communities...
  7. pmc Factors affecting trypanosome maturation in tsetse flies
    Ewan Thomas Macleod
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, United Kindgom
    PLoS ONE 2:e239. 2007
    ..The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse...
  8. pmc An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis
    Nicola A Wardrop
    Geography and Environment, University of Southampton, Highfield Campus, Southampton SO17 1BJ, United Kingdom
    BMC Infect Dis 12:316. 2012
    ....
  9. pmc Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda
    Kevin Bardosh
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Parasit Vectors 6:204. 2013
    ..This study explored insecticide sales, demand and use in four districts of Uganda where mass cattle treatments have been undertaken by the 'Stamp Out Sleeping Sickness' programme...
  10. pmc Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda
    Thomas Zoller
    Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117Berlin, Germany
    BMC Infect Dis 8:88. 2008
    ..e. within affected villages. In the present work, we use a case-control methodology to analyse both behavioural and spatial risk factors for HAT in an endemic area...
  11. ncbi request reprint Programmed cell death in African trypanosomes
    S C Welburn
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, EH25 9RG
    Parasitology 132:S7-S18. 2006
    ..Here we explore the implications of a programmed cell death pathway in the African tsetse-transmitted trypanosomes...
  12. ncbi request reprint Crisis, what crisis? Control of Rhodesian sleeping sickness
    Susan C Welburn
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Roslin, Midlothian, UK
    Trends Parasitol 22:123-8. 2006
    ..There are several methods for assessing the burden of this disease and there is a series of farmer-led methodologies that can be applied to reduce the burden of human and animal trypanosomiases...
  13. pmc Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions
    Sue Welburn
    Centre for Infectious Disease, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 2:e347. 2008
    ..brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasis despite the notoriously complex antigenic surface proteins in these parasites...
  14. ncbi request reprint Recent developments in human African trypanosomiasis
    Susan C Welburn
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland, UK
    Curr Opin Infect Dis 15:477-84. 2002
    ..Recently, Rhodesian sleeping sickness has also posed a health risk to travellers visiting game parks in East Africa...
  15. pmc Effects of cyclic nucleotides on midgut infections and maturation of T. b. brucei in G. m. morsitans
    Ewan T Macleod
    Centre for Infectious Diseases, The University of Edinburgh, Edinburgh, EH25 9RG, UK
    Parasit Vectors 1:5. 2008
    ..Continuous feeding of either cGMP or cAMP to tsetse had no effect on rates of maturation of established midgut infections suggesting that these two parts of the life cycle in tsetse are not linked...
  16. ncbi request reprint Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene
    S C Welburn
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, Edinburgh, UK
    Lancet 358:2017-9. 2001
    ..We investigated the use of a simple genetic marker to characterise parasites collected from cattle in villages within the new sleeping sickness focus in Soroti District, Uganda...
  17. ncbi request reprint Sleeping sickness: a tale of two diseases
    S C Welburn
    Sir Alexander Robertson Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin, EH25 9RG, Midlothian, UK
    Trends Parasitol 17:19-24. 2001
    ..In this review, Susan Welburn, Eric Fèvre, Paul Coleman, Martin Odiit and Ian Maudlin discuss the biology and distribution of these two diseases in relation to the evolution of hominids in Africa...
  18. ncbi request reprint Tsetse-trypanosome interactions: rites of passage
    S C Welburn
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, UK EH25 9RG
    Parasitol Today 15:399-403. 1999
    ..In this review, Susan Welburn and Ian Maudlin chart the progress of trypanosomes through the fly and identify some of the hazards faced by both parasite and fly that affect vector competence of tsetse...
  19. pmc Amplified fragment length polymorphism (AFLP) analysis of closely related wild and captive tsetse fly (Glossina morsitans morsitans) populations
    Gurdeep K Lall
    Centre for Infectious Disease, School of Biomedical Sciences, The University of Edinburgh, Summerhall, Edinburgh, EH9 1QH, UK
    Parasit Vectors 3:47. 2010
    ..In this study amplified fragment length polymorphism (AFLP) markers were developed to analyze genetic variation in Glossina morsitans morsitans from laboratory and field-collected populations from Zimbabwe...
