Roger Williams

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi The effect of surfactant shedding and gas diffusion on pressure wave propagation through an ultrasound contrast agent suspension
    Jean Pierre O'Brien
    Dept of Mathematics, Univ College London, UCL, London, United
    J Acoust Soc Am 133:3314. 2013
  2. doi Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients
    Alastair J O'Brien
    Department of Clinical Pharmacology, University College London, 5 University Street, London WC1E 6JF, UK
    Intensive Care Med 38:991-1000. 2012
  3. pmc Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model
    A J O'Brien
    The Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Institute, University Street, London WC1E 6JJ, UK
    Br J Pharmacol 133:351-60. 2001
  4. doi Nutrition in end-stage liver disease: principles and practice
    Alastair O'Brien
    Institute of Hepatology, Royal Free and University College Medical School, University College London, London, England
    Gastroenterology 134:1729-40. 2008
  5. pmc The neurodevelopmental progress of infants less than 33 weeks into adolescence
    F O'Brien
    Perinatal Brain Research Group, Department of Paediatrics, University College, London, UK Institute of Psychiatry, King s College, London, UK
    Arch Dis Child 89:207-11. 2004
  6. doi Variable effects of inhibiting iNOS and closing the vascular ATP-sensitive potassium channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock
    Alastair O'Brien
    Department of Medicine, University College London, United Kingdom
    Shock 31:535-41. 2009
  7. ncbi When texture takes precedence over motion in depth perception
    J O'BRIEN
    Department of Psychology, University College London, UK
    Perception 29:437-52. 2000
  8. pmc BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis
    Alastair J O'Brien
    Institute of Hepatology and Department of Medicine, University College, London, UK
    Shock 35:485-91. 2011
  9. ncbi Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure
    Rajeshwar P Mookerjee
    Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, London, UK
    Liver Transpl 13:400-5. 2007
  10. ncbi Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus
    Eirini I Rigopoulou
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    Antiviral Res 75:36-42. 2007

Detail Information

Publications110 found, 100 shown here

  1. doi The effect of surfactant shedding and gas diffusion on pressure wave propagation through an ultrasound contrast agent suspension
    Jean Pierre O'Brien
    Dept of Mathematics, Univ College London, UCL, London, United
    J Acoust Soc Am 133:3314. 2013
    ..Therefore, incorporating such time-dependent phenomena in ultrasound imaging algorithms should lead to better quantitative agreement with experiments...
  2. doi Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients
    Alastair J O'Brien
    Department of Clinical Pharmacology, University College London, 5 University Street, London WC1E 6JF, UK
    Intensive Care Med 38:991-1000. 2012
    ..Patients with decompensated liver cirrhosis who are admitted to intensive care units (ICU) are perceived, within the UK, as having a particularly poor prognosis...
  3. pmc Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model
    A J O'Brien
    The Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Institute, University Street, London WC1E 6JJ, UK
    Br J Pharmacol 133:351-60. 2001
    ..Moreover, conventional doses of L-NAME and AMG became increasingly ineffective over time. Thus, the choice of inhibitor merits careful consideration in long-term models...
  4. doi Nutrition in end-stage liver disease: principles and practice
    Alastair O'Brien
    Institute of Hepatology, Royal Free and University College Medical School, University College London, London, England
    Gastroenterology 134:1729-40. 2008
  5. pmc The neurodevelopmental progress of infants less than 33 weeks into adolescence
    F O'Brien
    Perinatal Brain Research Group, Department of Paediatrics, University College, London, UK Institute of Psychiatry, King s College, London, UK
    Arch Dis Child 89:207-11. 2004
    ..Several studies have shown an increased incidence of neurodevelopmental impairment in very preterm survivors at school age compared with controls...
  6. doi Variable effects of inhibiting iNOS and closing the vascular ATP-sensitive potassium channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock
    Alastair O'Brien
    Department of Medicine, University College London, United Kingdom
    Shock 31:535-41. 2009
    ..It therefore remains uncertain whether the iNOS pathway or the K(ATP) channel represents a potential target for drug development in the treatment of endotoxic shock...
  7. ncbi When texture takes precedence over motion in depth perception
    J O'BRIEN
    Department of Psychology, University College London, UK
    Perception 29:437-52. 2000
    ..The regularity of the texture pattern did not affect this weighting. Results are discussed in terms of models of cue combination and previous results with different types of texture and motion information...
