Gerard Ahern

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Polyamines are potent ligands for the capsaicin receptor TRPV1
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 281:8991-5. 2006
  2. ncbi request reprint Identification of functional type 1 ryanodine receptors in mouse dendritic cells
    Peta J O'Connell
    The John P Roberts Research Institute, London, Canada
    FEBS Lett 512:67-70. 2002
  3. pmc TRPA1 is a polyunsaturated fatty acid sensor in mammals
    Arianne L Motter
    Department of Pharmacology and Physiology, Georgetown University, Washington, District of Columbia, USA
    PLoS ONE 7:e38439. 2012
  4. doi request reprint Transient receptor potential channels and energy homeostasis
    Gerard P Ahern
    Department of Pharmacology and Physiology, Georgetown University, Washington DC 20007, USA Electronic address
    Trends Endocrinol Metab 24:554-60. 2013
  5. pmc Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation
    Gerard P Ahern
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    J Physiol 545:441-51. 2002
  6. ncbi request reprint Activation of TRPV1 by the satiety factor oleoylethanolamide
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 278:30429-34. 2003
  7. pmc 5-HT and the immune system
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, 3900 Reservoir Rd NW, Washington, DC 20007, United States
    Curr Opin Pharmacol 11:29-33. 2011
  8. ncbi request reprint Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    J Neurosci 25:5109-16. 2005
  9. pmc TRPV1 is a novel target for omega-3 polyunsaturated fatty acids
    JOSE A MATTA
    Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    J Physiol 578:397-411. 2007
  10. ncbi request reprint TRPV1 and synaptic transmission
    JOSE A MATTA
    National Institute of General Medical Sciences, Bethesda, MD, 20892, USA
    Curr Pharm Biotechnol 12:95-101. 2011

Research Grants

  1. Calcium Signaling in Dendritic Cell Function
    Gerard Ahern; Fiscal Year: 2006
  2. Molecular Pain Mechanisms
    Gerard P Ahern; Fiscal Year: 2010

Collaborators

  • LOUIS PREMKUMAR
  • Meyer Jackson
  • Niaz Sahibzada
  • JOSE A MATTA
  • Peta J O'Connell
  • Arianne L Motter
  • Paul M Cornett
  • Matilde Leon-Ponte
  • Bidhan C Bandyopadhyay
  • Sandeep C Pingle
  • Rosa L Miyares
  • Meaghan Stolk
  • Xiangbin Wang
  • Ken Abe
  • Mia Merrill
  • Rosa Linda Miyares
  • Vitaly A Klyachko

