Nathan H Lents

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. pmc Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer
    Maulik R Shah
    Department of Otolaryngology, Saint Louis University, Saint Louis, Missouri, USA
    J Exp Clin Cancer Res 28:84. 2009
  2. pmc Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D
    Nathan H Lents
    Department of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, New York 10019, USA
    Cell Cycle 7:1580-6. 2008
  3. ncbi request reprint [Any way you splice it: Mdm2 at the crossroads of tumor surveillance]
    Nathan H Lents
    Department of Sciences, John Jay College of Criminal Justice, The City University of New York New York, New York, USA
    Ai Zheng 27:993-7. 2008
  4. doi request reprint The rapid activation of N-Ras by alpha-thrombin in fibroblasts is mediated by the specific G-protein Galphai2-Gbeta1-Ggamma5 and occurs in lipid rafts
    Nathan H Lents
    Department of Sciences at John Jay College of Criminal Justice, City University of New York, New York, NY 10019, USA
    Cell Signal 21:1007-14. 2009
  5. pmc Teaching the process of molecular phylogeny and systematics: a multi-part inquiry-based exercise
    Nathan H Lents
    Department of Sciences, The City University of New York, New York, 10019, USA
    CBE Life Sci Educ 9:513-23. 2010
  6. ncbi request reprint XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
    Diego Acosta-Alvear
    New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 27:53-66. 2007
  7. ncbi request reprint Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2
    Nathan H Lents
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    J Biol Chem 277:47469-75. 2002
  8. ncbi request reprint Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression
    Susan M Keenan
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    J Biol Chem 279:5387-96. 2004

Collaborators

  • Yuval Kluger
  • Alexandre Blais
  • Yiming Zhou
  • Maulik R Shah
  • Diego Acosta-Alvear
  • Susan M Keenan
  • Claudette Klein
  • Mary K Hoyer
  • Nimah Jamaluddin
  • Joseph Baldassare
  • Christopher L Kriedt
  • Brian David Dynlacht
  • Mary Tsikitis
  • Christen J Lennon
  • Carolina Arias
  • Joseph J Baldassare

Detail Information

Publications8

  1. pmc Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer
    Maulik R Shah
    Department of Otolaryngology, Saint Louis University, Saint Louis, Missouri, USA
    J Exp Clin Cancer Res 28:84. 2009
    ..Thus, our studies form a solid proof-of-concept that direct intra-tumoral injection of zinc acetate could be a safe and effective treatment strategy for prostate cancer...
  2. pmc Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D
    Nathan H Lents
    Department of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, New York 10019, USA
    Cell Cycle 7:1580-6. 2008
    ..We thus conclude that this alternative spicing of Mdm2 may be an important mechanism to facilitate massive accumulation of p53 in response to genotoxic agents...
  3. ncbi request reprint [Any way you splice it: Mdm2 at the crossroads of tumor surveillance]
    Nathan H Lents
    Department of Sciences, John Jay College of Criminal Justice, The City University of New York New York, New York, USA
    Ai Zheng 27:993-7. 2008
    ....
  4. doi request reprint The rapid activation of N-Ras by alpha-thrombin in fibroblasts is mediated by the specific G-protein Galphai2-Gbeta1-Ggamma5 and occurs in lipid rafts
    Nathan H Lents
    Department of Sciences at John Jay College of Criminal Justice, City University of New York, New York, NY 10019, USA
    Cell Signal 21:1007-14. 2009
    ..We thus report the molecular elucidation of an extremely specific and rapid signal transduction pathway linking alpha-thrombin stimulation to the activation of Ras...
  5. pmc Teaching the process of molecular phylogeny and systematics: a multi-part inquiry-based exercise
    Nathan H Lents
    Department of Sciences, The City University of New York, New York, 10019, USA
    CBE Life Sci Educ 9:513-23. 2010
    ..By engaging students in modern phylogenetic activities, these students better understood how biologists are currently using molecular data to develop a more complete picture of the shared ancestry of all living things...
  6. ncbi request reprint XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
    Diego Acosta-Alvear
    New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 27:53-66. 2007
    ..Our results provide a detailed picture of the regulatory roadmap governed by XBP1 in distinct cell types as well as insight into unexplored functions of XBP1...
  7. ncbi request reprint Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2
    Nathan H Lents
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    J Biol Chem 277:47469-75. 2002
    ..Taken together, these data show a new role for ERK in G1 cell cycle progression: In addition to its role in stimulating cyclin D1 expression and nuclear translocation of CDK2, ERK regulates Thr-160 phosphorylation of CDK2-cyclin E...
  8. ncbi request reprint Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression
    Susan M Keenan
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    J Biol Chem 279:5387-96. 2004
    ..These data indicate that CDK2-cyclin E, without prior CDK4-cyclin D activity, can phosphorylate and inactivate pRb, activate E2F, and induce DNA synthesis...