  8. pmc BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis
    Alastair J O'Brien
    Institute of Hepatology and Department of Medicine, University College, London, UK
    Shock 35:485-91. 2011
    ..In conclusion, the BK channel does not appear to be integral to sepsis-induced hypotension but does affect survival through other mechanisms. The pressor effect of TEA may be related to effects on other potassium channels...
  9. ncbi Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure
    Rajeshwar P Mookerjee
    Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, London, UK
    Liver Transpl 13:400-5. 2007
    ..In conclusion, our data show a significant correlation between ADMA levels and proinflammatory cytokines, supporting a hypothesis that proinflammatory cytokines may regulate ADMA metabolism in ALF...
  10. ncbi Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus
    Eirini I Rigopoulou
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    Antiviral Res 75:36-42. 2007
    ..Here we investigated whether ribavirin directly affects HCV-specific reactivity of CD4+T-lymphocytes from patients with CH-C...
  11. ncbi Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis
    Sambit Sen
    Liver Failure Group, Institute of Hepatology, University College London Medical School, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 43:142-8. 2005
    ..This study evaluates the acute effects of albumin dialysis, using the Molecular Adsorbents Recirculating System (MARS), on portal pressure in AH...
  12. ncbi Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: antiviral and immunological activity
    Eirini I Rigopoulou
    Institute of Hepatology, Division of Medicine, University College London, London, UK
    Hepatology 42:1028-36. 2005
    ..However, IL-12 does not abolish HBV replication in HBeAg-positive patients and does not maintain inhibition of HBV replication after lamivudine withdrawal...
  13. ncbi Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
    Sambit Sen
    Liver Failure Group, The UCL Institute of Hepatology, Division of Medicine, Royal Free and University College Medical School, London
    Crit Care Med 34:158-64. 2006
    ....
  14. ncbi Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells
    Akeel Alisa
    Department of Medicine, Institute of Hepatology, University College London, London, UK
    J Immunol 180:5109-17. 2008
    ..Our data demonstrate that tumor Ags may contain epitopes which activate the expansion of inducible regulatory T cells, leading to evasion of tumor control...
  15. doi Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality
    Rajiv Jalan
    Liver Failure Group, Institute of Hepatology, University College London, London, United Kingdom
    Hepatology 50:555-64. 2009
    ..A significant negative correlation between IMAR and the fatty acid binding coefficients for sites 1 and 2 (P < 0.001 for both) was observed, indicating possible sites of association on the protein...
  16. ncbi Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure
    Lars M Ytrebø
    Liver Failure Group, Institute of Hepatology, Univ College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    Am J Physiol Gastrointest Liver Physiol 291:G373-81. 2006
    ..Furthermore, the kidneys are quantitatively as important as PDV in ammonia production, and the muscles play an important role in ammonia removal...
  17. ncbi Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization
    Lakshmana Ayaru
    Department of Medicine, University College London Institute of Hepatology, London
    J Immunol 178:1914-22. 2007
    ....
  18. ncbi Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study
    Sambit Sen
    Liver Failure Group, Institute of Hepatology, University College London, London, UK
    Liver Transpl 10:1109-19. 2004
    ..These results should temper the liberal use of MARS until further data is available...
  19. ncbi Increased gene and protein expression of the novel eNOS regulatory protein NOSTRIN and a variant in alcoholic hepatitis
    Rajeshwar P Mookerjee
    Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, London, England
    Gastroenterology 132:2533-41. 2007
    ..Our aims were to quantify and compare hepatic expression of eNOS, NOSTRIN, NOSIP, and caveolin-1 in alcoholic cirrhosis with or without superimposed alcoholic hepatitis and in normal livers...
  20. doi CD8(+) T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functions
    Sandra Phillips
    Institute of Hepatology, University College London, London, U K
    J Immunol 184:287-95. 2010
    ..These results provide direct evidence that virus-specific CD8(+) T cells efficiently control HBV replication by noncytolytic mechanisms, and this effect is mediated by IFN-gamma and TNF-alpha...
  21. ncbi Binding of bilirubin and bromosulphthalein to albumin: implications for understanding the pathophysiology of liver failure and its management
    Christian Steiner
    Institute of Hepatology, University College London, London, UK
    Liver Transpl 10:1531-8. 2004
    ..C(bilirubin)/C(alb) appears to be important in albumin dialysis, and generally in liver disease patients, reinforcing the importance of the toxin-binding functions of albumin in liver disease...
