M A Ghannoum

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation.
    Emily Larkin
    Antimicrob Agents Chemother 61:. 2017
  2. pmc Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
    Mahmoud Ghannoum
    Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
    MBio 7:. 2016
  3. pmc Multilaboratory Evaluation of In Vitro Antifungal Susceptibility Testing of Dermatophytes for ME1111
    M Ghannoum
    Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Microbiol 54:662-5. 2016
  4. pmc In vitro antifungal activity of ME1111, a new topical agent for onychomycosis, against clinical isolates of dermatophytes
    M Ghannoum
    Center for Medical Mycology, Case Western Reserve University, and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 59:5154-8. 2015
  5. pmc Ability of hydroxypropyl chitosan nail lacquer to protect against dermatophyte nail infection
    M A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 59:1844-8. 2015
  6. pmc Oral mycobiome analysis of HIV-infected patients: identification of Pichia as an antagonist of opportunistic fungi
    Pranab K Mukherjee
    OHARA ACTG Mycology Unit at Case Western Reserve University, Department of Dermatology, Cleveland, Ohio, United States of America Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS Pathog 10:e1003996. 2014
  7. doi request reprint Animal models to investigate fungal biofilm formation
    Jyotsna Chandra
    Center for Medical Mycology, Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44106, USA
    Methods Mol Biol 1147:141-57. 2014
  8. pmc In vitro antifungal activity of naftifine hydrochloride against dermatophytes
    M Ghannoum
    Case Western Reserve University, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 57:4369-72. 2013
  9. ncbi request reprint Molecular analysis of dermatophytes suggests spread of infection among household members
    Mahmoud A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Cutis 91:237-45. 2013
  10. pmc Metabolomics reveals differential levels of oral metabolites in HIV-infected patients: toward novel diagnostic targets
    Mahmoud A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Ohio 44106 5028, USA
    OMICS 17:5-15. 2013

Collaborators

Detail Information

Publications58

  1. pmc The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation.
    Emily Larkin
    Antimicrob Agents Chemother 61:. 2017
    ..SCY-078, the new orally bioavailable antifungal, had potent antifungal/antibiofilm activity against C. auris, indicating that further evaluation of this antifungal is warranted...
  2. pmc Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
    Mahmoud Ghannoum
    Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
    MBio 7:. 2016
    ....
  3. pmc Multilaboratory Evaluation of In Vitro Antifungal Susceptibility Testing of Dermatophytes for ME1111
    M Ghannoum
    Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Microbiol 54:662-5. 2016
    ..The MIC endpoint should be 80% inhibition compared with the growth control. T. rubrum ATCC MYA-4438 and T. mentagrophytes ATCC 28185 were selected as QC isolates, with an acceptable range of 0.12 to 1 μg/ml for the two strains. ..
  4. pmc In vitro antifungal activity of ME1111, a new topical agent for onychomycosis, against clinical isolates of dermatophytes
    M Ghannoum
    Center for Medical Mycology, Case Western Reserve University, and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 59:5154-8. 2015
    ..Our studies show that ME1111 possesses potent antifungal activity and suggest that it has low potential for the development of resistance in dermatophytes. ..
  5. pmc Ability of hydroxypropyl chitosan nail lacquer to protect against dermatophyte nail infection
    M A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 59:1844-8. 2015
    ..Unlike chemicals normally used in cosmetic treatments, repeated application of the HPCH nail solution may help prevent the establishment of new or recurring fungal nail infection. ..
  6. pmc Oral mycobiome analysis of HIV-infected patients: identification of Pichia as an antagonist of opportunistic fungi
    Pranab K Mukherjee
    OHARA ACTG Mycology Unit at Case Western Reserve University, Department of Dermatology, Cleveland, Ohio, United States of America Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS Pathog 10:e1003996. 2014
    ..The inhibitory activity of PSM was associated with secretory protein/s. Our findings provide the first evidence of interaction among members of the oral mycobiota, and identifies a potential novel antifungal. ..
  7. doi request reprint Animal models to investigate fungal biofilm formation
    Jyotsna Chandra
    Center for Medical Mycology, Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44106, USA
    Methods Mol Biol 1147:141-57. 2014
    ..In addition, the murine model of contact lens-associated Fusarium keratitis enables characterizing/comparing the formation of Fusarium biofilms on contact lenses in vitro and determining their role in vivo...
