Beatrice S Knudsen

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc A highly invasive human glioblastoma pre-clinical model for testing therapeutics
    Qian Xie
    Laboratory of Molecular Oncology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Transl Med 6:77. 2008
  2. pmc Migrating with myosin VI
    Beatrice Knudsen
    Fred Hutchinson Cancer Research Center, Program in Cancer Biology, Division of Public Health Sciences, 1100 Fairview Avenue North, M5 A864, Seattle, WA 98109, USA
    Am J Pathol 169:1523-6. 2006
  3. pmc Evaluation of the branched-chain DNA assay for measurement of RNA in formalin-fixed tissues
    Beatrice S Knudsen
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seatle, Washington, USA
    J Mol Diagn 10:169-76. 2008
  4. ncbi request reprint The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biochem 99:345-61. 2006
  5. pmc Regulation of hepatocyte activator inhibitor-1 expression by androgen and oncogenic transformation in the prostate
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Am J Pathol 167:255-66. 2005
  6. pmc Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition
    Ausra Bendoraite
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Gynecol Oncol 116:117-25. 2010
  7. ncbi request reprint Low-fat, low-glycemic load diet and gene expression in human prostate epithelium: a feasibility study of using cDNA microarrays to assess the response to dietary intervention in target tissues
    Daniel W Lin
    Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 16:2150-4. 2007
  8. pmc Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia
    Heather H Cheng
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 8:e69239. 2013
  9. pmc Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect
    Michael C Risk
    Departments of Urology and Pathology, University of Washington Medical Center, 1959 NW Pacific Street, Seattle, WA 98195, USA
    Clin Cancer Res 16:5414-23. 2010
  10. pmc Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases
    Aaron P Putzke
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington Department of Biology, Hope College, Holland, Michigan
    Am J Pathol 179:400-10. 2011

Detail Information

Publications40

  1. pmc A highly invasive human glioblastoma pre-clinical model for testing therapeutics
    Qian Xie
    Laboratory of Molecular Oncology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Transl Med 6:77. 2008
    ..This model has multiple unique features for investigating the pathobiology of intracranial tumor growth and for monitoring systemic and intracranial responses to antitumor agents...
  2. pmc Migrating with myosin VI
    Beatrice Knudsen
    Fred Hutchinson Cancer Research Center, Program in Cancer Biology, Division of Public Health Sciences, 1100 Fairview Avenue North, M5 A864, Seattle, WA 98109, USA
    Am J Pathol 169:1523-6. 2006
  3. pmc Evaluation of the branched-chain DNA assay for measurement of RNA in formalin-fixed tissues
    Beatrice S Knudsen
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seatle, Washington, USA
    J Mol Diagn 10:169-76. 2008
    ..It also appears to be well suited for the clinical analysis of FFPE tissues with diagnostic or prognostic gene expression biomarker panels for use in patient treatment and management...
  4. ncbi request reprint The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biochem 99:345-61. 2006
    ..However, several drug targets that are upregulated after androgen ablative therapy regulate cell adhesion and thus novel targeted therapies indirectly interfere with cell adhesion mechanisms in prostate cancer cells...
  5. pmc Regulation of hepatocyte activator inhibitor-1 expression by androgen and oncogenic transformation in the prostate
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Am J Pathol 167:255-66. 2005
    ..24). These results suggest that HAI-1 regulates the HGF Met axis on prostate epithelial cells and influences HGF mediated tumor invasion and metastasis...
  6. pmc Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition
    Ausra Bendoraite
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Gynecol Oncol 116:117-25. 2010
    ..Our objective was to characterize the expression and function of the miR-200 family of microRNAs (miRNA) in ovarian carcinogenesis...
  7. ncbi request reprint Low-fat, low-glycemic load diet and gene expression in human prostate epithelium: a feasibility study of using cDNA microarrays to assess the response to dietary intervention in target tissues
    Daniel W Lin
    Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 16:2150-4. 2007
    ..We examined the feasibility of using gene expression changes in human prostate epithelium as a measure of response to a dietary intervention...
  8. pmc Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia
    Heather H Cheng
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 8:e69239. 2013
    ....
  9. pmc Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect
    Michael C Risk
    Departments of Urology and Pathology, University of Washington Medical Center, 1959 NW Pacific Street, Seattle, WA 98195, USA
    Clin Cancer Res 16:5414-23. 2010
    ..We sought to determine if histologically benign prostate epithelium collected from men with prostate cancer exhibits features indicative of premalignancy or field effect...
