Ernest B Izevbigie

Summary

Affiliation: Jackson State University
Country: USA

Publications

  1. pmc Aqueous Vernomia amygdalina extracts alter MCF-7 cell membrane permeability and efflux
    Michael M Opata
    The Laboratory of Phytoceuticals, and Cancer Prevention and Therapies Department of Biology, Jackson State University, 1400 J R Lynch Street, P O Box 18540, Jackson, MS 39217, USA
    Int J Environ Res Public Health 3:174-9. 2006
  2. ncbi request reprint Ethanol modulates the growth of human breast cancer cells in vitro
    Ernest B Izevbigie
    The Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and Center for Environmental Health, Jackson State University, Jackson, Mississippi 39217, USA
    Exp Biol Med (Maywood) 227:260-5. 2002
  3. ncbi request reprint Discovery of water-soluble anticancer agents (edotides) from a vegetable found in Benin City, Nigeria
    Ernest B Izevbigie
    Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and Center for Environmental Health, Jackson State University, Jackson, Mississippi 39217, USA
    Exp Biol Med (Maywood) 228:293-8. 2003
  4. doi request reprint Isolation and characterization of the antibreast carcinoma cell growth components of Vernonia amygdalina extracts
    Xuan Luo
    Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA
    Exp Biol Med (Maywood) 235:1472-8. 2010
  5. pmc Vernonia amygdalina: anticancer activity, authentication, and adulteration detection
    Lecia J Gresham
    The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies, Jackson State University, Jackson, MS 39217, USA
    Int J Environ Res Public Health 5:342-8. 2008
  6. ncbi request reprint A novel natural inhibitor of extracellular signal-regulated kinases and human breast cancer cell growth
    Ernest B Izevbigie
    The Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and National Institutes of Health Center for Environmental Health, Jackson State University, Mississippi 39217, USA
    Exp Biol Med (Maywood) 229:163-9. 2004
  7. pmc Activity markers of the anti-breast carcinoma cell growth fractions of Vernonia amygdalina extracts
    Daniel A Oyugi
    Department of Biology, Jackson State University, Jackson, MS 39217, USA
    Exp Biol Med (Maywood) 234:410-7. 2009
  8. pmc Isolation and structure determination of a sesquiterpene lactone (vernodalinol) from Vernonia amygdalina extracts
    Xuan Luo
    Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA
    Pharm Biol 49:464-70. 2011
  9. ncbi request reprint Ethanol abrogates angiotensin II-stimulated vascular smooth muscle cell growth
    Monique L Cain
    Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and National Institutes of Health Center for Environmental Health, Jackson State University, Jackson, MS 39217, USA
    Med Sci Monit 12:BR162-8. 2006
  10. pmc Sensitivity and mechanisms of taxol-resistant prostate adenocarcinoma cells to Vernonia amygdalina extract
    Keyuna S Cameron
    The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies, United States
    Exp Toxicol Pathol 65:759-65. 2013

Collaborators

  • Carolyn B Howard
  • Yan Jiang
  • Xuan Luo
  • Ken S Lee
  • Daniel A Oyugi
  • Keyuna S Cameron
  • Cuiwu Lin
  • Lecia J Gresham
  • Monique L Cain
  • Michael M Opata
  • Paul B Tchounwou
  • Brandon J Hill
  • Frank R Fronczek
  • Brandon Hill
  • Jetaime Ross
  • Robert L Hester