  22. ncbi Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy
    Debbie L Shawcross
    Liver Failure Group, Institute of Hepatology, Royal Free and University College London Medical School, London, UK
    Hepatology 39:471-5. 2004
    ..These data suggest the need to exercise extreme caution in the use of terlipressin in these patients in view of its potentially deleterious consequences on cerebral hemodynamics...
  23. ncbi Endotoxemia produces coma and brain swelling in bile duct ligated rats
    Gavin Wright
    Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, 69 75 Chenies Mews, London, UK
    Hepatology 45:1517-26. 2007
    ..Although the exact mechanism of how hyperammonemia and LPS facilitate cytotoxic edema and pre-coma in cirrhosis is not clear, our data support an important role for the nitrosation of brain proteins...
  24. ncbi Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients
    Akeel Alisa
    Institute of Hepatology, University College London, UK
    Clin Cancer Res 11:6686-94. 2005
    ..The aim of this study was to analyze naturally occurring CD4(+) T-cell responses to AFP...
  25. ncbi Relationship between early HCV kinetics and T-cell reactivity in chronic hepatitis C genotype 1 during peginterferon and ribavirin therapy
    Kwok H Tang
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 43:776-82. 2005
    ..To gain understanding of inter-individual differences of treatment response in hepatitis C virus genotype 1 (HCV-G1) patients, we investigated simultaneously the early HCV kinetics and virus-specific T-cell reactivity...
  26. ncbi Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis
    Rajeshwar P Mookerjee
    Liver Failure Group, The UCL Institute of Hepatology, Division of Medicine, University College London, UK
    Hepatology 45:62-71. 2007
    ..Elevated dimethylarginines may serve as important biological markers of deleterious outcome in alcoholic hepatitis...
  27. ncbi Albumin dialysis: a new therapeutic strategy for intoxication from protein-bound drugs
    Sambit Sen
    Liver Failure Group, Institute of Hepatology, 69 75 Chenies Mews, London WC1E 6HX, UK
    Intensive Care Med 30:496-501. 2004
    ..The present study investigates whether albumin dialysis in the form of the Molecular Adsorbents Recirculating System (MARS) is effective in removal of protein-bound drugs...
  28. doi Cell-mediated immune responses to alpha-fetoprotein and other antigens in hepatocellular carcinoma
    Shahriar Behboudi
    The Institute of Hepatology, University College London, London, UK
    Liver Int 30:521-6. 2010
    ..Moreover, we discuss cytotoxic T lymphocyte and Th1 responses to tumour antigens in patients with HCC and evaluate the effects of conventional treatments on antitumour T-cell responses...
  29. ncbi Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis
    Rajiv Jalan
    Liver Failure Group, Institute of Hepatology, University College London Medical School and University College London Hospitals, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 38:24-31. 2003
    ..The aim of this paper is to assess the safety, efficacy and feasibility of using MARS in patients with severe AH...
  30. doi Induction of CD152 (CTLA-4) and LAP (TGF-β1) in human Foxp3- CD4+ CD25- T cells modulates TLR-4 induced TNF-α production
    Sandra Boswell
    UCL Institute of Liver and Digestive Health, University College London, London, UK
    Immunobiology 218:427-34. 2013
    ....
  31. doi Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy
    Jiannis Anastasiou
    Institute of Hepatology, UCL, Medical School, Chenies Mews
    Eur J Gastroenterol Hepatol 22:474-80. 2010
    ..In this study, we examined the value of transient elastography in a number of groups in comparison with the Fibrotest/Actitest (FT/AT), using the liver biopsy (LB) as the reference standard...
  32. doi The pervading influence of alcoholic liver disease in hepatology
    Roger Williams
    Institute of Hepatology, University College London Medical School, 69 75 Chenies Mews, London, WC1E 6HX, UK
    Alcohol Alcohol 43:393-7. 2008
    ..Even as the stringent regulatory measures needed to control rising alcohol consumption are introduced by government, the burden of liver disease in the UK will remain high for years to come...
  33. ncbi Genetic characteristics of hepatitis B virus genotypes as a factor for interferon-induced HBeAg clearance
    Jinlin Hou
    Institute of Hepatology, University College London, London WC1E 6HX, UK
    J Med Virol 79:1055-63. 2007
    ..The optimal duration of interferon-based therapies in chronic hepatitis B may vary between different HBV genotypes...
