L Velisek

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint New avenue of research: antiepileptic drug and estradiol neuroprotection in epilepsy
    LIBOR VELISEK
    The Saul R Korey of Department of Neurology, Einstein Montefiore Comprehensive Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Recent Pat CNS Drug Discov 3:128-37. 2008
  2. ncbi request reprint Estrogen treatment protects GABA(B) inhibition in the dentate gyrus of female rats after kainic acid-induced status epilepticus
    LIBOR VELISEK
    Department of Neurology K312, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
    Epilepsia 43:146-51. 2002
  3. ncbi request reprint Effects of brief seizures during development
    LIBOR VELISEK
    Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Einstein Montefiore Epilepsy Management Center, Bronx, NY 10461, USA
    Prog Brain Res 135:355-64. 2002
  4. ncbi request reprint Developmental aspects of the basal ganglia and therapeutic perspectives
    JANA VELISKOVA
    Deptartment of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Epileptic Disord 4:S73-82. 2002
  5. pmc Metabolic environment in substantia nigra reticulata is critical for the expression and control of hypoglycemia-induced seizures
    LIBOR VELISEK
    The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:9349-62. 2008
  6. ncbi request reprint Prenatal morphine exposure suppresses mineralocorticoid receptor-dependent basal synaptic transmission and synaptic plasticity in the lateral perforant path in adult male rats
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, K 314, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Brain Res Bull 61:571-6. 2003
  7. ncbi request reprint Temporal lobe epileptogenesis and epilepsy in the developing brain: bridging the gap between the laboratory and the clinic. Progression, but in what direction?
    L Velisek
    Department of Neurology K314, and Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
    Epilepsia 44:51-9. 2003
  8. ncbi request reprint Seizures in the developing brain
    JANA VELISKOVA
    Department of Neurology, Montofiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
    Epilepsia 45:6-12. 2004
  9. ncbi request reprint Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neurobiol Dis 18:346-55. 2005
  10. pmc Prenatal corticosteroid impact on hippocampus: implications for postnatal outcomes
    LIBOR VELISEK
    Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Einstein Montefiore Epilepsy Management Center, Bronx, NY 10461, USA
    Epilepsy Behav 7:57-67. 2005

Research Grants

  1. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
  2. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004

