Jian Tajbakhsh

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis
    Jian Tajbakhsh
    Chromatin Biology Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Translational Cytomics Group, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Electronic address
    Exp Cell Res 332:190-201. 2015
  2. doi request reprint Covisualization of methylcytosine, global DNA, and protein biomarkers for In Situ 3D DNA methylation phenotyping of stem cells
    Jian Tajbakhsh
    Translational Cytomics Group and Chromatin Biology Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Methods Mol Biol 1052:77-88. 2013
  3. pmc Early in vitro differentiation of mouse definitive endoderm is not correlated with progressive maturation of nuclear DNA methylation patterns
    Jian Tajbakhsh
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 6:e21861. 2011
  4. pmc DNA methylation topology: potential of a chromatin landmark for epigenetic drug toxicology
    Jian Tajbakhsh
    Chromatin Biology Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Epigenomics 3:761-70. 2011
  5. pmc Measuring topology of low-intensity DNA methylation sites for high-throughput assessment of epigenetic drug-induced effects in cancer cells
    Arkadiusz Gertych
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Exp Cell Res 316:3150-60. 2010
  6. pmc Nuclear DNA methylation and chromatin condensation phenotypes are distinct between normally proliferating/aging, rapidly growing/immortal, and senescent cells
    Jin Ho Oh
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Oncotarget 4:474-93. 2013
  7. pmc 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models
    Arkadiusz Gertych
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    BMC Pharmacol Toxicol 14:11. 2013
  8. pmc Automated quantification of DNA demethylation effects in cells via 3D mapping of nuclear signatures and population homogeneity assessment
    Arkadiusz Gertych
    Minimally Invasive Surgical Technologies Institute, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cytometry A 75:569-83. 2009
  9. pmc Rapid 3-D delineation of cell nuclei for high-content screening platforms
    Arkadiusz Gertych
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA Electronic address
    Comput Biol Med 69:328-38. 2016

Detail Information

Publications9

  1. pmc Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis
    Jian Tajbakhsh
    Chromatin Biology Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Translational Cytomics Group, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Electronic address
    Exp Cell Res 332:190-201. 2015
    ....
  2. doi request reprint Covisualization of methylcytosine, global DNA, and protein biomarkers for In Situ 3D DNA methylation phenotyping of stem cells
    Jian Tajbakhsh
    Translational Cytomics Group and Chromatin Biology Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Methods Mol Biol 1052:77-88. 2013
    ....
  3. pmc Early in vitro differentiation of mouse definitive endoderm is not correlated with progressive maturation of nuclear DNA methylation patterns
    Jian Tajbakhsh
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 6:e21861. 2011
    ..This concept of tracking epigenetic progression may prove useful in the selection of cell phenotypes for future regenerative medicine applications...
  4. pmc DNA methylation topology: potential of a chromatin landmark for epigenetic drug toxicology
    Jian Tajbakhsh
    Chromatin Biology Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Epigenomics 3:761-70. 2011
    ..Utilizing 3D DNA methylation patterns is a powerful precursor to a series of fully automatable assays that employ chromatin structure and higher organization as novel pharmacodynamic biomarkers for various epigenetic drug actions...
  5. pmc Measuring topology of low-intensity DNA methylation sites for high-throughput assessment of epigenetic drug-induced effects in cancer cells
    Arkadiusz Gertych
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Exp Cell Res 316:3150-60. 2010
    ..Measuring changes in the topology of low-intensity sites can potentially be a valuable component in the high-throughput assessment of demethylation and risk of chromatin reorganization in epigenetic-drug screening tasks...
  6. pmc Nuclear DNA methylation and chromatin condensation phenotypes are distinct between normally proliferating/aging, rapidly growing/immortal, and senescent cells
    Jin Ho Oh
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Oncotarget 4:474-93. 2013
    ..Companion high-resolution molecular profiling could provide information on possible underlying differences that would explain benign versus malign cell growth behaviors...
  7. pmc 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models
    Arkadiusz Gertych
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    BMC Pharmacol Toxicol 14:11. 2013
    ....
  8. pmc Automated quantification of DNA demethylation effects in cells via 3D mapping of nuclear signatures and population homogeneity assessment
    Arkadiusz Gertych
    Minimally Invasive Surgical Technologies Institute, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cytometry A 75:569-83. 2009
    ..In a comparison with other metrics, K-L divergence has proven to be a more valuable and robust tool for categorization of individual cells within a population, with potential applications in epigenetic drug screening...
  9. pmc Rapid 3-D delineation of cell nuclei for high-content screening platforms
    Arkadiusz Gertych
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA Electronic address
    Comput Biol Med 69:328-38. 2016
    ..In particular, the 3D-RSD method performs well in cell lines, which are often used in imaging-based HCS platforms and are afflicted by nuclear crowding and overlaps that hinder feature extraction. ..