M Y Hasan

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. ncbi request reprint Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
  2. ncbi request reprint Effects of ascorbic acid on lead induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle
    M Y Hasan
    Department of Pharmacology, Faculty of Medicine, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Life Sci 73:1017-25. 2003
  3. doi request reprint Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime
    S M Nurulain
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Neurotox Res 16:60-7. 2009
  4. doi request reprint Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 28:920-8. 2008
  5. ncbi request reprint Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride
    G A Petroianu
    UAE University, Al Ain, UAE
    J Appl Toxicol 25:562-7. 2005
  6. ncbi request reprint alpha-Tocopherol modifies lead induced functional changes at murine neuromuscular junction
    M Y Hasan
    Department of Pharmacology, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Free Radic Res 38:1321-8. 2004
  7. ncbi request reprint Effects of alpha-tocopherol on diabetes-induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle
    M Y Hasan
    Department of Physiology, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Endocr Res 29:419-28. 2003
  8. doi request reprint In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate
    D E Lorke
    UAE University, Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates
    J Appl Toxicol 28:422-9. 2008
  9. doi request reprint Effect of intrathecal pralidoxime administration upon survival of rats exposed to the organophosphate paraoxon
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    Neurotoxicology 29:663-70. 2008
  10. ncbi request reprint Paraoxon has only a minimal effect on pralidoxime brain concentration in rats
    G A Petroianu
    Department of Pharmacology and Therapeutics, FMHS, United Arab Emirates University, Al Ain, United Arab Emirates
    J Appl Toxicol 27:350-7. 2007

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
    ..Further studies involving different organophosphates and dosages, as well as different animal species, will be needed both to con fi rm these initial findings and to address the issue of the optimal timing for RAN preadministration...
  2. ncbi request reprint Effects of ascorbic acid on lead induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle
    M Y Hasan
    Department of Pharmacology, Faculty of Medicine, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Life Sci 73:1017-25. 2003
    ..This effect of ascorbic acid on lead induced neuromyopathy is probably mediated via a free radical scavenging mechanism or modification of Ca(2+) homeostasis...
  3. doi request reprint Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime
    S M Nurulain
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Neurotox Res 16:60-7. 2009
    ..Further studies in other species exposed to a broader spectrum of OPCs are, however, necessary before considering their use in humans...
  4. doi request reprint Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 28:920-8. 2008
    ..Dosage calculations based on in vitro IC50 measurements may therefore in future replace in vivo LD50 determinations, thereby reducing the number of animals required...
  5. ncbi request reprint Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride
    G A Petroianu
    UAE University, Al Ain, UAE
    J Appl Toxicol 25:562-7. 2005
    ..The protective effect of tiapride on cholinesterase could be of practical relevance in the pretreatment of organophosphate poisoning. It is concluded that in vivo testing of TIA as an organophosphate protective agent is warranted...
  6. ncbi request reprint alpha-Tocopherol modifies lead induced functional changes at murine neuromuscular junction
    M Y Hasan
    Department of Pharmacology, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Free Radic Res 38:1321-8. 2004
    ..alpha-Tocopherol appears to protect against lead induced neuromuscular dysfunction. These effects of alpha-tocopherol are possibly mediated via a free radical mechanism or modification of calcium homeostasis...
  7. ncbi request reprint Effects of alpha-tocopherol on diabetes-induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle
    M Y Hasan
    Department of Physiology, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Endocr Res 29:419-28. 2003
    ..Alpha-tocopherol exerts a protective role against diabetes-induced peripheral muscle dysfunction. This effect is probably mediated via a free radical scavenging mechanism or modification of Ca2+ homeostasis...
  8. doi request reprint In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate
    D E Lorke
    UAE University, Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates
    J Appl Toxicol 28:422-9. 2008
    ..8), obidoxime (1.5), HI-6 (0.8), trimedoxime (2.9) and methoxime (5.9), with K-107 (17), K-108 (20), and K-113 (16) being the outstanding compounds...
  9. doi request reprint Effect of intrathecal pralidoxime administration upon survival of rats exposed to the organophosphate paraoxon
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    Neurotoxicology 29:663-70. 2008
    ..Supplementary injection of pentobarbital, presumably by its anticonvulsive action, has a superior efficacy compared to 2-PAM i.p. alone, irrespective of additional intrathecal 2-PAM administration...
  10. ncbi request reprint Paraoxon has only a minimal effect on pralidoxime brain concentration in rats
    G A Petroianu
    Department of Pharmacology and Therapeutics, FMHS, United Arab Emirates University, Al Ain, United Arab Emirates
    J Appl Toxicol 27:350-7. 2007
    ..Brain perfusion does not significantly alter 2-PAM measurements and is therefore considered unnecessary...
  11. ncbi request reprint Early morphological remodeling of neuromuscular junction in a murine model of diabetes
    M A Fahim
    Department of Physiology, Faculty of Medicine, United Arab Emirates University, Al Ain, United Arab Emirates
    J Appl Physiol (1985) 89:2235-40. 2000
    ..These changes are possibly related to alterations in Ca(2+) mobilization across muscle membrane. Other mechanisms such as free radical-mediated actions may also be implicated in STZ-induced effects on skeletal muscle...
  12. ncbi request reprint The impact of vitamin C on diabetes induced alterations at murine neuromuscular junction
    M Y Hasan
    Department of Physiology, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Endocr Res 28:49-59. 2002
    ..6 +/- 0.2 g to 3.9 +/- 0.3 g), impacted delayed half time of decay and increased MEPPs frequencies. Vitamin C improves diabetes-induced nerve and muscle dysfunction possibly via a free radical scavenging mechanism...