  8. pmc In vitro antifungal activity of naftifine hydrochloride against dermatophytes
    M Ghannoum
    Case Western Reserve University, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 57:4369-72. 2013
    ..Thus, future clinical studies of naftifine hydrochloride against dermatophytes may be warranted for the treatment of superficial dermatophytoses. ..
  9. ncbi request reprint Molecular analysis of dermatophytes suggests spread of infection among household members
    Mahmoud A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Cutis 91:237-45. 2013
    ..This study is unique in that it used molecular evidence to demonstrate the association of certain strains with the spread of dermatophyte infection among members of the same household...
  10. pmc Metabolomics reveals differential levels of oral metabolites in HIV-infected patients: toward novel diagnostic targets
    Mahmoud A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Ohio 44106 5028, USA
    OMICS 17:5-15. 2013
    ....
  11. ncbi request reprint Optimization of an infected shoe model for the evaluation of an ultraviolet shoe sanitizer device
    Mahmoud A Ghannoum
    Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Am Podiatr Med Assoc 102:309-13. 2012
    ..In this study, we developed an in vitro model for culturing dermatophytes in footwear and used this model to evaluate the effectiveness of a commercial ultraviolet shoe sanitizer in eradicating the fungal elements residing in shoes...
  12. pmc Evaluation of the morphological effects of TDT 067 (terbinafine in Transfersome) and conventional terbinafine on dermatophyte hyphae in vitro and in vivo
    M Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 56:2530-4. 2012
    ..Our in vivo data confirm that TDT 067 can enter fungus in the nail bed of patients with onychomycosis and exert its antifungal effects...
  13. pmc Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor
    Mingyue Wang
    Center for Medical Mycology, Department of Dermatology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, USA
    BMC Microbiol 8:31. 2008
    ..However, the effect of CA-SIIF on secretion of other cytokines by monocytes is unknown, and detailed characterization of this factor has not been performed...
  14. ncbi request reprint Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Antimicrob Chemother 59:556-9. 2007
    ..with that of amphotericin B, caspofungin and fluconazole, in an immunocompetent murine model of haematogenously disseminated candidiasis caused by a fluconazole-resistant Candida albicans...
  15. pmc Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections
    M A Ghannoum
    Center for Medical Mycology, Department of Dermatology, University Hospitals Case Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5028, USA
    Antimicrob Agents Chemother 55:4430-1. 2011
    ..003% to 25% against bacterial strains (n = 175). B-Lock was also fungicidal against the majority of the Candida strains at 6% to 25%. B-Lock demonstrates potential value for the prevention and treatment of catheter-associated infections...
  16. pmc Activity of TDT 067 (terbinafine in Transfersome) against agents of onychomycosis, as determined by minimum inhibitory and fungicidal concentrations
    Mahmoud Ghannoum
    Center for Medical Mycology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Microbiol 49:1716-20. 2011
    ..The Transfersome vehicle appears to potentiate the antifungal activity of terbinafine. Clinical investigation of TDT 067 for the topical treatment of onychomycosis is warranted...
  17. pmc Repeated exposure of Candida spp. to miconazole demonstrates no development of resistance
    M A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106, USA
    Mycoses 54:e175-7. 2011
    ..Although an increase in MIC was noted in these two isolates, the MICON MIC was still very low (0.5 μg ml(-1)). In general, there was no increase in MIC demonstrated by repeated exposure to MICON in this study...
  18. pmc Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
    Mahmoud A Ghannoum
    Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS Pathog 6:e1000713. 2010
    ..This is the first study that identified the "basal mycobiome" of healthy individuals, and provides the basis for a detailed characterization of the oral mycobiome in health and disease...
  19. doi request reprint Comparison of the in vitro activity of terbinafine and lanoconazole against dermatophytes
    M A Ghannoum
    Center for Medical Mycology, University Hospital of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Mycoses 53:311-3. 2010
    ..Both LAN and TERB demonstrated potent antifungal activity against dermatophytes; however, the lack of fungicidal activity by LAN needs to be evaluated in terms of potential clinical efficacy...
  20. doi request reprint Differential in vitro activity of anidulafungin, caspofungin and micafungin against Candida parapsilosis isolates recovered from a burn unit
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Clin Microbiol Infect 15:274-9. 2009
    ..The results of this study provide evidence that differences exist between the activities of anidulafungin and the other echinocandins...
  21. doi request reprint Susceptibility of dermatophyte isolates obtained from a large worldwide terbinafine tinea capitis clinical trial
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Br J Dermatol 159:711-3. 2008
    ..Our group, in collaboration with seven other laboratories, has recently developed a method to determine the susceptibility of dermatophytes...
