W C De Mello

Summary

Affiliation: University of Puerto Rico

Publications

  1. ncbi request reprint Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components
    Mazen Kurdi
    Department of Medicine, The Cardiovascular Research Institute of the Texas A and M University System Health Science Center, College of Medicine, Scott and White Hospital, Temple, TX 76504, USA
    Int J Biochem Cell Biol 37:1357-67. 2005
  2. ncbi request reprint Renin increments the inward calcium current in the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, San Juan, Puerto Rico, USA
    J Hypertens 24:1181-6. 2006
  3. ncbi request reprint Electrical activity of the heart and angiotensin-converting enzyme inhibitors on the hyperpolarising action of enalapril
    W C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, San Juan, Puerto Rico, 00936, USA
    J Hum Hypertens 16:S89-92. 2002
  4. ncbi request reprint Cardiac intracrine renin angiotensin system. Part of genetic reprogramming?
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, PO Box 365067, San Juan, Puerto Rico
    Regul Pept 133:10-2. 2006
  5. ncbi request reprint Impaired cell communication in the diabetic heart. The role of the renin angiotensin system
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
    Mol Cell Biochem 296:53-8. 2007
  6. pmc Renin Angiotensin system as a regulator of cell volume. Implications to myocardial ischemia
    Walmor C De Mello
    Medical Sciences Campus, School of Medicine, UPR, San Juan, PR 00936 5067, USA
    Curr Cardiol Rev 5:65-8. 2009
  7. ncbi request reprint Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, School of Medicine, UPR, PR, USA
    J Renin Angiotensin Aldosterone Syst 8:74-80. 2007
  8. ncbi request reprint Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, School of Medicine, San Juan, PR 00936 5067, USA
    J Renin Angiotensin Aldosterone Syst 7:40-6. 2006
  9. doi request reprint Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume. Implications for myocardial ischaemia
    Walmor C De Mello
    Medical Sciences Campus, UPR, School of Medicine, San Juan, PR 00936 5067
    J Renin Angiotensin Aldosterone Syst 9:112-8. 2008
  10. pmc Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936 5067, USA
    Regul Pept 151:54-60. 2008

