Christopher A Koczor

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia
    Physiol Genomics 48:274-80. 2016
  2. pmc AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia
    Physiol Genomics 47:447-54. 2015
  3. pmc Ecstasy (MDMA) Alters Cardiac Gene Expression and DNA Methylation: Implications for Circadian Rhythm Dysfunction in the Heart
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia 30322
    Toxicol Sci 148:183-91. 2015
  4. pmc Methamphetamine and HIV-Tat alter murine cardiac DNA methylation and gene expression
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA 30322, United States Electronic address
    Toxicol Appl Pharmacol 288:409-19. 2015
  5. pmc p53 and mitochondrial DNA: their role in mitochondrial homeostasis and toxicity of antiretrovirals
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 180:2276-83. 2012
  6. pmc Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Physiol Genomics 45:597-605. 2013
  7. pmc Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA, USA
    Lab Invest 93:151-8. 2013
  8. pmc Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation
    Christopher A Koczor
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Physiol Genomics 45:590-6. 2013
  9. pmc Mitochondrial matrix P53 sensitizes cells to oxidative stress
    Christopher A Koczor
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Mitochondrion 13:277-81. 2013
  10. pmc The role of transporters in the toxicity of nucleoside and nucleotide analogs
    Christopher A Koczor
    Emory University, Pathology, Atlanta, GA 30322, USA
    Expert Opin Drug Metab Toxicol 8:665-76. 2012

Detail Information

Publications11

  1. pmc Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia
    Physiol Genomics 48:274-80. 2016
    ..Cardiac mitochondrial polymerase dysfunction alters nuclear DNA methylation. Furthermore, aging causes a robust change in cardiac DNA methylation that is partially associated with mitochondrial polymerase dysfunction...
  2. pmc AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia
    Physiol Genomics 47:447-54. 2015
    ..This mechanism for NRTI toxicity offers insight into long-term side effects from these commonly used antiviral agents. ..
  3. pmc Ecstasy (MDMA) Alters Cardiac Gene Expression and DNA Methylation: Implications for Circadian Rhythm Dysfunction in the Heart
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia 30322
    Toxicol Sci 148:183-91. 2015
    ..Moreover, MDMA induced gene expression of key elements of circadian rhythm regulatory genes. This suggests a fundamental organism-level event to explain some of the etiologies of MDMA dysfunction in the heart...
  4. pmc Methamphetamine and HIV-Tat alter murine cardiac DNA methylation and gene expression
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA 30322, United States Electronic address
    Toxicol Appl Pharmacol 288:409-19. 2015
    ..Data implicate Cav1.2 in calcium dysregulation and hypercontractility in the murine LV exposed to METH. They suggest a pathogenetic role for METH exposure to promote LV dysfunction that outweighs Tat-induced effects. ..
  5. pmc p53 and mitochondrial DNA: their role in mitochondrial homeostasis and toxicity of antiretrovirals
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 180:2276-83. 2012
    ..Data herein indicate that overexpression of p53 in the mitochondria reduces mtDNA abundance and increases the sensitivity of mammalian cells to NRTI exposure by reducing mitochondrial function...
  6. pmc Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Physiol Genomics 45:597-605. 2013
    ..This study documents that rigorous computational analysis applied to microarray analysis of healthy and diseased human heart samples helps to define clinically relevant DNA methylation and expressional changes in DCM. ..
  7. pmc Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA, USA
    Lab Invest 93:151-8. 2013
    ..Together, these results demonstrate that defective pol-γ function promotes cardiomyopathy, cardiac fibrosis, mtDNA depletion, and reduced mitochondrial energy production...
  8. pmc Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation
    Christopher A Koczor
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Physiol Genomics 45:590-6. 2013
    ..Epigenetic and genetic changes result in changes in mtDNA and in nucleotide substrates for mtDNA replication and underpin energy starvation in DCM...
  9. pmc Mitochondrial matrix P53 sensitizes cells to oxidative stress
    Christopher A Koczor
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Mitochondrion 13:277-81. 2013
    ..Our results demonstrate that mitochondrial matrix p53 sensitizes cells to oxidative stress by reducing mtDNA abundance and mitochondrial function...
  10. pmc The role of transporters in the toxicity of nucleoside and nucleotide analogs
    Christopher A Koczor
    Emory University, Pathology, Atlanta, GA 30322, USA
    Expert Opin Drug Metab Toxicol 8:665-76. 2012
    ..Tissue-specific cellular expression of these transporters enables nucleoside analogs to produce their tissue-specific toxic effects, a limiting factor in the treatment of retroviruses and cancer...
  11. doi Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA
    Christopher A Koczor
    Emory University, Department of Pathology, Atlanta, GA 30322, USA
    Expert Opin Drug Metab Toxicol 6:1493-504. 2010
    ..Though NRTIs inhibit HIV-1 replication, they exhibit side effects in human tissues that appear to result from NRTI inhibition of human mitochondrial polymerase γ (pol γ)...