Andrei D Iacobas

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine USA
    Front Integr Neurosci 1:10. 2007
  2. ncbi request reprint Connexin-dependent transcellular transcriptomic networks in mouse brain
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA
    Prog Biophys Mol Biol 94:169-85. 2007
  3. pmc Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Commun Adhes 15:195-206. 2008
  4. pmc Improved procedures to mine data obtained from spotted cDNA arrays
    Andrei D Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biomol Tech 13:5-19. 2002
  5. pmc Connexin43 and the brain transcriptome of newborn mice
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genomics 89:113-23. 2007
  6. ncbi request reprint Transcriptomic changes in developing kidney exposed to chronic hypoxia
    Dumitru A Iacobas
    Department of Neuroscience, Kennedy Center, Room 915C, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York, NY 10461, USA
    Biochem Biophys Res Commun 349:329-38. 2006
  7. pmc A stochastic two-dimensional model of intercellular Ca2+ wave spread in glia
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Biophys J 90:24-41. 2006
  8. ncbi request reprint Control and variability of gene expression in mouse brain and in a neuroblastoma cell line
    D A Iacobas
    Albert Einstein College of Medicine, Department of Neuroscience, Molecular Biology Core, Rose F Kennedy Center, Room 915C, 1410 Pelham Parkway South, New York, NY 10461, USA
    Rom J Physiol 39:71-90. 2002
  9. ncbi request reprint Sensitivity of the brain transcriptome to connexin ablation
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 915C, New York, NY 10461, United States
    Biochim Biophys Acta 1711:183-96. 2005
  10. pmc Hits and misses from gene expression ratio measurements in cDNA microarray studies
    Dumitru A Iacobas
    Department of Neuroscience, Molecular Biology Core, Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biomol Tech 13:143-57. 2002

