Diane Lipscombe

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Alternative splicing matters: N-type calcium channels in nociceptors
    Diane Lipscombe
    Department Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Channels (Austin) 1:225-7. 2007
  2. ncbi request reprint Calcium Channel CaVα₁ Splice Isoforms - Tissue Specificity and Drug Action
    Diane Lipscombe
    Department of Neuroscience, Brown University Providence, RI, USA
    Curr Mol Pharmacol 8:22-31. 2015
  3. pmc Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA
    Yu Qiu Jiang
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    Mol Pain 9:67. 2013
  4. pmc Control of neuronal voltage-gated calcium ion channels from RNA to protein
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA Electronic address
    Trends Neurosci 36:598-609. 2013
  5. pmc Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    Biochim Biophys Acta 1828:1522-9. 2013
  6. ncbi request reprint Neuronal proteins custom designed by alternative splicing
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Curr Opin Neurobiol 15:358-63. 2005
  7. ncbi request reprint L-type calcium channels: the low down
    Diane Lipscombe
    Department of Neuroscience, Brown University, 190 Thayer Street, Providence, RI 02912, USA
    J Neurophysiol 92:2633-41. 2004
  8. doi request reprint Tripping the HCN breaker
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 62:747-50. 2009
  9. ncbi request reprint Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Mol Neurobiol 26:21-44. 2002
  10. pmc Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing
    Arturo Andrade
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    Nat Neurosci 13:1249-56. 2010

Research Grants

  1. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2009

Collaborators

  • Robert B Darnell
  • Stefan I McDonough
  • A M Swensen
  • Nathalie Vergnolle
  • G W Zamponi
  • David J A Wyllie
  • Andrew J Castiglioni
  • Jesica Raingo
  • Arturo Andrade
  • Spiro Marangoudakis
  • Thomas D Helton
  • Yu Qiu Jiang
  • Annette C Gray
  • Christopher Thaler
  • Sylvia Denome
  • Summer E Allen
  • Lorin M Jakubek
  • William G Fairbrother
  • Christophe Altier
  • Kathryn S Richards
  • Thomas J Bell
  • Yingxin Lin
  • XinYuan Liu
  • Robert H Hurt
  • Will Fairbrother
  • Elizabeth A Matthews
  • Kevin Chapman
  • Rhian M Evans
  • Kurt Bommert
  • Anthony H Dickenson
  • Camila S Dale
  • Alexandra E Kisilevsky
  • Weifeng Xu

