Stephen R Williams

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint The back and forth of dendritic plasticity
    Stephen R Williams
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Neuron 56:947-53. 2007
  2. pmc Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro
    Stephen R Williams
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Physiol 539:469-83. 2002
  3. doi request reprint Direct measurement of somatic voltage clamp errors in central neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Neurosci 11:790-8. 2008
  4. ncbi request reprint Encoding and decoding of dendritic excitation during active states in pyramidal neurons
    Stephen R Williams
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 25:5894-902. 2005
  5. ncbi request reprint Spatial compartmentalization and functional impact of conductance in pyramidal neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Neurosci 7:961-7. 2004
  6. pmc Pathway-specific use-dependent dynamics of excitatory synaptic transmission in rat intracortical circuits
    Stephen R Williams
    Neurobiology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    J Physiol 585:759-77. 2007
  7. ncbi request reprint Voltage- and site-dependent control of the somatic impact of dendritic IPSPs
    Stephen R Williams
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Neurosci 23:7358-67. 2003
  8. doi request reprint Neuroscience: The chain reaction of dendritic integration
    Stephen R Williams
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 19:R956-7. 2009
  9. pmc Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons
    Susan E Atkinson
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    J Neurophysiol 102:735-51. 2009
  10. doi request reprint Action potential generation requires a high sodium channel density in the axon initial segment
    Maarten H P Kole
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Garran Road, Canberra ACT 0200, Australia
    Nat Neurosci 11:178-86. 2008

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The back and forth of dendritic plasticity
    Stephen R Williams
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Neuron 56:947-53. 2007
    ....
  2. pmc Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro
    Stephen R Williams
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Physiol 539:469-83. 2002
    ..Following the downregulation of I(H), synaptic inhibition can generate long periods (seconds) of quiescence, the duration of which can be controlled by climbing fibre activation and by the underlying 'tone' of parallel fibre activity...
  3. doi request reprint Direct measurement of somatic voltage clamp errors in central neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Neurosci 11:790-8. 2008
    ..These errors question the use of the somatic voltage clamp as a quantitative tool in dendritic neurons...
  4. ncbi request reprint Encoding and decoding of dendritic excitation during active states in pyramidal neurons
    Stephen R Williams
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 25:5894-902. 2005
    ..During active states, therefore, distal excitatory synaptic inputs decisively control the excitatory synaptic output of layer 5 neocortical pyramidal neurons and so powerfully influence network activity in the neocortex...
  5. ncbi request reprint Spatial compartmentalization and functional impact of conductance in pyramidal neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Neurosci 7:961-7. 2004
    ..The dendritic arborization and voltage-activated channel complement of rat neocortical pyramidal neurons are therefore optimized to allow distributed processing under realistic conductance states...
  6. pmc Pathway-specific use-dependent dynamics of excitatory synaptic transmission in rat intracortical circuits
    Stephen R Williams
    Neurobiology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    J Physiol 585:759-77. 2007
    ....
  7. ncbi request reprint Voltage- and site-dependent control of the somatic impact of dendritic IPSPs
    Stephen R Williams
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Neurosci 23:7358-67. 2003
    ....
  8. doi request reprint Neuroscience: The chain reaction of dendritic integration
    Stephen R Williams
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 19:R956-7. 2009
    ..A recent study shows how pyramidal neurons of the mammalian neocortex integrate synaptic input in a parallel manner, illustrating how a chain of dendritic integration mechanisms act to signal distal dendritic excitatory synaptic input...
  9. pmc Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons
    Susan E Atkinson
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    J Neurophysiol 102:735-51. 2009
    ..Thus an age-dependent increase in apical dendritic HCN channel density ensures that L5 pyramidal neurons develop from compact temporal integrators to compartmentalized integrators of basal and apical dendritic synaptic input...
