Lieju Liu

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Effects of capsaicin on VGSCs in TRPV1-/- mice
    Xuehong Cao
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Brain Res 1163:33-43. 2007
  2. ncbi request reprint Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons
    L Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 89:1387-401. 2003
  3. ncbi request reprint Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons
    Lieju Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 95:1478-90. 2006
  4. ncbi request reprint Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons
    Lieju Liu
    327 Bryan Research Building, 101 Research Drive, Duke University Medical Center, Durham NC 27710, USA
    J Neurophysiol 97:2001-15. 2007
  5. ncbi request reprint Voltage-gated ion channels in nociceptors: modulation by cGMP
    L Liu
    229 Bryan Research Bldg, Research Drive, Durham, NC 27710, USA
    J Neurophysiol 92:2323-32. 2004
  6. ncbi request reprint The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons
    Lieju Liu
    Department of Anesthesiology, Duke University Medical Center, Duke University, 329 Bryan Research Building, Durham, NC 27710, USA
    Pain 112:131-41. 2004
  7. ncbi request reprint Neuropeptides modulate rat chorda tympani responses
    S A Simon
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1494-505. 2003
  8. ncbi request reprint TRPV1b, a functional human vanilloid receptor splice variant
    Gang Lu
    Box 3209, Duke University Medical Center, Durham, NC 27710, USA
    Mol Pharmacol 67:1119-27. 2005
  9. ncbi request reprint Gustatory effects of capsaicin that are independent of TRPV1 receptors
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Chem Senses 30:i198-200. 2005
  10. ncbi request reprint Effect of interleukin-1beta on I(A) and I(K) currents in cultured murine trigeminal ganglion neurons
    Jianping Pan
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:131-4. 2007

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Effects of capsaicin on VGSCs in TRPV1-/- mice
    Xuehong Cao
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Brain Res 1163:33-43. 2007
    ..Thirdly, use-dependent blocks are induced at high stimulus frequency...
  2. ncbi request reprint Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons
    L Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 89:1387-401. 2003
    ..That activation, partially through the activation of cGMP-PKG and calmodulin-dependent pathways should result in increased excitability of capsaicin-sensitive nociceptors...
  3. ncbi request reprint Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons
    Lieju Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 95:1478-90. 2006
    ..In summary, the potentiation of INa through chronic IL-1beta signaling in nociceptive sensory neurons may be a critical component of inflammatory-associated hyperalgesia...
  4. ncbi request reprint Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons
    Lieju Liu
    327 Bryan Research Building, 101 Research Drive, Duke University Medical Center, Durham NC 27710, USA
    J Neurophysiol 97:2001-15. 2007
    ....
  5. ncbi request reprint Voltage-gated ion channels in nociceptors: modulation by cGMP
    L Liu
    229 Bryan Research Bldg, Research Drive, Durham, NC 27710, USA
    J Neurophysiol 92:2323-32. 2004
    ..This pathway may be a target for efforts to produce selective analgesics...
  6. ncbi request reprint The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons
    Lieju Liu
    Department of Anesthesiology, Duke University Medical Center, Duke University, 329 Bryan Research Building, Durham, NC 27710, USA
    Pain 112:131-41. 2004
    ..In summary, we found that genistein's ability to inhibit nociceptive neuron excitability arises primarily from its non-specific inhibition of voltage-dependent sodium channels...
  7. ncbi request reprint Neuropeptides modulate rat chorda tympani responses
    S A Simon
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1494-505. 2003
    ..Peptide-induced CT responses to quinine HCl or sucrose were too small to accurately detect. These data suggest that at short latencies, after local infusion via the LA, neuropeptides can alter CT responses in a peptide-specific manner...
  8. ncbi request reprint TRPV1b, a functional human vanilloid receptor splice variant
    Gang Lu
    Box 3209, Duke University Medical Center, Durham, NC 27710, USA
    Mol Pharmacol 67:1119-27. 2005
    ..Channels with similar activation properties were found in trigeminal ganglion neurons, suggesting that TRPV1b receptors are expressed in these cells and contribute to thermal nociception...
  9. ncbi request reprint Gustatory effects of capsaicin that are independent of TRPV1 receptors
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Chem Senses 30:i198-200. 2005
  10. ncbi request reprint Effect of interleukin-1beta on I(A) and I(K) currents in cultured murine trigeminal ganglion neurons
    Jianping Pan
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:131-4. 2007
    ..IL-1beta was found to selectively inhibit I(A) current in TG neurons and the effect may contribute to hyperalgesia under various inflammatory conditions...
  11. ncbi request reprint Effects of phorbol-12,13-dibuterate on sodium currents and potassium currents in rat trigeminal ganglion neurons
    Hui Liu
    Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:1-4. 2007
    ..3+/-3.2)% (n=5, P>0.05). It was concluded that PDBu inhibited I(Na)-total but enhanced I(Na)-TTXr, and inhibited I(K) without affecting I(A). These data suggested that the activation of PKC pathway could exert the actions...
  12. ncbi request reprint Different effects of capsaicin on I(A) and I(K) in pain-conduct neurons of rats
    Hui Fu
    Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 26:275-7. 2006
    ..It was concluded that capsaicin could selectively inhibit the I(A) current, and this effect might involve in the analgesic mechanisms of capsaicin...
  13. pmc Changes in osmolality modulate voltage-gated calcium channels in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Brain Res 1208:56-66. 2008
    ..In summary, although the effects of hypo- and hypertonicity show similar phenotype, receptor and intracellular signaling pathways were selective for hypo- versus hypertonicity-induced inhibition of I(HVA)...
  14. ncbi request reprint Effects of WIN 55,212-2 on I(K) current in cultured trigeminal ganglion neurons of rat
    Zhangyin Ming
    Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:124-6. 2005
    ..5 =10.74 +/- 5.27 mV, k = 17.33 +/- 2.96; WIN 55,212-2: V0.5 = 11.06 +/- 2.05 mV, k = 19.69 +/- 6.60; n = 7, P > 0.05 for V0.5 and k). These results suggested that WIN 55,212-2 has dual action, which might be through different receptors...
  15. ncbi request reprint Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits
    Yi Zhang
    Department of Physiology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:263-4, 268. 2005
    ..These results suggest that microinjection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of periphenal sympathetic nervous system...

Research Grants1

  1. Novel anesthetic mechanisms that desensitize nociceptors
    Lieju Liu; Fiscal Year: 2006
    ..This information will lead to novel anesthetic mechanisms that involve the reversible desensitization of nociceptors. ..