  20. pmc Sleeping sickness in Uganda: a thin line between two fatal diseases
    Kim Picozzi
    Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH25 9RG
    BMJ 331:1238-41. 2005
    ..To determine, through the use of molecular diagnostic tools, whether the two species of parasite that cause human African trypanosomiasis have become sympatric...
  21. ncbi request reprint A multiplex PCR that discriminates between Trypanosoma brucei brucei and zoonotic T. b. rhodesiense
    Kim Picozzi
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, Royal Dick School of Veterinary Science, The University of Edinburgh, Edinburgh EH25 9RG, UK
    Exp Parasitol 118:41-6. 2008
    ..b. rhodesiense), inclusion of GPI-PLC as an internal control indicates whether sufficient genomic material is present for detection of a single copy T. brucei gene in the PCR reaction...
  22. pmc Social factors affecting seasonal variation in bovine trypanosomiasis on the Jos Plateau, Nigeria
    Ayodele O Majekodunmi
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Parasit Vectors 6:293. 2013
    ..Here we investigate the epidemiology of trypanosomiasis as a re-emerging disease on the Plateau, examining the social factors that influence prevalence and seasonal variation of bovine trypanosomiasis...
  23. pmc Factors associated with acquisition of human infective and animal infective trypanosome infections in domestic livestock in Western Kenya
    Beatrix von Wissmann
    Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e941. 2011
    ..Busia District also remains endemic for human sleeping sickness with sporadic cases of sleeping sickness reported...
  24. pmc Spatial epidemiology of hospital-diagnosed brucellosis in Kampala, Uganda
    Kohei Makita
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, Scotland, EH16 4SB, UK
    Int J Health Geogr 10:52. 2011
    ..A retrospective case-control study was undertaken to examine the spatial risk factors for human brucellosis in Kampala, Uganda...
  25. ncbi request reprint Evidence-based identification of the most important livestock related zoonotic diseases in Kampala, Uganda
    Kohei Makita
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Science, College of Medicine and Veterinary Medicine, University of Edinburgh, UK
    J Vet Med Sci 73:991-1000. 2011
    ..Poor geographical correlation between animals in peri-urban and rural areas and patients in urban areas suggested that the majority of these zoonoses were caused by informally-marketed foods...
  26. pmc Herd prevalence of bovine brucellosis and analysis of risk factors in cattle in urban and peri-urban areas of the Kampala economic zone, Uganda
    Kohei Makita
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Science, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 Summerhall Square, Edinburgh, EH9 1QH, UK
    BMC Vet Res 7:60. 2011
    ..A cross-sectional study was designed to generate precise information on the prevalence of brucellosis in cattle and risk factors for the disease in its urban and peri-urban dairy farming systems...
  27. pmc The burden of human African trypanosomiasis
    Eric M Fèvre
    Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 2:e333. 2008
    ....
  28. pmc Characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the Luangwa Valley, Zambia
    Neil E Anderson
    Centre for Infectious Diseases, Division of Pathway Medicine, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e1211. 2011
    ..The objective of this study was to characterise the nature of the reservoir community for trypanosomiasis in the absence of influence from domesticated hosts...
  29. pmc Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda
    Eric M Fèvre
    Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, West Mains Road, Edinburgh, EH9 3JT, UK
    BMC Public Health 8:96. 2008
    ..T.b. rhodesiense occurs focally, and it is important to assess the burden at the scale at which resource-allocation decisions are made...
  30. pmc Canine and ovine tick-borne pathogens in camels, Nigeria
    Vincenzo Lorusso
    Division of Infection and Pathway Medicine, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh, United Kingdom
    Vet Parasitol 228:90-92. 2016
    ..The high prevalence detected for A. platys suggests a possible role of camels as carriers of this infection...
  31. pmc Bayesian geostatistical analysis and prediction of Rhodesian human African trypanosomiasis
    Nicola A Wardrop
    Centre for Infectious Diseases, Division of Pathway Medicine, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 4:e914. 2010
    ..Recent research has aimed to increase the evidence base for targeting control measures by focusing on the environmental and climatic factors that control the spatial distribution of the disease...
