Sean D McAllister
Affiliation: California Pacific Medical Center
- Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cellsSean D McAllister
California Pacific Medical Center Research Institute, 475 Brannan St, Suite 220, San Francisco, CA 94107, USA
J Neurooncol 74:31-40. 2005..Evidence of selective efficacy with WIN 55,212-2 was also observed but the selectivity was less profound, and the synthetic agonist produced a greater disruption of normal cell morphology compared to Delta(9)-THC...
- Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasisSean D McAllister
California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
Breast Cancer Res Treat 129:37-47. 2011....
- Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survivalJahan P Marcu
California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
Mol Cancer Ther 9:180-9. 2010..Our results suggest that the addition of cannabidiol to Delta(9)-THC may improve the overall effectiveness of Delta(9)-THC in the treatment of glioblastoma in cancer patients...
- An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding regionSean D McAllister
Forbes Norris ALS MDA Research Center, California Pacific Medical Center, San Francisco, California 94115, USA
J Med Chem 46:5139-52. 2003..Taken together, these results support modeling studies that identify the TMH3-4-5-6 aromatic microdomain as the binding region of SR141716A and WIN55,212-2, but not of anandamide...
- Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoidChandrasekaran Raman
Forbes Norris MDA ALS Research Center, 2351 Clay Street, Suite 416, California Pacific Medical Center, San Francisco, CA 94115, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 5:33-9. 2004..These cellular mechanisms may underlie the presumed neuroprotective effect in ALS. As Delta(9)-THC is well tolerated, it and other cannabinoids may prove to be novel therapeutic targets for the treatment of ALS...
- Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activationSean D McAllister
California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
J Biol Chem 279:48024-37. 2004..36(201) trans, W6.48(357) g+) --> (F3.36(201) g+, W6.48(357) trans). The F3.36(201)/W6.48(357) interaction therefore may represent a "toggle switch" for activation of CB(1)...
- Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expressionRyuichi Murase
Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan California Pacific Medical Center, Cancer Research Institute, 475 Brannan Street, Suite 220, San Francisco, CA 94107, USA
Cancer Lett 377:11-6. 2016....
- The Antitumor Activity of Plant-Derived Non-Psychoactive CannabinoidsSean D McAllister
California Pacific Medical Center Research Institute, 475 Brannan Street, Suite 220, San Francisco, CA, 94107, USA
J Neuroimmune Pharmacol 10:255-67. 2015..We will also discuss the ability of non-psychoactive cannabinoids to induce autophagy and apoptotic-mediated cancer cell death, and enhance the activity of first-line agents commonly used in cancer treatment. ..
- Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancerRyuichi Murase
California Pacific Medical Center, Research Institute, San Francisco, CA, USA
Br J Pharmacol 171:4464-77. 2014..Our goal was to discover a compound that could efficiently target both cannabinoid anti-tumour pathways...
- A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognitionSean D McAllister
Forbes Norris ALS MDA Research Center, California Pacific Medical Center, San Francisco, CA 94115, USA
Biochem Pharmacol 63:2121-36. 2002..These results underscore the importance of aromaticity at position CB(1) 5.39(275) and CB(2) 5.39(191) for ligand recognition in the cannabinoid receptors...
- Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cellsSean D McAllister
California Pacific Medical Center, Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA
Mol Cancer Ther 6:2921-7. 2007..In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness...
- CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoidsSean D McAllister
Forbes Norris ALS Research Center, California Pacific Medical Centre, 2351 Clay Street, Suite 416, San Francisco, CA 94115, USA
Prostaglandins Leukot Essent Fatty Acids 66:161-71. 2002..This review focuses upon the developments in endocannabinoid signal transduction from receptor-mediated activation of common G-protein linked effector pathways through downstream regulation of gene transcription...