Alaa F Badawi

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review)
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 20:1109-22. 2002
  2. ncbi Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer Invest 20:651-6. 2002
  3. ncbi Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 103:84-90. 2003
  4. ncbi Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 25:1681-8. 2004
  5. ncbi Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Res 64:1181-9. 2004
  6. ncbi Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids
    Suying Lu
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building 150 College Street, Ont M5S 3E2, Canada
    Cancer Lett 184:7-12. 2002
  7. ncbi Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate
    Alaa F Badawi
    Carcinogenesis 26:1650. 2005
  8. ncbi Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells
    Michael S Michael
    Novexpharma, Richmond Hills, ON L4C 5H2, Canada
    Int J Mol Med 11:733-6. 2003
  9. ncbi Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:329-33. 2002
  10. ncbi Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha 68198 6805, USA
    Carcinogenesis 24:697-702. 2003

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review)
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 20:1109-22. 2002
    ....
  2. ncbi Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer Invest 20:651-6. 2002
    ..The observed over-expression of COX-2 gene in human urinary bladder and the concomitant increases in PG synthesis may explain, at least in part, the mechanism by which cigarette smoking influences the development of urothelial neoplasia...
  3. ncbi Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 103:84-90. 2003
    ..Our results suggest that the altered expression of COX-2 and PPARgamma and the subsequent modulation in the tissue levels of PGE(2) and 15-d-PGJ(2) may influence the development of human breast cancer and its progression to metastasis...
  4. ncbi Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 25:1681-8. 2004
    ..Subsequently, COX-2 inhibitors can be considered as a promising class of agents to attenuate the increased cell survival and, hence, protect against tumorigenesis in the aging prostate...
  5. ncbi Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Res 64:1181-9. 2004
    ....
  6. ncbi Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids
    Suying Lu
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building 150 College Street, Ont M5S 3E2, Canada
    Cancer Lett 184:7-12. 2002
    ..This inhibition may be due to the effects of celecoxib on lipid metabolism as well as COX-2...
  7. ncbi Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate
    Alaa F Badawi
    Carcinogenesis 26:1650. 2005
  8. ncbi Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells
    Michael S Michael
    Novexpharma, Richmond Hills, ON L4C 5H2, Canada
    Int J Mol Med 11:733-6. 2003
    ..COX-2 and PPARgamma can be promising molecular targets for combinational chemoprevention or treatment of breast cancer...
  9. ncbi Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:329-33. 2002
    ....
  10. ncbi Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha 68198 6805, USA
    Carcinogenesis 24:697-702. 2003
    ..The levels of 4-CE and quinone conjugates were highly significant predictors of breast cancer. These results suggest that some catechol estrogen metabolites and conjugates could serve as biomarkers to predict risk of breast cancer...
  11. ncbi DNA alkylation and repair in the large bowel: animal and human studies
    Andrew C Povey
    Centre for Occupational and Environmental Health, School of Epidemiology and Health Sciences, University of Manchester, Manchester, M13 9PL, England
    J Nutr 132:3518S-3521S. 2002
    ..Human exposure to endogenous or exogenous alkylating agents may thus be an environmental determinant of colorectal cancer risk...
  12. ncbi Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 588:158-65. 2005
    ..In summary, the inclusion of ARP in the DB[a,l]P-DNA adduct-forming reaction traps and protects the nascent abasic sites, allowing an improved quantification of abasic sites...

Research Grants1

  1. Prevention of Breast Cancer-Targeting COX-2 & PPARgamma
    ALAA BADAWI; Fiscal Year: 2003
    ..abstract_text> ..