Lorenzo F Sempere

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. doi Recent advances in miRNA-based diagnostic applications
    Lorenzo F Sempere
    Department of Medicine, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Expert Rev Mol Diagn 12:557-9. 2012
  2. pmc Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer
    Lorenzo F Sempere
    Department of Medicine, Rubin 763 HB7936, Norris Cotton Cancer Center, 1 Medical Center Drive, Lebanon, NH 03756 1000, USA
    Expert Rev Mol Diagn 11:813-27. 2011
  3. pmc A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Cancer Biol Ther 12:198-207. 2011
  4. pmc Tumor-suppressive microRNAs in Lung cancer: diagnostic and therapeutic opportunities
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    ScientificWorldJournal 9:626-8. 2009
  5. ncbi Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer
    Lorenzo F Sempere
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 67:11612-20. 2007
  6. pmc Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Clin Cancer Res 16:4246-55. 2010
  7. pmc MicroRNAs and the advent of vertebrate morphological complexity
    Alysha M Heimberg
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 105:2946-50. 2008
  8. pmc MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
    Xi Liu
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Clin Invest 120:1298-309. 2010
  9. pmc Involvement of microRNAs in lung cancer biology and therapy
    Xi Liu
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Transl Res 157:200-8. 2011
  10. pmc Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genome Biol 5:R13. 2004