  34. ncbi Emerging indications for albumin dialysis
    Sambit Sen
    Institute of Hepatology, University College of London, 69 75 Chenies Mews, London WC1E 6HX, United Kingdom
    Am J Gastroenterol 100:468-75. 2005
    ....
  35. pmc Induction of latency-associated peptide (transforming growth factor-β(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-α production in a transforming growth factor-β-dependent manner
    Sandra Boswell
    The Institute of Hepatology, University College London, UK
    Immunology 133:278-87. 2011
    ..The results demonstrate that GPC(81-95) is a useful tool to study the functional properties of a subpopulation of LAP (TGF-β(1))(+) CD4(+) T cells and suggest a pathway that can be exploited to suppress inflammatory response...
  36. ncbi Liver failure: basis of benefit of therapy with the molecular adsorbents recirculating system
    Sambit Sen
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London, WC1E 6HX, UK
    Int J Biochem Cell Biol 35:1306-11. 2003
    ..The results of larger controlled clinical trials, as well as studies investigating the pathophysiological basis of its effect, are awaited...
  37. doi Identification of serum cytokine profiles associated with HBeAg seroconversion following antiviral treatment interruption
    Shilpa Chokshi
    1 Institute of Hepatology, Foundation for Liver Research, London, United Kingdom
    Viral Immunol 27:235-44. 2014
    ..Evaluating on-treatment serum cytokines in concert with virologic and clinical parameters may help to identify CHB patients who can successfully discontinue nucleos(t)ide analogue therapy...
  38. doi The diversity and management of chronic hepatitis B virus infections in the United Kingdom: a wake-up call
    Richard S Tedder
    Microbiology Services Colindale, Health Protection Agency, London, UK
    Clin Infect Dis 56:951-60. 2013
    ..Through migration, diversity of chronic hepatitis B virus (HBV) infection has changed, affecting disease burden and control. We describe clinical and viral characteristics of chronic HBV in the United Kingdom...
  39. ncbi Rapid diagnosis of Wilson disease in acute liver failure: no more waiting for the ceruloplasmin level?
    Alastair O'Brien
    Institute of Hepatology, University College London Medical School, University College London, 69 75 Chenies Mews, London, UK
    Hepatology 48:1030-2. 2008
  40. ncbi The elusive goal of liver support--quest for the Holy Grail
    Roger Williams
    UCL Institute of Hepatology, Division of Medicine, University College, London
    Clin Med 6:482-7. 2006
    ..The latter are the most highly efficient to date in toxin removal but whether survival is improved and the need for liver transplantation remain to be proven...
  41. ncbi Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen
    George K K Lau
    Institute of Hepatology, University College London, London, England
    Gastroenterology 122:614-24. 2002
    ..We characterized HBV-specific T-cell responses in chronic hepatitis B surface antigen carriers who received bone marrow from HLA-identical donors with natural immunity to HBV and seroconverted to antibody to hepatitis B surface antigen...
  42. ncbi Computational modeling of non-Fourier motion: further evidence for a single luminance-based mechanism
    C P Benton
    Department of Psychology, University College London, UK
    J Opt Soc Am A Opt Image Sci Vis 18:2204-8. 2001
    ..This demonstrates that the non-Fourier motion in some non-Fourier stimuli is directly available to luminance-based motion mechanisms operating on measurements of local spatial and temporal gradients...
  43. doi Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production
    Sandra Phillips
    Institute of Hepatology, Foundation for Liver Research, London, United Kingdom
    Gastroenterology 148:403-14.e7. 2015
    ..We investigated the effects of 2 cyclophilin inhibitors (alisporivir and NIM811) on HBV replication and hepatitis B surface antigen (HBsAg) production in cell lines...
  44. doi Lessons from look-back in acute liver failure? A single centre experience of 3300 patients
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London, United Kingdom
    J Hepatol 59:74-80. 2013
    ..We reviewed patients treated over a 35-year period at a specialist high-volume ICU, quantifying changes in disease aetiology, severity and evolution of ICU support and ELT use and outcome...
  45. ncbi Hepatology: a personal story
    Roger Williams
    Institute of Hepatology, University College London
    Clin Med (Lond) 8:25-8. 2008
    ..The new liver support devices are currently showing promise but on the negative side is the rising prevalence of alcohol-related liver disease and non-alcoholic fatty liver disease...
