C M Fan

Summary

Affiliation: Carnegie Institution
Country: USA

Publications

  1. ncbi A role for WNT proteins in induction of dermomyotome
    C M Fan
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 191:160-5. 1997
  2. pmc Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Proc Natl Acad Sci U S A 98:11347-52. 2001
  3. ncbi Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 236:17-29. 2001
  4. ncbi Growth arrest specific gene 1 is a positive growth regulator for the cerebellum
    Y Liu
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 236:30-45. 2001
  5. ncbi SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 127:109-18. 2000
  6. ncbi Embryonic expression patterns of the mouse and chick Gas1 genes
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Mech Dev 101:293-7. 2001
  7. pmc Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
    J A McMahon
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA amcmahon biosun harvar d edu
    Genes Dev 12:1438-52. 1998
  8. ncbi Early deletion of neuromeres in Wnt-1-/- mutant mice: evaluation by morphological and molecular markers
    G S Mastick
    Department of Biology, University of Michigan, Ann Arbor 48109, USA
    J Comp Neurol 374:246-58. 1996
  9. ncbi Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog
    C M Fan
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452
    Cell 79:1175-86. 1994
  10. ncbi Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
    C M Fan
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Mol Cell Neurosci 7:1-16. 1996

Collaborators

Detail Information

Publications12

  1. ncbi A role for WNT proteins in induction of dermomyotome
    C M Fan
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 191:160-5. 1997
    ....
  2. pmc Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Proc Natl Acad Sci U S A 98:11347-52. 2001
    ..Furthermore, ectopic expression of Gas1 in presomitic cells attenuates the response of these cells to SHH in vitro. Taken together, these data suggest that GAS1 functions to reduce the availability of active SHH within the dorsal somite...
  3. ncbi Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 236:17-29. 2001
    ..Furthermore, we provide evidence that the dorsal and ventral RPEs are maintained by distinct genetic components...
  4. ncbi Growth arrest specific gene 1 is a positive growth regulator for the cerebellum
    Y Liu
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 236:30-45. 2001
    ..These results support Gas1 as a common genetic component in coordinating EGL cell and BG cell proliferation, a link which has not been previously appreciated...
  5. ncbi SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 127:109-18. 2000
    ..Together, our results support the model that SHH-N at least in part employs SFRP2 to reduce WNT1/4 activity in the somitic mesoderm...
  6. ncbi Embryonic expression patterns of the mouse and chick Gas1 genes
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Mech Dev 101:293-7. 2001
    ..Furthermore, we have cloned the chick GAS1 gene and documented the similarity and divergence of Gas1 gene expression patterns between the two species...
  7. pmc Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
    J A McMahon
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA amcmahon biosun harvar d edu
    Genes Dev 12:1438-52. 1998
    ..Together these data demonstrate that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite...
  8. ncbi Early deletion of neuromeres in Wnt-1-/- mutant mice: evaluation by morphological and molecular markers
    G S Mastick
    Department of Biology, University of Michigan, Ann Arbor 48109, USA
    J Comp Neurol 374:246-58. 1996
    ..In addition, alterations in the Sim-2 expression domain in ventral prosencephalon, rostral to p1, provide novel evidence for Wnt-1 function in this region...
  9. ncbi Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog
    C M Fan
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452
    Cell 79:1175-86. 1994
    ....
  10. ncbi Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
    C M Fan
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Mol Cell Neurosci 7:1-16. 1996
    ..Our data suggest that the Sim genes play roles in directing the regionalization of tissues where they are expressed. Moreover, the expression pattern documented for Sim2 may provide insights into its potential roles in Down syndrome...
  11. ncbi Lateral and axial signals involved in avian somite patterning: a role for BMP4
    O Pourquie
    Institut d Embryologie du Centre National de la Recherche Scientifique et du Collège de France, Nogent sur Marne
    Cell 84:461-71. 1996
    ....
  12. pmc Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome
    M Muenke
    Children s Hospital of Philadelphia, PA 19104 4399, USA
    Am J Hum Genet 57:1074-9. 1995
    ..However, SIM2 does map within the Down syndrome critical region and thus is a candidate gene that might contribute to the Down syndrome phenotype...