  10. doi request reprint Action potential generation requires a high sodium channel density in the axon initial segment
    Maarten H P Kole
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Garran Road, Canberra ACT 0200, Australia
    Nat Neurosci 11:178-86. 2008
    ..In conclusion, action potential generation requires a high Na(+) channel density at the AIS, which is maintained by tight anchoring to the actin cytoskeleton...
  11. ncbi request reprint Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons
    Stephen R Williams
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Science 295:1907-10. 2002
    ..These findings reveal that distal EPSPs are ineffective sources of background somatic excitation, but through coincidence detection have a powerful transient signaling role...
  12. pmc Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex
    Christian Wozny
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Cereb Cortex 21:1818-26. 2011
    ..In contrast, NGFCs strongly inhibited L2/3 pyramidal neurons (n = 12 out 27 pairs tested). These data reveal a high specificity of excitatory and inhibitory connections in the superficial layers of the neocortex...
  13. ncbi request reprint Role of dendritic synapse location in the control of action potential output
    Stephen R Williams
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Trends Neurosci 26:147-54. 2003
    ..Taken together, these data emphasize the cell- and input-specific strategies used by neurons to enhance the impact of dendritic inputs on action potential generation...
  14. doi request reprint Postnatal development of intrinsic and synaptic properties transforms signaling in the layer 5 excitatory neural network of the visual cortex
    Sarah J Etherington
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 OQH, United Kingdom
    J Neurosci 31:9526-37. 2011
    ....
  15. ncbi request reprint Dopamine gates action potential backpropagation in midbrain dopaminergic neurons
    Luc J Gentet
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 27:1892-901. 2007
    ..These data suggest that the release of dopamine from axonal and somatodendritic sites are dissociable, and that dopamine levels within the midbrain are dynamically controlled by the somatodendritic spread of action potentials...
  16. doi request reprint Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus
    Susan E Atkinson
    Division of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Biol Rhythms 26:210-20. 2011
    ..VIP/cAMP-dependent signaling sustains the SCN molecular oscillator and action potential firing via mechanisms yet to be identified...
  17. ncbi request reprint MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the starch microsphere model of ischemia
    Neil G Harris
    Unit of Biophysics, Institute of Child Health, University of London, London, United Kingdom
    Magn Reson Imaging 20:221-30. 2002
    ..Differences between Gd-DTPA-enhancement and HRP may reflect differences in the molecular size of the tracers...
  18. ncbi request reprint Numerical study of the steady state fluctuation relations far from equilibrium
    Stephen R Williams
    Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Chem Phys 124:194102. 2006
    ..We see no evidence for a discontinuity at this field strength...
  19. doi request reprint The glass transition and the Jarzynski equality
    Stephen R Williams
    Research School of Chemistry, The Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Chem Phys 129:134504. 2008
    ..It is shown how to compute the free energy differences for the nonequilibrium history-dependent glassy state such that it remains consistent with the standard expression for the entropy and with the second law inequality...
  20. doi request reprint Dissipation in monotonic and non-monotonic relaxation to equilibrium
    Charlotte F Petersen
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Chem Phys 144:074107. 2016
    ..At times, the system appears to be moving away from a uniform density distribution. In both cases, the dissipation function satisfies the modified second law inequality, and the dissipation theorem is demonstrated. ..
  21. ncbi request reprint On the entropy of relaxing deterministic systems
    Denis J Evans
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, AustraliaQueensland Micro and Nanotechnology Centre and School of Biomolecular and Physical Sciences, Griffith University, Brisbane, QLD 4111, Australia
    J Chem Phys 135:194107. 2011
    ....
  22. ncbi request reprint A proof of Clausius' theorem for time reversible deterministic microscopic dynamics
    Denis J Evans
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Chem Phys 134:204113. 2011
    ..Our result relies on some recently derived theorems, such as the Evans-Searles and the Crooks fluctuation theorems and the recently discovered relaxation and dissipation theorems...
  23. ncbi request reprint Nonequilibrium dynamics and umbrella sampling
    Stephen R Williams
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    Phys Rev Lett 105:110601. 2010
    ..The umbrella weight, which is related to the nonequilibrium work, is easy to obtain and efficient to compute. Furthermore, its average may be obtained from the existing nonequilibrium free energy theorem...