  46. ncbi Correction of disturbed pathophysiology of hepatic failure by albumin dialysis
    Roger Williams
    Institute of Hepatology, University College London Medical School, 69 75 Chenies Mews, London, WC1E 6HX, UK
    Hepatobiliary Pancreat Dis Int 7:19-24. 2008
  47. ncbi Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS)
    Sambit Sen
    Institute of Hepatology, University College London Medical School and University College London Hospitals, England
    Epilepsia 44:265-7. 2003
    ..We attempted to demonstrate that severe PHT toxicity can be treated successfully with the Molecular Adsorbents Recirculating System (MARS). The mechanism of drug removal by the system also was studied...
  48. pmc Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy
    George J M Webster
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, United Kingdom
    J Virol 78:5707-19. 2004
    ..These findings have implications for the design of immunotherapy for chronic HBV infections...
  49. ncbi Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity
    Francesco Torre
    Institute of Hepatology, University College London, London, United Kingdom
    J Med Virol 72:370-6. 2004
    ....
  50. ncbi Role of hepatitis B virus specific cytotoxic T cells in liver damage and viral control
    A Bertoletti
    Institute of Hepatology, University College London, 69 75 Chenies Mews, WC1E 6HX London, UK
    Antiviral Res 60:61-6. 2003
    ....
  51. ncbi Bio-artificial liver support for acute liver failure: should we be using it to treat patients?
    Rajiv Jalan
    Institute of Hepatology, University College London Medical School, United Kingdom
    Transplantation 73:165-6. 2002
  52. ncbi Acute-on-chronic liver failure: pathophysiological basis of therapeutic options
    Rajiv Jalan
    Institute of Hepatology, University College, London Medical School and UCL Hospitals, London, UK
    Blood Purif 20:252-61. 2002
    ..Because liver failure, whether of the acute or acute-on-chronic variety, is potentially reversible, the stage is set for the application of newer liver-support strategies to enhance the recovery process...
  53. pmc Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection
    Stephanie Reignat
    Institute of Hepatology, University College London, London WC1 E6HX, United Kingdom
    J Exp Med 195:1089-101. 2002
    ....
  54. ncbi Categorizing sex and identity from the biological motion of faces
    H Hill
    Department of Psychology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Curr Biol 11:880-5. 2001
    ..Playing animations backward also reduced performance for sex judgements and emphasized the importance of direction specificity in admitting access to stored representations of characteristic male and female movements...
  55. ncbi Contrast inconstancy across changes in polarity
    C P Benton
    Department of Psychology, University College London, UK
    Vision Res 39:4076-84. 1999
    ..We propose that the difference in apparent contrast between the two patterns may be based upon spatial non-linearities in the combination of local contrast measures...
  56. ncbi Concurrent measurement of perceived speed and speed discrimination threshold using the method of single stimuli
    A Johnston
    Department of Psychology, University College London, UK
    Vision Res 39:3849-54. 1999
    ..5 degree/s) but not at high. We conclude that the effect of contrast on perceived speed is real, and not a methodological artefact, but that it is found only at low temporal frequencies...
  57. ncbi Investigating shape-from-shading illusions using solid objects
    A Johnston
    Department of Psychology, University College London, UK
    Vision Res 36:2827-35. 1996
    ..We show that both effects do occur for solid objects, and that the magnitude of these effects are equivalent regardless of whether subjects are presented with ray traced or solid objects...
  58. ncbi Computational modelling of interleaved first- and second-order motion sequences and translating 3f+4f beat patterns
    C P Benton
    Department of Psychology, University College London, Gower Street, London, UK
    Vision Res 40:1135-42. 2000
    ..The results demonstrate that a low-level luminance based approach can potentially provide a wider account of human motion processing than generally thought possible...
  59. ncbi Perception of motion direction in luminance- and contrast-defined reversed-phi motion sequences
    C P Benton
    Department of Psychology, University College London, U K
    Vision Res 37:2381-99. 1997
    ..These data suggest the possibility that a single mechanism may mediate the perception of luminance- and contrast-defined motion...
  60. ncbi First-order motion from contrast modulated noise?
    C P Benton
    Department of Psychology, University College London, U K
    Vision Res 37:3073-8. 1997
    ..We conclude that this class of stimuli remains an important tool for researchers wishing to study non-Fourier motion...