  32. pmc Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda
    Nicola A Batchelor
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 3:e563. 2009
    ....
  33. doi request reprint Priorities for the elimination of sleeping sickness
    Susan C Welburn
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    Adv Parasitol 79:299-337. 2012
    ..It is timely to take up the tools available and invest in new tools - including novel financial instruments - to eliminate this disease from Africa...
  34. pmc Ecological Monitoring and Health Research in Luambe National Park, Zambia: Generation of Baseline Data Layers
    Neil E Anderson
    The Royal Dick School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, EH25 9RG, UK
    Ecohealth 13:511-524. 2016
    ..This study provides a reliable framework for ecological monitoring of wild mammal densities and vegetation composition in remote, relatively inaccessible environments...
  35. pmc Trypanosome diversity in wildlife species from the serengeti and Luangwa Valley ecosystems
    Harriet Auty
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 6:e1828. 2012
    ..While new species of trypanosomes and their variants have been identified in tsetse populations, our knowledge of trypanosome species that are circulating in wildlife populations and their genetic diversity is limited...
  36. pmc How human brucellosis incidence in urban Kampala can be reduced most efficiently? A stochastic risk assessment of informally-marketed milk
    Kohei Makita
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e14188. 2010
    ....
  37. ncbi request reprint Human African trypanosomiasis: Epidemiology and control
    E M Fèvre
    Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian, EH25 9RG, UK
    Adv Parasitol 61:167-221. 2006
    ....
  38. pmc Tick-borne pathogens of zoonotic and veterinary importance in Nigerian cattle
    Vincenzo Lorusso
    Division of Infection and Pathway Medicine, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
    Parasit Vectors 9:217. 2016
    ..This study aimed to ascertain the occurrence of tick-borne pathogens of veterinary and zoonotic importance in cattle in Nigeria using molecular approaches...
  39. pmc Sleeping sickness and its relationship with development and biodiversity conservation in the Luangwa Valley, Zambia
    Neil E Anderson
    The Royal Dick School of Veterinary Studies, Easter Bush Campus, The University of Edinburgh, Roslin, Edinburgh, EH25 9RG, UK
    Parasit Vectors 8:224. 2015
    ..We conclude that improved understanding is required to identify specific circumstances where win-win trade-offs can be achieved between the conservation of biodiversity and the reduction of disease in the human population. ..
  40. ncbi request reprint Cattle owners' perceptions of African bovine trypanosomiasis and its control in Busia and Kwale Districts of Kenya
    Noreen Machila
    CTVM, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland EH25 9RG, Edinburgh, UK
    Acta Trop 86:25-34. 2003
    ..One third of drug treatments given to sick cattle were trypanocides, but over half of these trypanocidal treatments were given to cattle believed to have diseases other than trypanosomiasis...
  41. pmc Quantifying the association between bovine and human trypanosomiasis in newly affected sleeping sickness areas of Uganda
    Beatrix von Wissmann
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom Health Protection Scotland, Glasgow, Scotland, United Kingdom
    PLoS Negl Trop Dis 8:e2931. 2014
    ....
  42. pmc Ixodid ticks of traditionally managed cattle in central Nigeria: where Rhipicephalus (Boophilus) microplus does not dare (yet?)
    Vincenzo Lorusso
    Division of Pathway Medicine, Edinburgh University Medical School, The Chancellor s Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Parasit Vectors 6:171. 2013
    ..The aim of this study was to document the composition of tick species, assessing the burden of infestation, in traditionally managed cattle in an area of central Nigeria where acaricides have not been used historically...
  43. pmc The best practice for preparation of samples from FTA®cards for diagnosis of blood borne infections using African trypanosomes as a model system
    Heba A Ahmed
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Parasit Vectors 4:68. 2011
    ..Here we describe recommendations for the best practice approach for sample processing from FTA®cards for the molecular diagnosis of trypanosomiasis using PCR...