  24. doi request reprint Musings on thermostats
    Denis J Evans
    Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Chem Phys 133:104106. 2010
    ..Using the recently discovered relaxation theorem, we give a mathematical proof that this is true...
  25. ncbi request reprint Statistical mechanics of time independent nondissipative nonequilibrium states
    Stephen R Williams
    Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Chem Phys 127:184101. 2007
    ..The transient fluctuation relations thus provide an independent quantitative justification for the assumptions used in our statistical mechanical treatment of these systems...
  26. ncbi request reprint Time-dependent response theory and nonequilibrium free-energy relations
    Stephen R Williams
    Research School of Chemistry, The Australian National University, Canberra, ACT 0200, Australia
    Phys Rev E Stat Nonlin Soft Matter Phys 78:021119. 2008
    ..We make a few remarks concerning the maximum entropy production approximation...
  27. doi request reprint The instantaneous fluctuation theorem
    Charlotte F Petersen
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Chem Phys 139:184106. 2013
    ..We demonstrate this relation computationally for a number of phase functions in a shear flow system and show that this non-locality in time is an essential component of the instantaneous fluctuation theorem. ..
  28. doi request reprint A mathematical proof of the zeroth "law" of thermodynamics and the nonlinear Fourier "law" for heat flow
    Denis J Evans
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Chem Phys 137:194109. 2012
    ..This constitutes a proof of what was called the "heat death of the Universe" as was widely discussed in the latter half of the 19th century...
  29. doi request reprint Non-equilibrium umbrella sampling applied to force spectroscopy of soft matter
    Y X Gao
    Research School of Chemistry, The Australian National University, Canberra, ACT 0200, Australia
    J Chem Phys 136:054902. 2012
    ..Our model experimental system is a bead fluctuating in a time-varying optical trap. We also show this for simulated force spectroscopy on a complex soft molecule--a piston-rotaxane...
  30. doi request reprint On the probability of violations of Fourier's law for heat flow in small systems observed for short times
    Denis J Evans
    Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Chem Phys 132:024501. 2010
    ..Our expressions are tested using nonequilibrium molecular dynamics simulations of heat flow between thermostated walls...
  31. pmc Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics
    Vincenzo Crunelli
    School of Biosciences, University of Cardiff, Museum Avenue, Cardiff CF10 3US, UK
    Philos Trans R Soc Lond B Biol Sci 357:1675-93. 2002
    ..As some of these novel cellular and intracellular properties are not restricted to thalamic astrocytes and neurons, their significance may well apply to (patho)physiological functions of glial and neuronal elements in other brain areas...
  32. ncbi request reprint Heart energy metabolism after intestinal ischaemia and reperfusion
    Giorgio Stefanutti
    Department of Paediatric Surgery, Institute of Child Health, London, England, UK
    J Pediatr Surg 39:179-83; discussion 179-83. 2004
    ..This study investigates the effects of intestinal I/R on heart energy metabolism and evaluates the effects of moderate hypothermia...
  33. ncbi request reprint Temporal relation between the ADC and DC potential responses to transient focal ischemia in the rat: a Markov chain Monte Carlo simulation analysis
    Martin D King
    RCS Unit of Biophysics, Institute of Child Health, University College, London, UK
    J Cereb Blood Flow Metab 23:677-88. 2003
    ..This work demonstrates a general analytical approach to the multivariate, longitudinal data-processing problem that commonly arises in stroke and other biomedical research...
  34. ncbi request reprint Robust quantification of short echo time 1H magnetic resonance spectra using the Padé approximant
    David C Williamson
    Imaging Science and Biomedical Engineering, Manchester, United Kingdom
    Magn Reson Med 55:762-71. 2006
    ..02 ppm. We suggest that the discrepancy may be due to the baseline contamination as supported by the simulation results; however, without an in vivo gold standard this remains difficult to demonstrate...