  22. doi request reprint Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model
    Mahmoud A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
    Mycoses 52:35-43. 2009
    ..Evaluation of the 1%, 5% and 10% TNS in clinical trials for the treatment of dermatophytosis and onychomycosis is warranted...
  23. ncbi request reprint Antifungal resistance of candidal biofilms formed on denture acrylic in vitro
    J Chandra
    Center for Medical Mycology, University Hospitals of Cleveland and Case Western Reserve University, OH 44106-5028, USA
    J Dent Res 80:903-8. 2001
    ..In conclusion, results obtained by means of our biofilm model show that biofilm-associated C. albicans cells, compared with cells grown in planktonic form, are resistant to antifungals used to treat denture stomatitis...
  24. pmc Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins
    D M Kuhn
    Division of Infectious Diseases, Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 46:1773-80. 2002
    ..In conclusion, our data show that Candida biofilms show unique susceptibilities to echinocandins and AMB lipid formulations...
  25. ncbi request reprint Evaluation of antifungal efficacy in an optimized animal model of Trichophyton mentagrophytes-dermatophytosis
    M A Ghannoum
    Center for Medical Mycology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 5028, USA
    J Chemother 16:139-44. 2004
    ..The optimized guinea pig model was found to be highly reproducible, and useful in the primary screening and evaluation of the anti-dermatophytic efficacy of topical and oral formulations of antifungal agents...
  26. pmc Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance
    J Chandra
    Center for Medical Mycology, University Hospitals of Cleveland, and Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Bacteriol 183:5385-94. 2001
    ..The studies described here form the basis for investigations into the molecular mechanisms of Candida biofilm biology and antifungal resistance and provide the means to design novel therapies for biofilm-based infections...
  27. ncbi request reprint Antifungal activity of voriconazole (UK-109,496), fluconazole and amphotericin B against hematogenous Candida krusei infection in neutropenic guinea pig model
    M A Ghannoum
    Center for Medical Mycology, Mycology Reference Laboratory, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106 5028, USA
    J Chemother 11:34-9. 1999
    ..krusei from brain, liver and kidney tissue. These data indicate that voriconazole could be efficacious for the treatment of infections caused by fluconazole-resistant Candida, such as C. krusei...
  28. doi request reprint Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model
    M A Ghannoum
    Center for Medical Mycology, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5028, USA
    Med Mycol 48:491-7. 2010
    ..This apparent superiority may be due to the fungicidal activity of terbinafine compared to the fungistatic effect of the other two drugs...
  29. pmc Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces
    D M Kuhn
    Case Western Reserve University Division of Infectious DiseasesDepartment of Medicine, Department of Dermatology, University Hospitals of Cleveland, Cleveland, Ohio 44106
    Infect Immun 70:878-88. 2002
    ..In conclusion, our data show that C. albicans produces quantitatively larger and qualitatively more complex biofilms than other species, in particular, C. parapsilosis...
  30. ncbi request reprint Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivo
    P K Mukherjee
    Center for Medical Mycology, University Hospitals of Cleveland and Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
    Microbiology 147:2585-97. 2001
    ..albicans enhances the ability of this organism to cross the GI tract and disseminate haematogenously. These studies provide unequivocal evidence supporting a role for Plb1 during the course of infection by C. albicans...
  31. pmc Interlaboratory study of quality control isolates for a broth microdilution method (modified CLSI M38-A) for testing susceptibilities of dermatophytes to antifungals
    M A Ghannoum
    Center for Medical Mycology, University Hospitals Case Western Reserve University, EMBA, 11100 Euclid Avenue, Cleveland, OH 44106 5028, USA
    J Clin Microbiol 44:4353-6. 2006
    ..mentagrophytes isolate, were identified and submitted to the American Type Culture Collection (ATCC) for inclusion as reference strains. Ranges encompassing 95.2 to 97.9% of all data points for all seven drugs were established...
  32. doi request reprint Antifungal activity of miconazole against recent Candida strains
    N Isham
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106, USA
    Mycoses 53:434-7. 2010
    ..This indicates that recent clinical isolates remain susceptible to this antifungal and that MICON could be used as first-line treatment for oropharyngeal candidiasis...
  33. ncbi request reprint Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans
    S D Leidich
    Center for Medical Mycology, University Hospitals of Cleveland, and Case Western Reserve University, Cleveland, Ohio 44106 5028, USA
    J Biol Chem 273:26078-86. 1998
    ..Thus, phospholipase B may well contribute to the pathogenicity of C. albicans by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection...
