Lawrence M Roth

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi Macroscopic Sertoli cell nodule of the testis containing numerous spermatogonia
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA Electronic address
    Pathol Res Pract 212:943-945. 2016
  2. doi Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 462012 5120 Electronic address
    Hum Pathol 51:51-6. 2016
  3. doi Signet ring stromal cell tumor revisited and related signet ring cell lesions of the ovary
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46240 5120, USA Electronic address
    Hum Pathol 45:636-42. 2014
  4. doi The pathogenesis of ovarian myxoma: a neoplasm sometimes arising from other ovarian stromal tumors
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 32:368-78. 2013
  5. doi Recurrent cotyledonoid dissecting leiomyoma of the uterus
    Lawrence Max Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Int J Gynecol Pathol 32:215-20. 2013
  6. ncbi Recent advances in the pathology and classification of ovarian sex cord-stromal tumors
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Int J Gynecol Pathol 25:199-215. 2006
  7. doi Malignant Brenner tumor of the ovary with transformation to trabecular carcinoid: an immunocytochemical and electron microscopic study
    Lawrence Max Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 31:91-7. 2012
  8. doi Ovarian yolk sac tumors in older women arising from epithelial ovarian tumors or with no detectable epithelial component
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Int J Gynecol Pathol 30:442-51. 2011
  9. doi Perspectives on pure ovarian stromal neoplasms and tumor-like proliferations of the ovarian stroma
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Am J Surg Pathol 35:e15-33. 2011
  10. doi Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 27:496-506. 2008

