Stuart H Orkin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. Lessard S, Francioli L, Alföldi J, Tardif J, Ellinor P, MacArthur D, et al. Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci. Proc Natl Acad Sci U S A. 2017;114:E11257-E11266 pubmed publisher
    ....
  2. Xie H, Xu J, Hsu J, Nguyen M, Fujiwara Y, Peng C, et al. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 2014;14:68-80 pubmed publisher
    ..Taken together, our findings define developmental-stage-specific requirements for canonical PRC2 complexes in normal HSC function. ..
  3. Balbach S, Orkin S. An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation. Cancer Discov. 2016;6:700-2 pubmed publisher
    ..Cancer Discov; 6(7); 700-2. ©2016 AACR.See related article by Zhu and colleagues, p. 770...
  4. Xie H, Peng C, Huang J, Li B, Kim W, SMITH E, et al. Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. Cancer Discov. 2016;6:1237-1247 pubmed
    ..Cancer Discov; 6(11); 1237-47. ©2016 AACR.See related article by Scott et al., p. 1248This article is highlighted in the In This Issue feature, p. 1197. ..
  5. Luc S, Huang J, McEldoon J, Somuncular E, Li D, Rhodes C, et al. Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Rep. 2016;16:3181-3194 pubmed publisher
    ..Our studies define a mechanism for BCL11A in regulation of HSC function and have important implications for the design of therapeutic approaches to targeting BCL11A. ..
  6. Hsu J, Hubbell Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, et al. PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017;77:4613-4625 pubmed publisher
    ..i>Cancer Res; 77(17); 4613-25. ©2017 AACR. ..

Locale

Detail Information

Publications6

  1. Lessard S, Francioli L, Alföldi J, Tardif J, Ellinor P, MacArthur D, et al. Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci. Proc Natl Acad Sci U S A. 2017;114:E11257-E11266 pubmed publisher
    ....
  2. Xie H, Xu J, Hsu J, Nguyen M, Fujiwara Y, Peng C, et al. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 2014;14:68-80 pubmed publisher
    ..Taken together, our findings define developmental-stage-specific requirements for canonical PRC2 complexes in normal HSC function. ..
  3. Balbach S, Orkin S. An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation. Cancer Discov. 2016;6:700-2 pubmed publisher
    ..Cancer Discov; 6(7); 700-2. ©2016 AACR.See related article by Zhu and colleagues, p. 770...
  4. Xie H, Peng C, Huang J, Li B, Kim W, SMITH E, et al. Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. Cancer Discov. 2016;6:1237-1247 pubmed
    ..Cancer Discov; 6(11); 1237-47. ©2016 AACR.See related article by Scott et al., p. 1248This article is highlighted in the In This Issue feature, p. 1197. ..
  5. Luc S, Huang J, McEldoon J, Somuncular E, Li D, Rhodes C, et al. Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Rep. 2016;16:3181-3194 pubmed publisher
    ..Our studies define a mechanism for BCL11A in regulation of HSC function and have important implications for the design of therapeutic approaches to targeting BCL11A. ..
  6. Hsu J, Hubbell Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, et al. PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017;77:4613-4625 pubmed publisher
    ..i>Cancer Res; 77(17); 4613-25. ©2017 AACR. ..