Zhongxing Liang

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNA
    Zhongxing Liang
    Department of Radiology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 363:542-6. 2007
  2. pmc Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1
    Zhongxing Liang
    Department of Radiology, Emory University, Atlanta, GA 30322, USA
    Biochem Pharmacol 79:817-24. 2010
  3. pmc Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer
    Zhongxing Liang
    Department of Radiology, Emory University, Atlanta, GA 30322, USA Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA Electronic address
    Biochem Biophys Res Commun 477:461-6. 2016
  4. pmc Inhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, 30322, USA
    Breast Cancer Res Treat 146:535-42. 2014
  5. pmc MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, USA
    Pharm Res 30:1008-16. 2013
  6. pmc Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, USA
    Pharm Res 28:3091-100. 2011
  7. pmc Development of a unique small molecule modulator of CXCR4
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e34038. 2012
  8. ncbi request reprint CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models
    Younghyoun Yoon
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 67:7518-24. 2007
  9. pmc CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway
    Zhongxing Liang
    Department of Hematology Oncology, Winship Cancer Institute, 1365C Clifton Road, N E, Clinic C5008, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 359:716-22. 2007
  10. pmc Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
    Aizhi Zhu
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 53:8556-68. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNA
    Zhongxing Liang
    Department of Radiology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 363:542-6. 2007
    ..These data support the conclusion that miRNA against CXCR4 can serve as an alterative means of therapy to lower CXCR4 expression and to block the invasion and metastasis of breast cancer cells...
  2. pmc Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1
    Zhongxing Liang
    Department of Radiology, Emory University, Atlanta, GA 30322, USA
    Biochem Pharmacol 79:817-24. 2010
    ..These findings demonstrate for the first time the involvement of miRNAs in multidrug resistance mediated by MRP-1 and suggest that miR-326 may be an efficient agent for preventing and reversing MDR in tumor cells...
  3. pmc Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer
    Zhongxing Liang
    Department of Radiology, Emory University, Atlanta, GA 30322, USA Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA Electronic address
    Biochem Biophys Res Commun 477:461-6. 2016
    ..These findings demonstrate for the first time the involvement of miRNA-206 in TNBC invasion and angiogenesis and suggest that miR-206 may be an efficient agent for therapy of TNBC. ..
  4. pmc Inhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, 30322, USA
    Breast Cancer Res Treat 146:535-42. 2014
    ..These data suggest that miR-302a mimics are potential therapeutic agents for breast cancer metastasis. ..
  5. pmc MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, USA
    Pharm Res 30:1008-16. 2013
    ..The purpose of this study is to explore whether microRNA-302 is involved in radioresistance and can be exploited as a sensitizer to enhance sensitivity of breast cancer cells to radiation therapy...
  6. pmc Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, USA
    Pharm Res 28:3091-100. 2011
    ..To explore whether miR-19 is involved in the regulation of multidrug resistance (MDR), one of the main causes of breast cancer mortality, and modulates sensitivity of tumor cells to chemotherapeutic agents...
  7. pmc Development of a unique small molecule modulator of CXCR4
    Zhongxing Liang
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e34038. 2012
    ..The unique function of CXCR4 is to promote the homing of tumor cells to their microenvironment at the distant organ sites...
  8. ncbi request reprint CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models
    Younghyoun Yoon
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 67:7518-24. 2007
    ..injected. 686LN-Ms cells failed to metastasize in the CXCR4 antagonist-treated group, whereas they metastasized to the lungs in the control group. Our data indicate that CXCR4 is an important target to inhibit tumor progression in SCCHN...
  9. pmc CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway
    Zhongxing Liang
    Department of Hematology Oncology, Winship Cancer Institute, 1365C Clifton Road, N E, Clinic C5008, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 359:716-22. 2007
    ..Our findings suggest that targeting CXCR4 could provide a potential new anti-angiogenic therapy to suppress the formation of both primary and metastatic tumors...
  10. pmc Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
    Aizhi Zhu
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 53:8556-68. 2010
    ..These data demonstrate that dipyrimidine amines are unique CXCR4 antagonists with high potency and specificity...