  13. ncbi request reprint Tiapride pre-treatment in acute exposure to paraoxon: comparison of effects of administration at different points-in-time in rats
    G A Petroianu
    Department of Pharmacology, FMHS UAE University, Al Ain, UAE
    Mol Cell Biochem 285:79-86. 2006
    ..We also have shown recently that in rats coadministration of TIA with the organophosphate paraoxon significantly decreases mortality without having an impact on red blood cell cholinesterase (RBC-AChE) activity...
  14. ncbi request reprint Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride
    G A Petroianu
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Int J Toxicol 24:79-86. 2005
    ..The protective effect of TIA on cholinesterase could be of practical relevance in the treatment of OP poisoning. The authors conclude that in vivo testing of TIA as an OP protective agent is warranted...
  15. ncbi request reprint Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the rat brain: comparison with obidoxime
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 27:482-90. 2007
    ..As already observed for pralidoxime, injection of POX before oxime administration had no influence upon penetration across the blood-brain barrier...
  16. ncbi request reprint The organophosphate paraoxon has no demonstrable effect on the murine immune system following subchronic low dose exposure
    M J Fernandez-Cabezudo
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Int J Immunopathol Pharmacol 21:891-901. 2008
    ..These data suggest that although subchronic exposure to paraoxon induced a transient inhibition in AChE activity, it had no demonstrable effect on the host immune system...
  17. ncbi request reprint Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of ranitidine
    G A Petroianu
    Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:60-7. 2005
    ..The protective effect of RAN on cholinesterase could be of practical relevance in the treatment of POX poisoning. We conclude that in vivo testing of RAN as an organophosphate protective agent is warranted...
  18. ncbi request reprint Comparison of two pre-exposure treatment regimens in acute organophosphate (paraoxon) poisoning in rats: tiapride vs. pyridostigmine
    G A Petroianu
    Department of Pharmacology and Therapeutics, FMHS UAE University, United Arab Emirates
    Toxicol Appl Pharmacol 219:235-40. 2007
    ..Tiapride pretreatment only (G2) is inferior to pyridostigmine pretreatment only (G4). The best results are achieved with pyridostigmine pretreatment only or pralidoxime treatment only (G4 and G6)...
  19. ncbi request reprint PD-136,450: a CCK2 (gastrin) receptor antagonist with antisecretory, anxiolytic and antiulcer activity
    S M A Bastaki
    Department of Pharmacology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Mol Cell Biochem 252:83-90. 2003
    ..Thus, PD may have utility as an adjunct therapy in peptic ulcer disease by countering the actions of gastrin and increasing acid neutralization and mucosal protection...
  20. ncbi request reprint Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level
    M A Fahim
    Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Physiol Res 62:313-21. 2013
    ..0+/-2.4 pg/mg wet tissue). Daily treatment of PQ for three weeks induces selective dopaminergic neuronal loss in the substantia nigra and significant behavioral and peripheral motor deficit effects. ..
  21. ncbi request reprint Subchronic exposure to high-dose ACE-inhibitor moexipril induces catalase activity in rat liver
    E Adeghate
    Department of Anatomy, UAE University, Faculty of Medicine and Health Sciences, Al Ain, UAE
    Mol Cell Biochem 280:159-63. 2005
    ..We suggest that some of the long-term advantages of ACE inhibitor use - beyond mere BP lowering - might be due to a PPAR mediated effect...
  22. doi request reprint Chromatographic separation of antiviral/anticancer nucleoside reverse transcriptase inhibitor drugs
    H Kalasz
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Anal Bioanal Chem 398:295-312. 2010
    ..The most recent development in the field of detection of plasma NtRTIs shows a tendency toward the use double- or triple-focusing mass spectrometry, the most specific and sensitive monitoring technique...
  23. ncbi request reprint Distribution of neuroendocrine cells in the small and large intestines of the one-humped camel (Camelus dromedarius)
    M Al Haj Ali
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Neuropeptides 41:293-9. 2007
    ..Finally, the distribution of these bioactive agents may give clues as to how these agents aid in the function of the intestinal tract of this desert animal...
  24. ncbi request reprint In vivo metoclopramide protection of cholinesterase from paraoxon inhibition: direct comparison with pralidoxime in subchronic low-dose exposure
    M Y Hasan
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    J Appl Toxicol 24:257-60. 2004
    ..Metoclopramide, in addition to being less effective as an RBC-AChE protective agent, also caused a failure to thrive in the POX+MCP-exposed rats, as evidenced by the changes in body weight...
  25. ncbi request reprint Trace metal profiles in hair samples from children in urban and rural regions of the United Arab Emirates
    M Y Hasan
    Department of Pharmacology, Faculty of Medicine, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Vet Hum Toxicol 46:119-21. 2004
    ....
  26. ncbi request reprint HPLC analysis of K-48 concentration in plasma
    H Kalasz
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvarad ter 4, 1089 Budapest, Hungary
    Anal Bioanal Chem 385:1062-7. 2006
    ..After i.m. administration of 50 mumol K-48, the time course of the concentration can be approximated by a straight line between 15 and 120 min meaning the elimination follows zero-order kinetics...
  27. ncbi request reprint High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator
    K Tekes
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    J Chromatogr A 1122:84-7. 2006
    ..K-27 displays initial (from 15 trough 120 min) zero order elimination kinetics. Similar results have been found after intraperitoneal administration...
  28. ncbi request reprint Monitoring the metabolism of moexipril to moexiprilat using high-performance liquid chromatography-electrospray ionization mass spectrometry
    J Koti
    Spectroscopic Research Division, Gedeon Richter Ltd, Budapest, Hungary
    J Chromatogr Sci 44:214-8. 2006
    ..The calibration curve is linear in the ng/mL and microg/mL concentration range of the injected moexipril...