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine USA
    Front Integr Neurosci 1:10. 2007
    ..We propose that up- or down-regulation of genes linked to those targeted by the disease could potentially compensate for the pathological transcriptomic changes...
  2. ncbi request reprint Connexin-dependent transcellular transcriptomic networks in mouse brain
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA
    Prog Biophys Mol Biol 94:169-85. 2007
    ..The transcription factors also formed network hubs with genes from other functional categories, thus allowing regulation of one functional pathway through manipulation of another...
  3. pmc Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Commun Adhes 15:195-206. 2008
    ....
  4. pmc Improved procedures to mine data obtained from spotted cDNA arrays
    Andrei D Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biomol Tech 13:5-19. 2002
    ....
  5. pmc Connexin43 and the brain transcriptome of newborn mice
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genomics 89:113-23. 2007
    ..This study indicates striking redundancy of expression controls over functional pathways and suggests that certain genes may play roles similar to or opposite that of Cx43 in organizing the brain transcriptome...
  6. ncbi request reprint Transcriptomic changes in developing kidney exposed to chronic hypoxia
    Dumitru A Iacobas
    Department of Neuroscience, Kennedy Center, Room 915C, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York, NY 10461, USA
    Biochem Biophys Res Commun 349:329-38. 2006
    ..Transcriptional control was enhanced in CCH but not in CIH. Thus, CCH and CIH both alter gene expression and retard maturation with the more profound changes occurring in CCH than in CIH...
  7. pmc A stochastic two-dimensional model of intercellular Ca2+ wave spread in glia
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Biophys J 90:24-41. 2006
    ..Such modeling is expected to be useful for testing phenomenological hypotheses and in understanding consequences of alteration of system components under experimental or pathological conditions...
  8. ncbi request reprint Control and variability of gene expression in mouse brain and in a neuroblastoma cell line
    D A Iacobas
    Albert Einstein College of Medicine, Department of Neuroscience, Molecular Biology Core, Rose F Kennedy Center, Room 915C, 1410 Pelham Parkway South, New York, NY 10461, USA
    Rom J Physiol 39:71-90. 2002
    ..In brains of different animals and in separate cultures of N2A cells, unique sets ofgenes exhibited exceptional stability or were highly variable. Possible implications for such tight or loose transcriptional control are discussed...
  9. ncbi request reprint Sensitivity of the brain transcriptome to connexin ablation
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 915C, New York, NY 10461, United States
    Biochim Biophys Acta 1711:183-96. 2005
    ..These findings lead to the hypothesis that connexin expression may represent a central node in the regulation of gene expression patterns in brain...
  10. pmc Hits and misses from gene expression ratio measurements in cDNA microarray studies
    Dumitru A Iacobas
    Department of Neuroscience, Molecular Biology Core, Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biomol Tech 13:143-57. 2002
    ..These algorithms reduced the variability not associated with biological system to less than a quarter of its initial value and have substantially enhanced reliability in experiments on brain and cultured neuroblastoma cells...
  11. ncbi request reprint Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart
    Dumitru A Iacobas
    Department of Neuroscience Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Physiol Genomics 20:211-23. 2005
    ..These findings reinforce the proposal that the cardiac abnormality in Cx43 null animals may be contributed by altered innervation and indicate that Cx43 deletion has consequences in addition to reduced intercellular communication...
  12. pmc Array analysis of gene expression in connexin-43 null astrocytes
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, New York 10461, USA
    Physiol Genomics 15:177-90. 2003
    ..These data indicate a surprisingly high degree of impact of deletion of Cx43 on other astrocyte genes, implying that gap junction gene expression alters numerous processes in addition to intercellular communication...
  13. pmc Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival
    Dumitru A Iacobas
    DP Purpura Department of Neuroscience, Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Funct Integr Genomics 8:265-75. 2008
    ..Moreover, the transcriptomic networks were profoundly and differently remodeled by CCH and CIH...
  14. ncbi request reprint Gap junction and purinergic P2 receptor proteins as a functional unit: insights from transcriptomics
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Membr Biol 217:83-91. 2007
    ..It is proposed that coordination analysis of gene expression may provide a novel unbiased strategy for the identification of proteins belonging to supramolecular complexes...
  15. pmc Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia
    Chenhao Fan
    Departments of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Physiol Genomics 22:292-307. 2005
    ....
  16. ncbi request reprint Gene expression alterations in connexin null mice extend beyond the gap junction
    Dumitru A Iacobas
    Department of Neuroscience, Albert Einstein College of Medicine, Kennedy Center, Room 915C, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Neurochem Int 45:243-50. 2004
    ..Here we discuss those results in the context of the strategies and data analysis paradigms that we are using in such studies...
  17. ncbi request reprint Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Parasitol Res 91:187-96. 2003
    ..The regulated genes are interpreted in the pathogenesis of chagasic heart disease...
  18. ncbi request reprint Organizational principles of the connexin-related brain transcriptome
    David C Spray
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    J Membr Biol 218:39-47. 2007
    ..These findings suggest several principles regarding regulatory transcriptomic networks involving gap junction genes and raise the issue of the underlying cause of connexin null phenotypes as well as mechanisms of regulation...
  19. pmc Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis
    Elimor Brand-Schieber
    Department of Neurology, Albert Einstein College Medicine, Bronx, NY 10461, USA
    J Neurosci Res 80:798-808. 2005
    ..Our data support the notion that, in addition to damage of myelinating glia, altered astrocyte connectivity is a prominent feature of inflammatory demyelination...
  20. pmc Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes
    Regina Coeli Dos Santos Goldenberg
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Microbes Infect 11:1140-9. 2009
    ....
  21. pmc Heart rhythm genomic fabric in hypoxia
    Dumitru A Iacobas
    DP Purupura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biochem Biophys Res Commun 391:1769-74. 2010
    ....
  22. ncbi request reprint Fluid shear stress upregulates vascular endothelial growth factor gene expression in osteoblasts
    Mia M Thi
    Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, New York 10461, USA
    Ann N Y Acad Sci 1117:73-81. 2007
    ....

Research Grants1

  1. "Connexin-Dependent Transcriptomic Networks in Controlling the Heart Rhythm"
    DUMITRU ANDREI IACOBAS; Fiscal Year: 2010
    ..Our project has the unique feature of describing and quantifying the Cx40- and Cx43-dependent Gene Regulatory Networks of the heart rhythm, with the long term goal to open novel therapeutic horizons in cardiology. ..