  61. ncbi Speed discrimination thresholds for first--and second-order bars and edges
    A Johnston
    Department of Psychology, University College London, U K
    Vision Res 37:2217-26. 1997
    ..The results are discussed in relation to mechanisms for the explicit recovery of contrast modulations and the influence of the form of the carrier signal on visual performance in second-order motion tasks...
  62. pmc Induced motion at texture-defined motion boundaries
    A Johnston
    Department of Psychology, University College London, UK
    Proc Biol Sci 266:2441-50. 1999
    ..The induced motion investigated here appears distinct from classical induced effects resulting from motion contrast or the movement of a reference frame...
  63. ncbi Biological computation of image motion from flows over boundaries
    A Johnston
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol Paris 97:325-34. 2003
    ..We also provide novel interpretations of the roles of direction selective, bi-directional and pan-directional cells and of type I and type II cells in V5/MT...
  64. ncbi Urinary metabolic profiling by 1H NMR spectroscopy in patients with cirrhosis may discriminate overt but not covert hepatic encephalopathy
    Mark J W McPhail
    Liver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary s Campus, London, W2 1NY, UK
    Metab Brain Dis . 2016
    ..However, urinary 1H-NMR metabolic profiling did not discriminate patients with differing grades of HE or according to severity of underlying liver disease...
  65. doi Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection
    Antonio Riva
    Institute of Hepatology, Foundation for Liver Research, London, UK
    Hepatology 60:487-96. 2014
    ..005) compared to patients who became chronic. Patients who became persistently infected had higher proportions of cytokine-producing NK-cells, which were correlated with concentrations of truncated CXCL10 (r = 0.92, P < 0.001)...
  66. doi Association of water softness and heavy alcohol consumption with higher hospital admission rates for alcoholic liver disease
    Mark Howarth
    The Institute of Hepatology, Foundation for Liver Research, 69 75 Chenies Mews, London, WC1E 6HX, UK
    Alcohol Alcohol 47:688-96. 2012
    ..To test the hypothesis that regional variations in the prevalence of alcoholic liver disease are contributed to by regional variations in 'softness' of drinking water, i.e. its mineral content...
  67. ncbi Acute liver failure--practical management
    Roger Williams
    Institute of Hepatology, University College London Medical School, 69 75 Chenies Mews, London, WC1E 6HX, UK
    Acta Gastroenterol Belg 70:210-3. 2007
    ....
  68. ncbi Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease
    Stephen P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 42:365-70. 2005
    ..However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K1 in such patients...
  69. ncbi Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
    Debbie L Shawcross
    Liver Failure Group, Institute of Hepatology, University College London Medical School, 69 75, Chenies Mews, London WC1E 6HX, UK
    J Hepatol 40:247-54. 2004
    ..We tested the hypothesis that SIRS mediators, such as nitric oxide and proinflammatory cytokines, may exacerbate the neuropsychological effects of hyperammonemia in cirrhosis...
  70. ncbi The pathophysiological basis of acute-on-chronic liver failure
    Sambit Sen
    Institute of Hepatology, University College London Medical School and University College London Hospitals, London, UK
    Liver 22:5-13. 2002
    ..Because liver failure, whether of the acute or acute-on-chronic variety, is potentially reversible, the stage is set for the application of newer liver support strategies to enhance the recovery process...
  71. ncbi Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment
    Fabio Malacarne
    Institute of Hepatology, Royal Free Campus, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 187:679-82. 2003
    ..These findings suggest that the peripherally reconstituted HBV-specific CD8 T cells can originate from precursor cells within lymph nodes...
  72. ncbi Three-dimensional curvature contrast--geometric or brightness illusion?
    W Curran
    Department of Psychology, University College London, U K
    Vision Res 36:3641-53. 1996
    ..The observation that three-dimensional curvature contrast persists when the inducing surfaces are spatially separate from the test surface suggests that shape perception involves global, as well as local, operations...
  73. doi Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis
    Lee J L Markwick
    Institute of Hepatology, Foundation for Liver Research, London, UK Institute of Liver Studies, King s College London, King s College Hospital, London, UK
    Gastroenterology 148:590-602.e10. 2015
    ..However, their sustained hyperexpression promotes immune exhaustion and paralysis. We investigated the role of these immune inhibitory receptors in driving immune impairments in patients with alcoholic liver disease...