  34. pmc Determination of MICs of aminocandin for Candida spp. and filamentous fungi
    N Isham
    Center for Medical Mycology, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Clin Microbiol 44:4342-4. 2006
    ....
  35. pmc Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Clin Microbiol Rev 12:501-17. 1999
    ..For example, modification of enzymes which serve as targets for antimicrobial action and the involvement of membrane pumps in the extrusion of drugs are well characterized in both the eukaryotic and prokaryotic cells...
  36. ncbi request reprint Effects of fluconazole singly and in combination with 5-fluorocytosine or amphotericin B in the treatment of cryptococcal meningoencephalitis in an intracranial murine model
    M A Hossain
    Center for Medical Mycology, Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, OH 44106 5028, USA
    J Chemother 14:351-60. 2002
    ..Fluconazole prophylaxis led to a significant decrease in brain CFU. In conclusion, high dose fluconazole administered post-infection, or as prophylaxis, may be highly efficacious in the treatment and prevention of meningoencephalitis...
  37. ncbi request reprint Susceptibility testing of fungi and correlation with clinical outcome
    M A Ghannoum
    University Center for Medical Mycology, Department of Dermatology, University Hospital of Cleveland, Ohio, USA
    J Chemother 9:19-24. 1997
    ....
  38. pmc Successful treatment of fluconazole-resistant oropharyngeal candidiasis by a combination of fluconazole and terbinafine
    M A Ghannoum
    Center for Medical Mycology and Mycology Reference Laboratory, University Hospitals of Cleveland, and Case Western Reserve University, Cleveland, Ohio 44106 5028, USA
    Clin Diagn Lab Immunol 6:921-3. 1999
    ..Impressively, this combination resulted in the clearing of the clinical symptoms and the patient has successfully been asymptomatic for more than 12 months posttreatment...
  39. pmc Uses and limitations of the XTT assay in studies of Candida growth and metabolism
    D M Kuhn
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Clin Microbiol 41:506-8. 2003
    ..Also, significant signal was often missed in the absence of dimethyl sulfoxide extraction...
  40. pmc Agar-based disk diffusion assay for susceptibility testing of dermatophytes
    E I Nweze
    Center for Medical Mycology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Microbiol 48:3750-2. 2010
    ..Our results show that the method is reproducible, is simple, and could be used to determine the antifungal susceptibility of dermatophytes...
  41. pmc Intra- and interlaboratory study of a method for testing the antifungal susceptibilities of dermatophytes
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106 5028, USA
    J Clin Microbiol 42:2977-9. 2004
    ..Data from this study support consideration of this method as an amendment to the NCCLS M38-A standard for the testing of dermatophytes...
  42. pmc Identification of gentian violet concentration that does not stain oral mucosa, possesses anti-candidal activity and is well tolerated
    R J Jurevic
    Center for Medical Mycology, Case Western Reserve University, University Hospitals Case Medical Center, 11100 Euclid Avenue, LKS 5028, Cleveland, OH 44106, USA
    Eur J Clin Microbiol Infect Dis 30:629-33. 2011
    ..Gentian violet solution at the concentration of 0.00165% does not stain the oral mucosa, is stable and possesses potent antifungal activity...
  43. pmc Potential role of phospholipases in virulence and fungal pathogenesis
    M A Ghannoum
    Center for Medical Mycology, Mycology Reference Laboratory, University Hospitals of Cleveland, and Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106 5028, USA
    Clin Microbiol Rev 13:122-43, table of contents. 2000
    ..Since the importance of phospholipases in fungal virulence is already known, the next challenge will be to utilize these lytic enzymes as therapeutic and diagnostic targets...
  44. ncbi request reprint The exciting future of antifungal therapy
    M N Neely
    Department of Pediatrics, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, OH 44106, USA
    Eur J Clin Microbiol Infect Dis 19:897-914. 2000
    ..All of these strategies, although in their infancy, will enhance the clinician's ability to care for patients with invasive fungal infections...
  45. ncbi request reprint Echinocandins: are they all the same?
    P K Mukherjee
    Center for Medical Mycology and Mycology Reference Laboratory, Department of Dermatology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Chemother 23:319-25. 2011
    ..More investigation is warranted to determine if the observed differences among the echinocandins can translate to clinical advantages...