  44. doi request reprint Diagnosis of human sleeping sickness: sense and sensitivity
    Sally L Wastling
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, The Chancellor s Building, UK
    Trends Parasitol 27:394-402. 2011
    ..Here recent trends in the development of diagnostics for sleeping sickness are considered and progress towards a much-needed sensitive, specific and affordable point-of-care diagnostic is assessed...
  45. ncbi request reprint Reanalyzing the 1900-1920 sleeping sickness epidemic in Uganda
    E M Fèvre
    University of Edinburgh, Roslin, Midlothian, United Kingdom
    Emerg Infect Dis 10:567-73. 2004
    ..b. gambiense cases, but similar to T.b. rhodesiense. These findings suggest that T.b. rhodesiense was present in Uganda and contributed to the epidemic. The historic context is reassessed in the light of these data...
  46. doi request reprint Controlling sleeping sickness - a review
    S C Welburn
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Summerhall, Edinburgh, EH9 1QH
    Parasitology 136:1943-9. 2009
    ....
  47. ncbi request reprint The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda
    E M Fèvre
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, EH25 9RG, Scotland, UK
    Lancet 358:625-8. 2001
    ..Soroti District has been the subject of large-scale livestock restocking activities and, because domestic cattle are important reservoirs of T b rhodesiense, we investigated the role of cattle in the origins of the outbreak...
  48. ncbi request reprint Trypanosoma brucei: trypanosome strain typing using PCR analysis of mobile genetic elements (MGE-PCR)
    A Tilley
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Science, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland EH25 9RG, UK
    Exp Parasitol 104:26-32. 2003
    ..Furthermore, MGE-PCR detects high levels of variability within the T. b. brucei and T. b. rhodesiense groups and is therefore a powerful discriminatory tool for tracking individual T. brucei genotypes and strains...
  49. ncbi request reprint A burgeoning epidemic of sleeping sickness in Uganda
    E M Fèvre
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian, UK
    Lancet 366:745-7. 2005
    ..Targeted interventions are urgently needed to control epidemics and reduce the high mortality resulting from sleeping sickness...
  50. ncbi request reprint The endosymbionts of tsetse flies: manipulating host-parasite interactions
    C Dale
    The Alexander Robertson Centre for Tropical Veterinary Medicine, Easter Bush, Midlothian, EH25 9RG, Roslin, UK
    Int J Parasitol 31:628-31. 2001
    ..In particular, we focus on the chitinase/N-acetyl-D-glucosamine catabolic machinery of Sodalis which has previously been implicated in causing immune inhibition in tsetse...
  51. ncbi request reprint Central point sampling from cattle in livestock markets in areas of human sleeping sickness
    E M Fèvre
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Acta Trop 97:229-32. 2006
    ..We also find that animals infected with trypanosomiasis are more likely to be brought for sale in livestock markets in endemic areas; we discuss these results in relation to the prevention of the spread of sleeping sickness...
  52. pmc Extrachromosomal DNA of the symbiont Sodalis glossinidius
    A C Darby
    Centre of Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, UK
    J Bacteriol 187:5003-7. 2005
    ..The information suggests S. glossinidius is evolving towards an obligate association with tsetse flies...
  53. pmc The insect endosymbiont Sodalis glossinidius utilizes a type III secretion system for cell invasion
    C Dale
    Sir Alexander Robertson Center for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 98:1883-8. 2001
    ..These observations lend credence to a hypothesis suggesting that vertically transmitted mutualistic endosymbionts evolve from horizontally transmitted parasites through a parasitism-mutualism continuum...
  54. pmc Aphid-symbiotic bacteria cultured in insect cell lines
    A C Darby
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, Scotland, United Kingdom
    Appl Environ Microbiol 71:4833-9. 2005
    ..We propose the provisional taxon names "Candidatus Consessoris aphidicola" for T type and "Candidatus Adiaceo aphidicola" for U type...
  55. pmc A comparative evaluation of PCR- based methods for species- specific determination of African animal trypanosomes in Ugandan cattle
    Heba A Ahmed
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Parasit Vectors 6:316. 2013
    ..Individual variations in inter-species length makes the ITS region a useful marker for identification of multiple trypanosome species within a sample...