  10. pmc Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases
    Aaron P Putzke
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington Department of Biology, Hope College, Holland, Michigan
    Am J Pathol 179:400-10. 2011
    ....
  11. pmc Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries
    Stacia K Wyman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e5311. 2009
    ..A critical step toward these goals is to establish a comprehensive view of miRNAs expressed in epithelial ovarian cancer tissues as well as in normal ovarian surface epithelial cells...
  12. pmc Activation of the MEK-S6 pathway in high-grade ovarian cancers
    Aviva P Ventura
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Appl Immunohistochem Mol Morphol 18:499-508. 2010
    ..The phosphorylation of S6 as a specific biomarker for either MEK or PI3-kinase pathway activation should be used with caution...
  13. pmc Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases
    Canan Akfirat
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Pathol 230:291-7. 2013
    ..Altogether, this suggests that optimal therapeutic inhibition may require combinations of drugs that target both bone and soft tissue-specific survival pathways...
  14. ncbi request reprint Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression
    Chang Xu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Prostate 67:1621-9. 2007
    ..In particular we questioned whether the androgen therapy could adversely facilitate prostate cancer progression through an increase growth factor secretion by the bone microenvironment...
  15. pmc A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings
    Beatrice S Knudsen
    Department of Pathology, University of Washington Medical Center, NE Pacific, Seattle, WA, USA
    Appl Immunohistochem Mol Morphol 17:57-67. 2009
    ..These properties encourage further development of MET4 as a multipurpose molecular diagnostics reagent to help to guide appropriate selection of patients being considered for treatment with c-MET-antagonistic drugs...
  16. pmc Circulating microRNAs as stable blood-based markers for cancer detection
    Patrick S Mitchell
    Divisions of Human Biology, Clinical Research, and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 105:10513-8. 2008
    ..Our results establish the measurement of tumor-derived miRNAs in serum or plasma as an important approach for the blood-based detection of human cancer...
  17. ncbi request reprint Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue
    Michael P Gustafson
    Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cell Tissue Res 325:263-76. 2006
    ..Altogether, this in vitro model recapitulates certain aspects of in vivo growth regulation and differentiation and suggests that the loss of Rb family proteins in human cells trigger hyperplasia but is not sufficient for transformation...
  18. ncbi request reprint Influence of surgical manipulation on prostate gene expression: implications for molecular correlates of treatment effects and disease prognosis
    Daniel W Lin
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Clin Oncol 24:3763-70. 2006
    ..This study examines whether there are transcript alterations associated with surgical resection of the prostate gland by radical retropubic prostatectomy...
  19. ncbi request reprint Mechanisms of prostate cancer initiation and progression
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Adv Cancer Res 109:1-50. 2010
    ..These discoveries should help concentrate the efforts of drug development on key pathways and molecules, and finally translate the knowledge that is gained from mechanistic studies into effective treatments...
  20. ncbi request reprint Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia
    Tod A Brown
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 279:14772-83. 2004
    ..We suggest that the balance is altered by conversion of gp140 to p80 and by adhesion, providing a novel transmembrane phosphorylation signal in epithelial wounds...
  21. ncbi request reprint Analyzing patterns of staining in immunohistochemical studies: application to a study of prostate cancer recurrence
    Ruth Etzioni
    Translational and Outcomes Research, Fred Hutchinson Cancer Research Center, Mailstop M2 B230, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1040-6. 2005
    ..In this article, we introduce analytic approaches that explicitly consider both the frequency and intensity of tissue staining...
  22. ncbi request reprint Prostate cancer and the met hepatocyte growth factor receptor
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98125, USA
    Adv Cancer Res 91:31-67. 2004
    ..On the basis of the commonly observed overexpression of Met in metastatic prostate cancer, HGF/SF-Met-targeted imaging and therapeutic agents can now be applied toward diagnosis and treatment...
  23. doi request reprint Showering c-MET-dependent cancers with drugs
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, United States
    Curr Opin Genet Dev 18:87-96. 2008
    ..It is almost without question that combination therapies with c-MET-HGF/SF inhibitors will be required for most cancers to achieve a cytotoxic tumor response...
  24. ncbi request reprint Combining results of microarray experiments: a rank aggregation approach
    Robert P DeConde
    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stat Appl Genet Mol Biol 5:Article15. 2006
    ..We apply all three algorithms to aggregate the results of five microarray studies of prostate cancer...