Detail Information

Publications29

  1. ncbi request reprint Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components
    Mazen Kurdi
    Department of Medicine, The Cardiovascular Research Institute of the Texas A and M University System Health Science Center, College of Medicine, Scott and White Hospital, Temple, TX 76504, USA
    Int J Biochem Cell Biol 37:1357-67. 2005
    ..A greater understanding of these extra-system functions of the RAS components may aid in the development of novel treatments for hypertension, myocardial ischemia, and heart failure...
  2. ncbi request reprint Renin increments the inward calcium current in the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, San Juan, Puerto Rico, USA
    J Hypertens 24:1181-6. 2006
    ..It is unknown whether renin can change the inward calcium current (ICa) in the failing heart. This problem was investigated in the present study...
  3. ncbi request reprint Electrical activity of the heart and angiotensin-converting enzyme inhibitors on the hyperpolarising action of enalapril
    W C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, San Juan, Puerto Rico, 00936, USA
    J Hum Hypertens 16:S89-92. 2002
    ..The hyperpolarising action of enalapril is described and evidence is presented that the activation of the sodium-potassium pump is involved in the increment in membrane potential elicited by the ACE inhibitor...
  4. ncbi request reprint Cardiac intracrine renin angiotensin system. Part of genetic reprogramming?
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, PO Box 365067, San Juan, Puerto Rico
    Regul Pept 133:10-2. 2006
    ....
  5. ncbi request reprint Impaired cell communication in the diabetic heart. The role of the renin angiotensin system
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
    Mol Cell Biochem 296:53-8. 2007
    ..In conclusion, Cell communication and impulse propagation are significantly impaired in the ventricle from diabetic rats, a phenomenon partly related to the activation of the RAS...
  6. pmc Renin Angiotensin system as a regulator of cell volume. Implications to myocardial ischemia
    Walmor C De Mello
    Medical Sciences Campus, School of Medicine, UPR, San Juan, PR 00936 5067, USA
    Curr Cardiol Rev 5:65-8. 2009
    ....
  7. ncbi request reprint Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, School of Medicine, UPR, PR, USA
    J Renin Angiotensin Aldosterone Syst 8:74-80. 2007
    ..The presence of Angiotensin (1-7) (Ang 1-7) and ACE 2 in the ventricle of cardiomyopathic hamsters as well as the influence of Ang (1-7) on membrane potential, impulse propagation and cardiac excitability were investigated...
  8. ncbi request reprint Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, School of Medicine, San Juan, PR 00936 5067, USA
    J Renin Angiotensin Aldosterone Syst 7:40-6. 2006
    ..The effect of chronic administration of eplerenone on cardiac remodelling and electrical properties was investigated in the failing heart of cardiomyopathic hamsters (TO-2) at five months of age...
  9. doi request reprint Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume. Implications for myocardial ischaemia
    Walmor C De Mello
    Medical Sciences Campus, UPR, School of Medicine, San Juan, PR 00936 5067
    J Renin Angiotensin Aldosterone Syst 9:112-8. 2008
    ..This increase of cell volume elicited by extracellular renin plus Ao was related to the activation of the Na-K-2Cl cotransporter; e) intracellular Ang II (10(-8) M) reversed cell swelling induced by hypotonic solutions...
  10. pmc Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936 5067, USA
    Regul Pept 151:54-60. 2008
    ....
  11. ncbi request reprint Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936 5067, USA
    J Renin Angiotensin Aldosterone Syst 5:203-8. 2004
    ..The effect of angiotensin (1-7) (Ang 1-7) on membrane potential and excitability of rat heart muscle under ischaemia/reperfusion was investigated...
  12. ncbi request reprint Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart
    Walmor C De Mello
    Department of Pharmacology, University of Puerto Rico, San Juan, PR 00936 5067
    Hypertension 44:360-4. 2004
    ..Moreover, intracellular enalaprilat by itself reduced the peak I(Ca) density. These observations might indicate that endogenous Ang II is contributing to I(Ca) modulation in the failing heart...
  13. ncbi request reprint Heart failure: how important is cellular sequestration? The role of the renin-angiotensin-aldosterone system
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, University Puerto Rico, P O Box 365067, San Juan, PR 00936 5067, USA
    J Mol Cell Cardiol 37:431-8. 2004
    ....
  14. ncbi request reprint Angiotensin converting enzyme and the arrhythmogenic action of angiotensin I: cardiac cell membrane as a site of angiotensin I conversion
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, UPR, P O Box 365067, San Juan, PR 00936 5067, USA
    Regul Pept 121:83-8. 2004