  11. ncbi request reprint Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: potential regulation by ligand-dependent degradation and HIF-1alpha
    Hyunsuk Shim
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 346:252-8. 2006
    ..Our study suggests that CXCR4 levels in tumor cells are regulated by its microenvironment. These findings may enhance our ability to understand the biological behavior of breast cancers...
  12. pmc Symmetrical bis-tertiary amines as novel CXCR4 inhibitors
    Renren Bai
    Department of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Eur J Med Chem 118:340-50. 2016
    ..These data demonstrate that symmetrical bis-tertiary amines are unique CXCR4 inhibitors with high potency. ..
  13. pmc Whole-brain spectroscopic MRI biomarkers identify infiltrating margins in glioblastoma patients
    James S Cordova
    Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia J S C, Z L, S S G, C A H, H S Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia H G S, E S Winship Cancer Institute of Emory University, Atlanta, Georgia H G S, Z L, J J O, C G H, H S Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia S S G, L A D C, B K, H S Department of Biomedical informatics, Emory University School of Medicine, Atlanta, Georgia L A D C Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia J J O, C G H Department of Pathology, Emory University School of Medicine, Atlanta, Georgia S G N Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York C G H
    Neuro Oncol 18:1180-9. 2016
    ..Proton spectroscopic MRI (sMRI), a method reporting endogenous metabolism, may better define the tumor margin. Here, we develop a whole-brain sMRI pipeline and validate sMRI metrics with quantitative measures of tumor infiltration...
  14. pmc Silencing of CXCR4 blocks breast cancer metastasis
    Zhongxing Liang
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, 1701 Uppergate Drive, Atlanta, GA 30322, USA
    Cancer Res 65:967-71. 2005
    ..Moreover, our studies confirm the necessity of CXCR4 in breast cancer metastasis...
  15. pmc Benzenesulfonamides: a unique class of chemokine receptor type 4 inhibitors
    Suazette Reid Mooring
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA
    ChemMedChem 8:622-32. 2013
    ..0 nM) and the Matrigel invasion assay (100 % blockade of invasion at 10 nM). These data demonstrate that benzenesulfonamides are a unique class of CXCR4 inhibitors with high potency...
  16. ncbi request reprint Discovery of small molecule CXCR4 antagonists
    Weiqiang Zhan
    Department of Chemistry, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    J Med Chem 50:5655-64. 2007
    ....
  17. doi request reprint Synthesis and evaluation of 2,5 and 2,6 pyridine-based CXCR4 inhibitors
    Theresa Gaines
    Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
    Bioorg Med Chem 24:5052-5060. 2016
    ..Compounds 2g and 2w also inhibit inflammation in the same range as WZ811 in the paw edema test at 40% reduction in inflammation. These preliminary results are the promising foundation of a new class of pyridine-based CXCR4 antagonists...
  18. ncbi request reprint Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4
    Zhongxing Liang
    Department of Hematology Oncology, Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Cancer Res 64:4302-8. 2004
    ....
  19. ncbi request reprint Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model
    Seung Hee Kang
    Department of Hematology Oncology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:11991-7. 2006
    ....
  20. pmc Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library
    Renren Bai
    Department of Radiation Oncology, School of Medicine, Emory University, Atlanta, GA, USA
    Eur J Med Chem 126:464-475. 2016
    ....
  21. pmc A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma
    J Scott Cordova
    Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA
    Tomography 2:106-116. 2016
    ..In this work, we aim to set forth a systematic pipeline to stimulate histopathology-image validation of advanced MRI techniques, such as sMRI...
  22. ncbi request reprint Rickettsia rickettsii infection in the pine vole, Microtus pinetorum: kinetics of infection and quantitation of antioxidant enzyme gene expression by RT-PCR
    Marina E Eremeeva
    Viral and Rickettsial Zoonoses Branch, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 990:468-73. 2003
    ..rickettsii. Our results provide the first experimental evidence that R. rickettsii causes alteration(s) of the anti-oxidant system in vivo...