Ke Sheng Wang

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. Wang K, Liu X, Zheng S, Zeng M, Pan Y, Callahan K. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. Gene. 2012;500:80-4 pubmed publisher
    ..These findings offer the potential for new insights into the pathogenesis of BMI and obesity and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in BMI and obesity. ..
  2. request reprint
    Wang K, Mullersman J, Liu X. Family-based association analysis of the MAPT gene in Parkinson disease. J Appl Genet. 2010;51:509-14 pubmed
    ..021, respectively). Two-SNP haplotypes inferred from rs17563965 and rs17649641 also showed association with PD (P = 0.018) and age at onset (P = 0.026). These results provide further support for the role of MAPT in development of PD. ..
  3. Chen Y, Xu C, Harirforoosh S, Luo X, Wang K. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. J Psychiatr Res. 2018;96:65-72 pubmed publisher
    ..3 × 10-5). The present study is the first study providing evidence of several genetic variants within the PTPRK gene associated with the risk and AAO of AD, risk of cancer, LDL and total cholesterol levels...
  4. Wang K, Xu N, Wang L, Aragon L, Ciubuc R, Arana T, et al. NRG3 gene is associated with the risk and age at onset of Alzheimer disease. J Neural Transm (Vienna). 2014;121:183-92 pubmed publisher
    ..05). This is the first study demonstrating that genetic variants in the NRG3 gene play a role in AD. Our results also revealed that SNPs in the NRG3 genes were more strongly associated with AAO of AD. ..
  5. Wang K, Liu X, Aragam N, Mullersman J, Jian X, Pan Y, et al. Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. J Mol Neurosci. 2012;46:265-71 pubmed publisher
    ..In addition, the association of rs727532 with AD was confirmed in a replication study. This study reports some newly recognized associations between several genetic loci and both AD and three personality traits. ..
  6. request reprint
    Wang K, Wang L, Liu X, Zeng M. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction. J Genet. 2013;92:395-402 pubmed
    ..000625) for triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology. ..
  7. Gong S, Xu C, Wang L, Liu Y, Owusu D, Bailey B, et al. Genetic association analysis of polymorphisms in PSD3 gene with obesity, type 2 diabetes, and HDL cholesterol. Diabetes Res Clin Pract. 2017;126:105-114 pubmed publisher
    ..Common variants in PSD3 were associated with obesity, T2D and HDL level. These findings add important new insights into the pathogenesis of obesity, T2D and HDL cholesterol. ..
  8. Wang K, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. J Neuroimmunol. 2017;310:60-65 pubmed publisher
    ..The present study is the first study providing evidence of several genetic variants within the NAV2 gene influencing the risk and AAO of AD. ..
  9. Wang K, Liu X, Zhang Q, Wu L, Zeng M. Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. J Neural Transm (Vienna). 2012;119:425-33 pubmed publisher
    ..In conclusion, we identified several loci associated with AWS. These findings offer the potential for new insights into the pathogenesis of AD and AWS. ..
  10. Wang K, Liu X, Zhang Q, Zeng M. ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. Drug Alcohol Depend. 2012;124:325-32 pubmed publisher
    ..In conclusion, we identified several loci associated with ND through meta-analysis of two GWA studies. These findings offer the potential for new insights into the pathogenesis of ND. ..