Collaborators

Detail Information

Publications44

  1. ncbi request reprint New avenue of research: antiepileptic drug and estradiol neuroprotection in epilepsy
    LIBOR VELISEK
    The Saul R Korey of Department of Neurology, Einstein Montefiore Comprehensive Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Recent Pat CNS Drug Discov 3:128-37. 2008
    ....
  2. ncbi request reprint Estrogen treatment protects GABA(B) inhibition in the dentate gyrus of female rats after kainic acid-induced status epilepticus
    LIBOR VELISEK
    Department of Neurology K312, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
    Epilepsia 43:146-51. 2002
    ..Additionally, we determined whether the lost function could be preserved by using estrogen neuroprotection...
  3. ncbi request reprint Effects of brief seizures during development
    LIBOR VELISEK
    Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Einstein Montefiore Epilepsy Management Center, Bronx, NY 10461, USA
    Prog Brain Res 135:355-64. 2002
    ....
  4. ncbi request reprint Developmental aspects of the basal ganglia and therapeutic perspectives
    JANA VELISKOVA
    Deptartment of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Epileptic Disord 4:S73-82. 2002
    ..Better understanding of the influence of the endocrine system on brain development and neuronal activity may provide new insight into the treatment of age- and sex-dependent seizure disorders...
  5. pmc Metabolic environment in substantia nigra reticulata is critical for the expression and control of hypoglycemia-induced seizures
    LIBOR VELISEK
    The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:9349-62. 2008
    ..The results suggest that fasting and insulin-induced hypoglycemia can lead to impairment in the function of the SNR, leading thus to hypoglycemic seizures...
  6. ncbi request reprint Prenatal morphine exposure suppresses mineralocorticoid receptor-dependent basal synaptic transmission and synaptic plasticity in the lateral perforant path in adult male rats
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, K 314, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Brain Res Bull 61:571-6. 2003
    ....
  7. ncbi request reprint Temporal lobe epileptogenesis and epilepsy in the developing brain: bridging the gap between the laboratory and the clinic. Progression, but in what direction?
    L Velisek
    Department of Neurology K314, and Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, U S A
    Epilepsia 44:51-9. 2003
    ..Novel strategies for the prevention and treatment of mesial temporal lobe epilepsy and hippocampal sclerosis may include rational use of neuroprotective agents, hormonotherapy, immunizations, and immunotherapy...
  8. ncbi request reprint Seizures in the developing brain
    JANA VELISKOVA
    Department of Neurology, Montofiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
    Epilepsia 45:6-12. 2004
    ..By contrast, female SNR does not contain any region that mediates muscimol-related proconvulsant effects. As with the adult, immature female rats do not develop a proconvulsant SNR region at any age...
  9. ncbi request reprint Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neurobiol Dis 18:346-55. 2005
    ....
  10. pmc Prenatal corticosteroid impact on hippocampus: implications for postnatal outcomes
    LIBOR VELISEK
    Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Einstein Montefiore Epilepsy Management Center, Bronx, NY 10461, USA
    Epilepsy Behav 7:57-67. 2005
    ....
  11. ncbi request reprint Mifepristone (RU486) inhibits lateral perforant path long-term potentiation in hippocampal slices from prenatally morphine-exposed female rats
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Int J Dev Neurosci 23:559-65. 2005
    ....
  12. ncbi request reprint Prenatal exposure to betamethasone decreases anxiety in developing rats: hippocampal neuropeptide y as a target molecule
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuropsychopharmacology 31:2140-9. 2006
    ..This differentiation can lead to specific therapeutic interventions directed against the side effects without eliminating the beneficial main effect of the corticosteroid treatment...
  13. ncbi request reprint Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Neurol 201:203-11. 2006
    ..Although GABAergic inhibition in the SNR affects tonic-clonic seizures in developing rats, only the NMDA antagonist had consistent anticonvulsant effects throughout development...
  14. ncbi request reprint CNS aspects of prenatal drug exposure: drugs of abuse, toxins, and corticosteroids
    LIBOR VELISEK
    AECOM, K314, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Ann N Y Acad Sci 1074:577-89. 2006
    ....
  15. ncbi request reprint Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain
    LIBOR VELISEK
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 61:109-19. 2007
    ....
  16. ncbi request reprint [Effects of sex hormones in the CNS]
    J Veliskova
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cesk Fysiol 53:66-75. 2004
    ..Effects of sex hormones on seizure susceptibility and neuroprotective effects of beta-estradiol on status epilepticus-induced hippocampal damage will be discussed...
  17. ncbi request reprint Extracellular acidosis and high levels of carbon dioxide suppress synaptic transmission and prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Hippocampus 8:24-32. 1998
    ..3. The results suggest that extracellular acidosis associated with several pathological conditions in the CNS may significantly diminish the LTP induction, and thus negatively affect all physiological processes that utilize LTP...
  18. ncbi request reprint Increased susceptibility of brain slices from carbonic anhydrase II-deficient mice to low [Mg2+]O-induced seizures
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurosci Lett 207:143-6. 1996
    ..3...
  19. ncbi request reprint Site-specific effects of local pH changes in the substantia nigra pars reticulata on flurothyl-induced seizures
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 782:310-3. 1998
    ..7 and 7.4 on flurothyl seizures. In contrast in the posterior SNR, microinfusions with pH 6.7 had proconvulsant effects. The results suggest that local pH changes may have site-specific effects on seizure susceptibility in vivo...
  20. ncbi request reprint Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures
    J Veliskova
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Epilepsy Res 30:107-14. 1998
    ..Our data demonstrate that the BZD1 binding sites are involved in the SNR control of flurothyl seizures in adult and PN 15 male rats...
  21. ncbi request reprint Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 796:247-56. 1998
    ..The present data demonstrate that the anticonvulsant effects of P on seizure susceptibility requires the presence of E. Furthermore, prenatal morphine exposure alters ovarian steroid hormone-regulated seizure susceptibility...
  22. ncbi request reprint Enhanced epileptogenicity of area tempestas in the immature rat
    E F Sperber
    Department of Neurology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, N Y 10461, USA
    Dev Neurosci 20:540-5. 1998
    ..This study indicates that the area tempestas is particularly epileptogenic in the immature rat...
  23. ncbi request reprint Prenatal morphine exposure differentially alters seizure susceptibility in developing female rats
    J Veliskova
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Dev Brain Res 116:119-21. 1999
    ..At PN 38, morphine exposure did not influence either threshold. The data suggest that the effects of prenatal exposure to opioids on seizures are age-related and transient...