Detail Information

Publications20

  1. ncbi request reprint Polyamines are potent ligands for the capsaicin receptor TRPV1
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 281:8991-5. 2006
    ..Therefore, polyamine regulation of TRPV1 in these tissues may be relevant to a variety of physiological and pathophysiological states...
  2. ncbi request reprint Identification of functional type 1 ryanodine receptors in mouse dendritic cells
    Peta J O'Connell
    The John P Roberts Research Institute, London, Canada
    FEBS Lett 512:67-70. 2002
    ..Thus, the RyR1 channel may play an intrinsic role in Ca(2+) signaling in DC...
  3. pmc TRPA1 is a polyunsaturated fatty acid sensor in mammals
    Arianne L Motter
    Department of Pharmacology and Physiology, Georgetown University, Washington, District of Columbia, USA
    PLoS ONE 7:e38439. 2012
    ..We propose that PUFA-sensing by mammalian TRPA1 may regulate pain and gastrointestinal functions...
  4. doi request reprint Transient receptor potential channels and energy homeostasis
    Gerard P Ahern
    Department of Pharmacology and Physiology, Georgetown University, Washington DC 20007, USA Electronic address
    Trends Endocrinol Metab 24:554-60. 2013
    ..TRP agonists were shown to reduce body weight and adiposity, suggesting that they might be exploited as therapeutic targets. In this review I discuss the current knowledge of how TRP channels influence energy balance. ..
  5. pmc Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation
    Gerard P Ahern
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    J Physiol 545:441-51. 2002
    ..These results suggest that voltage interacts with agonists in a synergistic manner to augment VR current and this mechanism will be enhanced under conditions of inflammation when VRs are likely to be phosphorylated...
  6. ncbi request reprint Activation of TRPV1 by the satiety factor oleoylethanolamide
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 278:30429-34. 2003
    ..Further, after PKC stimulation, OEA activated TRPV1 channels in cell-free patches suggesting a direct mode of action. Thus, TRPV1 represents a potential target for OEA and may contribute to the excitatory action of OEA on sensory nerves...
  7. pmc 5-HT and the immune system
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, 3900 Reservoir Rd NW, Washington, DC 20007, United States
    Curr Opin Pharmacol 11:29-33. 2011
    ..Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed...
  8. ncbi request reprint Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling
    Gerard P Ahern
    Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    J Neurosci 25:5109-16. 2005
    ..Thus, the modulation of TRPV1 by cationic strength may contribute to inflammatory pain signaling...
  9. pmc TRPV1 is a novel target for omega-3 polyunsaturated fatty acids
    JOSE A MATTA
    Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    J Physiol 578:397-411. 2007
    ..Further, these results suggest that dietary supplementation with selective n-3 fatty acids would be most beneficial for the treatment of pain...
  10. ncbi request reprint TRPV1 and synaptic transmission
    JOSE A MATTA
    National Institute of General Medical Sciences, Bethesda, MD, 20892, USA
    Curr Pharm Biotechnol 12:95-101. 2011
    ..Here we discuss our current understanding of the potential roles for TRPV1 in synaptic transmission...
  11. pmc Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1
    Xiangbin Wang
    Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, DC 20057, USA
    J Physiol 564:541-7. 2005
    ..Further, OEA reduced 30-min food intake in wild-type but not in TRPV1-null mice. Thus, the acute behavioural effects of OEA may result from visceral malaise via the activation of TRPV1...
  12. pmc Voltage is a partial activator of rat thermosensitive TRP channels
    JOSE A MATTA
    Department of Pharmacology, Georgetown University, MedDent SW401, 3900 Reservoir Rd Washington, DC 20007, USA
    J Physiol 585:469-82. 2007
    ..Thus, voltage acts separately but in concert with other stimuli to regulate channel activation, and, therefore, a voltage-sensitive mechanism is unlikely to represent a final, gating mechanism for these channels...
  13. doi request reprint General anesthetics sensitize the capsaicin receptor transient receptor potential V1
    Paul M Cornett
    Department of Pharmacology, Georgetown University, 3900 Reservoir Rd, NW, Washington DC 20007, USA
    Mol Pharmacol 74:1261-8. 2008
    ..Thus, GAs can enhance the activation of TRPV1 that occurs during surgically induced tissue damage. These results support the hypothesis that some GAs, through direct actions at TRP channels, increase postsurgical pain and inflammation...
  14. pmc Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1
    Bidhan C Bandyopadhyay
    Department of Pharmacology, Georgetown University, 3900 Reservoir Rd, NW, Washington, DC 20007, USA
    J Leukoc Biol 89:57-62. 2011
    ..Together, these data demonstrate a novel, STIM2-dependent SOCE signaling pathway in DCs...
  15. ncbi request reprint cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO
    Gerard P Ahern
    Dept of Pharmacology, Georgetown University, Washington, DC, USA
    Trends Neurosci 25:510-7. 2002
    ..The existence of two effector pathways has important functional implications, expanding and enriching the possibilities for modulating neuronal excitability...
  16. pmc TRPV1-null mice are protected from diet-induced obesity
    Arianne L Motter
    Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, DC 20007, USA
    FEBS Lett 582:2257-62. 2008
    ..Thus, these data support a potential neurogenic mechanism by which TRPV1-sensitive sensory nerves may regulate energy and fat metabolism...
  17. pmc General anesthetics activate a nociceptive ion channel to enhance pain and inflammation
    JOSE A MATTA
    Departments of Pharmacology and Physiology and Biophysics, Georgetown University, 3900 Reservoir Road, NW, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 105:8784-9. 2008
    ..Thus, our results show that TRPA1 is essential for sensing noxious GAs. The pronociceptive effects of GAs combined with surgical tissue damage could lead to a paradoxical increase in postoperative pain and inflammation...
  18. ncbi request reprint Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1
    Peta J O'Connell
    Robarts Research Institute, 100 Perth Drive, P O Box 5015, London, Ont, Canada N6A 5K8
    FEBS Lett 579:5135-9. 2005
    ..Thus, our data do not support the hypothesis that DC express TRPV1 channels. Rather, signaling through TRPV1 in sensory nerves may modulate DC via neurogenic actions...
  19. pmc Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor
    Matilde Leon-Ponte
    Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada
    Blood 109:3139-46. 2007
    ....
  20. ncbi request reprint IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1
    Meaghan Stolk
    Robarts Research Institute, London, Ontario, Canada
    J Leukoc Biol 80:651-8. 2006
    ..Signaling via IP(3)R may therefore be sufficient to drive essential DC Ca(2+) signaling processes in the absence of RyR expression or function...

Research Grants2

  1. Calcium Signaling in Dendritic Cell Function
    Gerard Ahern; Fiscal Year: 2006
    ..Aim 2 tests the impact of endogenous and pharmacologic activators of RyR1 on DC. In Aim 3, we will elucidate the role of calcium-triggered secretion in DC. ..
  2. Molecular Pain Mechanisms
    Gerard P Ahern; Fiscal Year: 2010
    ..In Aim 3 we plan to identify nociceptive behaviors and pathology arising from cationic regulation of TRPV1. ..