  46. ncbi request reprint New developments in chemotherapy for non-invasive fungal infections
    M A Hossain
    Center for Medical Mycology, Department of Dermatology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106-5028, USA
    Expert Opin Investig Drugs 10:1501-11. 2001
    ..An overview of non-invasive fungal infections, antifungal agents in clinical use and recent developments in antifungal therapy is reviewed in this article...
  47. ncbi request reprint Extracellular phospholipases as universal virulence factor in pathogenic fungi
    M A Ghannoum
    Center for Medical Mycology, Mycology Reference Laboratory, Case Western Reserve University, Cleveland, Ohio, USA
    Nihon Ishinkin Gakkai Zasshi 39:55-9. 1998
    ..Understanding phospholipase as a common theme in fungal pathogenicity is critical for developing new antifungal strategies based on anti-virulence...
  48. pmc Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective
    D M Kuhn
    Division of Infectious Diseases, Department of Medicine, University Hospitals of Cleveland, and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Microbiol Rev 16:144-72. 2003
    ..To address issues of indoor mold-related illness, there is an urgent need for studies using objective markers of illness, relevant animal models, proper epidemiologic techniques, and examination of confounding factors...
  49. ncbi request reprint Human hyalohyphomycoses: a review of human infections due to Acremonium spp., Paecilomyces spp., Penicillium spp., and Scopulariopsis spp
    M K Schinabeck
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Chemother 15:5-15. 2003
    ..Paecilomyces spp., Penicillium spp., and Scopulariopsis spp., will be reviewed. Specific areas of focus will include the epidemiology, mycology, clinical presentations, and treatment options for each of these four hyaline molds...
  50. ncbi request reprint Choices aplenty: antifungal prophylaxis in hematopoietic stem cell transplant recipients
    N S Hamza
    Department of Medicine, University Hospitals of Cleveland, 11100 Euclid Ave, Wearn 341, Cleveland, OH 44106 5065, USA
    Bone Marrow Transplant 34:377-89. 2004
    ..Such approaches may alter the current treatment strategy from prophylaxis to pre-emptive therapy, thereby potentially decreasing cost and toxicity in high-risk patients...
  51. ncbi request reprint Candida: a causative agent of an emerging infection
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106 5028, USA
    J Investig Dermatol Symp Proc 6:188-96. 2001
    ..This paper discusses recent developments in the Candida field and the impact they have on patient management...
  52. pmc Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination
    L Liu
    The Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio
    Infect Immun 69:4695-7. 2001
    ..albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production...
  53. pmc Clinical evaluation of the Sensititre YeastOne colorimetric antifungal panel for antifungal susceptibility testing of the echinocandins anidulafungin, caspofungin, and micafungin
    M A Pfaller
    Department of Pathology, Medical Microbiology Division, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 46:2155-9. 2008
    ..The YeastOne colorimetric method appears to be comparable to the CLSI reference method for testing the susceptibility of Candida spp. to the echinocandins anidulafungin, caspofungin, and micafungin...
  54. pmc Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints
    M A Pfaller
    Department of Pathology, 200 Hawkins Drive, University of Iowa, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 46:2620-9. 2008
    ..Subsequently, the isolates should be submitted to a reference laboratory that will confirm the results by using a CLSI reference dilution method...
  55. pmc Correlation of MIC with outcome for Candida species tested against voriconazole: analysis and proposal for interpretive breakpoints
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 44:819-26. 2006
    ..The corresponding disk test breakpoints are as follows: S, > or = 17 mm; SDD, 14 to 16 mm; and R, < or = 13 mm...
  56. pmc Utility of 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenyl-amino)carbonyl]-2H-tetrazolium hydroxide (XTT) and minimum effective concentration assays in the determination of antifungal susceptibility of Aspergillus fumigatus to the lipopeptide class co
    S P Hawser
    Aventis, F-93235 Romainville, France
    J Clin Microbiol 39:2738-41. 2001
    ..fumigatus is susceptible to mulundocandin. Thus, the XTT-based assay might be useful for determination of the susceptibilities of molds to echinocandins. Further evaluation is warranted...
  57. pmc Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B
    M Gottfredsson
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 45:3231-3. 2001
    ....
  58. ncbi request reprint Zygomycosis: the re-emerging fungal infection
    M Chayakulkeeree
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, P O Box 3867, Durham, NC 27710, USA
    Eur J Clin Microbiol Infect Dis 25:215-29. 2006
    ..The clinical experience with adjunctive treatments like colony-stimulating factors, interferon-gamma, and hyperbaric oxygen therapy is still limited...