  24. ncbi request reprint Region-specific modulation of limbic seizure susceptibility by ovarian steroids
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Brain Res 842:132-8. 1999
    ....
  25. ncbi request reprint Prenatal morphine exposure enhances seizure susceptibility but suppresses long-term potentiation in the limbic system of adult male rats
    L Velisek
    Department of Neurology, K 312, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York, NY 10461, USA
    Brain Res 869:186-93. 2000
    ..These data suggest that prenatal morphine exposure enhances the susceptibility of entorhinal cortex to the induction of epileptiform activity, but shifts long-term plasticity of hippocampal synapses in favor of LTD...
  26. ncbi request reprint Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus
    J Veliskova
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Epilepsia 41:S30-5. 2000
    ..Estrogens have neuroprotective effects in ischemia, stroke, and other conditions leading to neuronal cell death (e.g., Alzheimer's disease). The present study examined whether estrogens may have neuroprotective effects after seizures...
  27. ncbi request reprint Sexual dimorphism and developmental regulation of substantia nigra function
    J Veliskova
    Department of Neurology, and Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 50:596-601. 2001
    ..The recognition of the existence of distinct sex- and age-specific substantia nigra features can be translated into new cures of disorders affecting the substantia nigra...
  28. ncbi request reprint The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific
    J Veliskova
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurosci Lett 316:108-10. 2001
    ..The region-specific effects in the SNR may provide an explanation for the previous conflicting reports regarding infusions of N-methyl-D-aspartate antagonists into this structure...
  29. ncbi request reprint Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures
    J Veliskova
    Department of Neurology, Albert Einstein College of Medicine, Bronyx, NY, USA
    Eur J Pharmacol 309:167-73. 1996
    ..There was no regional specificity. The data suggest that with maturation there is functional segregation of specific GABAA receptor subtypes involved in substantia nigra-mediated seizure control...
  30. ncbi request reprint Effect of ganaxolone on flurothyl seizures in developing rats
    S Liptáková
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    Epilepsia 41:788-93. 2000
    ..Epalons are classified as neuroactive steroids that interact at unique site of the GABAA receptor-Cl- channel complex in the central nervous system...
  31. ncbi request reprint Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461
    Epilepsy Res 14:115-21. 1993
    ..The exact mechanism of anticonvulsant action by CA inhibition, however, remains to be elucidated...
  32. ncbi request reprint Correlation between extracellular glucose and seizure susceptibility in adult rats
    Evan M Schwechter
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Ann Neurol 53:91-101. 2003
    ..Data indicate that, in the adult rats, high glucose concentrations are associated with proconvulsant effects...
  33. ncbi request reprint Electrical stimulation of substantia nigra pars reticulata is anticonvulsant in adult and young male rats
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Exp Neurol 173:145-52. 2002
    ..The data suggest that the SNR may be a candidate site for deep brain stimulation for the treatment of epilepsy...
  34. ncbi request reprint Resistance of hippocampal synaptic transmission to hypoxia in carbonic anhydrase II-deficient mice
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 671:245-53. 1995
    ....
  35. doi request reprint Oestradiol Regulates Neuropeptide Y Release and Gene Coupling with the GABAergic and Glutamatergic Synapses in the Adult Female Rat Dentate Gyrus
    J Veliskova
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA
    J Neuroendocrinol 27:911-20. 2015
    ....
  36. ncbi request reprint Age-dependent consequences of status epilepticus: animal models
    Morris H Scantlebury
    Korey Department of Neurology, Albert Einstein College of Medicine, Pelham Parkway South, Kennedy Center, Bronx, NY, USA
    Epilepsia 48:75-82. 2007
    ..Better understanding of the pathophysiologic mechanisms underlying the age-specific alterations to the brain induced by SE will lead to the development of novel and effective strategies to improve the deleterious consequences...
  37. ncbi request reprint The involvement of the substantia nigra pars reticulata in hypoglycemic seizures
    JANA VELISKOVA
    Department of Neurology, and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Epilepsia 48:106-8. 2007
    ..These data suggest that during hypoglycemia, the SNR seizure controlling system has different properties than in seizure models not involving a metabolic stress...
  38. ncbi request reprint Beta-estradiol increases dentate gyrus inhibition in female rats via augmentation of hilar neuropeptide Y
    JANA VELISKOVA
    Saul R Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine and the Einstein Montefiore Comprehensive Epilepsy Management Center, Bronx, New York 10461, USA
    J Neurosci 27:6054-63. 2007
    ....
  39. ncbi request reprint Low-frequency stimulation of the kindling focus delays basolateral amygdala kindling in immature rats
    LIBOR VELISEK
    Department of Neurology, Albert Einstein College of Medicine, K314, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neurosci Lett 326:61-3. 2002
    ..As the kindling and LFS stimulation patterns are similar to those used for induction of long-term potentiation and long-term depression (LTD), respectively, LTD or depotentiation may play a role in the mechanism of action...
  40. pmc Females, their estrogens, and seizures
    JANA VELISKOVA
    The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York 10461, USA
    Epilepsia 51:141-4. 2010
    ..The effects of estrogens on seizures are contradictory. More studies are necessary to determine under which conditions the estrogens have proconvulsant effects and when the estrogens may have beneficial action in patients with epilepsy...
  41. pmc Model of cryptogenic infantile spasms after prenatal corticosteroid priming
    LIBOR VELISEK
    The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Epilepsia 51:145-9. 2010
    ....
  42. ncbi request reprint The effect of electrical stimulation of the subthalamic nucleus on seizures is frequency dependent
    Fred A Lado
    Department of Neurology, Comprehensive Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, U S A
    Epilepsia 44:157-64. 2003
    ..Animal studies and anecdotal human case reports have indicated that the subthalamic nucleus (STN) may be a site of anticonvulsant action...
  43. pmc Sex-specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy
    T Chachua
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA
    Genes Brain Behav 13:702-12. 2014
    ..This suggests that either the BRD2 gene is directly responsible for influencing many traits of JME or it controls upstream regulators of individual phenotypes. ..
  44. pmc Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: insights from a novel animal model of infantile spasms
    D A Iacobas
    Department of Pathology, New York Medical College, Valhalla, NY, USA
    J Neuroendocrinol 25:964-79. 2013
    ..Changes in transcript expression and their coordination may contribute to a molecular substrate of permanent neurodevelopmental changes (including infantile spasms) found after prenatal exposure to corticosteroids. ..

Research Grants2

  1. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  2. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..