  56. pmc Development of real time PCR to study experimental mixed infections of T. congolense Savannah and T. b. brucei in Glossina morsitans morsitans
    Heba A Ahmed
    Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom Faculty of Veterinary Medicine, Zagazig University, Zagazig, Ash Sharqiyah, Egypt
    PLoS ONE 10:e0117147. 2015
    ..b. brucei and T. congolense savannah that we used when they co-exist in the fly midgut. ..
  57. pmc LAMP for human African trypanosomiasis: a comparative study of detection formats
    Sally L Wastling
    Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 4:e865. 2010
    ....
  58. ncbi request reprint Genetic and phenotypic analysis of Tunisian Theileria annulata clones
    L H Taylor
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland, UK
    Parasitology 126:241-52. 2003
    ..All 3 in vitro measures are likely to have relevance to parasite-host interactions in animals with clinical theileriosis, and should be acted on by within-host and between-host selection...
  59. pmc Contribution of draft cattle to rural livelihoods in a district of southeastern Uganda endemic for bovine parasitic diseases: an economic evaluation
    Walter O Okello
    Division of Infection and Pathway Medicine, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Parasit Vectors 8:571. 2015
    ....
  60. pmc A longitudinal survey of African animal trypanosomiasis in domestic cattle on the Jos Plateau, Nigeria: prevalence, distribution and risk factors
    Ayodele O Majekodunmi
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Parasit Vectors 6:239. 2013
    ..However, during the past two decades tsetse flies have invaded the Jos Plateau and animal trypanosomiasis has become a significant problem for livestock keepers...
  61. pmc Tsetse fly (G. f. fuscipes) distribution in the Lake Victoria basin of Uganda
    Mugenyi Albert
    Coordinating Office for Control of Trypanosomiasis in Uganda, Kampala, Uganda Division of Infection and Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, Scotland
    PLoS Negl Trop Dis 9:e0003705. 2015
    ..The predicted spatial distribution of tsetse in the Lake Victoria basin of Uganda will provide significant new information to assist with the spatial targeting of tsetse and trypanosomiasis control. ..
  62. ncbi request reprint The rapid isolation and growth dynamics of the tsetse symbiont Sodalis glossinidius
    Caroline Z Matthew
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
    FEMS Microbiol Lett 248:69-74. 2005
    ..In addition, the growth dynamics and changes in cell viability during liquid culture are described. The potential for culture of other endosymbiont taxa is discussed...
  63. pmc One Health: past successes and future challenges in three African contexts
    Anna L Okello
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 8:e2884. 2014
    ..A decade later, One Health advocates face increasing pressure to translate the approach from theory into action...
  64. ncbi request reprint Antioxidants promote establishment of trypanosome infections in tsetse
    E T MacLeod
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Parasitology 134:827-31. 2007
    ..The present work suggests that antioxidants reduce the midgut environment protecting trypanosomes from cell death induced by reactive oxygen species...
  65. pmc Movement Behaviour of Traditionally Managed Cattle in the Eastern Province of Zambia Captured Using Two-Dimensional Motion Sensors
    Caesar H Lubaba
    Division of Infection and Pathway Medicine, Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 10:e0138125. 2015
    ....
  66. pmc Prevalence of Endemic Pig-Associated Zoonoses in Southeast Asia: A Review of Findings from the Lao People's Democratic Republic
    Anna L Okello
    School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia National Animal Health Laboratory, Department of Livestock and Fisheries, Ministry of Agriculture, Vientiane, Lao People s Democratic Republic Department of Hygiene and Prevention, Ministry of Health, Vientiane, Lao People s Democratic Republic International Livestock Research Institute, Nairobi, Kenya Australian Animal Health Laboratory AAHL, CSIRO Animal, Food and Health Sciences, Geelong, Victoria, Australia Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom
    Am J Trop Med Hyg 92:1059-66. 2015
    ....