Locale

Detail Information

Publications19

  1. Wang K, Liu X, Zheng S, Zeng M, Pan Y, Callahan K. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. Gene. 2012;500:80-4 pubmed publisher
    ..These findings offer the potential for new insights into the pathogenesis of BMI and obesity and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in BMI and obesity. ..
  2. request reprint
    Wang K, Mullersman J, Liu X. Family-based association analysis of the MAPT gene in Parkinson disease. J Appl Genet. 2010;51:509-14 pubmed
    ..021, respectively). Two-SNP haplotypes inferred from rs17563965 and rs17649641 also showed association with PD (P = 0.018) and age at onset (P = 0.026). These results provide further support for the role of MAPT in development of PD. ..
  3. Chen Y, Xu C, Harirforoosh S, Luo X, Wang K. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. J Psychiatr Res. 2018;96:65-72 pubmed publisher
    ..3 × 10-5). The present study is the first study providing evidence of several genetic variants within the PTPRK gene associated with the risk and AAO of AD, risk of cancer, LDL and total cholesterol levels...
  4. Wang K, Xu N, Wang L, Aragon L, Ciubuc R, Arana T, et al. NRG3 gene is associated with the risk and age at onset of Alzheimer disease. J Neural Transm (Vienna). 2014;121:183-92 pubmed publisher
    ..05). This is the first study demonstrating that genetic variants in the NRG3 gene play a role in AD. Our results also revealed that SNPs in the NRG3 genes were more strongly associated with AAO of AD. ..
  5. Wang K, Liu X, Aragam N, Mullersman J, Jian X, Pan Y, et al. Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. J Mol Neurosci. 2012;46:265-71 pubmed publisher
    ..In addition, the association of rs727532 with AD was confirmed in a replication study. This study reports some newly recognized associations between several genetic loci and both AD and three personality traits. ..
  6. request reprint
    Wang K, Wang L, Liu X, Zeng M. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction. J Genet. 2013;92:395-402 pubmed
    ..000625) for triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology. ..
  7. Gong S, Xu C, Wang L, Liu Y, Owusu D, Bailey B, et al. Genetic association analysis of polymorphisms in PSD3 gene with obesity, type 2 diabetes, and HDL cholesterol. Diabetes Res Clin Pract. 2017;126:105-114 pubmed publisher
    ..Common variants in PSD3 were associated with obesity, T2D and HDL level. These findings add important new insights into the pathogenesis of obesity, T2D and HDL cholesterol. ..
  8. Wang K, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. J Neuroimmunol. 2017;310:60-65 pubmed publisher
    ..The present study is the first study providing evidence of several genetic variants within the NAV2 gene influencing the risk and AAO of AD. ..
  9. Wang K, Liu X, Zhang Q, Wu L, Zeng M. Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. J Neural Transm (Vienna). 2012;119:425-33 pubmed publisher
    ..In conclusion, we identified several loci associated with AWS. These findings offer the potential for new insights into the pathogenesis of AD and AWS. ..
  10. Wang K, Liu X, Zhang Q, Zeng M. ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. Drug Alcohol Depend. 2012;124:325-32 pubmed publisher
    ..In conclusion, we identified several loci associated with ND through meta-analysis of two GWA studies. These findings offer the potential for new insights into the pathogenesis of ND. ..
  11. Wang K, Zhang Q, Liu X, Wu L, Zeng M. PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. J Mol Neurosci. 2012;48:265-72 pubmed publisher
    ..12 × 10(-5)). In conclusion, we identified four new loci (PKNOX2, MYH13, PHF2, and GPC6) associated with FTD. These findings offer the potential for new insights into the pathogenesis of FTD and schizophrenia. ..
  12. request reprint
    Wang K, Liu X, Xie C, Liu Y, Xu C. Non-parametric Survival Analysis of EPG5 Gene with Age at Onset of Alzheimer's Disease. J Mol Neurosci. 2016;60:436-444 pubmed
    ..These findings from non-parametric survival analyses provide evidence for several genetic variants in EPG5 influencing the AAO of AD and will serve as a resource for replication in other populations. ..
  13. Owusu D, Pan Y, Xie C, Harirforoosh S, Wang K. Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. J Psychiatr Res. 2017;84:27-34 pubmed publisher
    ..Our results showed that several genetic variants in PDLIM5 gene influence AD, T2D and hypertension. These findings offer the potential for new insights into the pathogenesis of AD, T2D, and hypertension. ..
  14. Li L, Gong S, Xu C, Zhou J, Wang K. Sleep duration and smoking are associated with coronary heart disease among US adults with type 2 diabetes: Gender differences. Diabetes Res Clin Pract. 2017;124:93-101 pubmed publisher
    ..Such gender disparities should be considered in the prevention and treatment of T2D. ..
  15. Wang K, Liu X, Zhang Q, Aragam N, Pan Y. Parent-of-origin effects of FAS and PDLIM1 in attention-deficit/hyperactivity disorder. J Psychiatry Neurosci. 2012;37:46-52 pubmed publisher
    ..These results suggest several genes or regions with moderate parent-of-origin effects, and these findings will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in ADHD. ..
  16. Wang K, Liu X, Zhang Q, Aragam N, Pan Y. Genome-wide association analysis of age at onset in schizophrenia in a European-American sample. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:671-80 pubmed publisher
    ..05). These findings provide evidence of several genetic variants influencing AAO of SCZ. ..
  17. Wang K, Liu X, Zhang Q, Pan Y, Aragam N, Zeng M. A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. J Psychiatr Res. 2011;45:1419-25 pubmed publisher
    ..These findings offer the potential for new insights into the pathogenesis of alcohol dependence. ..
  18. Wang K, Zuo L, Pan Y, Xie C, Luo X. Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. J Psychiatr Res. 2015;71:1-7 pubmed publisher
    ..0274, 0.00346, and 0.0141, respectively). These findings provide the first evidence of common genetic variants in the CPNE5 gene influencing both the AD and obesity; and will serve as a resource for replication in other populations. ..
  19. Wang K, Liu X, Aragam N. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Schizophr Res. 2010;124:192-9 pubmed publisher
    ..These findings will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in schizophrenia and bipolar disorder. ..