Collaborators

Detail Information

Publications23

  1. doi Recent advances in miRNA-based diagnostic applications
    Lorenzo F Sempere
    Department of Medicine, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Expert Rev Mol Diagn 12:557-9. 2012
    ..There were also several industry-sponsored events showcasing miRNA technologies...
  2. pmc Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer
    Lorenzo F Sempere
    Department of Medicine, Rubin 763 HB7936, Norris Cotton Cancer Center, 1 Medical Center Drive, Lebanon, NH 03756 1000, USA
    Expert Rev Mol Diagn 11:813-27. 2011
    ..In this article, the challenges and opportunities for integration of miRNA-based assays in the clinical toolkit to improve care and management of patients afflicted with solid tumors will be discussed...
  3. pmc A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Cancer Biol Ther 12:198-207. 2011
    ....
  4. pmc Tumor-suppressive microRNAs in Lung cancer: diagnostic and therapeutic opportunities
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    ScientificWorldJournal 9:626-8. 2009
    ..Here, we discuss the clinical implications of these findings for lung cancer biology, therapy, and prevention...
  5. ncbi Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer
    Lorenzo F Sempere
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 67:11612-20. 2007
    ..Most significantly, early manifestation of altered miR-145 expression in atypical hyperplasia and carcinoma in situ lesions suggests that this miRNA may have a potential clinical application as a novel biomarker for early detection...
  6. pmc Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Clin Cancer Res 16:4246-55. 2010
    ..This ISH method was implemented to be compatible with routine clinical immunohistochemical (IHC) assays to enable the detection of miRNAs and protein markers in the same tissue section for colocalization and functional studies...
  7. pmc MicroRNAs and the advent of vertebrate morphological complexity
    Alysha M Heimberg
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 105:2946-50. 2008
    ..We hypothesize that lying behind the origin of vertebrate complexity is the dramatic expansion of the noncoding RNA inventory including miRNAs, rather than an increase in the protein-encoding inventory caused by GDEs...
  8. pmc MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
    Xi Liu
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Clin Invest 120:1298-309. 2010
    ..Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression...
  9. pmc Involvement of microRNAs in lung cancer biology and therapy
    Xi Liu
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Transl Res 157:200-8. 2011
    ..How these miRNA findings advance an understanding of lung cancer biology and how they could improve lung cancer therapy are discussed in this article...
  10. pmc Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genome Biol 5:R13. 2004
    ..lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study...
  11. pmc MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma
    Meir Preis
    Department of Medicine and Pathology, Dartmouth Hitchcock Medical Center, Lebanon, USA
    Clin Cancer Res 17:5812-21. 2011
    ..MicroRNAs (miRNA) are noncoding regulatory RNAs involved in initiation and progression of human cancers. In this study, we sought to determine whether miR-10b could serve as a biomarker for PDAC...
  12. pmc UBE1L causes lung cancer growth suppression by targeting cyclin D1
    Qing Feng
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Remsen 7650, Hanover, NH 03755, USA
    Mol Cancer Ther 7:3780-8. 2008
    ..Thus, a mechanism for UBE1L-mediated growth suppression was found by UBE1L-ISG15 preferentially inhibiting cyclin D1. Molecular therapeutic implications are discussed...
  13. doi A method for conducting highly sensitive microRNA in situ hybridization and immunohistochemical analysis in pancreatic cancer
    Lorenzo F Sempere
    Department of Medicine, Dartmouth Hitchcock Medical Center, Hanover, NH, USA
    Methods Mol Biol 980:43-59. 2013
    ....
  14. pmc Uncovering growth-suppressive MicroRNAs in lung cancer
    Xi Liu
    Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Clin Cancer Res 15:1177-83. 2009
    ..MicroRNA (miRNA) expression profiles improve classification, diagnosis, and prognostic information of malignancies, including lung cancer. This study uncovered unique growth-suppressive miRNAs in lung cancer...
  15. ncbi Phylogenetic distribution of microRNAs supports the basal position of acoel flatworms and the polyphyly of Platyhelminthes
    Lorenzo F Sempere
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Evol Dev 9:409-15. 2007
    ....
  16. pmc VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy
    J Louise Lines
    Authors Affiliations Medical Research Council Centre of Transplantation, Guy s Hospital Department of Immune Regulation and Intervention, King s College, King s Health Partners, London, United Kingdom Van Andel Research Institute, Grand Rapids, Michigan Departments of Medicine and Microbiology and Immunology, and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire and Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WisconsinAuthors Affiliations Medical Research Council Centre of Transplantation, Guy s Hospital Department of Immune Regulation and Intervention, King s College, King s Health Partners, London, United Kingdom Van Andel Research Institute, Grand Rapids, Michigan Departments of Medicine and Microbiology and Immunology, and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire and Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin
    Cancer Immunol Res 2:510-7. 2014
    ..In the future, treatment may involve combination therapy to target the multiple cell types and stages at which NCRs, including VISTA, act during adaptive immune responses...
  17. ncbi Shining the spotlight on shed KRAS in pancreatic cancer
    Lorenzo F Sempere
    Department of Medicine, Norris Cotton Cancer Center at Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH 03756, USA
    Cancer Biol Ther 7:361-3. 2008
  18. ncbi The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint
    Lorenzo F Sempere
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Exp Zool B Mol Dev Evol 306:575-88. 2006
    ....
  19. pmc Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence
    Angeline S Andrew
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH
    Int J Cancer 137:1158-66. 2015
    ..Our results highlight the need for further clinical studies of miR-34a as a guide for recurrence screening and as a possible candidate therapeutic target in the bladder...
  20. pmc Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer
    Todd A MacKenzie
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Am J Pathol 184:3217-25. 2014
    ..003)]. These findings suggest that the context of altered miR-21 expression provides clinically relevant information. Importantly, miR-21 expression was predominantly up-regulated and potentially prognostic in the tumor stroma of TNBC...
  21. pmc VISTA is an immune checkpoint molecule for human T cells
    J Louise Lines
    Authors Affiliations Medical Research Council Centre of Transplantation, Guy s Hospital, King s College London, King s Health Partners Department of Immune Regulation and Intervention, King s College London, London, United Kingdom Department of Medicine, Geisel School of Medicine at Dartmouth Department of Microbiology and Immunology, Dartmouth Medical School and Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Cancer Res 74:1924-32. 2014
    ..By analogy to PD-1 and PD-L1 blockade, VISTA blockade may offer an immunotherapeutic strategy for human cancer...
  22. pmc Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer
    Juan R Cubillos-Ruiz
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Cancer Res 72:1683-93. 2012
    ..Thus, we provide a platform, an optimized design, and a mechanistic rationale for the clinical testing of nonviral miRNA mimetics...
  23. ncbi Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 259:9-18. 2003
    ....