  67. pmc Domestic pigs as potential reservoirs of human and animal trypanosomiasis in Northern Tanzania
    Louise C Hamill
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Parasit Vectors 6:322. 2013
    ..Domestic pigs from the Arusha region of northern Tanzania were screened for trypanosomes using PCR-based methods to examine the role of pigs as a reservoir of human and animal trypanosomiasis...
  68. pmc Eliminating rabies in Tanzania? Local understandings and responses to mass dog vaccination in Kilombero and Ulanga districts
    Kevin Bardosh
    Centre of African Studies, School of Social and Political Science, College of Humanities and Social science, The University of Edinburgh, Edinburgh, United Kingdom Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 8:e2935. 2014
    ....
  69. pmc Constraints to estimating the prevalence of trypanosome infections in East African zebu cattle
    Andrew P Cox
    Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, 1 Summerhall Square, Edinburgh, EH9 1QH, UK
    Parasit Vectors 3:82. 2010
    ..New matrices for DNA capture have simplified large scale field PCR analyses but few studies have examined the impact of these techniques on prevalence estimations...
  70. doi request reprint One Health and the neglected zoonoses: turning rhetoric into reality
    Anna L Okello
    International Animal Health, MRCVS, College of Medicine and Veterinary Medicine, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Vet Rec 169:281-5. 2011
    ....
  71. ncbi request reprint Programmed cell death in procyclic form Trypanosoma brucei rhodesiense --identification of differentially expressed genes during con A induced death
    S C Welburn
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Scotland
    Mem Inst Oswaldo Cruz 94:229-34. 1999
    ..Evidence for an ancestral death machinery, 'proto-apoptosis' in single celled organisms is discussed...
  72. ncbi request reprint Are fitness costs associated with resistance to human serum in Trypanosoma brucei rhodesiense?
    Paul G Coleman
    Disease Control and Vector Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
    Trends Parasitol 20:311-5. 2004
  73. ncbi request reprint Using remote sensing and geographic information systems to identify villages at high risk for rhodesiense sleeping sickness in Uganda
    Martin Odiit
    Sleeping Sickness Programme, National Agricultural Research Organization, LIRI Hospital, P O Box 96, Tororo, Uganda
    Trans R Soc Trop Med Hyg 100:354-62. 2006
    ..These findings demonstrate the potential of remote sensing and GIS to characterize village-level risk of sleeping sickness in endemic regions...
  74. ncbi request reprint Sleeping sickness--a re-emerging disease in the Serengeti?
    Magai T Kaare
    Department of Veterinary Medicine and Public Health, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P O Box 3021, Morogoro, Tanzania
    Travel Med Infect Dis 5:117-24. 2007
    ..PCR analysis, directed against the human serum resistance associated gene SRA, identified human infective Trypanosoma brucei rhodesiense parasites in both cattle and warthogs...
  75. ncbi request reprint Death of a trypanosome: a selfish altruism
    Michael Duszenko
    Department of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Trends Parasitol 22:536-42. 2006
    ..As we discuss here, the most important point that needs to be addressed is whether a single-celled organism can undertake a process that is considered altruistic...
  76. pmc Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific
    O Clyde Hutchinson
    Department of Biochemistry, 80 Tennis Court Road, Cambridge, CB2 1GA, UK
    BMC Genomics 8:234. 2007
    ..The genome of Trypanosoma brucei contains a repertoire of > 1000 VSG sequences. The degree of conservation of the genomic VSG repertoire in different strains has not been investigated in detail...
  77. ncbi request reprint VSG structure: similar N-terminal domains can form functional VSGs with different types of C-terminal domain
    Oliver Clyde Hutchinson
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Mol Biochem Parasitol 130:127-31. 2003
  78. ncbi request reprint Characterisation of the QM gene of Trypanosoma brucei
    Simon G Lillico
    Wellcome Centre for Molecular Parasitology, University of Glasgow, The Anderson College, Glasgow G11 6NU, UK
    FEMS Microbiol Lett 211:123-8. 2002
    ..Immune fluorescence microscopy revealed co-localisation with the GPI:protein transamidase component, GPI8, a distribution indicative of ribosome association with the rough endoplasmic reticulum...