Detail Information

Publications10

  1. pmc Aqueous Vernomia amygdalina extracts alter MCF-7 cell membrane permeability and efflux
    Michael M Opata
    The Laboratory of Phytoceuticals, and Cancer Prevention and Therapies Department of Biology, Jackson State University, 1400 J R Lynch Street, P O Box 18540, Jackson, MS 39217, USA
    Int J Environ Res Public Health 3:174-9. 2006
    ..05). The amount of [3H]thymidine released into the medium was 1.7, 7.4, and 11.0 % for 0, 30, and 100 mug/ml VA respectively. Thus suggesting the membranes in VA-treated cells were compromised in a concentration-dependent fashion...
  2. ncbi request reprint Ethanol modulates the growth of human breast cancer cells in vitro
    Ernest B Izevbigie
    The Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and Center for Environmental Health, Jackson State University, Jackson, Mississippi 39217, USA
    Exp Biol Med (Maywood) 227:260-5. 2002
    ..02), and subsequent cell growth by 200% (P < 0.05) in a MEK1 inhibitor (PD098059)-sensitive fashion, thus suggesting that the Ras/MEK/MAPK signaling pathways are crucial for ethanol-induced MCF-7 cell growth...
  3. ncbi request reprint Discovery of water-soluble anticancer agents (edotides) from a vegetable found in Benin City, Nigeria
    Ernest B Izevbigie
    Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and Center for Environmental Health, Jackson State University, Jackson, Mississippi 39217, USA
    Exp Biol Med (Maywood) 228:293-8. 2003
    ..005). These results suggest that VA vegetable, if incorporated in the diet, may prevent or delay the on-set of breast cancer...
  4. doi request reprint Isolation and characterization of the antibreast carcinoma cell growth components of Vernonia amygdalina extracts
    Xuan Luo
    Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA
    Exp Biol Med (Maywood) 235:1472-8. 2010
    ..Further purification of A2B by high-speed countercurrent chromatography and confirmed by spectroscopic analysis revealed that the major active components of A2B (65% by weight) were steroid glucosides...
  5. pmc Vernonia amygdalina: anticancer activity, authentication, and adulteration detection
    Lecia J Gresham
    The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies, Jackson State University, Jackson, MS 39217, USA
    Int J Environ Res Public Health 5:342-8. 2008
    ..2 and 1 kbp genomic DNA that were Eco RI-insensitive but Hind III and Bam HI-sensitive. These pieces of information may be used to enhance the safety of medicinal botanical VA through authentication, and adulteration detection...
  6. ncbi request reprint A novel natural inhibitor of extracellular signal-regulated kinases and human breast cancer cell growth
    Ernest B Izevbigie
    The Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and National Institutes of Health Center for Environmental Health, Jackson State University, Mississippi 39217, USA
    Exp Biol Med (Maywood) 229:163-9. 2004
    ..In addition, the ERK signaling pathways may be one or more of the intracellular targets for V. amygdalina antineoplastic actions...
  7. pmc Activity markers of the anti-breast carcinoma cell growth fractions of Vernonia amygdalina extracts
    Daniel A Oyugi
    Department of Biology, Jackson State University, Jackson, MS 39217, USA
    Exp Biol Med (Maywood) 234:410-7. 2009
    ..Interestingly, all active fractions exhibited HPLC peaks at approximately 2 min. Therefore, the UV and HPLC peaks may be used as predictive tools to determine VA extracts activities...
  8. pmc Isolation and structure determination of a sesquiterpene lactone (vernodalinol) from Vernonia amygdalina extracts
    Xuan Luo
    Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA
    Pharm Biol 49:464-70. 2011
    ..VA; Asteraceae or Compositae) is a small tree growing throughout tropical Africa. It is widely used for food and medicinal purposes by local people. It was reported that it had several qualities, including anticancer activity...
  9. ncbi request reprint Ethanol abrogates angiotensin II-stimulated vascular smooth muscle cell growth
    Monique L Cain
    Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and National Institutes of Health Center for Environmental Health, Jackson State University, Jackson, MS 39217, USA
    Med Sci Monit 12:BR162-8. 2006
    ....
  10. pmc Sensitivity and mechanisms of taxol-resistant prostate adenocarcinoma cells to Vernonia amygdalina extract
    Keyuna S Cameron
    The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies, United States
    Exp Toxicol Pathol 65:759-65. 2013
    ..This study shows that TAX-resistant PC-3 cells are sensitive to VA, perhaps explained by differential regulatory patterns of MAPK, c-Myc, AKT, and Pgp activities/expressions...