Detail Information

Publications26

  1. ncbi request reprint Alternative splicing matters: N-type calcium channels in nociceptors
    Diane Lipscombe
    Department Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Channels (Austin) 1:225-7. 2007
    ....
  2. ncbi request reprint Calcium Channel CaVα₁ Splice Isoforms - Tissue Specificity and Drug Action
    Diane Lipscombe
    Department of Neuroscience, Brown University Providence, RI, USA
    Curr Mol Pharmacol 8:22-31. 2015
    ....
  3. pmc Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA
    Yu Qiu Jiang
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    Mol Pain 9:67. 2013
    ..Our findings show that the analgesic action of morphine, but not ziconotide or gabapentin, to thermal stimuli is linked to which Cacna1b exon, e37a or e37b, is selected during alternative pre-mRNA splicing...
  4. pmc Control of neuronal voltage-gated calcium ion channels from RNA to protein
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA Electronic address
    Trends Neurosci 36:598-609. 2013
    ....
  5. pmc Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    Biochim Biophys Acta 1828:1522-9. 2013
    ..This article is part of a Special Issue entitled: Calcium channels...
  6. ncbi request reprint Neuronal proteins custom designed by alternative splicing
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Curr Opin Neurobiol 15:358-63. 2005
    ..Recent studies of tissue-specific splicing factors are revealing how coordinated alterations in alternative splicing of RNA transcripts control synaptic function...
  7. ncbi request reprint L-type calcium channels: the low down
    Diane Lipscombe
    Department of Neuroscience, Brown University, 190 Thayer Street, Providence, RI 02912, USA
    J Neurophysiol 92:2633-41. 2004
    ..A more accurate view of neuronal L-type calcium channels encompasses a broad range of activation thresholds and recognizes their potential contribution to signaling cascades triggered by subthreshold depolarizations...
  8. doi request reprint Tripping the HCN breaker
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 62:747-50. 2009
    ..In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin...
  9. ncbi request reprint Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Mol Neurobiol 26:21-44. 2002
    ..Although the full extent of alternative splicing is not yet known for any of the major subtypes of voltage-gated Ca channels, it is already clear that it adds a rich layer of structural and functional diversity"...
  10. pmc Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing
    Arturo Andrade
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    Nat Neurosci 13:1249-56. 2010
    ..Our data suggest that highly specialized, discrete cellular responsiveness in vivo can be attributed to alternative splicing events regulated at the level of individual neurons...
  11. pmc Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors
    Jesica Raingo
    Department of Neuroscience, Brown University, Sidney E Frank Hall for Life Sciences, 185 Meeting Street, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:285-92. 2007
    ..Our data define the molecular origins of voltage-independent inhibition of N-type channels in the pain pathway...
  12. pmc Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms
    Spiro Marangoudakis
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 32:10365-9. 2012
    ..2 current density and increased sensitivity to the UPS. Cell-specific alternative splicing of e37a in nociceptors reduces Ca(V)2.2 channel ubiquitination and sensitivity to the UPS, suggesting a role in pain processing...
  13. ncbi request reprint Novel CaV2.1 clone replicates many properties of Purkinje cell CaV2.1 current
    Kathryn S Richards
    Department of Neuroscience, Brown University, Providence, RI, USA
    Eur J Neurosci 26:2950-61. 2007
    ..This strong resistance to inactivation parallels the property of Purkinje neurone P-type currents and is suggestive of a role for CaVbeta2a in modulating the inactivation properties of P-type calcium currents in Purkinje neurones...
  14. pmc Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels
    Andrew J Castiglioni
    Department of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
    J Physiol 576:119-34. 2006
    ..Our studies of the e37a/e37b splice site reveal a multifunctional domain in the C-terminus of Ca(V)2.2 that regulates the overall activity of N-type calcium channels in nociceptors...
  15. ncbi request reprint Cell-specific alternative splicing increases calcium channel current density in the pain pathway
    Thomas J Bell
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 41:127-38. 2004
    ..8. Cell-specific inclusion of exon 37a correlates closely with significantly larger N-type currents in nociceptive neurons. This unique splice isoform of the N-type channel could represent a novel target for pain management...
  16. pmc The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels
    Summer E Allen
    Department of Neuroscience, Brown University, Providence, RI, USA
    Channels (Austin) 4:483-9. 2010
    ..It is likely that coordinated alternative pre-mRNA splicing across related CaV2 genes by common splicing factors, allows neurons to orchestrate changes in synaptic protein function while maintaining a balanced and functioning system...
  17. ncbi request reprint Neuronal L-type calcium channels open quickly and are inhibited slowly
    Thomas D Helton
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 25:10247-51. 2005
    ....
  18. pmc Neuronal calcium channels: splicing for optimal performance
    Annette C Gray
    Department of Neuroscience, Brown University, Providence, RI 02912, United States
    Cell Calcium 42:409-17. 2007
    ....
  19. ncbi request reprint Alternative splicing in the voltage-sensing region of N-Type CaV2.2 channels modulates channel kinetics
    Yingxin Lin
    Deprtment of Neuroscience, Brown University, 192 Thayer St, Providence, RI 02912, USA
    J Neurophysiol 92:2820-30. 2004
    ..Our results suggest that alternative splicing in the S3-S4 linker influences the kinetics but not the voltage dependence of N-type channel gating...
  20. pmc Repressing the neuron within
    William G Fairbrother
    Department of Molecular Cell Biology and Biochemistry, Brown University, Laboratory of Molecular Medicine, Providence Rhode Island, USA
    Bioessays 30:1-4. 2008
    ..When the PTB brake is released, the cell splices like a neuron...
  21. pmc The inhibition of neuronal calcium ion channels by trace levels of yttrium released from carbon nanotubes
    Lorin M Jakubek
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Biomaterials 30:6351-7. 2009
    ..Our results have important implications for emerging nano-neurotechnology and highlight the critical role that trace components can play in the biological response to complex nanomaterials...
  22. ncbi request reprint Differential role of N-type calcium channel splice isoforms in pain
    Christophe Altier
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Neurosci 27:6363-73. 2007
    ..In contrast, both N-type channel isoforms (e37a- and e37b-containing) contribute to tactile neuropathic allodynia. Hence, exon 37a acts as a molecular switch that tailors the channels toward specific roles in pain...
  23. pmc Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit
    David J A Wyllie
    Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    J Physiol 574:477-89. 2006
    ..Our single-channel data, together with modelling using a kinetic scheme to describe channel activations, support our hypothesis that the S670G point mutation reduces the dwell time of glutamate in its binding site...
  24. ncbi request reprint Internalizing channels: a mechanism to control pain?
    Diane Lipscombe
    Nat Neurosci 9:8-10. 2006
  25. pmc Cumulative inactivation of N-type CaV2.2 calcium channels modified by alternative splicing
    Christopher Thaler
    Laboratory of Molecular Physiology, Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 101:5675-9. 2004
    ..2 splice isoforms to trains of action potential waveforms. Regulated alternative splicing of Ca(V)2.2 represents a possible mechanism for modulating short-term dynamics of synaptic efficacy in different regions of the nervous system...
  26. ncbi request reprint L-type calcium channels: highs and new lows
    Diane Lipscombe
    Circ Res 90:933-5. 2002

Research Grants1

  1. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2009
    ..2. This novel interaction is likely to mediate coupling of the CaV2.2 channel to the synaptic release machinery (aim 3). ..