Detail Information

Publications31

  1. doi Macroscopic Sertoli cell nodule of the testis containing numerous spermatogonia
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA Electronic address
    Pathol Res Pract 212:943-945. 2016
    ..Unlike incidental Sertoli cell nodules, macroscopic Sertoli cell nodules containing numerous germ cells can be mistaken for several other Sertoli cell and germ cell lesions and neoplasms...
  2. doi Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 462012 5120 Electronic address
    Hum Pathol 51:51-6. 2016
    ....
  3. doi Signet ring stromal cell tumor revisited and related signet ring cell lesions of the ovary
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46240 5120, USA Electronic address
    Hum Pathol 45:636-42. 2014
    ....
  4. doi The pathogenesis of ovarian myxoma: a neoplasm sometimes arising from other ovarian stromal tumors
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 32:368-78. 2013
    ..We believe that myxomas arising from different anatomic sites likely are genetically, histologically, and biologically distinct. For purposes of classification, they should be considered as separate tumor types...
  5. doi Recurrent cotyledonoid dissecting leiomyoma of the uterus
    Lawrence Max Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Int J Gynecol Pathol 32:215-20. 2013
    ..She was living and well 2.5 yr after hysterectomy with no evidence of disease...
  6. ncbi Recent advances in the pathology and classification of ovarian sex cord-stromal tumors
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Int J Gynecol Pathol 25:199-215. 2006
    ..The article concludes with a section discussing the pathogenesis of sex cord-stromal tumors...
  7. doi Malignant Brenner tumor of the ovary with transformation to trabecular carcinoid: an immunocytochemical and electron microscopic study
    Lawrence Max Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 31:91-7. 2012
    ....
  8. doi Ovarian yolk sac tumors in older women arising from epithelial ovarian tumors or with no detectable epithelial component
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Int J Gynecol Pathol 30:442-51. 2011
    ..However, 2 more recent patients treated aggressively with platinum-based chemotherapy designed to treat both epithelial and germ cell tumor components with stage 1 disease are living and have been disease free >1 year after operation...
  9. doi Perspectives on pure ovarian stromal neoplasms and tumor-like proliferations of the ovarian stroma
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Am J Surg Pathol 35:e15-33. 2011
    ..Wherever applicable, we discuss molecular techniques that are currently diagnostically useful...
  10. doi Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 27:496-506. 2008
    ....
  11. doi Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Int J Gynecol Pathol 27:213-22. 2008
    ..The treatment of choice for patients with HDFCO is local resection of the extraovarian tumor with subsequent thyroidectomy followed by radioactive iodine ablation...
  12. ncbi The enigma of struma ovarii
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Pathology 39:139-46. 2007
    ..This review emphasises articles both recent and past that have significantly advanced our knowledge of struma ovarii and related neoplasms...
  13. ncbi Recent advances in the pathology and classification of ovarian germ cell tumors
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Int J Gynecol Pathol 25:305-20. 2006
    ..This review will emphasize the articles written in the last 10 years and those that have significantly advanced our knowledge of germ cell tumors in past decades...
  14. doi Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 41:716-23. 2010
    ..Chromosome 12p fluorescence in situ hybridization combined with OCT4, CD30, and glypican 3 immunostains is useful in confirming the diagnosis of ovarian embryonal carcinoma...
  15. ncbi Cytokeratin and CD30 expression in dysgerminoma
    Paolo Cossu-Rocca
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Hum Pathol 37:1015-21. 2006
    ..Furthermore, the immunohistochemical staining patterns for cytokeratins, E-cadherin, and CD30 in dysgerminomas need to be considered when assessing differential diagnoses in difficult cases of primary ovarian tumors...
  16. ncbi Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications
    Michael Sever
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 18:1411-6. 2005
    ..Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options...
  17. ncbi Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis
    Paolo Cossu-Rocca
    Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 19:611-5. 2006
    ..FISH analyses for chromosome 12p abnormalities may be a useful diagnostic adjunct for confirming the diagnosis of dysgerminoma and for distinguishing it from nongerm cell malignancies that enter into the differential diagnosis...
  18. ncbi Recent advances in the pathology and classification of gonadal neoplasms composed of germ cells and sex cord derivatives
    Aleksander Talerman
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5244, USA
    Int J Gynecol Pathol 26:313-21. 2007
    ..The introduction of cisplatin-based chemotherapy and the application of tumor markers have dramatically improved the clinical outlook for those patients who develop secondary malignant germ cell neoplasms...
  19. ncbi Molecular genetic evidence supporting the neoplastic nature of the Leydig cell component of ovarian Sertoli-Leydig cell tumors
    Robert E Emerson
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Int J Gynecol Pathol 26:368-74. 2007
    ..Similarly, the heterologous components, when present, appear to share clonal origin with the Sertoli cell components...
  20. doi KIT gene mutation and amplification in dysgerminoma of the ovary
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 117:2096-103. 2011
    ..The purpose of this study was to analyze alterations of the KIT gene in a large series of dysgerminomas and correlate the findings with clinicopathological parameters...
  21. doi Cervical Carcinomas With Neuroendocrine Differentiation: A Report of 28 Cases With Immunohistochemical Analysis and Molecular Genetic Evidence of Common Clonal Origin With Coexisting Squamous and Adenocarcinomas
    Robert E Emerson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    Int J Gynecol Pathol 35:372-84. 2016
    ..Consistent staining for p16 is also seen. Concordant genetic alterations support common clonal origin for neuroendocrine carcinomas with a coexisting squamous or adenocarcinoma component. ..
  22. ncbi OCT4: a novel biomarker for dysgerminoma of the ovary
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Am J Surg Pathol 28:1341-6. 2004
    ..OCT4 may aid in the detection of small foci of metastatic dygerminoma in extraovarian sites and may also help distinguish dysgerminoma from other primary and metastatic tumors of the ovary...
  23. doi Evidence of a dual histogenetic pathway of sacrococcygeal teratomas
    Robert E Emerson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Histopathology 70:290-300. 2017
    ..We investigated the i(12p) status of a large number of primary sacrococcygeal teratomas in both children and adults, including cases with malignant germ cell tumour elements...
  24. doi Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread
    Stanley J Robboy
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Gynecol Pathol 28:405-22. 2009
    ..Overall, the survival rate for all patients was 89% at 10 years and 84% at 25 years, indicating the need for routine long-term follow-up...
  25. doi On the pathogenesis of sclerosing stromal tumor of the ovary: a neoplasm in transition
    Lawrence M Roth
    Department of Pathology L M R, L C, Indiana University School of Medicine, Indianapolis, Indiana Henry Ford Health System A R G, Detroit, Michigan
    Int J Gynecol Pathol 33:449-62. 2014
    ..The active SST components stained for inhibin, steroidogenic factor 1, and α-smooth muscle actin, but were negative or occasionally weakly positive for desmin. ..
  26. ncbi Ovarian endometrioid tumors of low malignant potential: a clinicopathologic study of 30 cases with comparison to well-differentiated endometrioid adenocarcinoma
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine and Hospital, Indianapolis, 46202 5280, USA
    Am J Surg Pathol 27:1253-9. 2003
    ..Thus, the prognosis of ETLMP, when defined by the above criteria, is favorable and is superior to that of well-differentiated endometrioid adenocarcinoma...
  27. doi On the histogenesis of mixed germ cell-sex cord stromal tumour of the gonads
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Clin Pathol . 2016
    ..In this investigation, we present additional evidence regarding the nature of the germ cells in testicular MGC-SCST...
  28. doi Perspectives on testicular germ cell neoplasms
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202 Electronic address
    Hum Pathol 59:10-25. 2017
    ..Integration of classical morphologic observations and emerging novel molecular studies will result in better understanding of the pathogenesis of GCTs and will optimize patient therapy...
  29. doi Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana
    Int J Gynecol Pathol 34:528-34. 2015
    ..Compared with other transcription factors studied, TSPY and its congener TSPYL1 have little value in the assessment of germ cell tumors because of their relatively wide range of expression in normal adult testis and in germ cell tumors. ..
  30. doi Perspectives on signet ring stromal cell tumor and related signet ring cell lesions of the gonads
    Lawrence M Roth
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN Department of Pathology, University of California Irvine, Irvine, CA
    Adv Anat Pathol 21:443-9. 2014
    ..The most useful antibodies in this regard are epithelial membrane antigen and vimentin. ..
  31. ncbi Two-tier grading system for ovarian epithelial cancer: has its time arrived?
    Lawrence M Roth
    Am J Surg Pathol 31:1285-7. 2007