  25. pmc Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Hum Mutat 34:149-56. 2013
    ..These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here...
  26. pmc A molecular correlate to the Gleason grading system for prostate adenocarcinoma
    Lawrence True
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:10991-6. 2006
    ..Furthermore, in identifying a profile of 86 genes that distinguish high- from low-grade carcinomas, we have generated a set of potential targets for modulating the development and progression of the lethal prostate cancer phenotype...
  27. ncbi request reprint Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer
    Elahe A Mostaghel
    Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Cancer Res 67:5033-41. 2007
    ..Optimal clinical efficacy will require testing of novel approaches targeting complete suppression of systemic and intracrine contributions to the prostatic androgen microenvironment...
  28. pmc Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains
    Vitor M Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e2425. 2008
    ..We have characterized the cell surface proteome and the proteins released into the extra-cellular milieu of three ovarian cancer cell lines, CaOV3, OVCAR3 and ES2 and of ovarian tumor cells enriched from ascites fluid...
  29. ncbi request reprint Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma
    Stacy Moore
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 114:563-71. 2005
    ..These results indicate that loss of SCD expression is a frequent event in prostate adenocarcinoma, and further supports a role for altered lipid metabolism as a factor in the process of carcinogenesis...
  30. ncbi request reprint The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    Claes Bavik
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Res 66:794-802. 2006
    ..These results support the concept that aging-related changes in the prostate microenvironment may contribute to the progression of prostate neoplasia...
  31. ncbi request reprint Regulation of migration of primary prostate epithelial cells by secreted factors from prostate stromal cells
    Xueke You
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Exp Cell Res 288:246-56. 2003
    ....
  32. pmc Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death
    Mathew J Edick
    Laboratory of Integrin Signaling, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Mol Biol Cell 18:2481-90. 2007
    ..Suppression of autophagy is sufficient to induce caspase activation and apoptosis in LM5-adherent primary prostate epithelial cells...
  33. ncbi request reprint High expression of the Met receptor in prostate cancer metastasis to bone
    Beatrice S Knudsen
    Department ofPathology, Weill Medical College of Cornell University, New York, New York, USA
    Urology 60:1113-7. 2002
    ....
  34. ncbi request reprint Syndecan-1 expression in locally invasive and metastatic prostate cancer
    David Chen
    Department of Urology, New York Presbyterian Hospital, New York, New York, USA
    Urology 63:402-7. 2004
    ..To determine the significance of syndecan-1 expression, a cell-surface heparan sulfate proteoglycan in localized and metastatic prostate cancer...
  35. ncbi request reprint Basal prostate epithelial cells stimulate the migration of prostate cancer cells
    Hsiao Man Yu
    Department of Pathology, Weill Medical College of Cornell University, New York, NY, USA
    Mol Carcinog 41:85-97. 2004
    ..Altogether, the possibility that basal epithelial cells assist in the invasion of in situ carcinoma cells is supported by the results from our in vitro system...
  36. pmc Proliferation and invasion: plasticity in tumor cells
    Chong Feng Gao
    Laboratory of Molecular Oncology, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 102:10528-33. 2005
    ....
  37. ncbi request reprint Radioimmunoscintigraphy of human met-expressing tumor xenografts using met3, a new monoclonal antibody
    Rick V Hay
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Clin Cancer Res 9:3839S-44S. 2003
    ..In this study, we evaluated the ability of radioiodinated anti-Met monoclonal antibodies from a single hybridoma clone to image human Met-expressing tumor xenografts...
  38. ncbi request reprint Nuclear imaging of Met-expressing human and canine cancer xenografts with radiolabeled monoclonal antibodies (MetSeek)
    Rick V Hay
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Clin Cancer Res 11:7064s-7069s. 2005
    ..In this study, we compared two antibodies, Met5 and Met3, for nuclear imaging of human and canine Met-expressing tumor xenografts in nude mice...
  39. ncbi request reprint A working group classification of focal prostate atrophy lesions
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, USA
    Am J Surg Pathol 30:1281-91. 2006
    ..In conclusion, these criteria for variants of focal prostate atrophy may facilitate studies to examine the relation between various patterns of prostate atrophy and prostate cancer...
  40. ncbi request reprint Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens
    Xiaojia Guo
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 62:1654-61. 2002
    ..Collectively, these data implicate aberrant retinoid metabolism in the process of prostatic carcinogenesis...