  74. ncbi Albumin dialysis and Molecular Adsorbents Recirculating System (MARS) for acute Wilson's disease
    Sambit Sen
    Liver Failure Group, Institute of Hepatology, University College London Hospitals, London, UK
    Liver Transpl 8:962-7. 2002
    ..These data suggest that MARS removes copper efficiently and can be used to bridge patients with Wilson's disease and ALF to LTx...
  75. ncbi Hepatitis C in 2006
    Roger Williams
    The UCL Institute of Hepatology, University College London Medical School, London, UK
    Eur J Gastroenterol Hepatol 18:309-11. 2006
  76. ncbi New liver support devices in acute liver failure: a critical evaluation
    Sambit Sen
    Institute of Hepatology, University College London, United Kingdom
    Semin Liver Dis 23:283-94. 2003
    ..They have to take into account the influence of transplantation, etiology, and other factors on outcome. Achieving a standard medical regime for these critically ill patients between different centers is also difficult...
  77. ncbi 'Nipped in the Budd': hepatic venous outflow obstruction in evolution
    Haris Karageorgiou
    Gastroenterology and Hepatology Unit, Department of Gastroenterology, University College London Hospitals, London, UK
    Eur J Gastroenterol Hepatol 17:65-8. 2005
    ....
  78. ncbi Acute liver failure: a review
    Shahid A Khan
    Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    Clin Liver Dis 10:239-58, vii-viii. 2006
    ..This article summarizes the basic patho-physiology underlying ALF, compares epidemiologic trends in the United States, the United Kingdom, and the Far East, and reviews prognostic markers and treatment options for ALF...
  79. ncbi Alpha-fetoprotein impairs APC function and induces their apoptosis
    Soon Ho Um
    Institute of Hepatology, University College London, United Kingdom
    J Immunol 173:1772-8. 2004
    ..In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control...
  80. ncbi Diagnostic value of Doppler assessment of the hepatic and portal vessels and ultrasound of the spleen in liver disease
    John O'Donohue
    Institute of Liver Studies, King s College Hospital, London, UK
    Eur J Gastroenterol Hepatol 16:147-55. 2004
    ....
  81. pmc Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions
    Ralf Schilling
    Institute of Hepatology, Department of Medicine, University College London, London WC1E 6HX, United Kingdom
    J Virol 77:8882-92. 2003
    ..These results suggest that HBs-specific IgG binds to hepatocytes and interacts with HBsAg within the cells. This may be relevant for the selection of surface antibody escape mutations...
  82. pmc Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study
    I Jane Cox
    I Jane Cox, Antonio Riva, Roger Williams, Institute of Hepatology, London, Foundation for Liver Research, London WC1E 6HX, United Kingdom
    World J Gastroenterol 22:4191-200. 2016
    ..To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and controls...
  83. pmc PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation
    Valeria Iansante
    Cell Signaling and Cancer Laboratory, Institute of Hepatology, Foundation for Liver Research, London WC1E 6HX, UK
    Nat Commun 6:7882. 2015
    ..Our findings indicate that the PARP14-JNK1-PKM2 regulatory axis is an important determinant for the Warburg effect in tumour cells and provide a mechanistic link between apoptosis and metabolism. ..
  84. doi MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis
    Christine Podrini
    Foundation for Liver Research, Institute of Hepatology, London, United Kingdom University College London UCL Institute for Liver and Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom and Physiology and Experimental Medicine Research Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    FASEB J 29:1676-87. 2015
    ..This study underlines the importance of the replacement of noncanonical histones in the regulation of genes involved in lipid metabolism in the progression of steatosis...
  85. doi Calorie and alcohol consumption in nonalcoholic fatty liver disease
    Peter Marks
    The Institute of Hepatology London, Foundation for Liver Research, London, UK
    Eur J Gastroenterol Hepatol 24:527-30. 2012
    ....
  86. pmc Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection
    Ornella Franzese
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, United Kingdom
    J Virol 79:3322-8. 2005
    ..The possible role of CD4+ CD25+ T cells in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have implications for optimizing future immunotherapeutic approaches to HBV treatment...
  87. ncbi Rifaximin, a nonabsorbed oral antibiotic, in the treatment of hepatic encephalopathy: antimicrobial activity, efficacy, and safety
    Roger Williams
    Institute of Hepatology, University College London Medical School, London, England
    Rev Gastroenterol Disord 5:S10-8. 2005
    ..The current database on rifaximin would be strengthened by results of placebo-controlled studies to quantify more precisely the benefits of therapy...