    ..The results indicated that Ang I (10(-8) M), added to the bath solution, reduced the peak ICa density by 26.3 +/- 2.6% (P < 0.05), an effect abolished by enalapril maleate (10(-8)M)...
  15. ncbi request reprint Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
    Regul Pept 115:31-6. 2003
    ....
  16. ncbi request reprint Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system
    Walmor De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
    Regul Pept 114:87-90. 2003
    ..Moreover, I discussed the most relevant information about the origin of cardiac renin, the presence of a cardiac renin-angiotensin aldosterone system and its possible relevance for heart cell physiology and pathology...
  17. ncbi request reprint Cardiac arrhythmias: the possible role of the renin-angiotensin system
    W C De Mello
    Department of Pharmacology, UPR, San Juan, Puerto Rico 00936 5067, USA
    J Mol Med (Berl) 79:103-8. 2001
    ..Particular emphasis is given to the effects of angiotensin II on the electrical properties of the failing heart and the beneficial effects of angiotensin-converting enzyme inhibitors and angiotensin II AT1 receptor blockade...
  18. ncbi request reprint Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936 5067, USA
    J Renin Angiotensin Aldosterone Syst 7:201-5. 2006
    ..05) by losartan. The % area of interstitial fibrosis measured in the wall of the left ventricle was reduced from 22+1.4% (n=18) to 14+1.3% (n=18) (p<0.05) after losartan administration...
  19. pmc Prolonged exposure of cardiac cells to renin plus angiotensinogen reduces intracellular renin in the failing heart. On the role of angiotensin II-AT1 complex internalization
    Walmor C De Mello
    Medical Sciences Campus, UPR, School of Medicine, San Juan, PR 00936 5067, USA
    Regul Pept 155:139-44. 2009
    ....
  20. ncbi request reprint Cell coupling and impulse propagation in the failing heart
    W C De Mello
    Department of Pharmacology, School of Medicine, University of Puerto Rico, San Juan, USA
    J Cardiovasc Electrophysiol 10:1409-20. 1999
    ....
  21. ncbi request reprint Chronic administration of losartan plus hydrochlorothiazide improves vascular status in young cardiomyopathic hamsters
    M J Crespo
    Department of Pharmacology, University of Puerto Rico School of Medicine, GPO Box 365067, San Juan, Puerto Rico 00936 5067, USA
    Eur J Pharmacol 420:133-41. 2001
    ....
  22. doi request reprint Further studies on the effects of intracrine and extracellular angiotensin II on the regulation of heart cell volume. On the influence of aldosterone and spironolactone
    W C De Mello
    Medical Sciences Campus, School of Medicine, University of Puerto Rico, San Juan, PR 00936 5067, USA
    Regul Pept 165:200-5. 2010
    ..The implications of these findings to the failing heart and myocardial ischemia are discussed...
  23. doi request reprint Novel aspects of angiotensin II action in the heart. Implications to myocardial ischemia and heart failure
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936 5067, USA
    Regul Pept 166:9-14. 2011
    ..The discovery of ACE2 and its relevance to heart pathology was also discussed...
  24. doi request reprint Angiotensin (1-7) reduces the cell volume of swollen cardiac cells and decreases the swelling-dependent chloride current. Implications for cardiac arrhythmias and myocardial ischemia
    Walmor C De Mello
    Medical Sciences Campus, UPR, School of Medicine, PO Box 365067, San Juan, PR 00936 5067, USA
    Peptides 31:2322-4. 2010
    ..The implications for myocardial ischemia and cardiac arrhythmias are discussed...
  25. pmc Cell swelling impairs dye coupling in adult rat ventricular myocytes. Cell volume as a regulator of cell communication
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, UPR, San Juan, PR 00936 5067
    Mol Cell Biochem 343:107-13. 2010
    ....
  26. doi request reprint Cell swelling, impulse conduction, and cardiac arrhythmias in the failing heart. Opposite effects of angiotensin II and angiotensin (1-7) on cell volume regulation
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, 00936 5067, USA
    Mol Cell Biochem 330:211-7. 2009
    ..Implications to myocardial ischemia are discussed...
  27. ncbi request reprint Aldosterone modulates the effect of angiotensin II on the electrical properties of rat heart
    Walmor C De Mello
    Department of Pharmacology, School of Medicine, UPR San Juan, Puerto Rico, USA
    J Cardiovasc Pharmacol 40:90-5. 2002
    ..These findings indicate that effect of angiotensin II on electrical and probably other properties of the heart must be evaluated considering the presence or absence of aldosterone...
  28. doi request reprint Metallothionein reverses the harmful effects of angiotensin II on the diabetic heart
    Walmor C De Mello
    J Am Coll Cardiol 52:667-9. 2008
  29. ncbi request reprint On the pathophysiological implications of an intracellular renin receptor
    Walmor C De Mello
    Circ Res 99:1285-6. 2006