  88. ncbi Single nucleotide polymorphisms in the interferon-gamma and interleukin-10 genes do not influence chronic hepatitis C severity or T-cell reactivity to hepatitis C virus
    William G H Abbott
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    Liver Int 24:90-7. 2004
    ..In 116 consecutive patients with CH-C, we tested the hypothesis that host genetic factors regulating IFN-gamma production and activity influence the severity of liver damage and hepatitis C virus (HCV)-specific T-cell reactivity...
  89. ncbi Global challenges in liver disease
    Roger Williams
    UCL Institute of Hepatology, Division of Medicine, Royal Free and University College Medical School, London, UK
    Hepatology 44:521-6. 2006
    ..Only through a concerted effort from governments, health agencies, healthcare professionals at all levels, and the pharmaceutical industry can this grim outlook for liver disease worldwide be reversed...
  90. ncbi Paracetamol: are therapeutic doses entirely safe?
    Rajiv Jalan
    UCL Institute of Hepatology, University College London, London WC1E 6HX, UK
    Lancet 368:2195-6. 2006
  91. ncbi Protocols and mechanisms for remote ischemic preconditioning: a novel method for reducing ischemia reperfusion injury
    Sanjeev Kanoria
    HPB and Liver Transplant Unit, University Department of Surgery, Royal Free Hospital, London, United Kingdom
    Transplantation 84:445-58. 2007
    ..RIPC protocols are organ and species specific and both humoral and neurogenic pathways are involved in triggering intracellular signal pathways for protection...
  92. ncbi Immunohistochemical differences in the portal tract and acinar infiltrates between primary biliary cirrhosis and autoimmune cholangitis
    John O'Donohue
    Institute of Liver Studies, King s College Hospital, London, UK
    Eur J Gastroenterol Hepatol 14:1143-50. 2002
    ..Antimitochondrial antibody-negative primary biliary cirrhosis, or autoimmune cholangitis, may be indistinguishable clinically and histologically from antimitochondrial antibody-positive primary biliary cirrhosis...
  93. ncbi Managing viral hepatitis
    Kwok H Tang
    Institute of Hepatology, University College London and UCL Hospitals, London
    Practitioner 247:537-42. 2003
  94. ncbi Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease
    Nanda Kerkar
    Institute of Hepatology, University College, London, United Kingdom
    J Immunol 170:1481-9. 2003
    ..The demonstrated similarity and cross-reactivity between CYP2D6(193-212) and two unrelated viruses suggests that multiple exposure to viruses mimicking self may represent an important pathway to the development of autoimmunity...
  95. ncbi Time perception: brain time or event time?
    A Johnston
    Department of Psychology and Institute of Cognitive Neuroscience, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Biol 11:R427-30. 2001
    ..Neural processing time delays are offered as an explanation of these temporal illusions, but equating perceived time with processing time leads to some thorny philosophical problems...
  96. ncbi Sexual dimorphism in the synchrony of joint growth hormone and cortisol dynamics in children with classic 21-hydroxylase deficiency
    E Charmandari
    London Centre for Paediatric Endocrinology, University College London, London, UK
    J Pediatr Endocrinol Metab 16:1119-30. 2003
    ..83 +/- 0.20) (p = 0.03). These findings suggest that females with classic 21-hydroxylase deficiency have a more irregular pattern of GH secretion and a more asynchronous joint GH and cortisol dynamics than their male counterparts...
  97. doi Perspectives on liver failure: past and future
    Stephen M Riordan
    Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
    Semin Liver Dis 28:137-41. 2008
    ..A particular challenge will be to reduce hepatocellular death without inhibiting the liver's regenerative potential, given the pleiotropic functions of some of the molecules involved in both processes...
  98. ncbi Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis
    Stephen M Riordan
    Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
    Hepatology 37:1154-64. 2003
    ..TLR2 likely contributes to increased circulating TNF-alpha and sTNFR levels in cirrhosis...
  99. ncbi Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Hepatol 38:419-25. 2003
    ..Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology...
  100. ncbi Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis
    Lars M Ytrebø
    Department of Digestive Surgery, University Hospital Northern Norway, Tromsø, Norway
    Scand J Gastroenterol 41:1350-60. 2006
    ....
  101. ncbi Infliximab and alcoholic hepatitis
    Rajeshwar P Mookerjee
    Hepatology 40:499-500; author reply 500-1. 2004